CXCR
Les CXCR sont une sous-famille de GPCR qui se lient aux chimiokines, de petites protéines de signalisation qui guident le déplacement des cellules immunitaires vers les sites d'inflammation, d'infection ou de lésion. Les CXCR jouent des rôles cruciaux dans les réponses immunitaires, la métastase du cancer et les maladies inflammatoires. Les modulateurs des CXCR sont étudiés pour leur potentiel dans le traitement des maladies auto-immunes, du cancer et des affections inflammatoires chroniques. Chez CymitQuimica, nous offrons une gamme de modulateurs de CXCR de haute qualité pour soutenir vos recherches en immunologie, oncologie et inflammation.
167 produits trouvés pour "CXCR".
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AMD-3329 hydrobromide
CAS :AMD-3329 hydrobromide: strong, selective anti-HIV agent, blocks virus replication by targeting CXCR4 co-receptor.Formule :C34H58Br8N8Couleur et forme :SolidMasse moléculaire :1218.13TIQ-15
CAS :TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.Formule :C23H32N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.53E6130
CAS :E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.Formule :C28H37ClF3N3O3Couleur et forme :SolidMasse moléculaire :556.06NUCC-390 dihydrochloride (1060524-97-1 free base)
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.Formule :C23H35Cl2N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.46Pentixafor
CAS :Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emissionFormule :C60H80N14O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1221.36CXCR4 antagonist 7
CAS :Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.Formule :C15H17N5O3Couleur et forme :SolidMasse moléculaire :315.33CXCR2-IN-1
CAS :CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.Formule :C19H20Cl2FN3O4SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :476.35CXCR2 antagonist 4
CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.Formule :C15H14F2N4OS2Couleur et forme :SolidMasse moléculaire :368.42CCX662
CAS :CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.Formule :C28H37N5O4SCouleur et forme :SolidMasse moléculaire :539.69CX3CR1-IN-2
CAS :CX3CR1-IN-2 (Compound 77) is a CX3CR1 inhibitor with an IC50 value of 0.04 μM. It effectively blocks the interaction between CX3CR1 and its ligand, fractalkine (CX3CL1). CX3CR1-IN-2 is useful in research on cardiovascular diseases, such as heart failure and cardiomyopathy.Formule :C19H24F3N5O4S2Masse moléculaire :507.55EMU-116
CAS :EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.Formule :C25H35N5Couleur et forme :SolidMasse moléculaire :405.58CXCR2 antagonist 7
CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.Formule :C14H14F2N6OSCouleur et forme :SolidMasse moléculaire :352.36CXCR2 antagonist 5
CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).Formule :C15H14F2N4O2SCouleur et forme :SolidMasse moléculaire :352.36DF-003
CAS :DF-003 is a selective, orally active, ATP-competitive ALPK1 inhibitor capable of crossing the blood-brain barrier. It effectively inhibits human ALPK1 and ALPK1[T237M] with IC50 values of 1.5 nM and 16 nM, respectively. The compound exhibits selectivity over the nearest kinase by more than 860-fold. DF-003 suppresses the upregulation of TNF, CXCL10, or CXCL8 in HEK-293 cells. It has applications in the study of retinopathy, optic nerve edema, splenomegaly, anhidrosis, and headaches associated with ROSAH syndrome.Formule :C24H21ClF2N4OSMasse moléculaire :486.97(R)-SCH 546738
CAS :(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.Formule :C23H31Cl2N7OCouleur et forme :SolidMasse moléculaire :492.45CXCR7 modulator 2
CAS :CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.Formule :C29H42N6O3Couleur et forme :SolidMasse moléculaire :522.68Paeoniflorin-6′-O-benzene sulfonate
CAS :Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.Formule :C29H32O13SCouleur et forme :SolidMasse moléculaire :620.622ACT-777991
CAS :ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.Formule :C20H20F6N8O2SCouleur et forme :SolidMasse moléculaire :550.48CXCR2 antagonist 6
CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).Formule :C17H16F2N4OSCouleur et forme :SolidMasse moléculaire :362.4CXCR7 antagonist-1 hydrochloride
CAS :CXCR7 antagonist-1 hydrochloride, Inhibits SDF-1 (CXCL12) or I-TAC binding to CXCR7, used for tumor and inflammation research.Formule :C21H20ClFN6ODegré de pureté :99.84%Couleur et forme :Gray SolidMasse moléculaire :426.87
