JAK
Les inhibiteurs de la kinase Janus (JAK) sont des composés qui ciblent la voie de signalisation JAK-STAT, impliquée dans la croissance cellulaire, la réponse immunitaire et l'angiogenèse. En inhibant JAK, ces composés peuvent réduire la signalisation qui conduit à la formation de nouveaux vaisseaux sanguins dans les tumeurs, inhibant ainsi la croissance tumorale. Les inhibiteurs de JAK sont importants dans le traitement des cancers et des maladies inflammatoires. Chez CymitQuimica, nous offrons une gamme diversifiée d'inhibiteurs de JAK de haute qualité pour soutenir vos recherches en oncologie, immunologie et angiogenèse.
243 produits trouvés pour "JAK"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
WHI-P154
CAS :Formule :C16H14BrN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.2047Ilginatinib hydrochloride
CAS :Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Formule :C21H21ClFN7Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :425.89Ref: TM-T12266L2
1mg70,00€5mg150,00€1mL*10mM (DMSO)166,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€200mg973,00€N-(3-Aminopropyl)cyclohexylamine
CAS :N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.Formule :C9H20N2Degré de pureté :98.05% - 98.82%Couleur et forme :Pale Yellow Clear LiquidMasse moléculaire :156.2685(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
CAS :Formule :C17H14N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :294.3047JAK2 Inhibitor V
CAS :JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Formule :C23H24N2ODegré de pureté :98.36% - 99.15%Couleur et forme :SolidMasse moléculaire :344.45Ref: TM-T3042
2mg37,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg80,00€25mg148,00€50mg259,00€100mg477,00€500mg1.063,00€Gusacitinib
CAS :Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).Formule :C24H28N8O2Degré de pureté :98.06% - 99.94%Couleur et forme :SolidMasse moléculaire :460.53Ref: TM-T14331
1mg39,00€5mg84,00€1mL*10mM (DMSO)110,00€10mg116,00€25mg178,00€50mg333,00€100mg495,00€200mg710,00€Ilginatinib maleate
CAS :Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.
Formule :C25H24FN7O4Degré de pureté :99.74% - 99.82%Couleur et forme :SolidMasse moléculaire :505.5Brepocitinib P-Tosylate
CAS :Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).Formule :C25H29F2N7O4SDegré de pureté :99.82% - 99.97%Couleur et forme :SolidMasse moléculaire :561.6WDR5-IN-6
CAS :WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6Formule :C13H8Cl2N2O2SDegré de pureté :99.69%Couleur et forme :SoildMasse moléculaire :327.19Golidocitinib
CAS :Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).Formule :C25H31N9O2Degré de pureté :98.87% - 99.88%Couleur et forme :SolidMasse moléculaire :489.57Nimucitinib
CAS :Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.Formule :C25H26F2N6O2Degré de pureté :99.58%Couleur et forme :SoildMasse moléculaire :480.51Ref: TM-T67907
1mg96,00€2mg139,00€5mg227,00€10mg354,00€25mg653,00€50mg938,00€100mg1.454,00€500mg2.822,00€Ilginatinib
CAS :Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.Formule :C21H20FN7Degré de pureté :98.4% - 99.01%Couleur et forme :SolidMasse moléculaire :389.43Ref: TM-T12266
1mg60,00€1mL*10mM (DMSO)126,00€5mg131,00€10mg177,00€25mg259,00€50mg371,00€100mg532,00€200mg705,00€Delgocitinib
CAS :Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.Formule :C16H18N6ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :310.35Ref: TM-T15096
1mg160,00€5mg295,00€1mL*10mM (DMSO)330,00€10mg462,00€25mg879,00€50mg1.341,00€100mg1.953,00€200mg2.628,00€PROTAC TYK2 degrader-1
CAS :PROTAC TYK2 degrader-1 (CPD-155) functions as a selective degrader of TYK2, demonstrating a degradation maximum (D max) greater than 60%. This compound effectively targets TYK2 for degradation, utilizing a linker to connect the TYK2 ligand with the VHL ligand Thalidomide, each color-coded for identification.Formule :C40H41N13O7Couleur et forme :SolidMasse moléculaire :815.84Adenosine receptor modulator 1
Adenosine receptor modulator 1 acts as an inducer of collagen VII (C7). It enhances the expression of COL7A1 mRNA in donor-derived keratinocytes and, in synergy with Gentamicin, increases the overall levels of C7.Formule :C25H28N6O3Couleur et forme :SolidMasse moléculaire :460.53OICR41114
OICR41114 (PROTAC4) is a PROTAC degrader targeting WDR5. It effectively degrades endogenous WDR5 with an EC50 of 40 nM and a Dmax of 49%. The degradation of HiBiT-tagged WDR5 by OICR41114 occurs in a proteasome-dependent manner. This compound is composed of a target protein ligand, Dimethyl-F-OICR-9429-COOH, an E3 ligase ligand, OICR-8268-acrylic acid, and a PROTAC linker, Amino-PEG9-amine. Notably, the conjugate of the E3 ligase ligand and the linker is OICR-8268-acrylic acid-amino-PEG9-amine.Formule :C70H83Cl2F6N9O15Couleur et forme :SolidMasse moléculaire :1475.36Tyk2-IN-22
CAS :Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.Formule :C16H16ClN5O2Couleur et forme :SolidMasse moléculaire :345.78MR44397
MR44397 is a ligand for WD40 repeat (WDR) 5 and is applicable in cancer research.Formule :C23H26N4O2SCouleur et forme :SolidMasse moléculaire :422.54JI069
CAS :JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.
Formule :C15H12Cl2N2O4SDegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :387.24JAK-IN-33
JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].Degré de pureté :98%Couleur et forme :Odour SolidJAK2-IN-10
CAS :JAK2-IN-10 (compound 5) is a potent inhibitor of JAK2v617f, with an IC50 value of ≤10 nM.Formule :C33H33D3FN9O2Couleur et forme :SolidMasse moléculaire :612.71TYD-68
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.Couleur et forme :Odour SolidS-Ruxolitinib
CAS :S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.
Formule :C17H18N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.37SJ988497
CAS :SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Formule :C36H36N10O5Couleur et forme :SolidMasse moléculaire :688.74Axltide
CAS :Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Formule :C63H107N19O20S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1514.77DBL-6-13
DBL-6-13 is an inhibitor of WDR5, displaying moderate binding affinity with dissociation constants (Kd) of 6.8 μM and 9.1 μM as determined by microscale thermophoresis analysis and fluorescence polarization analysis, respectively.Formule :C25H38N4O3Couleur et forme :SolidMasse moléculaire :442.59Povorcitinib phosphate
CAS :Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.Formule :C23H25F5N7O5PDegré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :605.45Ref: TM-T39113L
1mg46,00€5mg96,00€1mL*10mM (DMSO)128,00€10mg145,00€25mg236,00€50mg339,00€100mg460,00€200mg622,00€FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Couleur et forme :LiquidKinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidRef: TM-L1600
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderTyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase relatedCouleur et forme :Odour SolidRef: TM-L2200
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderJAK1/TYK2-IN-1
CAS :JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).Formule :C18H20F3N7OCouleur et forme :SolidMasse moléculaire :407.401JAK-2/3-IN-1
CAS :JAK-2/3-IN-1 inhibits JAK-2/3 isoforms with sub-250 nM Ki; from US patent US8163732B2.Formule :C20H12ClN3OCouleur et forme :SolidMasse moléculaire :345.79JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Couleur et forme :Odour SolidHAT-SIL-TG-1&AT
HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.Formule :C60H69N17O11SCouleur et forme :SolidMasse moléculaire :1236.36Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
CAS :Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.Formule :C88H138N20O34P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2082.1PROTAC TYK2 degradation agent1
CAS :PROTAC TYK2 Agent1 selectively degrades TYK2, with a 14 nM DC50, for autoimmune research.Formule :C55H69N13O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1056.28TYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.Formule :C23H21FN4O2Couleur et forme :SolidMasse moléculaire :404.16485LH168
LH168 is a potent and selective probe for WDR5, with a SPR Kd value of 13 nM.Formule :C29H31F3N6O2SCouleur et forme :SolidMasse moléculaire :584.66AS2553627
CAS :AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.Formule :C18H19N5OCouleur et forme :SolidMasse moléculaire :321.38NVP-BSK805 2HCl (1092499-93-8(free base))
NVP-BSK805 2HCl (1092499-93-8(free base)) (BSK 805)(IC50=0.5 nM), a specific and effective ATP-competitive JAK2 inhibitor, is more than 20-fold specificity overFormule :C27H28F2N6O·2HClDegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :563.47Ref: TM-T6294
1mg35,00€5mg99,00€10mg137,00€1mL*10mM (DMSO)215,00€25mg245,00€50mg346,00€100mg495,00€200mg677,00€SJ10542
CAS :SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formule :C41H46N12O5SCouleur et forme :SolidMasse moléculaire :818.95Pumecitinib
CAS :Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.
Formule :C17H20N8O2SDegré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :400.46JAK-STAT Compound Library
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;Couleur et forme :Odour SolidRef: TM-L3700
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderJAK-IN-15
CAS :JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).Formule :C22H23FN4O3SCouleur et forme :SolidMasse moléculaire :442.51WDR5 ligand 2
CAS :WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.Formule :C29H31F3N4O4Couleur et forme :SolidMasse moléculaire :556.576JAK1/STAT3-IN-1
JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).Formule :C30H33FN4O3SCouleur et forme :SolidMasse moléculaire :548.67SJ1008030
CAS :SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.
Formule :C42H43N13O7SCouleur et forme :SolidMasse moléculaire :873.94SJ1008030 formic
SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with anFormule :C43H45N13O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :919.96Deuruxolitinib
CAS :Deuruxolitinib functions as an inhibitor of JAK1/2.Formule :C17H18N6Couleur et forme :SolidMasse moléculaire :314.41SJ1008030 TFA
SJ1008030 (compound 8) TFA is a selective JAK2-degrading PROTAC that inhibits the growth of MHH-CALL-4 leukemia cells with an IC50 of 5.4 nM, indicating itsFormule :C44H44F3N13O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :987.96
