TGF-beta/Smad
Les inhibiteurs de la voie TGF-beta/Smad sont des composés qui interfèrent avec la voie de signalisation TGF-beta (Transforming Growth Factor-beta), médiée par les protéines Smad. Cette voie est impliquée dans la régulation de la croissance cellulaire, de la différenciation, de l'apoptose et de la fonction des cellules souches. La dérégulation de la signalisation TGF-beta/Smad est associée au cancer, à la fibrose et à d'autres maladies. Les inhibiteurs de cette voie sont des outils importants pour étudier ces conditions et développer des thérapies potentielles. Chez CymitQuimica, nous fournissons des inhibiteurs de TGF-beta/Smad pour soutenir vos recherches en signalisation cellulaire, en oncologie et en réparation des tissus.
58 produits trouvés pour "TGF-beta/Smad"
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Garetosmab
CAS :<p>Garetosmab (REGN 2477), a human IgG4 monoclonal antibody, inhibits activin A for potential cancer treatment and FOP study.</p>Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :146 kDaOxymatrine
CAS :<p>Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic.</p>Formule :C15H24N2O2Degré de pureté :98.72% - 99.72%Couleur et forme :SolidMasse moléculaire :264.36Ponsegromab
CAS :<p>Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.</p>Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.08 kDaHydrochlorothiazide
CAS :<p>Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。</p>Formule :C7H8ClN3O4S2Degré de pureté :99.43% - 99.50%Couleur et forme :Crystals Physical Description Crystals Or White Powder (Ntp 1992)Masse moléculaire :297.74Isoviolanthin
CAS :<p>Isoviolanthin, a flavonoid from Dendrobium Officinale, inhibits migration of TGF-β1-treated HCC cells, non-toxic to normal cells, potential HCC therapy.</p>Formule :C27H30O14Degré de pureté :99.25% - 99.66%Couleur et forme :SolidMasse moléculaire :578.52Tubastatin
CAS :<p>Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.</p>Formule :C21H22N2O2Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :334.41Emugrobart
<p>Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Couleur et forme :Odour LiquidCBT-295
<p>CBT-295, an orally active autotaxin (ATX) inhibitor, effectively decreases inflammatory cytokines including TGF-β, TNF-α, and IL-6, along with the bile duct proliferation marker CK-19, and ameliorates liver fibrosis. The compound's ability to reverse liver fibrosis contributes to lowered ammonia levels in the blood and brain, which in turn reduces ammonia-induced neuroinflammation. CBT-295 shows potential for the study of liver cirrhosis and related encephalopathy.</p>Formule :C18H20ClN3OCouleur et forme :SolidMasse moléculaire :329.82Linavonkibart
CAS :<p>Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.</p>Degré de pureté :97.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.4% (SDS-PAGE); 99.4% (SEC-HPLC)Couleur et forme :LiquidSotatercept
CAS :<p>Sotatercept (ACE-011) is an ActRIIA-Fc fusion protein and an inhibitor of activin signaling.</p>Degré de pureté :97% (SDS-PAGE); 97.8% (SEC-HPLC) - 97% (SDS-PAGE); 97.8% (SEC-HPLC)Couleur et forme :LiquidFresolimumab
CAS :<p>Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.</p>Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :144.4 kDaALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Formule :C20H23N7O2SCouleur et forme :SolidMasse moléculaire :425.51TGFβRI-IN-7
<p>TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.</p>Formule :C27H32N6O2Couleur et forme :SolidMasse moléculaire :472.582Cirevetmab
CAS :<p>Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa.</p>Couleur et forme :LiquidSLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS :<p>SLLK is a control peptide for LSKL.</p>Formule :C21H41N5O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.58Rilogrotug
<p>Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidLerdelimumab
CAS :<p>Lerdelimumab (CAT-152) is an IgG4 monoclonal antibody targeting TGF-β2, used in glaucoma scarring research.</p>Couleur et forme :LiquidBintrafusp alfa
CAS :<p>Bintrafusp alfa (M7824) is a protein consisting of the extracellular structural domain of TGF-βRII with a monoclonal antibody to human immunoglobulin G1.</p>Degré de pureté :96.1% (SDS-PAGE); 99.2% (SEC-HPLC) - 96.1% (SDS-PAGE); 99.2% (SEC-HPLC)Couleur et forme :LiquidSD-208
CAS :<p>SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.</p>Formule :C17H10ClFN6Degré de pureté :98.72% - 99.65%Couleur et forme :SolidMasse moléculaire :352.75SRI-011381 hydrochloride
CAS :<p>SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.</p>Formule :C20H32ClN3ODegré de pureté :99.32% - 99.41%Couleur et forme :SolidMasse moléculaire :365.94Asiaticoside
CAS :<p>Asiaticoside, in Centella asiatica, may treat wounds/burns.</p>Formule :C48H78O19Degré de pureté :98% - 99.96%Couleur et forme :PowderMasse moléculaire :959.12Chebulinic acid
CAS :<p>Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.</p>Formule :C41H32O27Degré de pureté :98.91% - 99.71%Couleur et forme :SolidMasse moléculaire :956.68(E)-SIS3
CAS :<p>(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!</p>Formule :C28H27N3O3·HClDegré de pureté :95.64% - 98%Couleur et forme :SolidMasse moléculaire :489.99R-268712
CAS :<p>R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.</p>Formule :C20H18FN5ODegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :363.39SJ000291942
CAS :<p>SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.</p>Formule :C16H15FN2O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :318.3LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Formule :C25H44F6N6O9Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :686.64Kartogenin
CAS :<p>Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.</p>Formule :C20H15NO3Degré de pureté :96.25% - 97.79%Couleur et forme :SolidMasse moléculaire :317.34ITD-1
CAS :<p>ITD-1 is a potent and highly selective TGFβ pathway inhibitor.</p>Formule :C27H29NO3Degré de pureté :99.89% - >99.99%Couleur et forme :SolidMasse moléculaire :415.52Galunisertib
CAS :<p>Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.</p>Formule :C22H19N5ODegré de pureté :97.09% - 99.98%Couleur et forme :SolidMasse moléculaire :369.42Alantolactone
CAS :<p>Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.</p>Formule :C15H20O2Degré de pureté :99.02% - 99.66%Couleur et forme :Crystalline PowderMasse moléculaire :232.32BMP signaling agonist sb4
CAS :<p>BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)</p>Formule :C14H10BrNOSDegré de pureté :99.48% - 99.805%Couleur et forme :SolidMasse moléculaire :320.2BMS986260
CAS :<p>BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).</p>Formule :C18H12ClFN6ODegré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :382.78BIO-013077-01
CAS :<p>BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.</p>Formule :C17H13N5Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :287.32Trimethylamine N-oxide dihydrate
CAS :<p>TMANO Dihydrate, from trimethylamine oxidation, stabilizes proteins against sharks' urea.</p>Formule :C3H13NO3Degré de pureté :98.75%Couleur et forme :White CrystalMasse moléculaire :111.14LY3200882
CAS :<p>LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).</p>Formule :C24H29N5O3Degré de pureté :99.46% - 99.63%Couleur et forme :SolidMasse moléculaire :435.52SRI-011381
CAS :<p>SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.</p>Formule :C20H31N3ODegré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :329.48Trevogrumab
CAS :<p>Trevogrumab is a human monoclonal antibody that inhibits myostatin (GDF8) to promote muscle growth, and is under research for treating age-related muscle loss (sarcopenia).</p>Degré de pureté :95% - 95%Couleur et forme :LiquidNisevokitug
CAS :<p>Nisevokitug (anti-TGF-β mAb) neutralizes TGF-β and is being studied for its ability to modulate the immunosuppressive tumor microenvironment.</p>Degré de pureté :95%Couleur et forme :LiquidMetelimumab
CAS :<p>Metelimumab (CAT-192) is a humanised monoclonal antibody targeting TGFβ1, which can be used to study diffuse systemic sclerosis (d-SSc).</p>Degré de pureté :95%Couleur et forme :LiquidLivmoniplimab
CAS :<p>Livmoniplimab (ABBV-151; ARGX-115) is a humanised monoclonal antibody targeting LRRC32 (GARP)/TGFβ1, which blocks TGFβ1 release mediated by LRRC32</p>Degré de pureté :95%Couleur et forme :LiquidHalofuginone
CAS :<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>Formule :C16H17BrClN3O3Degré de pureté :99.53%Couleur et forme :Off-White SolidMasse moléculaire :414.68Chromenone 1
CAS :<p>Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).</p>Formule :C18H10F3N3O2Degré de pureté :99.83% - 99.93%Couleur et forme :SolidMasse moléculaire :357.29Halofuginone hydrobromide
CAS :<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Formule :C16H17BrClN3O3·HBrDegré de pureté :97.01% - 99.73%Couleur et forme :SolidMasse moléculaire :495.59CJJ300
CAS :<p>CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.</p>Formule :C30H33N3Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :435.6(Rac)-SIS3 free base
CAS :SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Formule :C28H27N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.53TGFβRI-IN-1
CAS :<p>TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,</p>Formule :C20H14D3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.4SJ000063181
CAS :<p>SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.</p>Formule :C14H14ClFN2O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :296.723,7-DMF
CAS :3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Formule :C17H14O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29DT-6
CAS :<p>DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing</p>Formule :C89H130N20O29S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2008.23TGFβ-IN-5
CAS :<p>TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.</p>Formule :C20H16N4Degré de pureté :99.29% - 99.5%Couleur et forme :SolidMasse moléculaire :312.37Myristoyl tetrapeptide-12
CAS :<p>Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].</p>Formule :C32H63N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.89TP0427736
CAS :TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.Formule :C14H10N4S2Degré de pureté :97.26%Couleur et forme :SolidMasse moléculaire :298.39(+)-ITD-1
CAS :<p>(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).</p>Formule :C27H29NO3Couleur et forme :SolidMasse moléculaire :415.52CDD-1431
CAS :<p>CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.</p>Formule :C33H38N8O5SCouleur et forme :SolidMasse moléculaire :658.77TGFβ1-IN-1
CAS :<p>TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.</p>Formule :C22H24N2O3Degré de pureté :99.89% - 99.89%Couleur et forme :SolidMasse moléculaire :364.438TGFβRI-IN-3
CAS :<p>TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4.</p>Formule :C28H23N3O2SDegré de pureté :99.85%Couleur et forme :SoildMasse moléculaire :465.57Luspatercept
CAS :<p>Luspatercept (ACE-536), a recombinant modified ActRIIB fusion protein, selectively binds to transforming growth factor β superfamily ligands, thereby enhancing erythrocyte production and advancing the maturation of erythroid precursors. Moreover, by binding with GDF11, it inhibits Smad2/3 signaling. This compound is instrumental in anemia research [1].</p>Couleur et forme :LiquidDCN1-IN-2
CAS :<p>DCN1-IN-2, a DCN1 inhibitor, exhibits potent activity with an IC 50 of 2.96 nM. It effectively mitigates Ang II/TGFβ-induced activation of cardiac fibroblasts and diminishes ISO-induced cardiac fibrosis and remodeling in mice through the selective inhibition of cullin 3.</p>Formule :C18H14ClF3N4OSCouleur et forme :SolidMasse moléculaire :426.84
