STAT
Les protéines STAT sont des composants critiques de la voie de signalisation JAK/STAT, qui transmet les signaux extracellulaires des cytokines et des facteurs de croissance au noyau cellulaire, influençant ainsi l'expression génique. Les protéines STAT sont impliquées dans la régulation des réponses immunitaires, de la croissance cellulaire, de la différenciation et de la survie. La dérégulation de la signalisation STAT est impliquée dans diverses maladies, y compris le cancer, les troubles auto-immuns et l'inflammation chronique. Chez CymitQuimica, nous proposons une gamme complète de modulateurs de la voie STAT pour soutenir vos recherches en transduction de signal, immunologie et développement thérapeutique.
98 produits trouvés pour "STAT"
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Panaxadiol
CAS :<p>Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.</p>Formule :C30H52O3Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :460.73Tetramethylcurcumin
CAS :<p>Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also</p>Formule :C25H28O6Degré de pureté :97.69% - 99.94%Couleur et forme :SolidMasse moléculaire :424.49Stattic
CAS :<p>Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation.</p>Formule :C8H5NO4SDegré de pureté :98.32% - 99.76%Couleur et forme :SolidMasse moléculaire :211.19Homoharringtonine
CAS :<p>Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat leukemia and resistant NSC-LC.</p>Formule :C29H39NO9Degré de pureté :98.21% - 99.78%Couleur et forme :Off-White CrystMasse moléculaire :545.62inS3-54-A26
CAS :<p>inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.</p>Formule :C25H19ClN2O2Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :414.88STAT3-IN-B9
CAS :<p>STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.</p>Formule :C20H13NO5SDegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :379.39inS3-54A18
CAS :<p>inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.</p>Formule :C23H16ClNO2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :373.83Stafib-2
CAS :<p>Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,</p>Formule :C28H26N2O12P2Degré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :644.46ML115
CAS :<p>ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.</p>Formule :C15H15ClN2O4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :322.74STAT6-IN-3
CAS :<p>STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain.</p>Formule :C32H35IN3O7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :731.51STAT3-IN-20
CAS :<p>STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear</p>Formule :C30H27F4N7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.64Antitumor agent-73
CAS :<p>Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.</p>Formule :C50H82BrO4PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :858.06STAT6-IN-2
CAS :<p>STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.</p>Formule :C28H31N5O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :469.58WZ-2-033
CAS :<p>WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.</p>Formule :C25H18F3N3O4SCouleur et forme :SolidMasse moléculaire :513.49STAT3-IN-35
CAS :<p>STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.</p>Formule :C21H23NO4Couleur et forme :SolidMasse moléculaire :353.41PMMB-187
CAS :<p>PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.</p>Formule :C27H23BrN2O6S2Couleur et forme :SolidMasse moléculaire :615.52STAT3-IN-8
CAS :<p>"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."</p>Formule :C19H7F7N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.26STAT3-IN-36
CAS :<p>STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.</p>Formule :C30H24F2N2O9S2Couleur et forme :SolidMasse moléculaire :658.65
