MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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KRAS G12D inhibitor 6
CAS :<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Formule :C32H37ClN8O2Couleur et forme :SolidMasse moléculaire :601.15SOS1-IN-11
CAS :<p>SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).</p>Formule :C22H24F3N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :431.45PROTAC K-Ras Degrader-6
CAS :<p>Pan-KRAS degrader 5 (compound 102) is a cereblon-based PROTAC KRAS degrader with a DC50 value less than 100 nM, exhibiting anticancer activity.</p>Formule :C57H65F2N11O5Couleur et forme :SolidMasse moléculaire :1022.19Anti-osteoporosis agent-8
<p>Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.</p>Formule :C18H19F3N2O2SeMasse moléculaire :432.05638Cobimetinib (R-enantiomer)
CAS :<p>Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.</p>Formule :C21H21F3IN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.318PROTAC SOS1 degrader-4
<p>PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].</p>Formule :C53H65ClN8O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :993.65HRX-0233
CAS :<p>HRX-0233 is a small molecule inhibitor targeting MAP2K4. In vivo, HRX-0233 effectively reduces tumors in H358 KRASG12C mutant non-small cell lung cancer (NSCLC) without significant toxicity. This compound also prevents feedback activation of receptor tyrosine kinases (RTKs) when used as a monotherapy with the KRAS inhibitor Sotorasib, leading to more sustained and comprehensive inhibition of the MAPK signaling pathway. HRX-0233 holds potential for research in AR-negative prostate cancer, lung cancer, and colon cancer.</p>Formule :C24H21F2N5O3SCouleur et forme :SolidMasse moléculaire :497.52RTIL 13
CAS :<p>RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).</p>Formule :C30H55BrN2O3Couleur et forme :SolidMasse moléculaire :571.685PROTAC KRAS G12C degrader-2
CAS :<p>PROTAC KRAS G12C degrader-2 (compound 432) acts as a bifunctional modulator, enhancing the hydrolysis of K-Ras protein. One end of this compound features a cereblon inhibitor of apoptosis proteins (IAP), while the other end contains a moiety that binds to KRAS [1].</p>Formule :C51H53ClFN9O7Couleur et forme :SolidMasse moléculaire :958.47Enniatin B1
CAS :<p>Enniatin B1, a Fusarium mycotoxin, crosses the blood-brain barrier and modulates ERK, NF-κB, and ACAT with an IC50 of 73 μM.</p>Formule :C34H59N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :653.858JH295
CAS :<p>JH295: potent, selective Nek2 inhibitor (IC50 = 770 nM), irreversibly targets Cys22, no effect on Cdk1, Aurora B, Plk1, or spindle mechanisms.</p>Formule :C18H16N4O2Couleur et forme :SolidMasse moléculaire :320.352LC-2
CAS :<p>LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a</p>Formule :C59H71ClFN11O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1132.78Tunlametinib
CAS :<p>Tunlametinib is a MEK1/2 inhibitor (IC50=1.9 nM) for treating RAS/RAF-driven cancers.</p>Formule :C16H12F2IN3O3SDegré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :491.25Anti-ERK2 Antibody (5V598)
<p>Anti-ERK2 Antibody (5V598) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (5V598) can be used in ELISA.</p>Couleur et forme :Odour LiquidAnti-ERK2 Antibody (4F551)
<p>Anti-ERK2 Antibody (4F551) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (4F551) can be used in ELISA,FCM.</p>Couleur et forme :Odour LiquidAnti-ERK2 Antibody (9C922)
<p>Anti-ERK2 Antibody (9C922) is a Mouse antibody targeting ERK2. Anti-ERK2 Antibody (9C922) can be used in WB,ELISA.</p>Couleur et forme :Odour LiquidEnniatin B
CAS :<p>Enniatins B decreases the activation of ERK (p44/p42).</p>Formule :C33H57N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :639.831RAS GTPase inhibitor 1
CAS :<p>RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.</p>Formule :C27H28ClF4N5O2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :565.99TRPM4 inhibitor 8
CAS :<p>TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.</p>Formule :C11H17BrN2Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :257.17EM127
CAS :<p>EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.</p>Formule :C14H18ClN3O3Degré de pureté :97.61%Couleur et forme :SolidMasse moléculaire :311.76
