STAT
Les protéines STAT sont des composants critiques de la voie de signalisation JAK/STAT, qui transmet les signaux extracellulaires des cytokines et des facteurs de croissance au noyau cellulaire, influençant ainsi l'expression génique. Les protéines STAT sont impliquées dans la régulation des réponses immunitaires, de la croissance cellulaire, de la différenciation et de la survie. La dérégulation de la signalisation STAT est impliquée dans diverses maladies, y compris le cancer, les troubles auto-immuns et l'inflammation chronique. Chez CymitQuimica, nous proposons une gamme complète de modulateurs de la voie STAT pour soutenir vos recherches en transduction de signal, immunologie et développement thérapeutique.
98 produits trouvés pour "STAT"
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Artesunate
CAS :<p>Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.</p>Formule :C19H28O8Degré de pureté :97.67% - 99.9%Couleur et forme :White Crystalline PowderMasse moléculaire :384.42Fludarabine
CAS :<p>Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.</p>Formule :C10H12FN5O4Degré de pureté :99.65% - 99.89%Couleur et forme :White SolidMasse moléculaire :285.23STAT3-IN-1
CAS :<p>STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor</p>Formule :C28H29NO6Degré de pureté :95.89% - 95.89%Couleur et forme :SolidMasse moléculaire :475.53Diosgenin
CAS :<p>Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.</p>Formule :C27H42O3Degré de pureté :98.87% - 99.87%Couleur et forme :Flaky Or Needle CrystalMasse moléculaire :414.62L002
CAS :<p>L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.</p>Formule :C15H15NO5SDegré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :321.35Nifuroxazide
CAS :<p>Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.</p>Formule :C12H9N3O5Degré de pureté :99.79% - 99.95%Couleur et forme :Yellow SolidMasse moléculaire :275.22Niclosamide olamine
CAS :<p>Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.</p>Formule :C15H15Cl2N3O5Degré de pureté :99.89%Couleur et forme :Bright Yellow Crystalline Physical Description Yellow Solid Insoluble In Water (Ntp 1992)Masse moléculaire :388.20UC-514321
CAS :<p>UC-514321 directly targets STAT3/5 and represses TET1 expression.</p>Formule :C26H35NO5Degré de pureté :98.50%Couleur et forme :SolidMasse moléculaire :441.56Garcinone C
CAS :<p>Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.</p>Formule :C23H26O7Degré de pureté :99.13% - 99.92%Couleur et forme :SolidMasse moléculaire :414.45Niclosamide
CAS :<p>Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.</p>Formule :C13H8Cl2N2O4Degré de pureté :98.47% - 99.1%Couleur et forme :Pale Yellow Crystals SolidMasse moléculaire :327.12STAT3-IN-41
<p>STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.</p>Formule :C22H30F3NO7Couleur et forme :SolidMasse moléculaire :477.471Eflepedocokin alfa
CAS :<p>Eflepedocokin alfa is a recombinant IL-22/IgG2-Fc protein, potentially protecting cells and enhancing immune function and tissue repair.</p>Couleur et forme :LiquidSTAT4-IN-1
<p>STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.</p>Couleur et forme :Odour SolidNeocucurbitacin A
CAS :<p>Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].</p>Formule :C31H42O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :542.66STAT3-IN-39
CAS :<p>STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.</p>Formule :C20H17F3N2O3SCouleur et forme :SolidMasse moléculaire :422.42(R)-Lisofylline
CAS :<p>(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).</p>Formule :C13H20N4O3Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :280.32JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidSTAT3 HiBiT degrader 1
CAS :<p>STAT3HiBiT degrader 1 is a potent degrader of STAT3HiBiT, exhibiting a DC50 of less than 0.05 μM in A549 cells.</p>Formule :C58H63F4N10O14PSCouleur et forme :SolidMasse moléculaire :1263.21Anticancer agent 259
<p>Anticanceragent 259 (Compound 3g) is a telmisartan-based cell death regulator that disrupts the STAT5 signaling pathway, thereby increasing the sensitivity of resistant cells to imatinib, with an SC50 of 1.5 μM.</p>Formule :C30H26N2O2Couleur et forme :SolidMasse moléculaire :446.54CMD178
<p>CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.</p>Formule :C46H59N9O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :850.03STAT3-IN-37
CAS :<p>STAT3-IN-37 (Compound 101) is an inhibitor of STAT3, with an IC50 of 15 nM as measured by DNA-HTRF assay and 2 nM as determined through human whole blood SOCS3 qPCR assay.</p>Formule :C23H25Cl2N5O2Couleur et forme :SolidMasse moléculaire :474.38Eupalinolide K
CAS :<p>Eupalinolide K is a natural product</p>Formule :C20H26O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.42STAT5-IN-3
<p>STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.</p>Formule :C25H27N5OCouleur et forme :SolidMasse moléculaire :413.51STX-0119
CAS :<p>STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.</p>Formule :C22H14N4O3Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :382.37STAT3-IN-31
<p>STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).</p>Formule :C16H15NO3SCouleur et forme :SolidMasse moléculaire :301.36STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Formule :C19H16N2O4SCouleur et forme :SolidMasse moléculaire :368.41MNK8
CAS :<p>MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.</p>Formule :C15H12N2O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :252.27Stafib-1
CAS :<p>Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.</p>Formule :C26H24N2O11P2Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :602.42Balsalazide
CAS :<p>Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.</p>Formule :C17H15N3O6Degré de pureté :99.31%Couleur et forme :Yellow To Orange Crystalline PowderMasse moléculaire :357.32SC-43
CAS :<p>SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).</p>Formule :C21H13ClF3N3O2Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :431.8SH-4-54
CAS :<p>SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.</p>Formule :C29H27F5N2O5SDegré de pureté :98% - 99.12%Couleur et forme :SolidMasse moléculaire :610.59SC99
CAS :<p>SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.</p>Formule :C15H8Cl2FN3ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :336.15Pimozide
CAS :<p>Pimozide: antipsychotic that blocks type 2 dopamine, alpha-adrenergic, and 5-HT2 receptors, reducing tics and delusions.</p>Formule :C28H29F2N3ODegré de pureté :99.63% - >99.99%Couleur et forme :SolidMasse moléculaire :461.55WP1066
CAS :<p>WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.</p>Formule :C17H14BrN3ODegré de pureté :98.92% - 99.73%Couleur et forme :SolidMasse moléculaire :356.22Cucurbitacin I
CAS :<p>Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.</p>Formule :C30H42O7Degré de pureté :96.69% - 99.8%Couleur et forme :SolidMasse moléculaire :514.65RSVA405
CAS :<p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>Formule :C17H20N4O2Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :312.37Cryptotanshinone
CAS :<p>Cryptotanshinone: STAT3 inhibitor, IC50 4.6 μM; blocks STAT3 Tyr705 phosphorylation, minor effect on Ser727, no impact on STAT1/5.</p>Formule :C19H20O3Degré de pureté :97.94% - ≥95%Couleur et forme :Orange Needle CrystalMasse moléculaire :296.36Scutellarin
CAS :<p>Scutellarin from Scutellaria inhibits RANKL in osteoclasts and STAT3/Girdin/Akt in HCC cells.</p>Formule :C21H18O12Degré de pureté :97.12% - 99.75%Couleur et forme :SolidMasse moléculaire :462.36Brevilin A
CAS :<p>Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.</p>Formule :C20H26O5Degré de pureté :99.97% - >99.99%Couleur et forme :SolidMasse moléculaire :346.42AS2863619
CAS :<p>AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.</p>Formule :C16H14Cl2N8ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :405.24Atranorin
CAS :<p>Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.</p>Formule :C19H18O8Degré de pureté :98.76% - 99.57%Couleur et forme :SolidMasse moléculaire :374.34HO-3867
CAS :<p>HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.</p>Formule :C28H30F2N2O2Degré de pureté :91.18% - 99.21%Couleur et forme :SolidMasse moléculaire :464.55S3I-201
CAS :<p>S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.</p>Formule :C16H15NO7SDegré de pureté :97.83%Couleur et forme :SolidMasse moléculaire :365.36Morusin
CAS :<p>Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.</p>Formule :C25H24O6Degré de pureté :98.68% - 99.8%Couleur et forme :SolidMasse moléculaire :420.45STAT5-IN-1
CAS :<p>STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.</p>Formule :C16H11N3O3Degré de pureté :99.44% - ≥95%Couleur et forme :SolidMasse moléculaire :293.28Napabucasin
CAS :<p>Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.</p>Formule :C14H8O4Degré de pureté :98.43% - 99.85%Couleur et forme :SolidMasse moléculaire :240.21Arnicolide D
CAS :<p>Arnicolide D is a sesquiterpene lactone.</p>Formule :C19H24O5Degré de pureté :96.66%Couleur et forme :SolidMasse moléculaire :332.39Garcinone D
CAS :<p>Garcinone D is cytotoxic to CEM-SS cells (IC50=3.2 µg/ml), inhibits aromatase and p65 activation (IC50=3.2 µM).</p>Formule :C24H28O7Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :428.47Triacetylresveratrol
CAS :<p>Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.</p>Formule :C20H18O6Degré de pureté :99.81%Couleur et forme :Off White PowderMasse moléculaire :354.35HJC0152 hydrochloride
CAS :<p>HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.</p>Formule :C15H14Cl3N3O4Degré de pureté :99.01% - 99.06%Couleur et forme :SolidMasse moléculaire :406.64
