JNK
Les JNK (c-Jun N-terminal kinases) sont un sous-groupe de la famille MAPK qui répondent aux stimuli de stress, tels que les cytokines, les radiations ultraviolettes et les chocs thermiques, et sont impliqués dans le contrôle de l'apoptose, de l'inflammation et des réponses immunitaires. La signalisation JNK est cruciale pour la régulation des réponses cellulaires au stress et a été impliquée dans diverses maladies, y compris les troubles neurodégénératifs, le cancer et les affections inflammatoires. Chez CymitQuimica, nous offrons une gamme de modulateurs de la voie JNK pour soutenir vos recherches sur la signalisation du stress, l'apoptose et la pathologie des maladies.
105 produits trouvés pour "JNK".
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Tanzisertib
CAS :Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.Formule :C21H23F3N6O2Degré de pureté :99.28% - 99.59%Couleur et forme :SolidMasse moléculaire :448.44Chloramphenicol
CAS :Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.Formule :C11H12Cl2N2O5Degré de pureté :99.6% - 99.90%Couleur et forme :White SolidMasse moléculaire :323.13NBDHEX
CAS :NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).Formule :C12H15N3O4SDegré de pureté :97.38%Couleur et forme :Yellow SolidMasse moléculaire :297.33SU3327
CAS :SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Formule :C5H3N5O2S3Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :261.3Urolithin B
CAS :Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormule :C13H8O3Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :212.2Mefloquine
CAS :Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.Formule :C17H16F6N2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :378.31Ref: TM-T0860L
1mg66,00€5mg145,00€1mL*10mM (DMSO)152,00€10mg213,00€25mg356,00€50mg510,00€100mg715,00€200mg964,00€Mefloquine hydrochloride
CAS :Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Formule :C17H17ClF6N2ODegré de pureté :99% - 99.99%Couleur et forme :SolidMasse moléculaire :414.77JNK-IN-13
CAS :JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.Formule :C13H7ClN4SDegré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :286.74MAP4K4-IN-6
MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor with an IC50 of 80 nM. It reduces the phosphorylation of c-Jun and exhibits neuroprotective effects. Additionally, MAP4K4-IN-6 enhances the vitality of motor neurons and can be utilized in the study of amyotrophic lateral sclerosis (ALS).Couleur et forme :Odour SolidL-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Formule :C164H286N66O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.44Fasudil
CAS :Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formule :C14H17N3O2SDegré de pureté :99.79% - 99.97%Couleur et forme :White SolidMasse moléculaire :291.37PROTAC JNK1-targeted-1
PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader with a DC50 of 10 nM. It effectively reduces fibronectin levels and is useful in lung fibrosis research. [Pink: JNK1 inhibitor; Black: linker; Blue: CRBN Ligand]Formule :C35H32BrN9O6Couleur et forme :SolidMasse moléculaire :754.589JTP10-△-TATi TFA
JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.Formule :C120H213F3N48O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2833.28OVA-E1 peptide
CAS :OVA-E1 peptide, as SIINFEKL variant, triggers similar p38/JNK activation in mutant and normal thymocytes.Formule :C47H76N10O14Couleur et forme :SolidMasse moléculaire :1005.181D-JNKI-1
CAS :D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.Formule :C164H286N66O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.44n-Butyl α-D-fructofuranoside
CAS :N-Butyl α-D-fructofuranoside, extracted from the root barks of Ulmus davidiana var.Formule :C10H20O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :236.26JNK-IN-15, Cell-Permeable, Negative Control
JNK-IN-15, Cell-Permeable, Negative Control serves as the negative control for JNK-IN-15, Cell-Permeable. JNK-IN-15, Cell-Permeable functions as an inhibitor of JNK.Formule :C191H336N70O48SCouleur et forme :SolidMasse moléculaire :4410.57236JNK-IN-14
JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.Formule :C27H31N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.63Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidRef: TM-L1600
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderIQ-1S
CAS :IQ-1S is an inhibitor of NF-κB/activating protein 1 (AP-1) with an IC50 of 1.8 μM. It exhibits high binding affinity to all three JNKs, with Kd values for JNK3, JNK2, and JNK1 being 87 nM, 360 nM, and 390 nM, respectively.Formule :C15H8N3NaOCouleur et forme :SolidMasse moléculaire :269.23JNK2-IN-1
JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α andFormule :C30H26N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :522.55JNK-IN-12
JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor with an IC50 value of 66.3 nM, comprising a mitochondrial-specific cell-penetrating peptideFormule :C56H82N16O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1091.35JNK-IN-18
JNK-IN-18 (compound 23b) is a potent inhibitor of JNK1, boasting an IC50 of 2 nM. It demonstrates superior efficacy when compared to its IC50 values of 125 nM for JNK2 and 98 nM for BRAF(V600E).Couleur et forme :Odour SolidVacquinol-1
CAS :Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.Formule :C21H21ClN2ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :352.86JNK3 inhibitor-8
JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.Formule :C32H30FN7O3Couleur et forme :SolidMasse moléculaire :579.62BSO-07
BSO-07 is a ROS/JNK activator that exhibits potent anti-cancer properties, demonstrated by an IC50 of 24.81 μM in human breast cancer (BC) cells. The mechanism of action for BSO-07 involves JNK activation and the promotion of increased ROS levels, which lead to the induction of apoptosis (Apoptosis) and tumorigenic apoptosis. This includes enhanced expression of apoptosis-related proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, along with a reduction in the levels of anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL, and Survivin). BSO-07 holds promise for research in the field of breast cancer.Couleur et forme :Odour SolidOVA-E1 peptide TFA
CAS :OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.Formule :C49H77F3N10O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1119.19SET-171
CAS :SET-171 is a JNK (c-Jun N-terminal kinase) inhibitor that exhibits significant anticancer activity by suppressing the expression of hepatic pyruvate kinase (PKL) and offers potential in regulating lipid metabolism. In antitumor studies, SET-171 shows notable cytotoxicity against human liver cancer cell lines HepG2 and Huh7, with IC50 values of 8.82 μM and 2.97 μM, respectively. Additionally, in research related to non-alcoholic fatty liver disease (NAFLD), SET-171 significantly reduces triglyceride (TAG) levels and inhibits the expression of proteins associated with steatosis. This compound holds promise for hepatocellular carcinoma (HCC) and NAFLD research.Formule :C27H21BrN4O2SCouleur et forme :SolidMasse moléculaire :545.45JTP10-△-R9 TFA
JTP10-△-R9 TFA is a selective inhibitor of JNK2 peptide (IC50: 89 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.Formule :C119H214F3N53O26Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2860.31AS601245.2TFA (345987-15-7 free base)
CAS :AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3,Formule :C24H18F6N6O4SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :600.50D-JBD19
CAS :D-JBD19 is a non-permeable peptide with neuroprotective effects.Formule :C99H164N32O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2250.597JNK-1-IN-3
CAS :JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.Formule :C19H17FN4O3Degré de pureté :97.55%Couleur et forme :White SolidMasse moléculaire :368.36MyD88-IN-3
MyD88-IN-3 is an orally active, selective MyD88 inhibitor that specifically targets the TIR domain of MyD88 (KD= 28.5 μM). It prevents MyD88 self-aggregation and its interaction with TLRs, thereby suppressing the activation of the MAPK and NF-κB pathways. MyD88-IN-3 exhibits significant anti-inflammatory effects and effectively alleviates symptoms of acute lung injury in CLP (cecal ligation and puncture) and LPS (lipopolysaccharide)-induced ALI models. This compound is valuable for ALI research.CC-401
CAS :CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).Formule :C22H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.47JIP-1(153-163)
CAS :Peptide based on JIP-1(153-163) inhibits JNK with micromolar affinity; barely affects p38, ERK.Formule :C61H104N20O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1341.6MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Couleur et forme :Odour SolidRef: TM-L1400
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderJNK3 inhibitor-7
Potent, oral JNK3 inhibitor-7 crosses blood-brain barrier, IC50: 53 nM (JNK3), offers neuroprotection, potential in AD research.Formule :C32H31N7O3Couleur et forme :SolidMasse moléculaire :561.63JNK1 Protein, Human, Recombinant (GST)
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family.Couleur et forme :Transparent SolutionMasse moléculaire :75 kDa (predicted); 65 kDa (reducing conditions)Ezatiostat
CAS :Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.Formule :C27H35N3O6SDegré de pureté :98.54%Couleur et forme :White SolidMasse moléculaire :529.65Ref: TM-T5097
2mg37,00€5mg54,00€1mL*10mM (DMSO)79,00€10mg93,00€25mg157,00€50mg250,00€100mg432,00€200mg618,00€Bentamapimod
CAS :Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.Formule :C25H23N5O2SDegré de pureté :97.04% - 99.92%Couleur et forme :SolidMasse moléculaire :457.55Ref: TM-T2675
2mg43,00€5mg63,00€10mg94,00€25mg154,00€50mg187,00€100mg333,00€500mg1.089,00€1g1.972,00€2g2.655,00€Juglanin
CAS :Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.Formule :C20H18O10Degré de pureté :98.8% - 99.33%Couleur et forme :SolidMasse moléculaire :418.35JNK Inhibitor VIII
CAS :JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,Formule :C18H20N4O4Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :356.38Actein
CAS :Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.Formule :C37H56O11Degré de pureté :98% - ≥98%Couleur et forme :White SolidMasse moléculaire :676.83Anisomycin
CAS :Anisomycin (NSC-76712), an antibiotic from Streptomyces, blocks protein/DNA synthesis by targeting peptidyl transferase/80S ribosomes.Formule :C14H19NO4Degré de pureté :98.33% - 99.81%Couleur et forme :SolidMasse moléculaire :265.3TOMATIDINE HYDROCHLORIDE
CAS :Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.Formule :C27H46ClNO2Degré de pureté :99.75% - ≥95%Couleur et forme :White SolidMasse moléculaire :452.11Guggulsterone
CAS :Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Formule :C21H28O2Degré de pureté :99.4% - 99.8%Couleur et forme :SolidMasse moléculaire :312.45Ref: TM-T5574
1mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg93,00€25mg152,00€50mg205,00€100mg289,00€200mg432,00€Ro 31-8220 Mesylate
CAS :Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.Formule :C25H23N5O2S·CH4O3SDegré de pureté :98.79% - 99.02%Couleur et forme :Orange SolidMasse moléculaire :553.65Ref: TM-T6643
1mg49,00€2mg64,00€5mg92,00€1mL*10mM (DMSO)133,00€10mg150,00€25mg230,00€50mg319,00€100mg475,00€AS601245
CAS :AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.Formule :C20H16N6SDegré de pureté :98% - 99.02%Couleur et forme :SolidMasse moléculaire :372.45TRi-1
CAS :TRi-1 irreversibly inhibits TXNRD1 (IC50: 12 nM) with low mitochondrial toxicity for cancer treatment.Formule :C12H9ClN2O5SDegré de pureté :97.14%Couleur et forme :SolidMasse moléculaire :328.73Ref: TM-T5481
1mg70,00€2mg89,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg205,00€25mg340,00€50mg485,00€100mg700,00€BI-78D3
CAS :BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.Formule :C13H9N5O5S2Degré de pureté :98.24% - 99.90%Couleur et forme :SolidMasse moléculaire :379.37
