JNK
Les JNK (c-Jun N-terminal kinases) sont un sous-groupe de la famille MAPK qui répondent aux stimuli de stress, tels que les cytokines, les radiations ultraviolettes et les chocs thermiques, et sont impliqués dans le contrôle de l'apoptose, de l'inflammation et des réponses immunitaires. La signalisation JNK est cruciale pour la régulation des réponses cellulaires au stress et a été impliquée dans diverses maladies, y compris les troubles neurodégénératifs, le cancer et les affections inflammatoires. Chez CymitQuimica, nous offrons une gamme de modulateurs de la voie JNK pour soutenir vos recherches sur la signalisation du stress, l'apoptose et la pathologie des maladies.
97 produits trouvés pour "JNK"
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IQ-1S
CAS :<p>IQ-1S is an inhibitor of NF-κB/activating protein 1 (AP-1) with an IC50 of 1.8 μM. It exhibits high binding affinity to all three JNKs, with Kd values for JNK3, JNK2, and JNK1 being 87 nM, 360 nM, and 390 nM, respectively.</p>Formule :C15H8N3NaOCouleur et forme :SolidMasse moléculaire :269.23L-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Formule :C164H286N66O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.44JNK-IN-18
<p>JNK-IN-18 (compound 23b) is a potent inhibitor of JNK1, boasting an IC50 of 2 nM. It demonstrates superior efficacy when compared to its IC50 values of 125 nM for JNK2 and 98 nM for BRAF(V600E).</p>Couleur et forme :Odour SolidJNK3 inhibitor-8
<p>JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.</p>Formule :C32H30FN7O3Couleur et forme :SolidMasse moléculaire :579.62Vacquinol-1
CAS :<p>Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.</p>Formule :C21H21ClN2ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :352.86JNK2-IN-1
<p>JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α and</p>Formule :C30H26N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :522.55JNK-1-IN-3
CAS :<p>JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.</p>Formule :C19H17FN4O3Degré de pureté :97.551%Couleur et forme :SolidMasse moléculaire :368.36Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour SolidD-JBD19
CAS :<p>D-JBD19 is a non-permeable peptide with neuroprotective effects.</p>Formule :C99H164N32O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2250.597MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Couleur et forme :Odour SolidPROTAC JNK1-targeted-1
<p>PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader with a DC50 of 10 nM. It effectively reduces fibronectin levels and is useful in lung fibrosis research. [Pink: JNK1 inhibitor; Black: linker; Blue: CRBN Ligand]</p>Formule :C35H32BrN9O6Couleur et forme :SolidMasse moléculaire :754.589JNK-IN-14
<p>JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.</p>Formule :C27H31N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.63CC-401
CAS :<p>CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).</p>Formule :C22H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.47JIP-1(153-163)
CAS :<p>Peptide based on JIP-1(153-163) inhibits JNK with micromolar affinity; barely affects p38, ERK.</p>Formule :C61H104N20O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1341.6JNK1 Protein, Human, Recombinant (GST)
<p>Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :75 kDa (predicted); 65 kDa (reducing conditions)Ezatiostat
CAS :<p>Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.</p>Formule :C27H35N3O6SDegré de pureté :97.95%Couleur et forme :SolidMasse moléculaire :529.65Loureirin B
CAS :<p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>Formule :C18H20O5Degré de pureté :99.33% - 99.86%Couleur et forme :SolidMasse moléculaire :316.35Taurochenodeoxycholic Acid
CAS :<p>Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.</p>Formule :C26H45NO6SDegré de pureté :99.53% - 99.86%Couleur et forme :SolidMasse moléculaire :499.7Ro 31-8220 Mesylate
CAS :<p>Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.</p>Formule :C25H23N5O2S·CH4O3SDegré de pureté :98.79% - 99.02%Couleur et forme :SolidMasse moléculaire :553.65Astragaloside IV
CAS :<p>Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.</p>Formule :C41H68O14Degré de pureté :99% - 99.84%Couleur et forme :Hydroscopic Brown Or Yellow PowderMasse moléculaire :784.97
