TLR
Les récepteurs de type Toll (TLR) sont une classe de protéines qui jouent un rôle crucial dans le système immunitaire inné en reconnaissant les motifs moléculaires associés aux pathogènes (PAMP) et en initiant des réponses immunitaires. Les TLR sont impliqués dans la détection d'une large gamme de pathogènes, y compris les bactéries, les virus et les champignons, et sont essentiels pour l'activation des voies de signalisation inflammatoires. La dérégulation de la signalisation des TLR est associée à des maladies inflammatoires chroniques, des troubles auto-immuns et le cancer. Chez CymitQuimica, nous offrons une variété de modulateurs TLR de haute qualité pour soutenir vos recherches sur l'immunité innée, l'inflammation et les maladies infectieuses.
66 produits trouvés pour "TLR"
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TLR7/8 agonist 3
CAS :<p>TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.</p>Formule :C17H23N5ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :313.4CU-T12-9
CAS :<p>CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).</p>Formule :C17H13F3N4O2Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :362.31CU-CPT17e
CAS :<p>CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).</p>Formule :C27H24N2O8Degré de pureté :98.49%Couleur et forme :SolidMasse moléculaire :504.49IAXO-102
CAS :<p>IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.</p>Formule :C35H71NO5Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :585.94BMS-905
CAS :<p>BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.</p>Formule :C23H29N3Degré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :347.5CU-CPT22
CAS :<p>CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).</p>Formule :C19H22O7Degré de pureté :98.66% - 99.8%Couleur et forme :SolidMasse moléculaire :362.37TLR7/8 agonist 12
<p>TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.</p>Formule :C29H38N6O3Couleur et forme :SolidMasse moléculaire :518.65Ezeprogind
CAS :<p>Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can Trust</p>Formule :C25H44N6Degré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :428.66TLR7 agonist 17
CAS :<p>TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].</p>Formule :C25H37N7O3Couleur et forme :SolidMasse moléculaire :483.61TLR8 agonist 7
CAS :<p>TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.</p>Formule :C54H63N9O16Couleur et forme :SolidMasse moléculaire :1094.13TLR8 agonist 8
CAS :<p>TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.</p>Formule :C53H63N11O10Couleur et forme :SolidMasse moléculaire :1014.14Tomaralimab
CAS :<p>Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).</p>Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :145.32 kDaCU-115
CAS :<p>CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively.</p>Formule :C21H11F7INO2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :569.21Pam3CSK4-Biotin
CAS :<p>Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.</p>Formule :C103H192N14O17S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1962.85Pam2CSK4
CAS :<p>TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.</p>Formule :C65H126N10O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1271.83MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA
<p>MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA is the trifluoroacetate form of MC-Val-Cit-PAB-Amide-TLR7 agonist 4,a HER2-TLR7 and HER2- TLR8 immune agonist complexes.</p>Formule :C54H73F3N12O13Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :1155.22CRX 527
CAS :<p>CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.</p>Formule :C81H151N2O19PCouleur et forme :SolidMasse moléculaire :1488.04MTvkPABC-P5 TFA
<p>MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).</p>Couleur et forme :Odour SolidDesethyl chloroquine diphosphate
CAS :<p>Desethyl chloroquine diphosphate is the active metabolite of Desethylchloroquine, an inhibitor of TLRs with antiplasmodial activity and inhibition of autophagy.</p>Formule :C16H28ClN3O8P2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :487.81TLR7 agonist 3
CAS :<p>TLR7 agonist 3 is a Toll-like receptor 7 (TLR7) agonist that has anticancer activity and is used in the study of diseases of the immune system.</p>Formule :C18H24N4ODegré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :312.41Neoseptin-3
CAS :<p>Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2.</p>Formule :C29H34N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.59Toll-like receptor modulator
CAS :<p>Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.</p>Formule :C15H13F5N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.27Pam3CSK4
CAS :<p>Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.</p>Formule :C81H156N10O13SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1510.23Bropirimine
CAS :<p>Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.</p>Formule :C10H8BrN3ODegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :266.09TLR7 agonist 2
CAS :<p>TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).</p>Formule :C17H16N6O2Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :336.35TLR7/8 agonist 1
CAS :<p>TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.</p>Formule :C22H25N5Degré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :359.47Telratolimod
CAS :<p>Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.</p>Formule :C36H59N5O2Degré de pureté :98.61%Couleur et forme :SolidMasse moléculaire :593.89Enpatoran
CAS :<p>Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM).</p>Formule :C16H15F3N4Degré de pureté :97.08% - 99.38%Couleur et forme :SolidMasse moléculaire :320.31Gardiquimod
CAS :<p>Gardiquimod, an imidazoquinoline TLR7 agonist, inhibits HIV-1 in macrophages and PBMCs under 10μM.</p>Formule :C17H23N5ODegré de pureté :98.02% - 99.68%Couleur et forme :SolidMasse moléculaire :313.4CU-CPT-8m
CAS :<p>CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)</p>Formule :C14H12N4ODegré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :252.27SM-324405
CAS :<p>SM-324405 is an agonist of TLR7.</p>Formule :C19H23N5O4Degré de pureté :97.83%Couleur et forme :SolidMasse moléculaire :385.42CU-CPT9b
CAS :<p>CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).</p>Formule :C16H13NO2Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :251.28MD2-IN-1
CAS :<p>MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM for the recombinant human MD2 (rhMD2).</p>Formule :C20H22O6Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :358.39C29
CAS :<p>C29 inhibits TLR2/1 and TLR2/6 in human cells, but only TLR2/1 in mouse macrophages.</p>Formule :C16H15NO4Degré de pureté :96.34% - 97.37%Couleur et forme :SolidMasse moléculaire :285.29TLR3-IN-1
CAS :<p>TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the TNF-α and IL-1β.</p>Formule :C18H13ClFNO3SDegré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :377.82CU-CPT-9a
CAS :<p>CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-</p>Formule :C17H15NO2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :265.31TLR7/8/9-IN-1
CAS :<p>TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.</p>Formule :C27H37N3O2Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :435.6Pam3CSK4 TFA (112208-00-1 free base)
CAS :<p>Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2.Cost-effective and quality-assured.</p>Formule :C87H159F9N10O19SDegré de pureté :96.4% - 99.01%Couleur et forme :SolidMasse moléculaire :1852.33TLR4-IN-C34
CAS :<p>TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis</p>Formule :C17H27NO9Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :389.41V209
CAS :<p>1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.</p>Formule :C16H17N5O5Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :359.34TH1020
CAS :<p>TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.</p>Formule :C23H15N7S2Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :453.54Motolimod
CAS :<p>Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.</p>Formule :C28H34N4O2Degré de pureté :97.43% - 99.66%Couleur et forme :SolidMasse moléculaire :458.6TLR7/8 agonist 1 dihydrochloride
CAS :<p>TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.</p>Formule :C22H27Cl2N5Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :432.39Robinin
CAS :<p>Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.</p>Formule :C33H40O19Degré de pureté :98.78% - 99.13%Couleur et forme :SolidMasse moléculaire :740.66Paridiprubart
CAS :<p>Paridiprubart (NI-0101) is a humanised monoclonal antibody targeting TLR4, ameliorative effects in COVID-19 patients with ARDS and rheumatoid arthritis.</p>Degré de pureté :95% - 95%Couleur et forme :LiquidCL264
CAS :<p>CL264, a selective agonist of TLR7, can be used in studies about innate immune signals.</p>Formule :C19H23N7O4Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :413.43AXC-715 trihydrochloride
CAS :<p>AXC-715 trihydrochloride is a TLR7/8 agonist used to make PD-L1 adjuvanted antibody immunocouplings.</p>Formule :C18H28Cl3N5Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :420.81TLR7 agonist 1
CAS :<p>TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).</p>Formule :C21H25N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :363.46AZD8848
CAS :<p>AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.</p>Formule :C29H43N7O5Couleur et forme :SolidMasse moléculaire :569.7TL8-506
CAS :<p>TL8-506 is a selective and potent TLR8 agonist that induces cytokine and chemokine production.TL8-506 alleviates inflammatory and autoimmune diseases.</p>Formule :C20H17N3O2Degré de pureté :95% - 99.97%Couleur et forme :SolidMasse moléculaire :331.37
