Signalisation JAK/STAT
Les inhibiteurs de la signalisation JAK/STAT sont des composés qui perturbent la voie des kinases Janus (JAK) et du transducteur et activateur de transcription (STAT), impliquée dans la signalisation des cytokines, la croissance cellulaire et la réponse immunitaire. Ces inhibiteurs sont des outils importants pour étudier la régulation de cette voie et son rôle dans diverses maladies, notamment les cancers, les troubles immunitaires et les affections inflammatoires. Les inhibiteurs JAK/STAT sont également en cours de développement en tant que thérapies ciblées pour ces maladies. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de haute qualité de la signalisation JAK/STAT pour soutenir vos recherches en biologie moléculaire, oncologie et immunologie.
Sous-catégories appartenant à la catégorie "Signalisation JAK/STAT"
365 produits trouvés pour "Signalisation JAK/STAT"
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JMS-053
CAS :JMS-053 is a phosphatase DUSP3 inhibitor that inhibits CDC25B and prevents VEGF from disrupting the microvascular endothelial barrier.Formule :C13H8N2O2SDegré de pureté :≥98.0%Couleur et forme :SolidMasse moléculaire :256.28TP-5801
CAS :TP-5801 is an orally active non-receptor tyrosine kinase (TNK1) inhibitor with an IC50 value of 1.40 nM and antitumor effects.Formule :C24H31BrN8OCouleur et forme :SolidMasse moléculaire :527.46AC430
CAS :AC430, a specific JAK2 inhibitor for cancer and autoimmune therapy, excels in preclinical trials with low doses. Developed by Ambit.Formule :C19H16FN5OCouleur et forme :SolidMasse moléculaire :349.36CAY10784
CAS :CAY10784(STAT3-IN-17) is a STAT3 inhibitor with antiproliferative and antitumor activities. CAY10784 showed antibacterial activity against Clostridium difficileFormule :C11H6F3N3O3SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :317.24inS3-54-A26
CAS :inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.Formule :C25H19ClN2O2Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :414.88Ref: TM-T27613
500mgÀ demander1mg109,00€2mg163,00€5mg241,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€JAK-IN-30
CAS :JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50Formule :C19H26N8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.53JAK-IN-28
CAS :JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].Formule :C20H18ClN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.86AZD-1897
CAS :AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.Formule :C18H23N3O3SDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :361.46M-110
CAS :M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).Formule :C22H28ClN5O3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :445.94JAK1-IN-4
CAS :JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).Formule :C26H32FN9O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.59JAK3/BTK-IN-2
CAS :JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.
Formule :C25H32N8O2Degré de pureté :99.64% - 99.87%Couleur et forme :SolidMasse moléculaire :476.57Lorpucitinib
CAS :Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.Formule :C22H28N6O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :408.5JAK3i
CAS :JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.Formule :C18H15FN4O3Degré de pureté :98.61% - 99.81%Couleur et forme :SolidMasse moléculaire :354.34Jaspamycin
CAS :Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.Formule :C12H12N4O5Couleur et forme :SolidMasse moléculaire :292.25PIM-1 Inhibitor 2
CAS :PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.Formule :C17H11ClN4ODegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :322.75SD-1029
CAS :SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.Formule :C25H32Br2Cl2N2O3Couleur et forme :SolidMasse moléculaire :639.25NT219
CAS :NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Formule :C16H14BrNO5SDegré de pureté :98.06% - 99.72%Couleur et forme :SolidMasse moléculaire :412.26JAK-STAT-IN-1
CAS :JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Formule :C21H21N5O2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :375.42STS-E412
CAS :STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.Formule :C15H15ClN4O2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :318.76Izencitinib
CAS :Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.Formule :C22H26N8Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :402.50Ref: TM-T35898
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg281,00€25mg567,00€50mg888,00€100mg1.431,00€200mg1.963,00€Butyzamide
CAS :Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.Formule :C29H32Cl2N2O5SDegré de pureté :99.39% - 99.83%Couleur et forme :SoildMasse moléculaire :591.55Ref: TM-T67894
1mg149,00€5mg253,00€1mL*10mM (DMSO)329,00€10mg371,00€25mg573,00€50mg862,00€100mg1.305,00€200mg1.755,00€JAK1-IN-8
CAS :JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Formule :C22H23FN4O3SDegré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :442.51Tubulin/JAK2-IN-1
CAS :Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significantFormule :C22H20N6O3Couleur et forme :SolidMasse moléculaire :416.43inS3-54A18
CAS :inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.Formule :C23H16ClNO2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :373.83Ref: TM-T15582
2mg39,00€5mg62,00€1mL*10mM (DMSO)67,00€10mg87,00€25mg152,00€50mg215,00€100mg304,00€200mg427,00€STAT3-IN-20
CAS :STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclearFormule :C30H27F4N7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.64Antitumor agent-73
CAS :Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.Formule :C50H82BrO4PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :858.06PM-43I
CAS :PM-43I is a potent inhibitor of both STAT5- and STAT6-dependent allergic airway disease in mice.Formule :C38H50F2N3O10PCouleur et forme :SolidMasse moléculaire :777.79STAT3-IN-B9
CAS :STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.Formule :C20H13NO5SDegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :379.39Ref: TM-T28865
1mg109,00€2mg154,00€5mg235,00€1mL*10mM (DMSO)255,00€10mg349,00€25mg532,00€50mg745,00€100mg999,00€200mg1.333,00€ABBV-712
CAS :ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseasesFormule :C24H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.5JAK-IN-17
"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."Formule :C33H38F2N6O8Couleur et forme :SolidMasse moléculaire :684.69Tyk2-IN-9
CAS :Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.Formule :C20H17N9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :383.41TCJL37
CAS :TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.Formule :C17H11ClF2N4O2Couleur et forme :SolidMasse moléculaire :376.74ML115
CAS :ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.Formule :C15H15ClN2O4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :322.74Ref: TM-T35544
1mg89,00€5mg215,00€1mL*10mM (DMSO)239,00€10mg340,00€25mg597,00€50mg835,00€100mg1.125,00€200mg1.513,00€500mg2.232,00€JAK2-IN-4
CAS :JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.Formule :C23H27N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.56JAK-IN-24
CAS :JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.Formule :C20H25N5O2Couleur et forme :SolidMasse moléculaire :367.44Upadacitinib tartrate
CAS :Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.Formule :C21H33F3N6O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.521STAT6-IN-1
CAS :STAT6-IN-1: STAT6 inhibitor, IC50=0.028 µM, targets SH2 domain, for allergy and cancer research.Formule :C33H37IN3O7PCouleur et forme :SolidMasse moléculaire :745.54JAK-IN-5
CAS :JAK-IN-5 is a JAK inhibitor.Formule :C27H31FN6ODegré de pureté :98.1% - 99.37%Couleur et forme :SolidMasse moléculaire :474.57Ref: TM-T11710
1mg177,00€5mg370,00€1mL*10mM (DMSO)537,00€10mg552,00€25mg879,00€50mg1.189,00€100mg1.603,00€500mg3.205,00€Brepocitinib
CAS :Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).Formule :C18H21F2N7ODegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :389.4Ref: TM-TQ0010
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg99,00€25mg205,00€50mg371,00€100mg595,00€200mg833,00€JAK-IN-4
CAS :JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.Formule :C18H21N4Na2O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.341PIM1-IN-4
CAS :PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.Formule :C27H25BrCl2CuN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :663.88Nezulcitinib
CAS :Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.Formule :C30H37N7O2Couleur et forme :SolidMasse moléculaire :527.66FM-479
CAS :FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.
Formule :C25H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.523Ginsenoside Rk1
CAS :Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formule :C42H70O12Degré de pureté :98.46% - 99.13%Couleur et forme :SolidMasse moléculaire :767.00STAT3 degrader-2
CAS :STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and variousFormule :C59H62N9O13PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1136.15FD1024
CAS :FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.Formule :C21H20F2N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.47Lepzacitinib
CAS :Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Formule :C18H21N5O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :355.39Ref: TM-T78207
1mg50,00€5mg104,00€1mL*10mM (DMSO)114,00€10mg167,00€25mg340,00€50mg505,00€100mg712,00€200mg1.009,00€TCS 21311
CAS :TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formule :C27H25F3N4O4Degré de pureté :99.39% - ≥98%Couleur et forme :SolidMasse moléculaire :526.51JAK-IN-26
CAS :JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormule :C22H24N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46STAT3-IN-14
CAS :STAT3-IN-14 is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 can directly bind to the hinge region of STAT3 .Formule :C14H10O5Couleur et forme :SolidMasse moléculaire :258.23
