CXCR
Les CXCR sont une sous-famille de GPCR qui se lient aux chimiokines, de petites protéines de signalisation qui guident le déplacement des cellules immunitaires vers les sites d'inflammation, d'infection ou de lésion. Les CXCR jouent des rôles cruciaux dans les réponses immunitaires, la métastase du cancer et les maladies inflammatoires. Les modulateurs des CXCR sont étudiés pour leur potentiel dans le traitement des maladies auto-immunes, du cancer et des affections inflammatoires chroniques. Chez CymitQuimica, nous offrons une gamme de modulateurs de CXCR de haute qualité pour soutenir vos recherches en immunologie, oncologie et inflammation.
158 produits trouvés pour "CXCR"
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KRH-1636
CAS :KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.Formule :C32H37N7O2Couleur et forme :SolidMasse moléculaire :551.68SB02024
CAS :SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.Formule :C16H22F3N3O2Couleur et forme :SolidMasse moléculaire :345.36SCH 546738
CAS :SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.Formule :C23H31Cl2N7ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :492.45SX-517
CAS :SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.Formule :C19H16BFN2O3SDegré de pureté :99.9% - 99.90%Couleur et forme :SolidMasse moléculaire :382.22HF51116
CAS :HF51116 blocks XCR4, hinders SDF-1α cell effects & HIV-1; potential for HIV, stem cells, cancer spread.Formule :C29H46N8OCouleur et forme :SolidMasse moléculaire :522.73Burixafor hydrobromide
CAS :Burixafor hydrobromide is an oral CXCR4 blocker with anti-angiogenic properties, potentially treating choroid neovascularization.Formule :C27H52BrN8O3PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.644GSK812397
CAS :GSK812397 inhibits X4-tropic HIV-1 with high potency, targeting CXCR4 receptor noncompetitively and showing broad efficacy and good pharmacokinetics.Formule :C24H32N6OCouleur et forme :SolidMasse moléculaire :420.55CXCR4 antagonist 8
CAS :CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.Formule :C21H26N6Couleur et forme :SolidMasse moléculaire :362.47HF50731
CAS :HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).Formule :C26H46N4Couleur et forme :SolidMasse moléculaire :414.67TN-14003
CAS :TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.Formule :C90H141N33O18S2Couleur et forme :SolidMasse moléculaire :2037.42FC131
CAS :CXCR4 antagonistFormule :C36H47N11O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :729.83BC-1485
CAS :BC-1485 is a small molecule inhibitor of FIEL1 that inhibits the degradation of PIAS4 and ameliorates fibrosis in a mouse model.Formule :C19H21N5O5SDegré de pureté :97.03% - 97.15%Couleur et forme :SolidMasse moléculaire :431.47GPR35 agonist 1
CAS :GPR35 agonist 1 is a highly effective and specific GPR35/CXCR8 agonist (EC50: 5.8 nM).Formule :C10H4BrN5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.07VUF11211
CAS :VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.Formule :C26H35Cl2N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.49PS372424
CAS :PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.Formule :C33H44N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :588.74AZ10397767
CAS :AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.Formule :C15H14ClFN4O2S2Couleur et forme :SolidMasse moléculaire :400.88AMD 3465
CAS :AMD 3465 (GENZ-644494) blocks CXCR4, hinders X4 HIV replication (IC50: 1-10 nM), ineffective against R5 viruses, IC50: 0.75 nM (12G5 mAb), 18 nM (CXCL12AF647).Formule :C24H38N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :410.60Mavorixafor
CAS :Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.Formule :C21H27N5Degré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :349.47Ref: TM-TQ0174
1mg39,00€2mg50,00€5mg84,00€10mg123,00€25mg215,00€50mg348,00€100mg557,00€1mL*10mM (DMSO)92,00€IT1t dihydrochloride
CAS :IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.Formule :C21H36Cl2N4S2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :479.57Ref: TM-T11693L
2mg34,00€5mg50,00€10mg92,00€25mg166,00€50mg289,00€100mg420,00€200mg583,00€1mL*10mM (DMSO)56,00€AZD8797
CAS :AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.Formule :C19H25N5OS2Degré de pureté :98.73% - 99.68%Couleur et forme :SolidMasse moléculaire :403.56Ref: TM-T14384
1mg80,00€5mg170,00€10mg253,00€25mg442,00€50mg620,00€100mg845,00€1mL*10mM (DMSO)187,00€AZD8309
CAS :AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.
Formule :C15H14F2N4O2S2Degré de pureté :98.35% - 99.67%Couleur et forme :SolidMasse moléculaire :384.42Elubrixin
CAS :Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).Formule :C17H17Cl2FN4O4SDegré de pureté :98.65% - 99.78%Couleur et forme :SolidMasse moléculaire :463.31Ref: TM-T11179
1mg109,00€5mg235,00€10mg349,00€25mg532,00€50mg745,00€100mg999,00€200mg1.333,00€1mL*10mM (DMSO)253,00€NUCC-390
CAS :NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.Formule :C23H33N5ODegré de pureté :97.08%Couleur et forme :SolidMasse moléculaire :395.54Ref: TM-T12269
1mg109,00€5mg260,00€10mg409,00€25mg730,00€50mg1.018,00€100mg1.369,00€200mg1.783,00€1mL*10mM (DMSO)268,00€Pentixafor
CAS :Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emissionFormule :C60H80N14O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1221.36(R,R)-CXCR2-IN-2
CAS :'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'Formule :C18H23ClN2O5SCouleur et forme :SolidMasse moléculaire :414.9(±)-AMG 487
AMG 487 is an effective and selective antagonist of chemokine receptor 3.Formule :C32H28F3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.59NUCC-390 dihydrochloride (1060524-97-1 free base)
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.Formule :C23H35Cl2N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.46CXCR2 antagonist 2
CAS :CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.Formule :C17H17FN2O4SCouleur et forme :SolidMasse moléculaire :364.39E6130
CAS :E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.Formule :C28H37ClF3N3O3Couleur et forme :SolidMasse moléculaire :556.06AMD-3329 hydrobromide
CAS :AMD-3329 hydrobromide: strong, selective anti-HIV agent, blocks virus replication by targeting CXCR4 co-receptor.Formule :C34H58Br8N8Couleur et forme :SolidMasse moléculaire :1218.13AMD-3329 free base
CAS :AMD-3329 is a potent anti-HIV agent that blocks virus replication by targeting CXCR4, a key receptor for X4 viruses' entry.Formule :C34H50N8Couleur et forme :SolidMasse moléculaire :570.81AZD0233
CAS :AZD0233, Oral CX3CR1 antagonist, modulates CX3CR1/CX3CL1 axis, improves cardiac function in DCM models.Formule :C19H29FN6O4SCouleur et forme :SolidMasse moléculaire :456.54CXCR4 antagonist 7
CAS :Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.Formule :C15H17N5O3Couleur et forme :SolidMasse moléculaire :315.33CXCR4 antagonist 6
CAS :CXCR4 antagonist 6 is a potent small-molecule inhibitor of CXCL12/CXCR4 signaling that suppresses cell migration and metastasis in cancer models.Formule :C21H30N6Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :366.5CXCR2-IN-2
CAS :CXCR2-IN-2, Selective CXCR2 antagonist (IC50=5.2 nM), BBB penetration, oral bioavailability, inhibits Gro-α-induced CD11b expression in blood.Formule :C18H23ClN2O5SCouleur et forme :SolidMasse moléculaire :414.9Ladarixin Sodium
CAS :Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.Formule :C11H12F3NNaO6S2Couleur et forme :SolidMasse moléculaire :398.32CXCR2 antagonist 3
CAS :Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.Formule :C17H15FN2O4SCouleur et forme :SolidMasse moléculaire :362.38TIQ-15
CAS :TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.Formule :C23H32N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.53CXCR2-IN-1
CAS :CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.Formule :C19H20Cl2FN3O4SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :476.35ACT-777991
CAS :ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.Formule :C20H20F6N8O2SCouleur et forme :SolidMasse moléculaire :550.48ACT-672125
CAS :ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.Formule :C25H25F3N10O2SCouleur et forme :SolidMasse moléculaire :586.59CXCR4 modulator-1
CAS :CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.Formule :C23H27N5O2Couleur et forme :SolidMasse moléculaire :405.49CXCR2 antagonist 7
CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.Formule :C14H14F2N6OSCouleur et forme :SolidMasse moléculaire :352.36CXCR2 antagonist 4
CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.Formule :C15H14F2N4OS2Couleur et forme :SolidMasse moléculaire :368.42(R)-SCH 546738
CAS :(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.Formule :C23H31Cl2N7OCouleur et forme :SolidMasse moléculaire :492.45SCH 563705
CAS :SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Formule :C23H27N3O5Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :425.48CCX662
CAS :CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.Formule :C28H37N5O4SCouleur et forme :SolidMasse moléculaire :539.69CXCR2 antagonist 5
CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).
Formule :C15H14F2N4O2SCouleur et forme :SolidMasse moléculaire :352.36Paeoniflorin-6′-O-benzene sulfonate
CAS :Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.Formule :C29H32O13SCouleur et forme :SolidMasse moléculaire :620.622CXCR7 modulator 2
CAS :CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.Formule :C29H42N6O3Couleur et forme :SolidMasse moléculaire :522.68
