MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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KRAS G12D inhibitor 9
CAS :<p>KRAS G12D inhibitor 9 targets RAS protein, key in growth, showing promise against KRAS G12D cancer.</p>Formule :C33H43N7O2Couleur et forme :SolidMasse moléculaire :569.74KRAS G12D inhibitor 28
CAS :<p>KRAS G12D inhibitor 28 (Compound 1) is an inhibitor of KRAS G12D and can be utilized in cancer research.</p>Formule :C35H32Cl2FN5OCouleur et forme :SolidMasse moléculaire :628.57MLKL-IN-1
<p>MLKL-IN-1 is a covalent inhibitor of MLKL with a Kd value of 50 μM.</p>Formule :C19H20N2O3Couleur et forme :SolidMasse moléculaire :324.37INCB159020
CAS :<p>INCB159020 is an orally active inhibitor of KRAS G12D, exhibiting a KRAS G12D SPR value of 2.2 nM. It demonstrates anti-tumor activity.</p>Formule :C37H35ClFN7O2Couleur et forme :SolidMasse moléculaire :664.171GDC-6036-NH
CAS :<p>GDC-6036-NH is a precursor of compound 17a /b, which is a RAS inhibitor that can be used in cancer research.</p>Formule :C26H30ClF4N7ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :568.01JH295 hydrate
<p>JH295 hydrate: potent, irreversible Nek2 inhibitor (IC50 = 770 nM), selective, doesn't target Cdk1, Aurora B or Plk1.</p>Formule :C18H18N4O3Couleur et forme :SolidMasse moléculaire :338.36KRAS inhibitor-13
CAS :<p>KRAS inhibitor-13 blocks KRAS G12C (IC50: 0.883 μM) and p-ERK in some cancer cells; promising for pancreatic, colorectal, lung cancer research.</p>Formule :C25H19ClFN3O2SCouleur et forme :SolidMasse moléculaire :479.95KRAS G12C inhibitor 46
CAS :<p>KRAS G12C inhibitor 46 is a potent inhibitor of KRAS G12C.</p>Formule :C32H33F2N7O2Couleur et forme :SolidMasse moléculaire :585.65HPK1-IN-42
CAS :<p>HPK1-IN-42 (compound 185) is an inhibitor of HPK1, displaying potent activity with an IC50 of 0.24 nM [1].</p>Formule :C26H30N6OSCouleur et forme :SolidMasse moléculaire :474.62AMG-548 hydrochloride
<p>AMG-548 hydrochloride: orally active, p38α inhibitor (Ki=0.5 nM), 1000x less for p38γ/δ, also blocks TNFα (IC50=3 nM) & inhibits casein kinase 1 δ/ε.</p>Formule :C29H28ClN5OCouleur et forme :SolidMasse moléculaire :498.02SHR902275
CAS :<p>SHR902275: potent RAF inhibitor, hits RAS mutations, oral use. cRAF IC50=1.6 nM, bRAFwt IC50=10 nM, bRAFV600E IC50=5.7 nM, hinders cell growth.</p>Formule :C26H23F3N4O4Couleur et forme :SolidMasse moléculaire :512.48JD123
CAS :<p>JD123 inhibits the activity of JNK1 and the expression of cJun (1-135). It is an ATP-competitive inhibitor specific to p38-γ MAPK and has no effect on ERK1, ERK2, p38-α, p38-β, and p38-δ.</p>Formule :C12H11N5S2Couleur et forme :SolidMasse moléculaire :289.379JD118
CAS :<p>JD118 is an inhibitor of JNK. It effectively suppresses the activity of JNK1 and the expression of cJun (1 - 135).</p>Formule :C13H12N4S2Couleur et forme :SolidMasse moléculaire :288.391ERK1/2 inhibitor 6
CAS :<p>ERK1/2 inhibitor 6 - potent cancer/inflammation treatment from WO2021063335A1.</p>Formule :C27H29ClFN7O5Couleur et forme :SolidMasse moléculaire :586.01KRAS inhibitor-34
CAS :<p>KRAS inhibitor-34 (compound 27) is a KRAS inhibitor with an IC50 of 6.4 nM and is utilized in oncological research.</p>Formule :C43H41F3N6O3Couleur et forme :SolidMasse moléculaire :746.82RSK4-IN-1
CAS :<p>RSK4-IN-1 is a compound exhibiting potent inhibition of RSK4, demonstrated by an IC50 value of 9.5 nM.</p>Formule :C19H20F2N4O3Couleur et forme :SolidMasse moléculaire :390.38JNK-1-IN-5
CAS :<p>JNK-1-IN-5 (Compound 14) is a potent JNK1 inhibitor with sub-nanomolar efficacy. It effectively inhibits TGF-β-induced epithelial-mesenchymal transition and shows promise for research targeting JNK1 as an anti-pulmonary fibrosis agent.</p>Formule :C23H21BrN6O3Couleur et forme :SolidMasse moléculaire :509.355HPK1-IN-3
<p>HPK1-IN-3: Selective HPK1 inhibitor, ATP-competitive, IC50=0.25nM; boosts IL-2 in PBMCs, EC50=108nM.</p>Formule :C23H22F4N6O2Couleur et forme :SolidMasse moléculaire :490.45SOS1-IN-9
<p>SOS1-IN-9 is a potent inhibitor of SOS1 that acts on KRAS G12C-SOS1 (IC50: 116.5 nM).</p>Formule :C22H28F3N5OCouleur et forme :SolidMasse moléculaire :435.49KRAS inhibitor-41
CAS :<p>KRAS inhibitor-41 is a KRAS inhibitor with an IC50 value of less than 0.01 μM for both KRAS G12D and KRAS G12V mutations. It effectively inhibits RAS mutant cell lines GP2D (KRAS-G12D) and SW620 (KRAS-G12V). KRAS inhibitor-41 is applicable for cancer research.</p>Formule :C30H37FN10OSCouleur et forme :SolidMasse moléculaire :604.745
