JNK
Les JNK (c-Jun N-terminal kinases) sont un sous-groupe de la famille MAPK qui répondent aux stimuli de stress, tels que les cytokines, les radiations ultraviolettes et les chocs thermiques, et sont impliqués dans le contrôle de l'apoptose, de l'inflammation et des réponses immunitaires. La signalisation JNK est cruciale pour la régulation des réponses cellulaires au stress et a été impliquée dans diverses maladies, y compris les troubles neurodégénératifs, le cancer et les affections inflammatoires. Chez CymitQuimica, nous offrons une gamme de modulateurs de la voie JNK pour soutenir vos recherches sur la signalisation du stress, l'apoptose et la pathologie des maladies.
97 produits trouvés pour "JNK"
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Mefloquine hydrochloride
CAS :<p>Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.</p>Formule :C17H17ClF6N2ODegré de pureté :99% - 99.74%Couleur et forme :Off-White To Yellow SolidMasse moléculaire :414.77Tanzisertib
CAS :<p>Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.</p>Formule :C21H23F3N6O2Degré de pureté :98.66% - 99.28%Couleur et forme :SolidMasse moléculaire :448.44SU3327
CAS :<p>SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).</p>Formule :C5H3N5O2S3Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :261.3NBDHEX
CAS :<p>NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).</p>Formule :C12H15N3O4SDegré de pureté :97.38%Couleur et forme :SolidMasse moléculaire :297.33JNK-IN-13
CAS :<p>JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.</p>Formule :C13H7ClN4SDegré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :286.74Metacetamol
CAS :<p>Metacetamol, a non-toxic acetaminophen derivative, is an OTC analgesic/antipyretic and synthesis intermediate.</p>Formule :C8H9NO2Degré de pureté :99.76% - 99.90%Couleur et forme :Physical Description Light Gray Solid (Ntp 1992)Masse moléculaire :151.16Mefloquine
CAS :<p>Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.</p>Formule :C17H16F6N2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :378.31Chloramphenicol
CAS :<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>Formule :C11H12Cl2N2O5Degré de pureté :99.6% - 99.84%Couleur et forme :Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidMasse moléculaire :323.13Urolithin B
CAS :<p>Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical</p>Formule :C13H8O3Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :212.2Fasudil
CAS :<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formule :C14H17N3O2SDegré de pureté :99.79% - 99.84%Couleur et forme :SolidMasse moléculaire :291.37JNK-1-IN-3
CAS :<p>JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.</p>Formule :C19H17FN4O3Degré de pureté :97.551%Couleur et forme :SolidMasse moléculaire :368.36OVA-E1 peptide TFA
CAS :<p>OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.</p>Formule :C49H77F3N10O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1119.19SP 600125, negative control
CAS :<p>SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125.</p>Formule :C15H10N2ODegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :234.25JNK-IN-18
<p>JNK-IN-18 (compound 23b) is a potent inhibitor of JNK1, boasting an IC50 of 2 nM. It demonstrates superior efficacy when compared to its IC50 values of 125 nM for JNK2 and 98 nM for BRAF(V600E).</p>Couleur et forme :Odour SolidMAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Couleur et forme :Odour SolidD-JBD19
CAS :<p>D-JBD19 is a non-permeable peptide with neuroprotective effects.</p>Formule :C99H164N32O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2250.597Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour SolidJNK-IN-12
<p>JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor with an IC50 value of 66.3 nM, comprising a mitochondrial-specific cell-penetrating peptide</p>Formule :C56H82N16O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1091.35MAP4K4-IN-6
<p>MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor with an IC50 of 80 nM. It reduces the phosphorylation of c-Jun and exhibits neuroprotective effects. Additionally, MAP4K4-IN-6 enhances the vitality of motor neurons and can be utilized in the study of amyotrophic lateral sclerosis (ALS).</p>Couleur et forme :Odour SolidCC-401
CAS :<p>CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).</p>Formule :C22H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.47n-Butyl α-D-fructofuranoside
CAS :<p>N-Butyl α-D-fructofuranoside, extracted from the root barks of Ulmus davidiana var.</p>Formule :C10H20O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :236.26BRAFV600E/JNK-IN-1
<p>BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3, and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM, and 0.009 μM, respectively. It also inhibits the phosphorylation of MEK1/2 and ERK1/2. Additionally, BRAFV600E/JNK-IN-1 suppresses tumor cell proliferation, NO release, and PGE2 production, exhibiting both antitumor and anti-inflammatory activities.</p>Couleur et forme :Odour SolidL-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Formule :C164H286N66O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.44JNK2-IN-1
<p>JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α and</p>Formule :C30H26N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :522.55JNK3 inhibitor-8
<p>JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.</p>Formule :C32H30FN7O3Couleur et forme :SolidMasse moléculaire :579.62JNK-1-IN-2
<p>"JNK-1-IN-2 (Compound c6) is a potent inhibitor of JNK-1 with an IC50 of 33.5 nM, and also exhibits inhibitory effects on JNK-2 and JNK-3 with IC50 values of</p>Formule :C16H20BrN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.27AS601245.2TFA (345987-15-7 free base)
CAS :AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3,Formule :C24H18F6N6O4SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :600.50JNK-IN-14
<p>JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.</p>Formule :C27H31N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.63JNK3 inhibitor-7
<p>Potent, oral JNK3 inhibitor-7 crosses blood-brain barrier, IC50: 53 nM (JNK3), offers neuroprotection, potential in AD research.</p>Formule :C32H31N7O3Couleur et forme :SolidMasse moléculaire :561.63IQ-1S
CAS :<p>IQ-1S is an inhibitor of NF-κB/activating protein 1 (AP-1) with an IC50 of 1.8 μM. It exhibits high binding affinity to all three JNKs, with Kd values for JNK3, JNK2, and JNK1 being 87 nM, 360 nM, and 390 nM, respectively.</p>Formule :C15H8N3NaOCouleur et forme :SolidMasse moléculaire :269.23Vacquinol-1
CAS :<p>Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.</p>Formule :C21H21ClN2ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :352.86JIP-1(153-163)
CAS :<p>Peptide based on JIP-1(153-163) inhibits JNK with micromolar affinity; barely affects p38, ERK.</p>Formule :C61H104N20O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1341.6OVA-E1 peptide
CAS :<p>OVA-E1 peptide, as SIINFEKL variant, triggers similar p38/JNK activation in mutant and normal thymocytes.</p>Formule :C47H76N10O14Couleur et forme :SolidMasse moléculaire :1005.181PROTAC JNK1-targeted-1
<p>PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader with a DC50 of 10 nM. It effectively reduces fibronectin levels and is useful in lung fibrosis research. [Pink: JNK1 inhibitor; Black: linker; Blue: CRBN Ligand]</p>Formule :C35H32BrN9O6Couleur et forme :SolidMasse moléculaire :754.589Ezatiostat
CAS :<p>Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.</p>Formule :C27H35N3O6SDegré de pureté :97.95%Couleur et forme :SolidMasse moléculaire :529.65JNK1 Protein, Human, Recombinant (GST)
<p>Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family.</p>Couleur et forme :Lyophilized PowderMasse moléculaire :75 kDa (predicted); 65 kDa (reducing conditions)WHI-P258
CAS :<p>WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.</p>Formule :C16H15N3O2Degré de pureté :99.66% - 99.92%Couleur et forme :SolidMasse moléculaire :281.31IMM-H007
CAS :<p>IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression</p>Formule :C22H23N5O8Degré de pureté :97.73%Couleur et forme :SolidMasse moléculaire :485.45AS601245
CAS :<p>AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.</p>Formule :C20H16N6SDegré de pureté :98% - 99.02%Couleur et forme :SolidMasse moléculaire :372.45JNK Inhibitor VIII
CAS :<p>JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,</p>Formule :C18H20N4O4Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :356.38Taurochenodeoxycholic Acid
CAS :<p>Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.</p>Formule :C26H45NO6SDegré de pureté :99.53% - 99.86%Couleur et forme :SolidMasse moléculaire :499.7DB07268
CAS :<p>DB07268 is a potent and selective JNK1 inhibitor.</p>Formule :C17H15N5O2Degré de pureté :98.2% - 98.91%Couleur et forme :SolidMasse moléculaire :321.33SP600125
CAS :<p>SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive</p>Formule :C14H8N2ODegré de pureté :97.63% - 99.82%Couleur et forme :SolidMasse moléculaire :220.23BI-78D3
CAS :<p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>Formule :C13H9N5O5S2Degré de pureté :97.89% - >99.99%Couleur et forme :SolidMasse moléculaire :379.37Anisomycin
CAS :<p>Anisomycin (NSC-76712), an antibiotic from Streptomyces, blocks protein/DNA synthesis by targeting peptidyl transferase/80S ribosomes.</p>Formule :C14H19NO4Degré de pureté :98.33% - 99.81%Couleur et forme :White Crystalline SolidMasse moléculaire :265.3Loureirin B
CAS :<p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>Formule :C18H20O5Degré de pureté :99.33% - 99.86%Couleur et forme :SolidMasse moléculaire :316.35TOMATIDINE HYDROCHLORIDE
CAS :<p>Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.</p>Formule :C27H46ClNO2Degré de pureté :99.75% - ≥95%Couleur et forme :SolidMasse moléculaire :452.11Actein
CAS :<p>Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.</p>Formule :C37H56O11Degré de pureté :≥98%Couleur et forme :Brown PowderMasse moléculaire :676.83Polyphyllin I
CAS :<p>Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,</p>Formule :C44H70O16Degré de pureté :98% - 99.5%Couleur et forme :SolidMasse moléculaire :855.02Ro 31-8220 Mesylate
CAS :<p>Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.</p>Formule :C25H23N5O2S·CH4O3SDegré de pureté :98.79% - 99.02%Couleur et forme :SolidMasse moléculaire :553.65
