TLR
Les récepteurs de type Toll (TLR) sont une classe de protéines qui jouent un rôle crucial dans le système immunitaire inné en reconnaissant les motifs moléculaires associés aux pathogènes (PAMP) et en initiant des réponses immunitaires. Les TLR sont impliqués dans la détection d'une large gamme de pathogènes, y compris les bactéries, les virus et les champignons, et sont essentiels pour l'activation des voies de signalisation inflammatoires. La dérégulation de la signalisation des TLR est associée à des maladies inflammatoires chroniques, des troubles auto-immuns et le cancer. Chez CymitQuimica, nous offrons une variété de modulateurs TLR de haute qualité pour soutenir vos recherches sur l'immunité innée, l'inflammation et les maladies infectieuses.
74 produits trouvés pour "TLR"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Robinin
CAS :Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Formule :C33H40O19Degré de pureté :98.78% - 99.13%Couleur et forme :SolidMasse moléculaire :740.66Paridiprubart
CAS :Paridiprubart (NI-0101) is a humanised monoclonal antibody targeting TLR4, ameliorative effects in COVID-19 patients with ARDS and rheumatoid arthritis.Degré de pureté :95% - 96.9% (SDS-PAGE); 98.5% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.16 kDaTLR7 agonist 1
CAS :TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).Formule :C21H25N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :363.46AXC-715 trihydrochloride
CAS :AXC-715 trihydrochloride is a TLR7/8 agonist used to make PD-L1 adjuvanted antibody immunocouplings.Formule :C18H28Cl3N5Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :420.81CL264
CAS :CL264, a selective agonist of TLR7, can be used in studies about innate immune signals.Formule :C19H23N7O4Degré de pureté :98.01% - 99.87%Couleur et forme :SolidMasse moléculaire :413.43Ref: TM-T10833
1mg49,00€5mg110,00€10mg182,00€25mg289,00€50mg399,00€100mg530,00€200mg715,00€1mL*10mM (DMSO)122,00€DSR-6434
CAS :DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.Formule :C19H28N8O2Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :400.48AZD8848
CAS :AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.Formule :C29H43N7O5Couleur et forme :SolidMasse moléculaire :569.7TLR7/8-IN-1
CAS :TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research.Cost-effective and quality-assured.Formule :C29H40N8O2Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :532.68M62812
CAS :TLR4 inhibitor blocks LPS-induced NF-κB (IC50=2.4μg/mL), cytokines in PBMCs/HUVECs, and extends life in septic shock mice.Formule :C13H13Cl2N3OSDegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :330.23AT791
CAS :AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.Formule :C23H31N3O3Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :397.51Ref: TM-T61882
1mg69,00€5mg147,00€10mg224,00€25mg358,00€50mg512,00€100mg707,00€200mg982,00€1mL*10mM (DMSO)164,00€BBIQ
CAS :BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of 59.1Formule :C21H22N4Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :330.43SM360320
CAS :SM360320 (CL-087) is a selective TLR7 agonist that blocks HCV replication in hepatocytes and aids immunology research.
Formule :C15H17N5O3Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :315.33Rabeximod
CAS :Rabeximod, an immunomodulator, eases autoimmune diseases, inhibits arthritis, and aids brain recovery post-injury by blocking inflammation.Formule :C22H24ClN5ODegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :409.91TLR7 agonist 23
CAS :TLR7 agonist23 (compound 12b) is a potent agonist of Toll-like receptor-7 (TLR7), with an EC50 value of 0.15 uM. It is suitable for research in immune diseases.Formule :C21H22N4O2Couleur et forme :SolidMasse moléculaire :362.42TLR9-IN-1
CAS :TLR9-IN-1: selective, potent human TLR9 inhibitor (IC50: 7 nM), useful for researching immune-related diseases.Formule :C23H31N7OCouleur et forme :SolidMasse moléculaire :421.541Z105
CAS :1Z105, an orally active TLR4/MD2 ligand, facilitates dendritic cell maturation and antigen presentation, thereby preventing arthritis.Formule :C25H26N4O2SCouleur et forme :SolidMasse moléculaire :446.57CU-CPD107
CAS :CU-CPD107 selectively activates TLR8 and ssRNA, inhibits TLR8 with R848 (IC50=13.7 μM), and coactivates with ssRNA.Formule :C16H21IN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.25ABR-238901
CAS :ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end productsFormule :C11H9BrClN3O4SDegré de pureté :98.71% - 99.04%Couleur et forme :SolidMasse moléculaire :394.63Ref: TM-T39115
1mg116,00€5mg281,00€10mg447,00€25mg710,00€50mg973,00€100mg1.333,00€1mL*10mM (DMSO)310,00€Creatine ethyl ester
CAS :Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.Formule :C6H13N3O2Couleur et forme :SolidMasse moléculaire :159.186SARM1-IN-5
CAS :SARM1-IN-5 (compound 1-23-a) is an inhibitor of SARM1, useful for researching diseases related to axonal degeneration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).Formule :C18H17FN6OCouleur et forme :SolidMasse moléculaire :352.37LHC-165
CAS :LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.Formule :C29H32F2N3O7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.55SARM1-IN-4
CAS :SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.Formule :C13H17F2N3O2Couleur et forme :SolidMasse moléculaire :285.29TLR7 agonist 28
CAS :TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.Formule :C26H25N9O7Couleur et forme :SolidMasse moléculaire :575.533TLR7/8/9 antagonist 2
CAS :TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.Formule :C23H31N7Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :405.54
