JNK
Les JNK (c-Jun N-terminal kinases) sont un sous-groupe de la famille MAPK qui répondent aux stimuli de stress, tels que les cytokines, les radiations ultraviolettes et les chocs thermiques, et sont impliqués dans le contrôle de l'apoptose, de l'inflammation et des réponses immunitaires. La signalisation JNK est cruciale pour la régulation des réponses cellulaires au stress et a été impliquée dans diverses maladies, y compris les troubles neurodégénératifs, le cancer et les affections inflammatoires. Chez CymitQuimica, nous offrons une gamme de modulateurs de la voie JNK pour soutenir vos recherches sur la signalisation du stress, l'apoptose et la pathologie des maladies.
104 produits trouvés pour "JNK".
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OVA-E1 peptide
CAS :OVA-E1 peptide, as SIINFEKL variant, triggers similar p38/JNK activation in mutant and normal thymocytes.Formule :C47H76N10O14Couleur et forme :SolidMasse moléculaire :1005.181JTP10-△-R9 TFA
JTP10-△-R9 TFA is a selective inhibitor of JNK2 peptide (IC50: 89 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.Formule :C119H214F3N53O26Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2860.31SET-171
CAS :SET-171 is a JNK (c-Jun N-terminal kinase) inhibitor that exhibits significant anticancer activity by suppressing the expression of hepatic pyruvate kinase (PKL) and offers potential in regulating lipid metabolism. In antitumor studies, SET-171 shows notable cytotoxicity against human liver cancer cell lines HepG2 and Huh7, with IC50 values of 8.82 μM and 2.97 μM, respectively. Additionally, in research related to non-alcoholic fatty liver disease (NAFLD), SET-171 significantly reduces triglyceride (TAG) levels and inhibits the expression of proteins associated with steatosis. This compound holds promise for hepatocellular carcinoma (HCC) and NAFLD research.Formule :C27H21BrN4O2SCouleur et forme :SolidMasse moléculaire :545.45D-JNKI-1
CAS :D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.Formule :C164H286N66O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.44JNK3 inhibitor-8
JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.Formule :C32H30FN7O3Couleur et forme :SolidMasse moléculaire :579.62IQ-1S
CAS :IQ-1S is an inhibitor of NF-κB/activating protein 1 (AP-1) with an IC50 of 1.8 μM. It exhibits high binding affinity to all three JNKs, with Kd values for JNK3, JNK2, and JNK1 being 87 nM, 360 nM, and 390 nM, respectively.Formule :C15H8N3NaOCouleur et forme :SolidMasse moléculaire :269.23AS601245.2TFA (345987-15-7 free base)
CAS :AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3,Formule :C24H18F6N6O4SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :600.50D-JBD19
CAS :D-JBD19 is a non-permeable peptide with neuroprotective effects.Formule :C99H164N32O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2250.597JNK-1-IN-3
CAS :JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.Formule :C19H17FN4O3Degré de pureté :97.55%Couleur et forme :White SolidMasse moléculaire :368.36Fasudil
CAS :Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formule :C14H17N3O2SDegré de pureté :99.79% - 99.97%Couleur et forme :White SolidMasse moléculaire :291.37PROTAC JNK1-targeted-1
PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader with a DC50 of 10 nM. It effectively reduces fibronectin levels and is useful in lung fibrosis research. [Pink: JNK1 inhibitor; Black: linker; Blue: CRBN Ligand]Formule :C35H32BrN9O6Couleur et forme :SolidMasse moléculaire :754.589Vacquinol-1
CAS :Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.Formule :C21H21ClN2ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :352.86JNK3 inhibitor-7
Potent, oral JNK3 inhibitor-7 crosses blood-brain barrier, IC50: 53 nM (JNK3), offers neuroprotection, potential in AD research.Formule :C32H31N7O3Couleur et forme :SolidMasse moléculaire :561.63CC-401
CAS :CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).Formule :C22H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.47JIP-1(153-163)
CAS :Peptide based on JIP-1(153-163) inhibits JNK with micromolar affinity; barely affects p38, ERK.Formule :C61H104N20O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1341.6MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Couleur et forme :Odour SolidRef: TM-L1400
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderJNK1 Protein, Human, Recombinant (GST)
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family.Couleur et forme :Transparent SolutionMasse moléculaire :75 kDa (predicted); 65 kDa (reducing conditions)Ezatiostat
CAS :Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.Formule :C27H35N3O6SDegré de pureté :98.54%Couleur et forme :White SolidMasse moléculaire :529.65Ref: TM-T5097
2mg37,00€5mg54,00€1mL*10mM (DMSO)79,00€10mg93,00€25mg157,00€50mg250,00€100mg432,00€200mg618,00€Juglanin
CAS :Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.Formule :C20H18O10Degré de pureté :98.8% - 99.33%Couleur et forme :SolidMasse moléculaire :418.35JNK Inhibitor VIII
CAS :JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,Formule :C18H20N4O4Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :356.38
