STAT
Les protéines STAT sont des composants critiques de la voie de signalisation JAK/STAT, qui transmet les signaux extracellulaires des cytokines et des facteurs de croissance au noyau cellulaire, influençant ainsi l'expression génique. Les protéines STAT sont impliquées dans la régulation des réponses immunitaires, de la croissance cellulaire, de la différenciation et de la survie. La dérégulation de la signalisation STAT est impliquée dans diverses maladies, y compris le cancer, les troubles auto-immuns et l'inflammation chronique. Chez CymitQuimica, nous proposons une gamme complète de modulateurs de la voie STAT pour soutenir vos recherches en transduction de signal, immunologie et développement thérapeutique.
108 produits trouvés pour "STAT".
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(R)-Lisofylline
CAS :(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).Formule :C13H20N4O3Degré de pureté :99.50% - 99.85%Couleur et forme :White SolidMasse moléculaire :280.32STAT3-IN-37
CAS :STAT3-IN-37 (Compound 101) is an inhibitor of STAT3, with an IC50 of 15 nM as measured by DNA-HTRF assay and 2 nM as determined through human whole blood SOCS3 qPCR assay.Formule :C23H25Cl2N5O2Couleur et forme :SolidMasse moléculaire :474.38STAT3-IN-28
STAT3-IN-28 (compound 18) is an inhibitor of STAT3. It can suppress the activation of microglia and exhibits anti-neuroinflammatory effects. Additionally, STAT3-IN-28 is capable of crossing the blood-brain barrier.Formule :C20H23N3O2Couleur et forme :SolidMasse moléculaire :337.17903APTSTAT3-9R acetate
APTSTAT3-9R acetate is a selective peptide binding STAT3 with antiproliferative and antitumor activity.Formule :C225H334N80O53Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5007.56STAT3-IN-31
STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).Formule :C16H15NO3SCouleur et forme :SolidMasse moléculaire :301.36STAT3-IN-34
STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.Formule :C19H16N2O4SCouleur et forme :SolidMasse moléculaire :368.41CMD178
CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.Formule :C46H59N9O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :850.03STAT3-IN-23
CAS :STAT3-IN-23 (PY*LKTK) acts as a potent inhibitor of STAT3 [1].Formule :C36H61N8O12PCouleur et forme :SolidMasse moléculaire :828.89JAK-STAT Compound Library
A unique collection of xnum JAK/STAT signaling targeted compounds for high throughput and high content screening;Couleur et forme :Odour SolidRef: TM-L3700
1mgÀ demander10μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)6.810,00€Ac-GpYLPQTV-NH2 acetate
Ac-GpYLPQTV-NH2 acetate is a STAT3 inhibitor with an IC50 value of 0.33 μM. It also exhibits antitumor properties.Formule :C38H60N9O14P·xC2H4O2Couleur et forme :SolidMasse moléculaire :897.91 (free base)Stafib-1
CAS :Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Formule :C26H24N2O11P2Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :602.42Balsalazide
CAS :Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Formule :C17H15N3O6Degré de pureté :99.31%Couleur et forme :Orange SolidMasse moléculaire :357.321-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
CAS :SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.Formule :C21H13ClF3N3O2Degré de pureté :97.56%Couleur et forme :White SolidMasse moléculaire :431.795Ref: TM-T22424
1mg39,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg120,00€25mg250,00€50mg409,00€100mg590,00€200mg827,00€HJC0152 hydrochloride
CAS :HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.Formule :C15H14Cl3N3O4Degré de pureté :99.01% - 99.06%Couleur et forme :SolidMasse moléculaire :406.64TPCA-1
CAS :TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinasesFormule :C12H10FN3O2SDegré de pureté :95.03% - 99.90%Couleur et forme :SolidMasse moléculaire :279.29AS1810722
CAS :AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM.Formule :C25H25F2N7ODegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :477.51BP-1-102
CAS :BP-1-102 is an orally active, effective and specific STAT3 inhibitor.Formule :C29H27F5N2O6SDegré de pureté :99.25% - 99.44%Couleur et forme :White SolidMasse moléculaire :626.59Ref: TM-T3708
1mg37,00€2mg49,00€5mg79,00€1mL*10mM (DMSO)99,00€10mg113,00€25mg200,00€50mg334,00€100mg495,00€Balsalazide disodium dihydrate
CAS :Balsalazide sodium hydrate treats mild-to-moderate ulcerative colitis; higher doses enhance remission maintenance; it's safe and effective.Formule :C17H17N3Na2O8Degré de pureté :98.95% - 99.71%Couleur et forme :SolidMasse moléculaire :437.312-(1,8-naphthyridin-2-yl)phenol
CAS :2-NP is a STAT1 enhancer.Formule :C14H10N2ODegré de pureté :99.82% - 99.94%Couleur et forme :SolidMasse moléculaire :222.24Ref: TM-T2168
5mg57,00€1mL*10mM (DMSO)63,00€10mg90,00€25mg177,00€50mg281,00€100mg444,00€200mg647,00€500mg982,00€Astaxanthin
CAS :Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.Formule :C40H52O4Degré de pureté :95.10% - 99.79%Couleur et forme :SolidMasse moléculaire :596.84
