MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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Xl-281
CAS :<p>XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.</p>Formule :C24H19ClN4O4Degré de pureté :95.77% - 98.83%Couleur et forme :SolidMasse moléculaire :462.89K-Ras G12C-IN-4
CAS :<p>K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。</p>Formule :C31H33ClN4O4Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :561.07ACBI3
CAS :<p>ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.</p>Formule :C50H62N14O6S2Degré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :1019.25ERK5-IN-6
CAS :<p>ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.</p>Formule :C23H21N3Degré de pureté :98.59%Couleur et forme :SoildMasse moléculaire :339.43ARS-1630
CAS :<p>ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.</p>Formule :C21H17ClF2N4O2Degré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :430.84MK2-IN-3 hydrate
CAS :<p>MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)</p>Formule :C21H18N4O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :358.39INH154
CAS :<p>INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.</p>Formule :C22H24N4OSDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :392.52RMC-6236
CAS :<p>RMC-6236 is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.</p>Formule :C44H58N8O5SDegré de pureté :98.24% - 99.92%Couleur et forme :SolidMasse moléculaire :811.05Dilmapimod
CAS :<p>Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.</p>Formule :C23H19F3N4O3Degré de pureté :97.53%Couleur et forme :SolidMasse moléculaire :456.42Pepinh-TRIF TFA
<p>Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interaction</p>Formule :C180H279F3N58O40S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4014.09741ERK5-IN-5
CAS :<p>ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.</p>Formule :C19H16ClN3ODegré de pureté :99.77%Couleur et forme :SoildMasse moléculaire :337.8(R)-Ketorolac
CAS :<p>(R)-Ketorolac ((+)-Ketorolac) is the R-enantiomer of Ketorolac, with potent analgesic activity.</p>Formule :C15H13NO3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :255.27ETC-206
CAS :<p>ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).</p>Formule :C25H20N4O2Degré de pureté :99.72% - 99.79%Couleur et forme :SolidMasse moléculaire :408.45SU3327
CAS :<p>SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).</p>Formule :C5H3N5O2S3Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :261.3MRTX-1257
CAS :<p>MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.</p>Formule :C33H39N7O2Degré de pureté :97.3% - 99.07%Couleur et forme :SolidMasse moléculaire :565.71BI-3406
CAS :<p>BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.</p>Formule :C23H25F3N4O3Degré de pureté :99.2% - 99.66%Couleur et forme :SolidMasse moléculaire :462.46Divarasib
CAS :<p>Divarasib (GDC-6036), an investigational KRAS G12C inhibitor for solid tumors, has an IC50 of <0.01 μM.</p>Formule :C29H32ClF4N7O2Degré de pureté :99.237% - 99.83%Couleur et forme :SolidMasse moléculaire :622.06PF-3644022
CAS :<p>PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.</p>Formule :C21H18N4OSDegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :374.46Regorafénib N-oxyde (M2)
CAS :<p>Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.</p>Formule :C21H15ClF4N4O4Degré de pureté :98.03% - 98.26%Couleur et forme :SolidMasse moléculaire :498.81Azelnidipine
CAS :<p>Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.</p>Formule :C33H34N4O6Degré de pureté :99.78%Couleur et forme :Light Yellowish PowderMasse moléculaire :582.65AX-15836
CAS :<p>AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).</p>Formule :C32H40N8O5SDegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :648.78B-Raf IN 2
CAS :<p>B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.</p>Formule :C20H17F2N5O4SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :461.44JNK-IN-13
CAS :<p>JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.</p>Formule :C13H7ClN4SDegré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :286.74Cephradine
CAS :<p>Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.</p>Formule :C16H19N3O4SDegré de pureté :99.63%Couleur et forme :White Crystalline Powder; Polymorphic SolidMasse moléculaire :349.40HI-TOPK-032
CAS :<p>HI-TOPK-032 is an effective and specific inhibitor of TOPK.</p>Formule :C20H11N5OSDegré de pureté :98.52%Couleur et forme :SolidMasse moléculaire :369.4LUT014
CAS :<p>LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.</p>Formule :C27H19F3N8ODegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :528.49CC-90003
CAS :<p>CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.</p>Formule :C22H21F3N6O2Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :458.44Tanzisertib
CAS :<p>Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.</p>Formule :C21H23F3N6O2Degré de pureté :98.66% - 99.28%Couleur et forme :SolidMasse moléculaire :448.44MAP4K4-IN-3
CAS :<p>MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.</p>Formule :C15H12ClN5Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :297.74Methylthiouracil
CAS :<p>Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.</p>Formule :C5H6N2OSDegré de pureté :99.89% - >99.99%Couleur et forme :Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Masse moléculaire :142.18MRTX0902
CAS :<p>MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.</p>Formule :C22H24N6ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :388.47KRAS G12C inhibitor 19
CAS :<p>KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.</p>Formule :C25H19ClF2N4O3SDegré de pureté :97.46%Couleur et forme :SolidMasse moléculaire :528.96GW806742X
CAS :<p>GW806742X inhibits MLKL with Kd 9.3 μM, preventing necroptosis; also targets VEGFR2.</p>Formule :C25H22F3N7O4SDegré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :573.55KRAS inhibitor-38
CAS :<p>KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.</p>Formule :C53H68ClF2N9O8SCouleur et forme :SolidMasse moléculaire :1064.68NecroX-2
CAS :<p>NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.</p>Formule :C25H32N4O4S2Degré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :516.68JNK3 inhibitor-8
<p>JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.</p>Formule :C32H30FN7O3Couleur et forme :SolidMasse moléculaire :579.62Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour SolidRac1 Inhibitor W56
CAS :<p>Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.</p>Formule :C74H117N19O23SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1671.93LC 2 Epimer
CAS :<p>Negative control for LC 2.</p>Formule :C59H71ClFN11O7SCouleur et forme :SolidMasse moléculaire :1132.8KRAS G12C inhibitor 60
<p>KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and</p>Formule :C31H30F5N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.61KRAS G12C inhibitor 18
CAS :<p>KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.</p>Formule :C25H20ClFN4O3SCouleur et forme :SolidMasse moléculaire :510.97GNE-9815
CAS :<p>GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selective</p>Formule :C26H22FN5O2Degré de pureté :99.08% - 99.1%Couleur et forme :SolidMasse moléculaire :455.48HPK1-IN-8
CAS :<p>HPK1-IN-8 is an allosteric, inactive, conformation-selective triazolopyrimidine ketone HPK1 inhibitor.</p>Formule :C19H17FN6O2SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :412.44KG5
CAS :<p>KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).</p>Formule :C20H16F3N7OSDegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :459.45KRAS G12C inhibitor 69
<p>KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.</p>Formule :C29H29ClF3N5O3Couleur et forme :SolidMasse moléculaire :588.02MC 976
CAS :<p>MC 976 is a derivative of Vitamin D3.</p>Formule :C27H42O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.63SS47
CAS :<p>SS47 is a PROTAC that degrades immunosuppressive HPK1 via proteasome; boosts BCMA CAR-T cell cancer therapy.</p>Formule :C49H56N6O12SCouleur et forme :SolidMasse moléculaire :953.07MEK/RAF-IN-1
<p>MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.</p>Formule :C28H29F3N6O5SCouleur et forme :SolidMasse moléculaire :618.63DS03090629
<p>DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.</p>Formule :C25H26ClN5O2Couleur et forme :SolidMasse moléculaire :463.9612-Oxo phytodienoic acid
CAS :<p>12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.</p>Formule :C18H28O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.41
