Signalisation JAK/STAT
Les inhibiteurs de la signalisation JAK/STAT sont des composés qui perturbent la voie des kinases Janus (JAK) et du transducteur et activateur de transcription (STAT), impliquée dans la signalisation des cytokines, la croissance cellulaire et la réponse immunitaire. Ces inhibiteurs sont des outils importants pour étudier la régulation de cette voie et son rôle dans diverses maladies, notamment les cancers, les troubles immunitaires et les affections inflammatoires. Les inhibiteurs JAK/STAT sont également en cours de développement en tant que thérapies ciblées pour ces maladies. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité de la signalisation JAK/STAT pour soutenir vos recherches en biologie moléculaire, oncologie et immunologie.
Sous-catégories appartenant à la catégorie "Signalisation JAK/STAT"
363 produits trouvés pour "Signalisation JAK/STAT"
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STAT3 HiBiT degrader 1
CAS :STAT3HiBiT degrader 1 is a potent degrader of STAT3HiBiT, exhibiting a DC50 of less than 0.05 μM in A549 cells.Formule :C58H63F4N10O14PSCouleur et forme :SolidMasse moléculaire :1263.21PM-81I
CAS :PM-81I: Potent STAT6 inhibitor for allergic and pulmonary conditions, cancer research. Reduces STAT6 phosphorylation.Formule :C43H58F2N3O10PCouleur et forme :SolidMasse moléculaire :845.91R8-T198wt
CAS :Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.Formule :C111H211N59O26SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2820.33JAK2-IN-10
CAS :JAK2-IN-10 (compound 5) is a potent inhibitor of JAK2v617f, with an IC50 value of ≤10 nM.Formule :C33H33D3FN9O2Couleur et forme :SolidMasse moléculaire :612.71SJ10542
CAS :SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formule :C41H46N12O5SCouleur et forme :SolidMasse moléculaire :818.95DU-14 (PTP1B/TC-PTP PROTAC)
CAS :DU-14 (PTP1B/TC-PTPPROTAC) is a potent and selective dual PROTAC degrader for PTP1B and TC-PTP, exhibiting IC50 values of 24.2 nM and 30.1 nM for the phosphatase activity of PTP1B and TC-PTP, respectively. It enhances IFN-γ signaling, promotes T cell activation, and possesses antitumor activity.Formule :C74H85BrF2N9O14PSMasse moléculaire :1505.46HAT-SIL-TG-1&AT
HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.Formule :C60H69N17O11SCouleur et forme :SolidMasse moléculaire :1236.36STAT3-IN-34
STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.Formule :C19H16N2O4SCouleur et forme :SolidMasse moléculaire :368.41JAK-IN-29
JAK-IN-29 (Compound 3) is a potent inhibitor of Janus kinases (JAK) [1].Formule :C17H14ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.78Fulipiftide
CAS :Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.Formule :C144H227N41O47Couleur et forme :SolidMasse moléculaire :3284.59SD-2301
CAS :SD-2301 is a PROTAC degrader of STAT3.Formule :C64H80N13O15PS2Couleur et forme :SolidMasse moléculaire :1366.50Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidRef: TM-L1600
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderDBL-6-13
DBL-6-13 is an inhibitor of WDR5, displaying moderate binding affinity with dissociation constants (Kd) of 6.8 μM and 9.1 μM as determined by microscale thermophoresis analysis and fluorescence polarization analysis, respectively.Formule :C25H38N4O3Couleur et forme :SolidMasse moléculaire :442.59STAT3 ligand 5
STAT3ligand 5 is a STAT3 ligand, serving as a target protein ligand for the synthesis of the PROTAC degrader [SD-436].Formule :C36H39F4N6O12PSCouleur et forme :SolidMasse moléculaire :886.76OSM-SMI-10B
OSM-SMI-10B, a variant of OSM-SMI-10, inhibits OSM-induced STAT3 activation in cancer cells.Formule :C21H14O7Couleur et forme :SolidMasse moléculaire :378.33Tyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase relatedCouleur et forme :Odour SolidRef: TM-L2200
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderDeuruxolitinib
CAS :Deuruxolitinib functions as an inhibitor of JAK1/2.Formule :C17H18N6Couleur et forme :SolidMasse moléculaire :314.41PROTAC STAT3 degrader-2
CAS :PROTAC STAT3 degrader-2 selectively breaks down STAT3 (DC50: 3.54μM, Molm-16) with cancer research potential.Formule :C59H60F2N9O13PCouleur et forme :SolidMasse moléculaire :1172.13AS2553627
CAS :AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.Formule :C18H19N5OCouleur et forme :SolidMasse moléculaire :321.38Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
CAS :Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.Formule :C88H138N20O34P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2082.1FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Couleur et forme :LiquidSTAT5-IN-3
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.Formule :C25H27N5OCouleur et forme :SolidMasse moléculaire :413.51JAK1/STAT3-IN-1
JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).Formule :C30H33FN4O3SCouleur et forme :SolidMasse moléculaire :548.67JAK-STAT Compound Library
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;Couleur et forme :Odour SolidRef: TM-L3700
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderMR44397
MR44397 is a ligand for WD40 repeat (WDR) 5 and is applicable in cancer research.Formule :C23H26N4O2SCouleur et forme :SolidMasse moléculaire :422.54Adenosine receptor modulator 1
Adenosine receptor modulator 1 acts as an inducer of collagen VII (C7). It enhances the expression of COL7A1 mRNA in donor-derived keratinocytes and, in synergy with Gentamicin, increases the overall levels of C7.Formule :C25H28N6O3Couleur et forme :SolidMasse moléculaire :460.53S-Ruxolitinib
CAS :S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.
Formule :C17H18N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.37AK-2292
AK-2292: potent STAT5 PROTAC degrader, DC50 0.10 μM, degrades STAT5A/B, may shrink leukemia tumors in mice.Formule :C52H54F2N7O10PS2Couleur et forme :SolidMasse moléculaire :1070.13TP-5801 TFA
TP-5801 TFA is an orally active inhibitor of TNK1, a non-receptor tyrosine kinase, with an IC50 value of 1.40 nM, demonstrating anti-tumor activity [1].Formule :C26H32BrF3N8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :641.48STAT4-IN-1
STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.Couleur et forme :Odour SolidAxltide
CAS :Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Formule :C63H107N19O20S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1514.77SJ1008030 formic
SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with anFormule :C43H45N13O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :919.96Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Couleur et forme :Odour SolidSTAT3-IN-37
CAS :STAT3-IN-37 (Compound 101) is an inhibitor of STAT3, with an IC50 of 15 nM as measured by DNA-HTRF assay and 2 nM as determined through human whole blood SOCS3 qPCR assay.Formule :C23H25Cl2N5O2Couleur et forme :SolidMasse moléculaire :474.38TYD-68
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.Couleur et forme :Odour SolidLH168
LH168 is a potent and selective probe for WDR5, with a SPR Kd value of 13 nM.Formule :C29H31F3N6O2SCouleur et forme :SolidMasse moléculaire :584.66STAT3 degrader-1
CAS :STAT3 Degrader-1 (Compound 295) is a potent degrader of STAT3, utilized in anticancer research [1].Formule :C58H63F5N9O12PSCouleur et forme :SolidMasse moléculaire :1236.2JAK-IN-15
CAS :JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).Formule :C22H23FN4O3SCouleur et forme :SolidMasse moléculaire :442.51SJ988497
CAS :SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Formule :C36H36N10O5Couleur et forme :SolidMasse moléculaire :688.74Pim-1/2 kinase inhibitor 1
CAS :Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Formule :C11H9NO3SDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :235.26DTP3
CAS :DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formule :C26H35N7O5Couleur et forme :SolidMasse moléculaire :525.6Atinvicitinib
CAS :Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.Formule :C16H17FN6O3Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :360.35Ref: TM-T39646
1mg138,00€1mL*10mM (DMSO)264,00€5mg334,00€10mg550,00€25mg1.063,00€50mg1.738,00€100mg2.547,00€Itacitinib adipate
CAS :Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.Formule :C32H33F4N9O5Couleur et forme :SolidMasse moléculaire :699.66CHZ868
CAS :CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.Formule :C22H19F2N5O2Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :423.42Ilunocitinib
CAS :Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.Formule :C17H17N7O2SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :383.43Ref: TM-T38571
1mg92,00€5mg230,00€1mL*10mM (DMSO)251,00€10mg356,00€25mg713,00€50mg1.189,00€100mg1.791,00€200mg2.412,00€Stafib-1
CAS :Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Formule :C26H24N2O11P2Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :602.42SD-436
CAS :SD-436 is a selective and highly efficient STAT3 PROTAC degrader (DC50 = 0.5 μM), with an IC50 of 19 nM for STAT3, significantly higher than for STAT1/4/5/6. SD-436 depletes STAT3 and induces tumour regression in mouse leukaemia and lymphoma xenograft models.Formule :C58H62F4N9O14PSDegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :1248.2AK-1690
CAS :AK-1690 is a potent and selective STAT6 PROTAC degrader that induces degradation of STAT6 proteins in cells and depletes STAT6 proteins in mouse tissues.Formule :C51H56F2N5O11PSDegré de pureté :99.95% - 99.96%Couleur et forme :SolidMasse moléculaire :1016.05Ifidancitinib
CAS :Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.Formule :C20H18FN5O3Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :395.395,15-DPP
CAS :5,15-Diphenylporphyrin (5,15-DPP) is a selective STAT3-SH2 antagonist with IC 50s of 0.28 μM and 10 μM for STAT3 and STAT1, respectively [1].Formule :C32H22N4Couleur et forme :SolidMasse moléculaire :462.54
