MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
902 produits trouvés pour "MAPK".
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LUT014
CAS :LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Formule :C27H19F3N8ODegré de pureté :99.03%Couleur et forme :Yellow SolidMasse moléculaire :528.49K-Ras G12C-IN-4
CAS :K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。Formule :C31H33ClN4O4Degré de pureté :99.41%Couleur et forme :White SolidMasse moléculaire :561.07Ref: TM-T11738
1mg71,00€5mg161,00€1mL*10mM (DMSO)192,00€10mg236,00€25mg403,00€50mg532,00€100mg783,00€200mg1.054,00€TINK-IN-1
CAS :TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.Formule :C24H24N4O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :416.47Ref: TM-T77660
1mg39,00€2mg50,00€5mg82,00€10mg120,00€25mg236,00€50mg353,00€100mg517,00€500mg1.099,00€MK2-IN-3 hydrate
CAS :MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Formule :C21H18N4O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :358.39Ref: TM-T12058
1mg34,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg87,00€25mg172,00€50mg250,00€100mg350,00€200mg480,00€AX-15836
CAS :AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Formule :C32H40N8O5SDegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :648.78Ref: TM-T14360
1mg54,00€2mg77,00€5mg114,00€1mL*10mM (DMSO)164,00€10mg167,00€25mg281,00€50mg401,00€100mg567,00€500mg1.161,00€CC-90003
CAS :CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Formule :C22H21F3N6O2Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :458.44Ref: TM-T14894
2mg35,00€1mg46,00€5mg50,00€1mL*10mM (DMSO)50,00€10mg86,00€25mg156,00€50mg215,00€100mg319,00€INH154
CAS :INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.Formule :C22H24N4OSDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :392.52Ref: TM-T11657
2mg34,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg82,00€25mg136,00€50mg203,00€100mg299,00€200mg416,00€Azelnidipine
CAS :Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.Formule :C33H34N4O6Degré de pureté :99.78%Couleur et forme :White SolidMasse moléculaire :582.65Ref: TM-T0121
2mg34,00€5mg49,00€1mL*10mM (DMSO)59,00€10mg64,00€25mg103,00€50mg167,00€100mg260,00€200mg385,00€B-Raf IN 2
CAS :B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.Formule :C20H17F2N5O4SDegré de pureté :98.86%Couleur et forme :White SolidMasse moléculaire :461.44JNK-IN-13
CAS :JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.Formule :C13H7ClN4SDegré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :286.74ERK5-IN-6
CAS :ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.Formule :C23H21N3Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :339.43ERK5-IN-5
CAS :ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Formule :C19H16ClN3ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :337.8Ref: TM-T77734
1mg81,00€2mg105,00€5mg170,00€10mg264,00€25mg532,00€50mg868,00€100mg1.378,00€500mg2.673,00€PD 198306
CAS :PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Formule :C18H16F3IN2O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :476.23Ref: TM-T21980
1mg60,00€5mg131,00€1mL*10mM (DMSO)152,00€10mg178,00€25mg314,00€50mg447,00€100mg622,00€500mg1.224,00€BAY 2965501
CAS :BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.Formule :C20H19FN4O3SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :414.45(R)-BI-2852
CAS :(R)-5-hydroxy isoindolin-1-one is an RAS protein inhibitor with antiproliferative and antitumor properties.Formule :C31H28N6O2Degré de pureté :97.80%Couleur et forme :SolidMasse moléculaire :516.59BI-3406
CAS :BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Formule :C23H25F3N4O3Degré de pureté :99.2% - 99.66%Couleur et forme :SolidMasse moléculaire :462.46Ref: TM-T12979
1mg70,00€5mg152,00€1mL*10mM (DMSO)155,00€10mg236,00€25mg439,00€50mg628,00€100mg872,00€500mg1.738,00€PF-3644022
CAS :PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.Formule :C21H18N4OSDegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :374.46Ref: TM-T16501
1mg34,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg192,00€25mg394,00€50mg587,00€100mg788,00€500mg1.575,00€(R)-Ketorolac
CAS :(R)-Ketorolac ((+)-Ketorolac) is the R-enantiomer of Ketorolac, with potent analgesic activity.Formule :C15H13NO3Degré de pureté :99.55%Couleur et forme :White SolidMasse moléculaire :255.27Ref: TM-T12624
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg222,00€50mg313,00€100mg437,00€HI-TOPK-032
CAS :HI-TOPK-032 is an effective and specific inhibitor of TOPK.Formule :C20H11N5OSDegré de pureté :98.52%Couleur et forme :SolidMasse moléculaire :369.4Cephradine
CAS :Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.Formule :C16H19N3O4SDegré de pureté :99.63%Couleur et forme :White Crystalline Powder; Polymorphic SolidMasse moléculaire :349.40Ro-3201195
CAS :Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.Formule :C19H18FN3O4Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :371.36Ref: TM-T68134
1mg122,00€5mg289,00€1mL*10mM (DMSO)311,00€10mg432,00€25mg707,00€50mg973,00€100mg1.333,00€500mg2.665,00€Xl-281
CAS :XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Formule :C24H19ClN4O4Degré de pureté :95.77% - 98.83%Couleur et forme :White SolidMasse moléculaire :462.89MRTX0902
CAS :MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Formule :C22H24N6ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :388.47BAS 00489700
CAS :BAS 00489700 is a N-UTR interaction inhibitor. BAS 00489700 inhibits virus replication in cell culture.Formule :C19H16N2O4Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :336.34Ref: TM-T67854
1mg85,00€5mg170,00€1mL*10mM (DMSO)170,00€10mg250,00€25mg371,00€50mg522,00€100mg712,00€200mg954,00€Divarasib
CAS :Divarasib (GDC-6036), an investigational KRAS G12C inhibitor for solid tumors, has an IC50 of <0.01 μM.Formule :C29H32ClF4N7O2Degré de pureté :99.23% - 99.83%Couleur et forme :White SolidMasse moléculaire :622.06Ref: TM-T9972
1mg220,00€5mg522,00€1mL*10mM (DMSO)707,00€10mg737,00€25mg1.161,00€50mg1.603,00€100mg2.133,00€SU3327
CAS :SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Formule :C5H3N5O2S3Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :261.3ARS-1630
CAS :ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Formule :C21H17ClF2N4O2Degré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :430.84Ref: TM-T10376
1mg38,00€5mg86,00€1mL*10mM (DMSO)88,00€10mg112,00€25mg216,00€50mg310,00€100mg408,00€200mg580,00€ETC-206
CAS :ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).Formule :C25H20N4O2Degré de pureté :99.72% - 99.79%Couleur et forme :SolidMasse moléculaire :408.45Ref: TM-T15250
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg92,00€25mg140,00€50mg215,00€100mg318,00€500mg692,00€ACBI3
CAS :ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.Formule :C50H62N14O6S2Degré de pureté :99.24% - 99.41%Couleur et forme :White SolidMasse moléculaire :1019.25MAP4K4-IN-3
CAS :MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.Formule :C15H12ClN5Degré de pureté :98.07%Couleur et forme :White SolidMasse moléculaire :297.74Ref: TM-T11942
5mg44,00€1mL*10mM (DMSO)48,00€10mg74,00€25mg144,00€50mg222,00€100mg354,00€200mg523,00€500mg797,00€KRAS G12C inhibitor 19
CAS :KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.Formule :C25H19ClF2N4O3SDegré de pureté :97.46%Couleur et forme :SolidMasse moléculaire :528.96MRTX-1257
CAS :MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Formule :C33H39N7O2Degré de pureté :96.76% - 97.3%Couleur et forme :Yellow SolidMasse moléculaire :565.71Ref: TM-T16143
1mg60,00€2mg85,00€5mg124,00€1mL*10mM (DMSO)166,00€10mg195,00€25mg351,00€50mg512,00€100mg743,00€200mg982,00€Cobimetinib (R-enantiomer)
CAS :Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Formule :C21H21F3IN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.318BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Formule :C47H62N8O4SCouleur et forme :SolidMasse moléculaire :835.11ADT-007
CAS :ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Formule :C26H24FNO5Degré de pureté :98.82%Couleur et forme :Yellow SolidMasse moléculaire :449.47Ref: TM-T85316
1mg47,00€5mg96,00€1mL*10mM (DMSO)104,00€10mg124,00€25mg200,00€50mg353,00€100mg602,00€200mg982,00€KRAS-IN-43
KRAS-IN-43 (Compound 9) is a broad-spectrum KRAS inhibitor with IC50 values of 0.15 μM for KRASG12V, 0.14 μM for KRASG12C, and 0.47 μM for wild-type KRAS. It disrupts the interaction between KRAS and cRAF and suppresses ERK phosphorylation. KRAS-IN-43 shows potential for research in KRAS mutation-associated cancers, including pancreatic, colorectal, and lung cancers.Couleur et forme :Odour SolidERK1/2 inhibitor 10
ERK1/2 inhibitor 10 (Compound 36c) is a potent inhibitor of ERK1 and ERK2, with IC50 values of 0.11 nM and 0.08 nM, respectively. It effectively hinders the phosphorylation of downstream substrates p90RSK and c-Myc. Additionally, ERK1/2 inhibitor 10 induces apoptosis and incomplete autophagy-related cell death. This compound demonstrates significant antitumor efficacy in models of triple-negative breast cancer and colorectal cancer harboring BRAF and RAS mutations.Formule :C23H20ClN5O2SMasse moléculaire :465.10262R18
CAS :14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Formule :C101H157N27O29S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2309.69RTIL 13
CAS :RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).Formule :C30H55BrN2O3Couleur et forme :SolidMasse moléculaire :571.685Antimicrobial agent-21
CAS :Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFormule :C18H13N3OSDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :319.38Ref: TM-T67942
1mg54,00€5mg116,00€10mg172,00€1mL*10mM (DMSO)180,00€25mg278,00€50mg371,00€100mg510,00€200mg687,00€ASP6918
ASP6918 is a potent, orally active KRAS G12C inhibitor with an IC50 of 0.028 µM. It inhibits cell growth and demonstrates antitumor activity.Formule :C36H43N7O3Couleur et forme :SolidMasse moléculaire :621.34274TAT-PAK18 R192A
TAT-PAK18 R192A is an inactive Tat-Pak peptide. It does not influence Rac1 translocation triggered by any tested proteins.Formule :C143H247N55O37Masse moléculaire :3326.91369HPK1-IN-4
CAS :HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.Formule :C23H26N6O3Degré de pureté :97.06%Couleur et forme :Yellow SolidMasse moléculaire :434.49Ref: TM-T40350
1mg123,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg447,00€25mg782,00€50mg1.071,00€100mg1.468,00€MS432
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.Formule :C50H65F3IN7O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1076.06(S,R,S)-AHPC-Me-C10-Br
CAS :(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate and ligand-linker for E3 ligase, MS432 for MEK1/2 inhibitors and a VHL E3 ligase linker.Formule :C34H51BrN4O4SDegré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :691.76Ref: TM-T18668
10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander1mg34,00€5mg70,00€1mL*10mM (DMSO)101,00€MEK/RAF-IN-1
MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.Formule :C28H29F3N6O5SCouleur et forme :SolidMasse moléculaire :618.63Mitogen-activated protein kinase 1
CAS :Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Degré de pureté :98%Couleur et forme :SolidKRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Formule :C51H65F4N9O9S2Couleur et forme :SolidMasse moléculaire :1088.24LYMTAC-2
LYMTAC-2 is a lysosome-targeting chimera (LYMTAC) developed to degrade membrane-associated proteins through lysosomal membrane proteins (LMP) such as RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with target proteins like KRASG12D, facilitating their relocation to lysosomes and resulting in ubiquitin-dependent degradation. This compound has potential for studying membrane protein regulation and devising strategies to counter resistance in KRAS-driven signaling pathways.Couleur et forme :SolidMasse moléculaire :1248.44NK7-902 TFA
NK7-902 TFA is a CRBN molecular glue degrader of NEK7. It effectively degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. While NK7-902 TFA achieves deep and lasting NEK7 degradation, it temporarily blocks NLRP3 inflammasome activation in non-human primates when administered orally. Additionally, NK7-902 TFA demonstrates activity in mouse systems.Couleur et forme :Odour Solid
