MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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JNK-IN-21
CAS :<p>JNK-IN-21 (Compound 62) is an inhibitor of JNK-1.</p>Formule :C19H16N2O2SCouleur et forme :SolidMasse moléculaire :336.408KRAS G12C inhibitor 15
CAS :<p>KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .</p>Formule :C25H21ClF2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.91CK1δ-IN-9
CAS :<p>CK1δ-IN-9 (Compound 8) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ with an IC50 of 1.4 nM. The compound also inhibits p38α and p38β with IC50 values of 0.25 μM and 0.78 μM, respectively. CK1δ-IN-9 exhibits favorable pharmacokinetic properties, including high oral bioavailability (70%) and moderate clearance.</p>Formule :C16H12FN5Couleur et forme :SolidMasse moléculaire :293.298p38-α MAPK-IN-10
CAS :<p>p38-α MAPK-IN-10 (Compound 6) is an inhibitor of p38α, with an IC50 value of 4 nM.</p>Formule :C27H34Cl2N6Couleur et forme :SolidMasse moléculaire :513.505p38-α MAPK-IN-9
CAS :<p>p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor with a Ki value of 0.057 nM. It effectively inhibits LPS-induced TNFα production in hPBMC cells, exhibiting an IC50 of 18 nM.</p>Formule :C19H20N8O2Couleur et forme :SolidMasse moléculaire :392.414Casein kinase 1δ-IN-31
CAS :<p>Casein kinase1δ-IN-31 (Compound 16) is an inhibitor of casein kinase (CK), specifically targeting CK1α, CK1δ, and p38α, with IC50 values of 196 nM, 17 nM, and 18 nM, respectively. Additionally, Casein kinase1δ-IN-31 inhibits Double Homeobox 4 (DUX4) with an IC50 of 1200 nM.</p>Formule :C17H13FN4Couleur et forme :SolidMasse moléculaire :292.31pan-KRAS-IN-17
CAS :<p>pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.</p>Formule :C34H33F3N5O8PCouleur et forme :SolidMasse moléculaire :727.623AM-001
CAS :AM-001 is a non-competitive inhibitor of Epac1, preventing the activation of its downstream effector Rap1 in cultured cells. This compound is utilized in research related to cardiac diseases.Formule :C24H16FN3OS2Couleur et forme :SolidMasse moléculaire :445.53J-104871
CAS :<p>J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.</p>Formule :C38H32N2O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :708.67KRAS inhibitor-37
CAS :<p>KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.</p>Formule :C32H33ClFN7O3Couleur et forme :SolidMasse moléculaire :618.10KRAS G12C inhibitor 20
CAS :<p>KRAS G12C inhibitor 20 is a KRAS G12C inhibitor.</p>Formule :C33H37ClFN7O3Couleur et forme :SolidMasse moléculaire :634.14KRAS G12C inhibitor 56
CAS :<p>KRAS G12C inhibitor 56, a powerful inhibitor of SOS1 with an inhibitory concentration (IC50) of 1.6 nM, holds promise for use in cancer research.</p>Formule :C32H39N7O4SCouleur et forme :SolidMasse moléculaire :617.76p38α MAPK/CK1δ inhibitor-1
CAS :<p>p38αMAPK/CK1δ inhibitor-1 (Compound 3) exhibits inhibitory activity against p38αMAPK and CK1δ, with IC50 values of 0.185 µM and 0.089 µM, respectively.</p>Formule :C24H17FN6O2Couleur et forme :SolidMasse moléculaire :440.429EBI-1051
CAS :<p>EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).</p>Formule :C18H15F2IN2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.22G-479
CAS :<p>G-479, a potent MEK inhibitor and improved analogue of GDC-0623, has distributed polarity enhancing bioactivity.</p>Formule :C16H15FIN5O4Couleur et forme :SolidMasse moléculaire :487.22NHTD
CAS :<p>NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).</p>Formule :C24H26N2O5Couleur et forme :SolidMasse moléculaire :422.47SOS2 ligand 1
CAS :<p>SOS2 ligand 1 (compound 2) is a selective ligand for son of sevenless 2 (SOS2), exhibiting a KD value of 4.6 µM.</p>Formule :C19H21N5OCouleur et forme :SolidMasse moléculaire :335.403Brimarafenib
CAS :<p>Brimarafenib is a selective RAF dimerization inhibitor, which can inhibit BRAF and CRAF, and exhibits inhibitory effects on a variety of RAF mutations.</p>Formule :C24H17F3N4O4Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :482.41KRAS G12D inhibitor 16
CAS :<p>KRAS G12D inhibitor 16 targets KRAS G12D with IC50 of 0.7 nM and mutant form at 0.35 μM, useful in various cancer studies.</p>Formule :C32H39IN6O3Couleur et forme :SolidMasse moléculaire :682.59pan-KRAS degrader 1
CAS :<p>Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.</p>Formule :C22H26N8OSCouleur et forme :SolidMasse moléculaire :450.56
