MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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GAGGVGKSAL
CAS :<p>GAGGVGKSAL, a wild-type KRAS G12D 10mer peptide, serves as an immunogenic neoantigen in cancer immunotherapy research [1].</p>Formule :C34H61N11O12Couleur et forme :SolidMasse moléculaire :815.91IPS-06061
<p>IPS-06061 is an orally active molecular glue that forms a ternary complex with CRBN and KRASG12D, capable of degrading KRAS G12D, with a DC50 of less than 500 nM.</p>Formule :C22H26O3Couleur et forme :SolidMasse moléculaire :338.44SW083688
CAS :<p>SW083688 is a potent and highly selective inhibitor of Thousand-And-One Kinase 2 (TAOK2) with an IC 50 value of 1.3 µmol/L.</p>Formule :C23H25N3O5SCouleur et forme :SolidMasse moléculaire :455.53Vem-L-Cy5
<p>Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAF</p>Formule :C63H68F5N7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1194.31MEK4 inhibitor-1
CAS :<p>MEK4 inhibitor-1 targets MEK4 enzyme in pancreatic cancer, IC50=61 nM.</p>Formule :C13H10FN3O2SCouleur et forme :SolidMasse moléculaire :291.3Anti-inflammatory agent 7
<p>Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.</p>Formule :C36H40N4O9Couleur et forme :SolidMasse moléculaire :672.72StRIP16
<p>Rab8a GTPase-binding stapled peptide (Kd = 12.7 μM). Cell permeable; localizes to the endomembrane system.</p>Couleur et forme :SolidPROTAC JNK1-targeted-1
<p>PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader with a DC50 of 10 nM. It effectively reduces fibronectin levels and is useful in lung fibrosis research. [Pink: JNK1 inhibitor; Black: linker; Blue: CRBN Ligand]</p>Formule :C35H32BrN9O6Couleur et forme :SolidMasse moléculaire :754.589KRASG12C IN-2
<p>KRASG12C IN-2 (compound 17) is an orally active inhibitor of KRAS G12C, which effectively suppresses tumor growth in mice [1].</p>Couleur et forme :SolidMRTF-A-IN-1
<p>MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Formule :C22H21N3Couleur et forme :SolidMasse moléculaire :327.42MEK/RAF-IN-1
<p>MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.</p>Formule :C28H29F3N6O5SCouleur et forme :SolidMasse moléculaire :618.63PPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Formule :C54H69N11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1000.26JNK3 inhibitor-9
<p>JNK3inhibitor-9 (Compound 24a) is a potent, selective JNK3 inhibitor capable of crossing the blood-brain barrier (BBB), demonstrating an IC50 value of 12 nM. It effectively inhibits GSK3α/β, which is involved in Tau phosphorylation, with IC50 values of 14 nM and 35 nM, respectively. JNK3inhibitor-9 also reduces the phosphorylation of c-Jun and APP and protects neurons from Aβ1-42 toxicity.</p>Formule :C25H27N7O2Couleur et forme :SolidMasse moléculaire :457.528BSc5367
CAS :<p>BSc5367 is a potent inhibitor of the structural domain of Nek1 kinase.cell cycle regulation, DNA repair, and microtubule regulation. ALS, PKD.</p>Formule :C20H15N3O2Degré de pureté :98.72%Couleur et forme :SoildMasse moléculaire :329.35R18
CAS :<p>14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.</p>Formule :C101H157N27O29S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2309.69Anti-inflammatory agent 31
<p>Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.</p>Formule :C19H30O3Couleur et forme :SolidMasse moléculaire :306.44Pan-RAS-IN-6
Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.Formule :C46H60N8O5SCouleur et forme :SolidMasse moléculaire :837.08Cyclotraxin B
CAS :<p>TrkB receptor antagonist; inhibits BDNF-TrkB signaling (IC50 = 0.30 nM); alters receptor shape; may reduce anxiety in mice.</p>Formule :C48H73N13O17S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1200.36SAH-SOS1A TFA
<p>SAH-SOS1A TFA inhibits SOS1/KRAS interaction, binding wild/mutant KRAS with 106-175 nM affinity and blocks ERK-MAPK signaling, reducing cancer cell viability.</p>Formule :C102H160N27F3O30Couleur et forme :SolidMasse moléculaire :2301.55NK7-902
<p>NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.</p>Couleur et forme :Odour SolidNUCC-0200808
<p>NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.</p>Couleur et forme :Odour SolidRP03707
CAS :<p>RP03707 is a PROTAC degrader of KRASG12D.</p>Formule :C55H58F3N11O4Couleur et forme :SolidMasse moléculaire :994.12SP 600125, negative control
CAS :<p>SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125.</p>Formule :C15H10N2ODegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :234.25RTIL 13
CAS :<p>RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).</p>Formule :C30H55BrN2O3Couleur et forme :SolidMasse moléculaire :571.685PROTAC SOS1 degrader-1
CAS :<p>PROTAC SOS1 degrader-1: potent, DC50 98.4 nM, inhibits KRAS mutant cancer cells, low-toxic antitumor.</p>Formule :C57H76O4ClFN10SCouleur et forme :SoildMasse moléculaire :1050.54443KRAS inhibitor-33
<p>KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.</p>Formule :C33H39ClF2N6O3Couleur et forme :SolidMasse moléculaire :641.15Cyclorasin 9A5 TFA
<p>Cyclorasin 9A5 TFA is a cell-penetrating cyclic peptide consisting of 11 residues that inhibits the interaction between Ras and Raf proteins, with an IC50 of 120 nM.</p>Formule :C75H108FN25O13·xC2HF3O2Couleur et forme :SolidMasse moléculaire :1586.82 (free base)HPK1-IN-39
<p>HPK1-IN-39 (Compound 10n), a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) with an inhibitory concentration (IC50) of 29 nM, impedes the</p>Formule :C26H27N7O2Couleur et forme :SolidMasse moléculaire :469.54YN14
<p>YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low</p>Degré de pureté :98%Couleur et forme :Odour Solidp38 MAP Kinase Inhibitor Ⅵ
CAS :<p>p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.</p>Formule :C16H13FN2OS2Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :332.42Divarasib adipate
CAS :<p>Divarasib (GDC-6036) adipate is a selective and highly potent KRAS G12C inhibitor with an impressively low IC 50 value of <0.01 μM, designed for oral administration. It covalently attaches to the switch II (SW-II) pocket in KRAS G12C, irreversibly maintaining the protein in its inactive GDP-bound state [1] [2].</p>Formule :C35H42ClF4N7O6Couleur et forme :SolidMasse moléculaire :768.2Rineterkib hydrochloride
CAS :<p>Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.</p>Formule :C26H28BrClF3N5O2Couleur et forme :SolidMasse moléculaire :614.89Deltasonamide 1 TFA
CAS :<p>Deltasonamide 1 TFA: PDE6δ-KRas inhibitor, K D 203 pM, used in tumor research.</p>Formule :C32H40ClF3N6O6S2Couleur et forme :SolidMasse moléculaire :761.28PROTAC K-Ras Degrader-5
CAS :<p>Pan-KRAS degrader 4 (compound 69) is a cereblon-based PROTAC KRAS degrader exhibiting anticancer activity with a DC50 value of less than 100 nM.</p>Formule :C57H63F3N10O5Couleur et forme :SolidMasse moléculaire :1025.17BI1701963
<p>BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.</p>Formule :C47H62N8O4SCouleur et forme :SolidMasse moléculaire :835.11Natsudaidain
<p>Natsudaidain is a useful organic compound for research related to life sciences and the catalog number is T124974.</p>Formule :C21H22O9Couleur et forme :SolidMasse moléculaire :418.398KRAS inhibitor-42
<p>KRAS inhibitor-42 (compound 8) is an effective USP7 inhibitor that exhibits high affinity for GDP-bound KRASG12D, with a Ki value of 2.7 μM.</p>Formule :C34H47ClN8O4S2Couleur et forme :SolidMasse moléculaire :730.28502Pan-RAS-IN-7
CAS :<p>Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.</p>Formule :C59H76N8O8Couleur et forme :SolidMasse moléculaire :1025.28AS601245.2TFA (345987-15-7 free base)
CAS :AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3,Formule :C24H18F6N6O4SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :600.50Ibetazol
<p>Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.</p>Formule :C13H11F3N2OSCouleur et forme :SolidMasse moléculaire :300.3KRAS G12D inhibitor 6
CAS :<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Formule :C32H37ClN8O2Couleur et forme :SolidMasse moléculaire :601.15KRas G12R inhibitor 1
<p>KRas G12R inhibitor 1 targets mutant cysteines in K-Ras, binds irreversibly, and is used in cancer research.</p>Formule :C39H38ClF7N6O9Couleur et forme :SolidMasse moléculaire :903.2Talmapimod hydrochloride
CAS :<p>Talmapimod hydrochloride: selective p38α inhibitor, 9 nM IC50, 10x less effective on p38β, >2000-fold selective vs 20+ kinases.</p>Formule :C27H31Cl2FN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :549.46HPK1-IN-20
CAS :<p>HPK1-IN-19 is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1).</p>Formule :C26H28N6O2Couleur et forme :SolidMasse moléculaire :456.55Cobimetinib (R-enantiomer)
CAS :<p>Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.</p>Formule :C21H21F3IN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.318PROTAC SOS1 degrader-4
<p>PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].</p>Formule :C53H65ClN8O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :993.65Debromohymenialdisine
CAS :<p>Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.</p>Formule :C11H11N5O2Couleur et forme :SolidMasse moléculaire :245.242KRAS G12D inhibitor 7
CAS :<p>KRAS G12D inhibitor 7, is a highly potent inhibitor specifically targeting KRAS G12D.</p>Formule :C32H38N8O3Couleur et forme :SolidMasse moléculaire :582.709PD 198306
CAS :<p>PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.</p>Formule :C18H16F3IN2O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :476.23Enniatin B1
CAS :<p>Enniatin B1, a Fusarium mycotoxin, crosses the blood-brain barrier and modulates ERK, NF-κB, and ACAT with an IC50 of 73 μM.</p>Formule :C34H59N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :653.858S6K1-IN-DG2
CAS :<p>S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.</p>Formule :C16H17BrN6ODegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :389.25LC-2
CAS :<p>LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a</p>Formule :C59H71ClFN11O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1132.78Tunlametinib
CAS :<p>Tunlametinib is a MEK1/2 inhibitor (IC50=1.9 nM) for treating RAS/RAF-driven cancers.</p>Formule :C16H12F2IN3O3SDegré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :491.25Anti-ERK2 Antibody (5V598)
<p>Anti-ERK2 Antibody (5V598) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (5V598) can be used in ELISA.</p>Couleur et forme :Odour LiquidAnti-ERK2 Antibody (4F551)
<p>Anti-ERK2 Antibody (4F551) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (4F551) can be used in ELISA,FCM.</p>Couleur et forme :Odour LiquidAnti-ERK2 Antibody (9C922)
<p>Anti-ERK2 Antibody (9C922) is a Mouse antibody targeting ERK2. Anti-ERK2 Antibody (9C922) can be used in WB,ELISA.</p>Couleur et forme :Odour LiquidTAK1-IN-3
CAS :<p>TAK1-IN-3 is a novel ATP-competitive TAK1 inhibitor for the study of cancer.</p>Formule :C16H19N3O2SDegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :317.41Enniatin B
CAS :<p>Enniatins B decreases the activation of ERK (p44/p42).</p>Formule :C33H57N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :639.831TRPM4 inhibitor 8
CAS :<p>TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.</p>Formule :C11H17BrN2Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :257.17JH295
CAS :<p>JH295: potent, selective Nek2 inhibitor (IC50 = 770 nM), irreversibly targets Cys22, no effect on Cdk1, Aurora B, Plk1, or spindle mechanisms.</p>Formule :C18H16N4O2Couleur et forme :SolidMasse moléculaire :320.352EM127
CAS :<p>EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.</p>Formule :C14H18ClN3O3Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :311.76RAS GTPase inhibitor 1
CAS :<p>RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.</p>Formule :C27H28ClF4N5O2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :565.99IACS-13909
CAS :<p>IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.</p>Formule :C17H18Cl2N6Degré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :377.27Gypenoside L
CAS :<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Formule :C42H72O14Degré de pureté :99.42% - 99.65%Couleur et forme :SolidMasse moléculaire :801.01L-779450
CAS :<p>L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.</p>Formule :C20H14ClN3ODegré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :347.8CC-90001
CAS :<p>CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.</p>Formule :C16H27N5O2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :321.42A-674563 2HCl(552325-73-2(fb-2hcl))
<p>A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.</p>Formule :C22H24Cl2N4ODegré de pureté :94.66%Couleur et forme :SolidMasse moléculaire :431.36NG25
CAS :<p>NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.</p>Formule :C29H30F3N5O2Degré de pureté :98.32% - ≥95%Couleur et forme :SolidMasse moléculaire :537.58K-Ras(G12C) inhibitor 6
CAS :<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Formule :C17H22Cl2N2O3SDegré de pureté :89.07% - 97.09%Couleur et forme :SolidMasse moléculaire :405.34K-Ras(G12C) inhibitor 9
CAS :<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Formule :C16H21ClIN3O4SDegré de pureté :97.33% - 97.45%Couleur et forme :SolidMasse moléculaire :513.78Cichoric Acid
CAS :<p>Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues.</p>Formule :C22H18O12Degré de pureté :97.87% - 98.77%Couleur et forme :SolidMasse moléculaire :474.37methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
CAS :<p>methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.</p>Formule :C13H13NO5Degré de pureté :97.69%Couleur et forme :SolidMasse moléculaire :263.25AZD8330
CAS :<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Formule :C16H17FIN3O4Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :461.23Kobe2602
CAS :<p>Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.</p>Formule :C14H9F4N5O4SDegré de pureté :98.36% - 99.39%Couleur et forme :SolidMasse moléculaire :419.31GS87
CAS :<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Formule :C16H11N5O2SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :337.36Belvarafenib
CAS :<p>Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.</p>Formule :C23H16ClFN6OSDegré de pureté :98% - 99.65%Couleur et forme :SolidMasse moléculaire :478.93Agerafenib
CAS :<p>Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.</p>Formule :C24H22F3N5O5Degré de pureté :95.78% - 99.23%Couleur et forme :SolidMasse moléculaire :517.46SCH772984
CAS :<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Formule :C33H33N9O2Degré de pureté :97.565% - 98.75%Couleur et forme :SolidMasse moléculaire :587.67Deltarasin HCl
CAS :<p>Deltarasin hinders KRAS-PDEδ, impairs cancer cell growth via a PDEδ pocket, disrupting RAS/RAF signaling and autophagy.</p>Formule :C40H37N5O·xHClCouleur et forme :SolidMasse moléculaire :713.144RAF709
CAS :<p>RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.</p>Formule :C28H29F3N4O4Degré de pureté :99.28% - 99.8%Couleur et forme :SolidMasse moléculaire :542.55NVP-BHG712
CAS :<p>NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and</p>Formule :C26H20F3N7ODegré de pureté :97.32% - 98.63%Couleur et forme :SolidMasse moléculaire :503.48ASK1-IN-1
CAS :<p>ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.</p>Formule :C19H19N9O2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :405.41PROTAC BRAF-V600E degrader-1
CAS :<p>PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.</p>Formule :C48H54F2N10O10SDegré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :1001.07R1487
CAS :<p>R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.</p>Formule :C19H18F2N4O3Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :388.37ASP2453
CAS :<p>ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.</p>Formule :C40H48F3N7O4Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :747.85PLX-4720
CAS :<p>PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.</p>Formule :C17H14ClF2N3O3SDegré de pureté :97.78% - 99.83%Couleur et forme :SolidMasse moléculaire :413.83ERK-IN-3
CAS :<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Formule :C22H25ClFN7O2Degré de pureté :99.55% - 99.76%Couleur et forme :SolidMasse moléculaire :473.93GNE-495
CAS :<p>GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).</p>Formule :C22H20FN5O2Degré de pureté :99.22% - 99.57%Couleur et forme :SolidMasse moléculaire :405.42BAY-293
CAS :<p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>Formule :C25H28N4O2SDegré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :448.58(S)-AMG-510
CAS :<p>(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.</p>Formule :C30H30F2N6O3Degré de pureté :99.05% - 99.76%Couleur et forme :SolidMasse moléculaire :560.594B-Raf IN 11
CAS :<p>B-Raf IN 11 is a novel selective inhibitor.</p>Formule :C17H14BrF2N3O3SDegré de pureté :99.947%Couleur et forme :SolidMasse moléculaire :458.28Compound 3344 hydrochloride
<p>Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>Formule :C24H27ClN2O3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :426.94Locostatin
CAS :<p>Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.</p>Formule :C14H15NO3Degré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :245.27SB 239063
CAS :<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Formule :C20H21FN4O2Degré de pureté :99.42% - 99.81%Couleur et forme :SolidMasse moléculaire :368.4AZ7550
CAS :<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formule :C27H31N7O2Degré de pureté :97.07% - 99.75%Couleur et forme :SolidMasse moléculaire :485.58IQ-3
CAS :<p>IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.</p>Formule :C20H11N3O3Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :341.32BMS582949
CAS :<p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>Formule :C22H26N6O2Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :406.48CC-401 Hydrochloride
CAS :<p>CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.</p>Formule :C22H25ClN6ODegré de pureté :99.71% - ≥95%Couleur et forme :SolidMasse moléculaire :424.93Maohuoside A
CAS :<p>Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.</p>Formule :C27H32O12Degré de pureté :98.91% - 99.57%Couleur et forme :SolidMasse moléculaire :548.54BI-78D3
CAS :<p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>Formule :C13H9N5O5S2Degré de pureté :97.89% - >99.99%Couleur et forme :SolidMasse moléculaire :379.37
