MALT
Le tissu lymphoïde associé aux muqueuses (MALT) est un composant essentiel du système immunitaire qui protège les surfaces muqueuses contre les agents pathogènes. Le MALT comprend des structures telles que les amygdales, les plaques de Peyer et l'appendice, qui sont impliquées dans l'initiation des réponses immunitaires aux antigènes rencontrés au niveau des surfaces muqueuses. La recherche sur le MALT est cruciale pour comprendre les mécanismes de l'immunité muqueuse et pour le développement de vaccins et de traitements contre les infections muqueuses. Chez CymitQuimica, nous offrons une gamme de réactifs et d'outils pour soutenir vos recherches en immunologie muqueuse, inflammation et maladies infectieuses.
23 produits trouvés pour "MALT"
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MLT-231
<p>MLT-231: potent MALT1 Inhibitor, IC50=9 nM; blocks BCL10 cleavage, IC50=160 nM; exhibits antitumor efficacy in mouse ABC-DLBCL model.</p>Couleur et forme :SolidMLT-985
CAS :<p>MLT-985 is a highly selective allosteric MALT1 inhibitor with an IC 50 value of 3 nM.</p>Formule :C17H15Cl2N9O2Couleur et forme :SolidMasse moléculaire :448.27MALT1 inhibitor MI-2
CAS :<p>MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.</p>Formule :C19H17Cl3N4O3Degré de pureté :98% - 99.87%Couleur et forme :SolidMasse moléculaire :455.72Cladribine
CAS :<p>Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.</p>Formule :C10H12ClN5O3Degré de pureté :99.58% - >99.99%Couleur et forme :White Crystalline SolidMasse moléculaire :285.69MLT-943
CAS :<p>MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].</p>Formule :C16H14ClF3N6O2Degré de pureté :99.72% - 99.82%Couleur et forme :SolidMasse moléculaire :414.77MLT-748
CAS :<p>MLT-748 is an effective, selective, and allosteric MALT1 inhibitor. It binds MALT1 in the allosteric Trp580 pocket (IC50: 5 nM).</p>Formule :C19H19Cl2N9O3Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :492.32(R)-MLT-985
CAS :<p>(R)-MLT-985 (compound 11) is a MALT1 protease inhibitor with IC50 of 3 nM, also blocking IL-2 in Jurkat cells and ABC-DLBCL cell growth.</p>Formule :C17H15Cl2N9O2Couleur et forme :SolidMasse moléculaire :448.27MALT1-IN-3
CAS :<p>MALT1-IN-3 is a potent inhibitor of MALT1 protease (IC50: 0.06 μM) with IC50 values of 0.14 and 0.13 μM for human IL6 and IL10, respectively, in OCI-LY3 cells.</p>Formule :C21H19F3N8O2Couleur et forme :SolidMasse moléculaire :472.42MALT1-IN-8
CAS :<p>MALT1-IN-8: potent MALT1 inhibitor, IC50=2 nM; hinders OCI-LY3 cells, IC50=1.16 μM; anticancer, from patent WO2018165385A1.</p>Formule :C20H15Cl2N7OCouleur et forme :SolidMasse moléculaire :440.29MLT-747
CAS :<p>MLT-747 is an effective and allosteric inhibitor of MALT1. It binds MALT1 in the allosteric Trp580 pocket (IC50: 14 nM).</p>Formule :C20H21Cl2N7O3Couleur et forme :SolidMasse moléculaire :478.33Z-VRPR-FMK
CAS :<p>Z-VRPR-FMK: irreversible MALT1 inhibitor, halts growth/invasion of diffused B-cell lymphoma by blocking NF-κB activation and MMP expression.</p>Formule :C31H49FN10O6Couleur et forme :SolidMasse moléculaire :676.78(R)-MALT1-IN-3
CAS :<p>(R)-MALT1-IN-3 (121) inhibits MALT1 protease (IC50: 20 nM) and IL6/IL10 in OCI-LY3 (IC50: 60/40 nM).</p>Formule :C21H19F3N8O2Couleur et forme :SolidMasse moléculaire :472.42JNJ-67856633
CAS :<p>JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease .</p>Formule :C20H11F6N5O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :467.32(R)-MALT1-IN-7
CAS :<p>(R)-MALT1-IN-7 (compound 142a) is a potent inhibitor of MALT1 protease and has potential for cancer research.</p>Formule :C19H17F3N8O2SCouleur et forme :SolidMasse moléculaire :478.45MALT1-IN-9
CAS :<p>MALT1-IN-9: potent MALT1 protease inhibitor, IC50 <500 nM in Raji cells, significant anticancer effects.</p>Formule :C16H12ClF3N6OCouleur et forme :SolidMasse moléculaire :396.75NVS-MALT1
CAS :<p>NVS-MALT1 is an allosteric inhibitor of MALT1 [1].</p>Formule :C24H27ClF3N5O4SCouleur et forme :SolidMasse moléculaire :574.02MALT1-IN-7
CAS :<p>MALT1-IN-7 (compound 142b) is a potent inhibitor of MALT1 protease with potential for cancer research.</p>Formule :C19H17F3N8O2SCouleur et forme :SolidMasse moléculaire :478.45MALT1-IN-6
CAS :<p>MALT1-IN-6 is a MALT1 protease inhibitor (Ki: 9 nM) that exhibits anticancer activity.</p>Formule :C18H12Cl2F3N9OCouleur et forme :SolidMasse moléculaire :498.25RGT-068A
CAS :<p>RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .</p>Formule :C17H16ClN9O2Couleur et forme :SolidMasse moléculaire :413.82MALT1-IN-11
CAS :<p>MALT1-IN-11: MALT1 inhibitor, IC50 <10-100 nM, reduces IL10, for cancer/autoimmune research.</p>Formule :C20H16F4N8OCouleur et forme :SolidMasse moléculaire :460.39(S,R,S)-AHPC-Boc derivative 1
CAS :<p>(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).</p>Formule :C28H40N4O6SCouleur et forme :SolidMasse moléculaire :560.705MALT1-IN-5
CAS :<p>MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.</p>Formule :C17H17ClF2N6O3Couleur et forme :SolidMasse moléculaire :426.80(S)-MALT1-IN-5
CAS :<p>(S)-MALT1-IN-5: Potent MALT1 protease inhibitor, may help in abnormal T/B-cell signalling and MALT1-linked diseases.</p>Formule :C17H17ClF2N6O3Couleur et forme :SolidMasse moléculaire :426.80
