MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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AKP-001
CAS :<p>AKP-001 is a selective inhibitor of MAPK of the p38α isoform and is used in the study of immune and digestive disorders.</p>Formule :C21H13ClF2N4O2Degré de pureté :99.50% - 99.92%Couleur et forme :SolidMasse moléculaire :426.8p38 MAPK Inhibitor
CAS :<p>p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.</p>Formule :C20H13ClFN3ODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :365.79NMDAR/TRPM4-IN-2
CAS :<p>Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.</p>Formule :C11H19BrCl2N2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :330.092SB 203580 sulfone
CAS :<p>SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 μM for IL-1 inhibition and 0.03 μM for CSBP-mediated signaling inhibition [1].</p>Formule :C21H16FN3O2SCouleur et forme :SolidMasse moléculaire :393.43KRAS G12C inhibitor 49
CAS :<p>KRAS G12C inhibitor 49 is an orally active KRAS G12C inhibitor that exhibits antitumour effects.</p>Formule :C31H31ClN6O3Couleur et forme :SolidMasse moléculaire :571.07SOS1-IN-5
CAS :<p>SOS1-IN-5, a potent pyrimidine inhibitor, disrupts RAS-SOS1, blocking KRAS activation.</p>Formule :C26H31F3N4O5Couleur et forme :SolidMasse moléculaire :536.54KRAS inhibitor-12
CAS :<p>KRAS inhibitor-12 blocks KRAS G12C (IC50: 0.537 μM) and p-ERK in cancer cells; promising for pancreatic, colorectal, lung cancer study.</p>Formule :C19H16Cl2FN5OSCouleur et forme :SolidMasse moléculaire :452.33Ras inhibitor 134
CAS :<p>Ras inhibitor 134 can be used in studies about Ras.</p>Formule :C23H21ClFN5O3Couleur et forme :SoildMasse moléculaire :469.9SOS1-IN-8
CAS :<p>SOS1-IN-8 is an inhibitor of SOS1 and acts on SOS1-G12D (IC50: 11.6 nM) and SOS1-G12V (IC50: 40.7 nM).</p>Formule :C24H26F3N3O4Couleur et forme :SolidMasse moléculaire :477.48KRAS G12C mutant protein inhibitor A-1
CAS :<p>KRAS G12C mutant protein inhibitor A-1 can be used in studies about Ras.</p>Formule :C31H26ClF4N7O2Couleur et forme :SolidMasse moléculaire :640.03ERK1/2 inhibitor 7
CAS :<p>ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).</p>Formule :C23H22FN7OSCouleur et forme :SolidMasse moléculaire :463.53GGTI-297
CAS :<p>GGTI-297 is a potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to Farnesyl Transferase (FTase).</p>Formule :C26H31N3O3SCouleur et forme :SolidMasse moléculaire :465.61SOS1-IN-14
CAS :<p>SOS1-IN-14 是选择性的、有效的、口服具有活力的 SOS1 抑制剂 (IC50: 3.9 nM)。SOS1-IN-14 能够利用 P-糖蛋白介导的外排机制在肠道内被吸收。SOS1-IN-14 能够用于 KRAS 突变的癌症的研究，且抑瘤效果比 BI-3406 好。</p>Formule :C29H29F3N6O2Couleur et forme :SolidMasse moléculaire :550.57CMP3a
CAS :<p>CMP3a, a NEK2 inhibitor, hinders GBM in mice and enhances radiotherapy by disrupting EZH2.</p>Formule :C28H27F3N6O2SCouleur et forme :SolidMasse moléculaire :568.61SOS1-IN-16
CAS :<p>SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 of</p>Formule :C30H31F3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :552.59KRAS inhibitor-18
CAS :<p>KRAS inhibitor-18 targets KRAS G12C; IC50: 4.74 μM. Inhibits p-ERK in cancer cells. Promising for pancreatic, colorectal, lung cancer research.</p>Formule :C20H15ClF3N3O2SCouleur et forme :SolidMasse moléculaire :453.87HPK1-IN-27
CAS :<p>HPK1-IN-27 inhibits HPK1 (MAP4K1), a kinase with potential for cancer treatment, per patent WO2019016071A1, compound 38.</p>Formule :C26H23F3N4O4Couleur et forme :SolidMasse moléculaire :512.48ZG1077
CAS :<p>ZG1077, a covalent KRAS G12C inhibitor, is utilized in non-small cell lung cancer (NSCLC) research.</p>Formule :C33H33F2N5O5SCouleur et forme :SolidMasse moléculaire :649.71SOS1-IN-4
CAS :<p>SOS1-IN-4 is a potent inhibitor of SOS1 (IC50: 56 nM) and can be used in the study of KRAS-C12C/SOS1 interactions.</p>Formule :C24H29F2N4O2PCouleur et forme :SolidMasse moléculaire :474.48KRAS G12C inhibitor 35
CAS :<p>KRAS G12C inhibitor 35 targets KRAS G12C in cancer research (CN112920183A, compound 3).</p>Formule :C31H27ClF2N6O3Couleur et forme :SolidMasse moléculaire :605.03AMG-548 hydrochloride (864249-60-5 free base)
<p>AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective</p>Formule :C29H28ClN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.02KRAS G12C inhibitor 21
CAS :<p>KRAS G12C inhibitor 21 is a KRAS G12C inhibitor.</p>Formule :C34H30ClN3O4Couleur et forme :SolidMasse moléculaire :580.07KRAS G12C inhibitor 25
CAS :<p>KRAS G12C inhibitor 25 blocks SOS1-mediated GDP/GTP swap in KRAS-G12C mutants; IC50: 0.48 nM (WO2021216770A1, comp. 3).</p>Formule :C32H41N7O2Couleur et forme :SolidMasse moléculaire :555.71HPK1-IN-33
CAS :<p>HPK1-IN-33 inhibits HPK1 with 1.7 nM potency, reduces IL-2 in Jurkat cells with 286 nM EC50, and is less effective in HPK1 KO cells.</p>Formule :C18H16ClFN6Couleur et forme :SolidMasse moléculaire :370.81KRAS G12C inhibitor 53
CAS :<p>KRAS G12C inhibitor 53 (Compound 1) is a KRAS G12C inhibitor.</p>Formule :C21H14ClF2N5O2Couleur et forme :SolidMasse moléculaire :441.82HPK1-IN-11
CAS :<p>HPK1-IN-11 is a potent HPK1 inhibitor. HPK1-IN-11 has potential for the study of HPK1-related diseases.</p>Formule :C27H25N5O2Couleur et forme :SolidMasse moléculaire :451.52MS934
CAS :<p>MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM.</p>Formule :C52H69F3IN7O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1104.11KRAS G12C inhibitor 32
CAS :<p>KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].</p>Formule :C29H30Cl3FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :635.94Org OD 02-0
CAS :<p>10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activate</p>Formule :C22H30O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.47B-Raf IN 15
CAS :<p>B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.</p>Formule :C19H15N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :333.41DL-threo dihydrosphingosine
CAS :<p>DL-threo dihydrosphingosine blocks ERK, inhibits smooth muscle proliferation, and works against growth factor/G-protein ERK activation.</p>Formule :C18H39NO2Couleur et forme :SolidMasse moléculaire :301.51HPK1-IN-13
CAS :<p>HPK1-IN-13 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.</p>Formule :C25H24FN5O2Couleur et forme :SolidMasse moléculaire :445.49Inflachromene
CAS :<p>Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene is used in the study of epilepsy.</p>Formule :C21H19N3O4Degré de pureté :97.36% - 99.88%Couleur et forme :SolidMasse moléculaire :377.39KRAS G12C inhibitor 61
CAS :<p>KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.</p>Formule :C31H33ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.09Glecirasib
CAS :<p>Glecirasib (JAB-21822,KRAS G12C inhibitor 36) is an orally active KRAS G12C inhibitor that selectively binds to and inhibits KRAS G12C-dependent signaling</p>Formule :C31H26ClF4N7O2Degré de pureté :99.7% - >99.99%Couleur et forme :SolidMasse moléculaire :640.03KRAS G12C inhibitor 30
CAS :<p>KRAS G12C inhibitor 30 is an inhibitor of KRAS G12C and can be used to study cancer.</p>Formule :C25H22ClFN6O3Couleur et forme :SolidMasse moléculaire :508.93L 731734
CAS :<p>L 731734 is a farnesyltransferase inhibitor.</p>Formule :C19H38N4O3SCouleur et forme :SolidMasse moléculaire :402.6Pan-RAF kinase inhibitor 1
CAS :<p>Potent Pan-RAF inhibitor 1 targets RAF/MAPK pathway, curbing RAS-mutated cancer cell growth. (Patent WO2021110141A1, compound 16B)</p>Formule :C26H24F3N3O4Couleur et forme :SolidMasse moléculaire :499.48Laxiflorin B
CAS :<p>Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].</p>Formule :C20H24O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :344.4KRAS G12C inhibitor 51
CAS :<p>KRAS G12C inhibitor 51 is a KRAS G12C inhibitor.</p>Formule :C33H35FN6O3Couleur et forme :SolidMasse moléculaire :582.67HPK1-IN-10
CAS :<p>HPK1-IN-10 inhibits HPK1, a MAP4K kinase from progenitor cells, with potential in treating HPK1 diseases, detailed in patent WO2021213317A1.</p>Formule :C31H34N6O2Couleur et forme :SolidMasse moléculaire :522.64SOS1/KRAS-IN-1
CAS :<p>SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].</p>Formule :C24H26F3N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.49GNE 220 hydrochloride
CAS :<p>GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).</p>Formule :C25H27ClN8Couleur et forme :SolidMasse moléculaire :474.99p38 Kinase inhibitor 4
CAS :<p>Compound 135, also known as p38 Kinase Inhibitor 4, is a potent inhibitor of p38 [1].</p>Formule :C12H9Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.13FGTI-2734 mesylate (1247018-19-4 free base)
CAS :<p>FGTI-2734 mesylate hinders KRAS, overcoming resistance and targeting pancreatic tumors; inhibits FT and GGT with IC50s of 250 nM, 520 nM.</p>Formule :C27H35FN6O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :606.73ERK-IN-2 free base
CAS :<p>ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.</p>Formule :C16H17N5O2Couleur et forme :SolidMasse moléculaire :311.34CXJ-2
CAS :<p>CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.</p>Formule :C55H87N15O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1310.37Ilaprazole sodium hydrate
CAS :<p>Ilaprazole sodium hydrate (IY-81149 sodium hydrate) is a proton pump inhibitor that blocks the transport of HSV particles.</p>Formule :C19H21N4NaO4SDegré de pureté :99.2%Couleur et forme :SolidMasse moléculaire :424.45B-Raf IN 16
CAS :<p>B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.</p>Formule :C20H19N5O3SDegré de pureté :99.31% - 99.78%Couleur et forme :SolidMasse moléculaire :409.46ERK1/2 inhibitor 5
CAS :<p>ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.</p>Formule :C28H32ClFN6O5Couleur et forme :SolidMasse moléculaire :587.04
