MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
893 produits trouvés pour "MAPK". Les 500 premiers sont affichés.
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HCI-2184
CAS :HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.Formule :C23H28ClN7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.03GSK649A
CAS :GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.Formule :C15H12ClFN6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.81CP-281384
CAS :CP-281384 is a potent, p38alpha-selective inhibitor.Formule :C18H14F2N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :340.33DDO3711
CAS :"DDO3711, a PHORC, links an ASK1 inhibitor to a PP5 activator, inhibiting ASK1 (IC50=164.1 nM), dephosphorylating p-ASK1, and showing anti-cancer potential."Formule :C42H41N9O6Couleur et forme :SolidMasse moléculaire :767.83JNK3 inhibitor-2
CAS :JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.Formule :C20H14N2O2Couleur et forme :SolidMasse moléculaire :314.34KRAS G12C inhibitor 31
CAS :KRAS G12C inhibitor 31 is an inhibitor of KRAS G12C that can be used to study cancer.Formule :C25H22ClFN6O3Couleur et forme :SolidMasse moléculaire :508.93RBC6
CAS :RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.Formule :C16H14Cl2N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.21PB1
CAS :PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Formule :C14H22BO4PCouleur et forme :SolidMasse moléculaire :296.11KRas G12C inhibitor 4
CAS :KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.Formule :C33H38ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :600.15Tpl2 Kinase Inhibitor 1
CAS :Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor.Formule :C21H14ClFN6Degré de pureté :98%Couleur et forme :Yellow SolidMasse moléculaire :404.83KRAS G12C inhibitor 48
KRAS G12C inhibitor 48: potent with IC50 639.91 nM; hampers H358, H23, A549 cell growth with IC50s of 0.796, 6.33, 16.14 µM, respectively.Formule :C36H39ClN8O2Couleur et forme :SolidMasse moléculaire :651.2TOPK-p38/JNK-IN-1
CAS :TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFormule :C17H15F3N2O4Couleur et forme :SolidMasse moléculaire :368.31KRAS G12C inhibitor 29
CAS :KRAS G12C inhibitor 29 is an inhibitor of KRAS G12C and can be used to study cancer.Formule :C23H21ClFN5O2Couleur et forme :SolidMasse moléculaire :453.9HPK1-IN-25
CAS :HPK1-IN-25, an HPK1 inhibitor, IC50 129 nM, may aid cancer research.Formule :C23H25N5OCouleur et forme :SolidMasse moléculaire :387.48CP-944629
CAS :CP-944629 is a novel, potent, and selective inhibitor of p38alpha.Formule :C19H15F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.34BNC-1
CAS :BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Formule :C16H14N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.29KRAS inhibitor-7
CAS :KRAS inhibitor-7 is a potent KRAS G12C inhibitor.Formule :C26H27ClF2N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.98Migoprotafib
CAS :Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Formule :C25H26N8ODegré de pureté :98.31%Couleur et forme :Yellow SolidMasse moléculaire :454.53Ref: TM-T62798
1mg130,00€5mg313,00€1mL*10mM (DMSO)341,00€10mg497,00€25mg982,00€50mg1.603,00€100mg2.592,00€PF-04880594
CAS :PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].Formule :C19H16F2N8Couleur et forme :SolidMasse moléculaire :394.38LY-2584702 hydrochloride
CAS :Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.Formule :C21H20ClF4N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.88SX 011
CAS :SX 011 is a p38α inhibitor.Formule :C26H27ClFN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :483.96(2Z,3Z)-U0126
CAS :U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Formule :C18H16N6S2Couleur et forme :SolidMasse moléculaire :380.49Antifungal agent 46
CAS :Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Formule :C26H28BrF3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.43KRas G12C inhibitor 3
CAS :KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Formule :C32H36ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.13HPK1-IN-29
CAS :"HPK1-IN-29 suppresses HPK1, boosting anti-tumor immunity; potential for immune disease research."Formule :C26H18F3N5O2Couleur et forme :SolidMasse moléculaire :489.45ML 3403
CAS :p38 MAPK inhibitor; IC50: 0.38μM. Reduces IL-1β & TNF-α release in PBMC assay; IC50: 0.039μM & 0.16μM.Formule :C23H21FN4SCouleur et forme :SolidMasse moléculaire :404.5Spiclomazine HCl
CAS :Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.Formule :C22H25Cl2N3OS2Couleur et forme :SolidMasse moléculaire :482.49CCG-232601
CAS :CCG-232601 is a inhibitor of the Rho/MRTF/SRF transcriptional pathway.Formule :C24H20ClF2N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :455.88Tinlorafenib
CAS :Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Formule :C19H19ClF2N4O3SCouleur et forme :SolidMasse moléculaire :456.89MTBT
CAS :MTBT is the proliferation of cancer cells inhibitor. It induces cell cycle arrest and activates p38 MAPK.Formule :C14H11NO2S2Couleur et forme :SolidMasse moléculaire :289.37p38 MAP Kinase Inhibitor IV
CAS :p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.Formule :C12H4Cl6O4SCouleur et forme :SolidMasse moléculaire :456.94ARS-2102
CAS :ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .Formule :C28H31ClF2N6O2Couleur et forme :SolidMasse moléculaire :557.03ERK5-IN-4
CAS :ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Formule :C16H11Cl2FN4O2Couleur et forme :SolidMasse moléculaire :381.19KRAS inhibitor-15
CAS :KRAS inhibitor-15 blocks KRAS G12C and p-ERK in cancer cells; potent against pancreatic and lung cancers. IC50: 0.954 μM (KRAS), 2.03/>33.3 μM (p-ERK).Formule :C20H17Cl2FN4OSCouleur et forme :SolidMasse moléculaire :451.34KRAS inhibitor-10
CAS :KRAS inhibitor-10: potent, selective KRAS protein blocker; effective in various cancers; oral; tetrahydroisoquinoline class.Formule :C30H37N3O5Couleur et forme :SolidMasse moléculaire :519.63ERK5-IN-3
CAS :ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).Formule :C24H23Cl2FN4O2Couleur et forme :SolidMasse moléculaire :489.37SR-3737
CAS :SR-3737 is potent both JNK3 and p38 inhibitor.Formule :C29H25FN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.53KRAS G12C inhibitor 45
CAS :KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .Formule :C32H33F2N5O5SCouleur et forme :SolidMasse moléculaire :637.7JNK3 inhibitor-4
CAS :JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.Formule :C28H27N7OCouleur et forme :SolidMasse moléculaire :477.56HPK1-IN-17
CAS :HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.Formule :C26H28N6OCouleur et forme :SolidMasse moléculaire :440.54(R)-CE3F4
CAS :(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM),Formule :C11H10Br2FNOCouleur et forme :SolidMasse moléculaire :351.01PHT-7.3
CAS :PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitorFormule :C24H23N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.52KRAS inhibitor-17
CAS :KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.Formule :C21H18Cl2FN3O2SCouleur et forme :SolidMasse moléculaire :466.36BRAF V600E/CRAF-IN-2
CAS :Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.Formule :C30H30F3N5O2Couleur et forme :SolidMasse moléculaire :549.59JNK-1-IN-1
CAS :JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.Formule :C24H22N6SCouleur et forme :SolidMasse moléculaire :426.54BAY-846
CAS :BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Formule :C19H13F4IN4O4SCouleur et forme :SolidMasse moléculaire :596.29CK1-IN-2
CAS :CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.Formule :C17H12FN3O2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :309.296-T-GDP
CAS :6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.Formule :C10H15N5O10P2SCouleur et forme :SolidMasse moléculaire :459.27B-Raf IN 7
CAS :"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."Formule :C15H16N6O3Couleur et forme :SolidMasse moléculaire :328.33BRAF inhibitor
CAS :BRAF inhibitor is an inhibitor of B-Raf.Formule :C22H18F2N4O3SDegré de pureté :98.2% - 98.41%Couleur et forme :SolidMasse moléculaire :456.47Ref: TM-T10599
1mg44,00€5mg87,00€1mL*10mM (DMSO)99,00€10mg137,00€25mg236,00€50mg371,00€100mg530,00€200mg770,00€
