MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
887 produits trouvés pour "MAPK"
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PHT-7.3
CAS :<p>PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitor</p>Formule :C24H23N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.52BRAF V600E/CRAF-IN-1
CAS :<p>BRAF V600E/CRAF-IN-1: potent BRAF/CRAF inhibitor, induces cell cycle arrest and apoptosis in HCT-116 cells, promising for cancer research.</p>Formule :C25H17F6N3O2Couleur et forme :SolidMasse moléculaire :505.41KRAS inhibitor-6
CAS :<p>KRAS inhibitor-6 is a potent KRAS G12C inhibitor.</p>Formule :C27H30ClF2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :546.01(R)-STU104
CAS :<p>(R)-STU104 is a TAK1-MKK3 protein-protein interaction (PPI) inhibitor. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.</p>Formule :C18H18O4Degré de pureté :98.91% - 99.42%Couleur et forme :SolidMasse moléculaire :298.33REDX05358
CAS :<p>REDX05358: Selective pan RAF inhibitor for BRAF/RAS mutant tumors with high affinity, safety, and low paradoxical activation.</p>Formule :C26H21ClN4O3Couleur et forme :SolidMasse moléculaire :472.92KRAS inhibitor-3
CAS :<p>KRAS inhibitor-3 targets WT/oncogenic KRAS; high affinity (KD: 0.28-0.74 μM); disrupts KRAS-Raf interaction.</p>Formule :C25H27N5OCouleur et forme :SolidMasse moléculaire :413.51Spiclomazine HCl
CAS :Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.Formule :C22H25Cl2N3OS2Couleur et forme :SolidMasse moléculaire :482.49PF-04880594
CAS :<p>PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].</p>Formule :C19H16F2N8Couleur et forme :SolidMasse moléculaire :394.38KRAS G12C inhibitor 48
<p>KRAS G12C inhibitor 48: potent with IC50 639.91 nM; hampers H358, H23, A549 cell growth with IC50s of 0.796, 6.33, 16.14 µM, respectively.</p>Formule :C36H39ClN8O2Couleur et forme :SolidMasse moléculaire :651.2KRAS G12C inhibitor 31
CAS :<p>KRAS G12C inhibitor 31 is an inhibitor of KRAS G12C that can be used to study cancer.</p>Formule :C25H22ClFN6O3Couleur et forme :SolidMasse moléculaire :508.93Nek2-IN-6
CAS :<p>Nek2-IN-6 inhibitor .</p>Formule :C33H33F3N6O4SCouleur et forme :SolidMasse moléculaire :666.71L-167307
CAS :<p>L-167307 is a p38 kinase inhibitor.</p>Formule :C22H17FN2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.45KRAS4b-IN-D14
CAS :<p>KRAS4b-IN-D14 inhibits oncogenic KRAS4b, shrinks tumors, and induces cancer cell apoptosis.</p>Formule :C24H24ClN5O4Couleur et forme :SolidMasse moléculaire :481.93HPK1-IN-15
CAS :<p>HPK1-IN-15 selectively inhibits HPK1, a MAP4K family kinase, potentially aiding in cancer treatment.</p>Formule :C24H21ClF3N5Couleur et forme :SolidMasse moléculaire :471.91KRAS G12D inhibitor 13
CAS :<p>KRAS G12D inhibitor 13 targets KRAS G12D-mediated cancers with potency (WO2021108683A1, cmpd 142).</p>Formule :C31H33F2N7O3Couleur et forme :SolidMasse moléculaire :589.64KRAS G12C inhibitor 42
CAS :<p>KRAS G12C inhibitor 42 targets KRAS G12C for potential cancer therapy. (Patent WO2020146613A1, compound 10)</p>Formule :C33H34FN7O2Couleur et forme :SolidMasse moléculaire :579.67p38-α MAPK-IN-4
CAS :<p>p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM.</p>Formule :C17H13BrN2OCouleur et forme :SolidMasse moléculaire :341.2LCRF-0004
CAS :<p>LCRF-0004 inhibits RON kinase, key in KRAS-driven pancreatic cancer, reducing cell migration and enhancing chemo sensitivity.</p>Formule :C28H18F4N6O2SCouleur et forme :SolidMasse moléculaire :578.54KRAS G12C inhibitor 39
CAS :<p>KRAS G12C inhibitor 39 effectively targets KRAS G12C, a key protein in cancer research.</p>Formule :C37H43N9O2Couleur et forme :SolidMasse moléculaire :645.8CBS-3595
CAS :<p>CBS-3595: potent p38α MAPK/PDE-4 dual inhibitor, strong anti-inflammatory, low toxicity.</p>Formule :C18H17FN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.42GP17
CAS :<p>GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.</p>Formule :C26H21F3N4OCouleur et forme :SolidMasse moléculaire :462.47JNK-1-IN-1
CAS :<p>JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.</p>Formule :C24H22N6SCouleur et forme :SolidMasse moléculaire :426.54ADTL-EI1712
CAS :<p>ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.</p>Formule :C22H18Cl2N4O2S2Couleur et forme :SolidMasse moléculaire :505.44JX 401
CAS :<p>JX 401 is a p38α inhibitor.</p>Formule :C21H25NO2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.49SB 204900
CAS :<p>SB 204900 inhibit the release of histamine and TNF-α from RBL-2H3 cells.</p>Formule :C18H17NO2Couleur et forme :SolidMasse moléculaire :279.33HPK1-IN-29
CAS :<p>"HPK1-IN-29 suppresses HPK1, boosting anti-tumor immunity; potential for immune disease research."</p>Formule :C26H18F3N5O2Couleur et forme :SolidMasse moléculaire :489.45DDO3711
CAS :<p>"DDO3711, a PHORC, links an ASK1 inhibitor to a PP5 activator, inhibiting ASK1 (IC50=164.1 nM), dephosphorylating p-ASK1, and showing anti-cancer potential."</p>Formule :C42H41N9O6Couleur et forme :SolidMasse moléculaire :767.83KRAS G12C inhibitor 29
CAS :<p>KRAS G12C inhibitor 29 is an inhibitor of KRAS G12C and can be used to study cancer.</p>Formule :C23H21ClFN5O2Couleur et forme :SolidMasse moléculaire :453.98-CPT-2Me-cAMP, sodium salt
CAS :<p>8-CPT-2Me-cAMP sodium activates Epac GEFS, targets Rap1/2, has 2.2 μM EC50 for Epac1, doesn't activate PKA, and prompts Ca2+ release in β-cells.</p>Formule :C17H16ClN5NaO6PSCouleur et forme :SolidMasse moléculaire :507.82SCH-53870
CAS :<p>SCH-53870 inhibits p21-hRas nucleotide exchange in vitro.</p>Formule :C18H18N2O4SCouleur et forme :SolidMasse moléculaire :358.41KRAS inhibitor-16
CAS :<p>KRAS inhibitor-16 blocks KRAS G12C and p-ERK in cancer cells; potential for pancreatic, colorectal, lung cancer treatment. IC50: 0.457 μM.</p>Formule :C20H16Cl2FN3O2SCouleur et forme :SolidMasse moléculaire :452.33SOS1-IN-12
CAS :<p>SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).</p>Formule :C23H26F3N5Couleur et forme :SolidMasse moléculaire :429.48MTBT
CAS :<p>MTBT is the proliferation of cancer cells inhibitor. It induces cell cycle arrest and activates p38 MAPK.</p>Formule :C14H11NO2S2Couleur et forme :SolidMasse moléculaire :289.37ARS-2102
CAS :<p>ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .</p>Formule :C28H31ClF2N6O2Couleur et forme :SolidMasse moléculaire :557.03ERK5-IN-4
CAS :<p>ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.</p>Formule :C16H11Cl2FN4O2Couleur et forme :SolidMasse moléculaire :381.19KRAS inhibitor-15
CAS :<p>KRAS inhibitor-15 blocks KRAS G12C and p-ERK in cancer cells; potent against pancreatic and lung cancers. IC50: 0.954 μM (KRAS), 2.03/>33.3 μM (p-ERK).</p>Formule :C20H17Cl2FN4OSCouleur et forme :SolidMasse moléculaire :451.34(S)-p38 MAPK Inhibitor III
CAS :<p>(S)-p38 MAPK inhibitor III: a cell-permeable, methylsulfanylimidazole; IC50s: 0.90 µM for p38 MAPK, 0.37 µM TNF-α, 0.044 µM IL-1β.</p>Formule :C23H21FN4SCouleur et forme :SolidMasse moléculaire :404.5(R)-PD 0325901CL
CAS :<p>(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.</p>Formule :C16H14ClF2IN2O4Couleur et forme :SolidMasse moléculaire :498.65RAS inhibitor Abd-7
CAS :<p>Abd-7: potent RAS inhibitor (Kd=51 nM) that blocks RAS-effector PPI, disrupting KRAS, NRAS Q61H, HRAS G12V signaling.</p>Formule :C23H25N3O3Couleur et forme :SolidMasse moléculaire :391.46RAF-IN-1
CAS :<p>RAF-IN-1: strong b/cRAF inhibitor; cRAF IC50=3.8 nM; bRAFwt IC50=36 nM; bRAFV600E IC50=29.4 nM; A375/H358 bRAFV600E GI50=3.4/2.9 nM.</p>Formule :C26H22F3N3O4Couleur et forme :SolidMasse moléculaire :497.47KRAS inhibitor-4
CAS :<p>KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor.</p>Formule :C30H39ClN8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :563.14Anti-inflammatory agent 33
CAS :<p>Agent 33: potent p38α inhibitor, reduces NO, iNOS, COX-2, p-p38α, p-MK2; shows anti-inflammatory effects.</p>Formule :C22H15N3O5SCouleur et forme :SolidMasse moléculaire :433.44RSK2-IN-3
CAS :<p>RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.</p>Formule :C24H26N4O5Couleur et forme :SolidMasse moléculaire :450.49MLKL-IN-5
CAS :<p>MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .</p>Formule :C18H20N6O4SCouleur et forme :SolidMasse moléculaire :416.45HPK1-IN-28
CAS :<p>HPK1-IN-28 inhibits HPK1, boosts anti-tumor immunity, and shows promise in immune disease research per patent WO2021175270A1.</p>Formule :C25H22F3N5O4Couleur et forme :SolidMasse moléculaire :513.47JTP-70902
CAS :<p>JTP-70902 is a protein kinase inhibitor with antineoplastic activity.</p>Formule :C24H21BrFN5O5SCouleur et forme :SolidMasse moléculaire :590.42Antifungal agent 46
CAS :<p>Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].</p>Formule :C26H28BrF3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.43p38 MAP Kinase Inhibitor IV
CAS :<p>p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.</p>Formule :C12H4Cl6O4SCouleur et forme :SolidMasse moléculaire :456.94KRAS inhibitor-10
CAS :<p>KRAS inhibitor-10: potent, selective KRAS protein blocker; effective in various cancers; oral; tetrahydroisoquinoline class.</p>Formule :C30H37N3O5Couleur et forme :SolidMasse moléculaire :519.63KRAS G12C inhibitor 45
CAS :<p>KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .</p>Formule :C32H33F2N5O5SCouleur et forme :SolidMasse moléculaire :637.7
