TLR
Les récepteurs de type Toll (TLR) sont une classe de protéines qui jouent un rôle crucial dans le système immunitaire inné en reconnaissant les motifs moléculaires associés aux pathogènes (PAMP) et en initiant des réponses immunitaires. Les TLR sont impliqués dans la détection d'une large gamme de pathogènes, y compris les bactéries, les virus et les champignons, et sont essentiels pour l'activation des voies de signalisation inflammatoires. La dérégulation de la signalisation des TLR est associée à des maladies inflammatoires chroniques, des troubles auto-immuns et le cancer. Chez CymitQuimica, nous offrons une variété de modulateurs TLR de haute qualité pour soutenir vos recherches sur l'immunité innée, l'inflammation et les maladies infectieuses.
87 produits trouvés pour "TLR".
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TLR7/8 agonist 3
CAS :TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.Formule :C17H23N5ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :313.4Ref: TM-T13167
1mg60,00€5mg133,00€1mL*10mM (DMSO)147,00€10mg215,00€25mg349,00€50mg482,00€100mg665,00€200mg893,00€CU-CPT22
CAS :CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).Formule :C19H22O7Degré de pureté :98.66% - 99.80%Couleur et forme :Red SolidMasse moléculaire :362.37Ref: TM-T15020
1mg49,00€2mg66,00€5mg94,00€1mL*10mM (DMSO)108,00€10mg159,00€25mg296,00€50mg444,00€100mg647,00€200mg888,00€IAXO-102
CAS :IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.Formule :C35H71NO5Degré de pureté :98.17%Couleur et forme :White SolidMasse moléculaire :585.94CU-CPT17e
CAS :CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).Formule :C27H24N2O8Degré de pureté :98.49%Couleur et forme :White SolidMasse moléculaire :504.49CU-T12-9
CAS :CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Formule :C17H13F3N4O2Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :362.31Ref: TM-T15017
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg160,00€25mg268,00€50mg409,00€100mg583,00€BMS-905
CAS :BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.Formule :C23H29N3Degré de pureté :99.94%Couleur et forme :White SolidMasse moléculaire :347.5Pam3CSK4
CAS :Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.Formule :C81H156N10O13SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1510.23Lipopolysaccharides, from Klebsiella pneumoniae
Lipopolysaccharides from Klebsiella pneumoniae (LPS, from bacterial [Klebsiella pneumoniae]) are lipid-polysaccharide endotoxins and TLR4 activators originating from Klebsiella pneumoniae, classified as S-type LPS. They exhibit a characteristic tripartite structure comprising an O-antigen, a core oligosaccharide, and lipid A. These lipopolysaccharides may contribute to bacterial immune evasion by inhibiting complement-mediated killing and suppressing host antimicrobial peptide secretion, thus helping bacteria evade immune defenses. Possessing high viscosity and serum resistance, they can potentially induce sepsis. Additionally, these lipopolysaccharides are utilized in the development of animal models for sepsis/septicemia.MTT5
MTT5, a toll-like receptor 7 (TLR7) agonist, can be conjugated with Deruxtecan to exert antitumor activity in HER2-positive solid tumors through tumor cell killing and immune activation.Formule :C22H27N7O4Couleur et forme :SolidMasse moléculaire :453.49TLR7 agonist 21
TLR7 agonist21 (Compound 27B) is a selective activator of Toll-like receptor 7 (TLR7), with an EC50 of 17.53 nM for human TLR7 and 41.7 nM for mouse TLR7. It induces the secretion of pro-inflammatory cytokines, including IL-6, TNF-α, IFN-α1, and IL-4. Acting as a vaccine adjuvant, TLR7 agonist21 enhances IgG and IgA levels, offering protection for mice against influenza virus infection.Formule :C22H33N7OMasse moléculaire :411.27466TLR2 antagonist-1
TLR2antagonist-1 is a selective antagonist of Toll-like receptor 2 (TLR2). It effectively inhibits excessive activation of TLR2, with an IC50 value of 11.41 μM, and reduces the production of inflammatory factors. TLR2antagonist-1 exhibits metabolic stability, with a half-life (T1/2) of 16.67 minutes in mouse liver microsomes. This compound is useful for research in inflammation, immunology, and neurological disorders.PTD-N5-1
CAS :PTD-N5-1 (N5-1) is an IRF5 inhibitory peptide. It can block the production of IL-12 induced by β-glucan in both wild-type and Clec2d-deficient bone marrow-derived dendritic cells (BMDC) that are activated by IFN-γ. PTD-N5-1 modulates antifungal immunity by inhibiting IRF5-mediated IL-12 production.Formule :C148H248N52O30SCouleur et forme :SolidMasse moléculaire :3267.95Pam3CSK4-Biotin
CAS :Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.Formule :C103H192N14O17S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1962.85Pam2CSK4
CAS :TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.Formule :C65H126N10O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1271.83Ezeprogind
CAS :Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can TrustFormule :C25H44N6Degré de pureté :99.28%Couleur et forme :White SolidMasse moléculaire :428.66CRX 527
CAS :CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.Formule :C81H151N2O19PCouleur et forme :SolidMasse moléculaire :1488.04MTvkPABC-P5 TFA
MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).Couleur et forme :Odour SolidTLR7/8 agonist 12
TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.Formule :C29H38N6O3Couleur et forme :SolidMasse moléculaire :518.65TLR8 agonist 8
CAS :TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.Formule :C53H63N11O10Couleur et forme :SolidMasse moléculaire :1014.14TLR8 agonist 7
CAS :TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.Formule :C54H63N9O16Couleur et forme :SolidMasse moléculaire :1094.13TLR7 agonist 17
CAS :TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].Formule :C25H37N7O3Couleur et forme :SolidMasse moléculaire :483.61L07-2
CAS :L07-2 (Compound 6) is an active scaffold that includes a TLR7/8 agonist. It is suitable for the synthesis of immune-stimulating antibody conjugates (ISACs) used in cancer research.Formule :C56H83N15O14Couleur et forme :SolidMasse moléculaire :1190.35Tilsotolimod sodium
CAS :Tilsotolimod sodium, a synthetic Toll-like receptor 9 (TLR9) agonist, has shown antitumor activity in preclinical models.Formule :C223H262N74Na22O115P22S22Couleur et forme :SolidMasse moléculaire :7711.51(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 serves as the E3 ubiquitin ligase ligand and linker for PROTAC(R)-NX-2127, utilized in cancer research.Formule :C29H33N5O4Couleur et forme :SolidMasse moléculaire :515.6ODN 4084-F
CAS :ODN 4084-F, a class B ('broadly-active') inhibitory ODN, is a potent inhibitor of TLR9-induced B cells and macrophages.Couleur et forme :SolidRKH
PKH is a TLR4 antagonist, and it is a new tripeptide derived from Akkermansia muciniphila. PKH reduces inflammation-related cell activation and the overproduction of pro-inflammatory factors induced by sepsis.Formule :C18H33N9O4Couleur et forme :SolidMasse moléculaire :439.26555IPH33
IPH33 is a human monoclonal antibody (mAb) targeting TLR3/CD283. It is useful for research in cancer and inflammation.Couleur et forme :Odour LiquidTLR7 agonist 24
TLR7 agonist24 (Compound 21) is an agonist of TLR7 with an EC50 of 3.72 μM. When combined with Aluminum Hydroxide, it can be employed as a vaccine adjuvant to enhance the immune response to antigens from SARS-CoV-2 and hepatitis B.Couleur et forme :Odour SolidRKH acetate
RKH acetate offers protective effects against mortality and organ damage caused by sepsis. It can directly bind to Toll-like receptor 4 (TLR4) and inhibit TLR4 signaling in immune cells.Formule :C18H33N9O4·xC2H4O2Couleur et forme :SolidAtibuclimab
CAS :Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region.Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :145.28 kDa3D-Monophosphoryl Lipid A-5 free acid
CAS :3D-Monophosphoryl Lipid A-5 (free acid) is a TLR agonist used as an adjuvant in vaccines to enhance their immunogenicity.Formule :C82H155N2O20PCouleur et forme :SolidMasse moléculaire :1520.08CU-115
CAS :CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively.Formule :C21H11F7INO2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :569.21MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA
MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA is the trifluoroacetate form of MC-Val-Cit-PAB-Amide-TLR7 agonist 4,a HER2-TLR7 and HER2- TLR8 immune agonist complexes.Formule :C54H73F3N12O13Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :1155.22Diprovocim-1
CAS :Diprovocim-1 is a highly potent, small-molecule TLR1/TLR2 dual agonist with an EC₅₀ of 110 pM for human TLR1/TLR2.Formule :C56H56N6O6Degré de pureté :99.64%Couleur et forme :Yellow SolidMasse moléculaire :909.10PSMα3 TFA
PSMα3 TFA is a peptide utilized in directing dendritic cells (DCs) towards a tolerogenic state, pivotal for DC vaccination approaches.Anti-Dectin-1 Antibody (2M24)
Anti-Dectin-1 Antibody (2M24) is a humanized IgG1 monoclonal antibody targeting Dectin-1.CNTO-3157
CNTO-3157 is a human IgG4 monoclonal antibody (mAb) targeting TLR3/CD283. It is applicable for research in asthma and ulcerative colitis.Ste2Cys
CAS :Ste2Cys is a diacylglycerol cysteine immune adjuvant lipid molecule that binds to TLR2 and activates the NF-κB signaling pathway. It enhances the expression of MHCII molecules on the surface of mouse bone marrow-derived D1 dendritic cells. Ste2Cys is applicable in research for developing immune vaccines.Formule :C42H81NO6SMasse moléculaire :728.17TLR7 agonist 3
CAS :TLR7 agonist 3 is a Toll-like receptor 7 (TLR7) agonist that has anticancer activity and is used in the study of diseases of the immune system.Formule :C18H24N4ODegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :312.41Ref: TM-T38614
1mg73,00€5mg161,00€1mL*10mM (DMSO)172,00€10mg259,00€25mg425,00€50mg605,00€100mg803,00€Toll-like receptor modulator
CAS :Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.Formule :C15H13F5N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.27Neoseptin-3
CAS :Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2.Formule :C29H34N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.59TLR7 agonist 2
CAS :TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).Formule :C17H16N6O2Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :336.35Motolimod
CAS :Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.Formule :C28H34N4O2Degré de pureté :97.43% - 99.66%Couleur et forme :SolidMasse moléculaire :458.6TLR7/8 agonist 1 dihydrochloride
CAS :TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.Formule :C22H27Cl2N5Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :432.39Robinin
CAS :Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Formule :C33H40O19Degré de pureté :98.78% - 99.96%Couleur et forme :White SolidMasse moléculaire :740.66C29
CAS :C29 inhibits TLR2/1 and TLR2/6 in human cells, but only TLR2/1 in mouse macrophages.Formule :C16H15NO4Degré de pureté :96.34% - 97.37%Couleur et forme :SolidMasse moléculaire :285.29TLR3-IN-1
CAS :TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the TNF-α and IL-1β.Formule :C18H13ClFNO3SDegré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :377.82Ref: TM-T22698
1mg52,00€5mg103,00€1mL*10mM (DMSO)113,00€10mg168,00€25mg353,00€50mg504,00€100mg708,00€RS09 2TFA (1449566-36-2 free base)
RS09 2TFA is a TLR4 agonist enhancing NF-κB and cytokines in macrophages; it's an adjuvant that boosts X-15 antibodies.Formule :C35H51F6N9O13Degré de pureté :99.96%Couleur et forme :White SolidMasse moléculaire :919.82CU-CPT-9a
CAS :CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-Formule :C17H15NO2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :265.31Ref: TM-T7317
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg119,00€25mg225,00€50mg409,00€100mg605,00€
