MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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KRAS G12C inhibitor 18
CAS :<p>KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.</p>Formule :C25H20ClFN4O3SCouleur et forme :SolidMasse moléculaire :510.97JTP10-△-TATi TFA
<p>JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.</p>Formule :C120H213F3N48O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2833.28MRTX849 analog 24
CAS :<p>MRTX849 analog 24, a KRAS G12C inhibitor with an alkyne for click probes, aids in studying MRTX849's functionality.</p>Formule :C36H39ClFN7O2Couleur et forme :SolidMasse moléculaire :656.2GNE-9815
CAS :<p>GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selective</p>Formule :C26H22FN5O2Degré de pureté :99.08% - 99.1%Couleur et forme :SolidMasse moléculaire :455.48MAP4K4-IN-6
<p>MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor with an IC50 of 80 nM. It reduces the phosphorylation of c-Jun and exhibits neuroprotective effects. Additionally, MAP4K4-IN-6 enhances the vitality of motor neurons and can be utilized in the study of amyotrophic lateral sclerosis (ALS).</p>Couleur et forme :Odour Solid(R)-BI-2852
CAS :<p>(R)-5-hydroxy isoindolin-1-one is an RAS protein inhibitor with antiproliferative and antitumor properties.</p>Formule :C31H28N6O2Degré de pureté :97.78%Couleur et forme :SoildMasse moléculaire :516.59HSND80
<p>HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.</p>Couleur et forme :Odour SolidPROTAC K-Ras Degrader-6
CAS :<p>Pan-KRAS degrader 5 (compound 102) is a cereblon-based PROTAC KRAS degrader with a DC50 value less than 100 nM, exhibiting anticancer activity.</p>Formule :C57H65F2N11O5Couleur et forme :SolidMasse moléculaire :1022.19MC 976
CAS :<p>MC 976 is a derivative of Vitamin D3.</p>Formule :C27H42O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.63Rac1 Inhibitor W56
CAS :<p>Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.</p>Formule :C74H117N19O23SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1671.93MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Couleur et forme :Odour SolidKRAS G12D inhibitor 7
CAS :<p>KRAS G12D inhibitor 7, is a highly potent inhibitor specifically targeting KRAS G12D.</p>Formule :C32H38N8O3Couleur et forme :SolidMasse moléculaire :582.709SEPT9-IN-1
<p>SEPT9-IN-1 (compound 8b) is a SEPT9 inhibitor with an IC50 value of 94.83 μM. It exhibits cytotoxicity against human oral squamous carcinoma cells, with an IC50 of 21 µM.</p>Formule :C26H30ClN3O3Couleur et forme :SolidMasse moléculaire :467.988NecroX-2
CAS :<p>NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.</p>Formule :C25H32N4O4S2Degré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :516.68PROTAC K-Ras Degrader-2
CAS :<p>PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V/RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.</p>Formule :C52H60F4N8O5Couleur et forme :SolidMasse moléculaire :953.077KRAS inhibitor-38
CAS :<p>KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.</p>Formule :C53H68ClF2N9O8SCouleur et forme :SolidMasse moléculaire :1064.68Ras Inhibitory Peptide acetate
<p>Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.</p>Formule :C55H95N19O13Degré de pureté :96.63%Couleur et forme :SolidMasse moléculaire :1230.46JNK3 inhibitor-8
<p>JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.</p>Formule :C32H30FN7O3Couleur et forme :SolidMasse moléculaire :579.62MEK1/2-IN-3
<p>MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.</p>Formule :C28H23F3IN3O4Couleur et forme :SolidMasse moléculaire :649.4HPK1-IN-39
<p>HPK1-IN-39 (Compound 10n), a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) with an inhibitory concentration (IC50) of 29 nM, impedes the</p>Formule :C26H27N7O2Couleur et forme :SolidMasse moléculaire :469.54
