MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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SB-682330A
CAS :<p>SB-682330A is a Raf kinase inhibitor.</p>Formule :C28H27N3O3Couleur et forme :SolidMasse moléculaire :453.53TC13172
CAS :<p>TC13172 is a potent, covalent MLKL inhibitor, selective over RIPK1/RIPK3. It blocks TSZ-induced necroptosis (EC50=2nM) and MLKL oligomerization at 100nM.</p>Formule :C17H16N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.4Kras binder 12
CAS :<p>Kras binder 12 can be used in studies about Ras.</p>Formule :C29H47N9O6Couleur et forme :SoildMasse moléculaire :617.74Cobimetinib racemate
CAS :<p>Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated</p>Formule :C21H21F3IN3O2Degré de pureté :98.00% - 99.71%Couleur et forme :SolidMasse moléculaire :531.31SHP2-IN-22
CAS :<p>SHP2-IN-22, a potent SHP2 allosteric inhibitor, exhibits an IC50 value of 17.7 nM and effectively suppresses proliferation, migration, and invasion in MIA PaCa-</p>Formule :C23H22Cl2N8OCouleur et forme :SolidMasse moléculaire :497.38ARQ-736
CAS :<p>ARQ 736 effectively targets and inhibits BRAF, crucial in MAPK pathway, beneficial for treating melanomas and certain colon cancers.</p>Formule :C25H25N8Na2O8PSCouleur et forme :SolidMasse moléculaire :674.54B-Raf IN 16
CAS :<p>B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.</p>Formule :C20H19N5O3SDegré de pureté :99.31% - 99.78%Couleur et forme :SolidMasse moléculaire :409.46KRAS G12C inhibitor 17
CAS :<p>KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.</p>Formule :C24H20ClF2N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.88ARS-1323-alkyne
CAS :ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.Formule :C28H27ClF2N6O3Degré de pureté :98.00% - 99%Couleur et forme :SolidMasse moléculaire :569ERK1/2 inhibitor 5
CAS :<p>ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.</p>Formule :C28H32ClFN6O5Couleur et forme :SolidMasse moléculaire :587.04KRAS inhibitor-18
CAS :<p>KRAS inhibitor-18 targets KRAS G12C; IC50: 4.74 μM. Inhibits p-ERK in cancer cells. Promising for pancreatic, colorectal, lung cancer research.</p>Formule :C20H15ClF3N3O2SCouleur et forme :SolidMasse moléculaire :453.87ARS-1323
CAS :<p>ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.</p>Formule :C21H17ClF2N4O2Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :430.84HPK1 antagonist-1
CAS :<p>HPK1 antagonist-1 (I-792) is an inhibitor targeting HPK1, with potential applications in cancer and immune disease research [1].</p>Formule :C28H29FN6O2Couleur et forme :SolidMasse moléculaire :500.57TH-Z827
CAS :<p>TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).</p>Formule :C30H38N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.66HPK1-IN-9
CAS :<p>HPK1-IN-9: Potent MAP4K family kinase inhibitor targeting hematopoietic progenitor cells; potential in HPK1 diseases. (Patent WO2021213317A1)</p>Formule :C30H33N7O2Couleur et forme :SolidMasse moléculaire :523.63Uplarafenib
CAS :<p>Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.</p>Formule :C22H21F3N4O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :494.49KRAS G12C inhibitor 28
CAS :<p>KRAS G12C Inhibitor 28 is a compound that effectively inhibits the KRAS G12C mutation, exhibiting potent antitumor effects with an inhibitory concentration (</p>Formule :C33H36F2N5O4PCouleur et forme :SolidMasse moléculaire :635.64K-Ras G12C-IN-2
CAS :<p>K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.</p>Formule :C21H27ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :418.92CHI-000-667
CAS :<p>CHI-000-667 can be used in studies about Ras.</p>Formule :C21H16ClNO4SCouleur et forme :SolidMasse moléculaire :413.87KRAS G12C inhibitor 40
CAS :<p>KRAS G12C inhibitor 40 targets KRAS G12C in cancer research (WO2021129824A1, compound 70).</p>Formule :C34H36ClFN10O2Couleur et forme :SolidMasse moléculaire :671.17KRAS G12C inhibitor 49
CAS :<p>KRAS G12C inhibitor 49 is an orally active KRAS G12C inhibitor that exhibits antitumour effects.</p>Formule :C31H31ClN6O3Couleur et forme :SolidMasse moléculaire :571.07JWG-071
CAS :<p>JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.</p>Formule :C34H44N8O3Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :612.77ZYF0033
CAS :<p>ZYF0033(HPK1-IN-22) is an orally effective inhibitor of HPK1 that inhibits the phosphorylation of MBP proteins and decreases the phosphorylation of SLP76.</p>Formule :C26H30N4O2SDegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :462.61Exarafenib
CAS :<p>Exarafenib (RAF/KIN_2787) is an oral pan-RAF inhibitor with antitumor properties, targeting MAPK signaling in cancer research.</p>Formule :C26H34F3N5O3Degré de pureté :98.36% - 99.84%Couleur et forme :SolidMasse moléculaire :521.58HG6-64-1
CAS :<p>HG6-64-1 (HMSL 10017-101-1, compound 9 (XI-1)) is a potent and selective B-Raf inhibitor with an IC50 = 0.09 μM in B-raf V600E-transformed Ba/F3 cells.</p>Formule :C32H34F3N5O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :577.64Kras4B G12D-IN-1
CAS :<p>Kras4B G12D-IN-1 is an inhibitor of Kras4B G12D with anticancer activity.Kras4B G12D-IN-1 inhibits Kras protein expression.</p>Formule :C16H21ClN2O4SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :372.87BI-2493
CAS :<p>BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth.Cost-effective and quality-assured.</p>Formule :C24H27N7OSDegré de pureté :97.74% - 99.88%Couleur et forme :SoildMasse moléculaire :461.58MK-8353
CAS :<p>MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)</p>Formule :C37H41N9O3SDegré de pureté :96.15% - 97.19%Couleur et forme :SolidMasse moléculaire :691.84Pan-RAS-IN-1
CAS :<p>Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.</p>Formule :C36H41Cl2F3N6O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :717.65KRAS inhibitor-8
CAS :<p>KRAS inhibitor-8 is a potent KRAS G12C inhibitor.</p>Formule :C26H24ClF4N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.95MK2-IN-4
CAS :<p>MK2-IN-4 is a MAPKAPK2 (MK2) inhibitor (IC50: 45 nM). MK2-IN-4 can be used in cancer, inflammation and immunology studies.</p>Formule :C25H24N4O2Couleur et forme :SolidMasse moléculaire :412.48KRAS inhibitor-36
CAS :<p>KRAS inhibitor-36 (compound Abd2) directly inhibits KRAS Q61H.</p>Formule :C14H13NO4Couleur et forme :SolidMasse moléculaire :259.26KRASG12C IN-12
CAS :<p>KRASG12C IN-12 (compound-1) acts as an inhibitor of KRASG12C. It forms a ternary complex with intracellular CYPA and the activated mutant of KRASG12C.</p>Formule :C29H39N5O6S2Couleur et forme :SolidMasse moléculaire :617.78KRAS G12D inhibitor 19
CAS :<p>KRAS G12D inhibitor 19 (Compound 7) is used in cancer research [1]. As a specific inhibitor of KRAS G12D, it targets and potentially suppresses this mutation, which is frequently associated with various cancers.</p>Formule :C35H34F2N6O3Couleur et forme :SolidMasse moléculaire :624.68KRAS ligand 3
CAS :<p>KRAS ligand 3 (compound 1), a BTX-6654 target-binding ligand, exhibits synergistic tumor growth inhibition through its capacity to bind a KRAS inhibitor [1].</p>Formule :C24H28F3N5Couleur et forme :SolidMasse moléculaire :443.51PAT-IN-1
CAS :<p>PAT-IN-1, a protein acyl transferases (PAT) inhibitor, competitively inhibits Erf2 autopalmitoylation (WO2017011518A1; compound 13) [1].</p>Formule :C45H68N4OCouleur et forme :SolidMasse moléculaire :681.05AZD4625
<p>AZD4625 (Compound 21) is a selective, potent, orally active, covalent and mutagenic mutant GTPaseKRASG12C inhibitor.</p>Formule :C24H21ClF2N4O3Couleur et forme :SolidMasse moléculaire :486.9Calderasib
CAS :<p>Calderasib (MK-1084) is a selective KRAS G12C inhibitor (IC50 1.2 nM) with anticancer activity, usable as monotherapy or combined with PD-1 inhibitors</p>Formule :C32H31ClF2N6O4Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :637.08BBO-8520
CAS :<p>BBO-8520 is a dual KRASG12C inhibitor that blocks ON and OFF states, disables effector binding, suppresses signaling, and induces tumor regression.</p>Formule :C35H33F6N7O2SDegré de pureté :97.879%Couleur et forme :SolidMasse moléculaire :729.74KRAS G12C inhibitor 46
CAS :<p>KRAS G12C inhibitor 46 is a potent inhibitor of KRAS G12C.</p>Formule :C32H33F2N7O2Couleur et forme :SolidMasse moléculaire :585.65KRAS inhibitor-35
CAS :<p>KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.</p>Formule :C38H32F4N6O3SCouleur et forme :SolidMasse moléculaire :728.76COTI-219
CAS :<p>COTI-219 is an oral inhibitor of KRAS with antitumor properties [1].</p>Formule :C17H18N6SCouleur et forme :SolidMasse moléculaire :338.43pan-KRAS-IN-6
CAS :<p>Pan-KRAS-IN-6 (compound 12) is a potent pan-KRAS inhibitor, with IC50 values of 9.79 nM for Kras G12D and 6.03 nM for Kras G12V.</p>Formule :C29H30ClF3N6O3SCouleur et forme :SolidMasse moléculaire :635.10KRASG12D-IN-3-d3
CAS :KRASG12D-IN-3-d3 is the deuterium labeled KRASG12D-IN-3. KRASG12D-IN-3 (compound Z1084) is a KRASG12D inhibitor with oral bioactivity that can effectively inhibit the growth of tumor cells AGS and AsPC-1, with IC50 values of 0.38 nM and 1.23 nM, respectively.Formule :C31H27D3ClF6N7O2Couleur et forme :SoildMasse moléculaire :685.08KRAS inhibitor-21
CAS :<p>KRAS inhibitor-21 (22b) is a KRAS G12C inhibitor (IC50<0.01 μM) that can be used in cancer research.</p>Formule :C33H41N5O3Couleur et forme :SolidMasse moléculaire :555.71Famlasertib
CAS :<p>Famlasertib is a potent inhibitor of the mitogen-activated protein kinase kinase kinase kinase (MAP4K) family, capable of penetrating the brain. It exhibits an IC50 value of 0.3 nM for HGK (MAP4K4) and 23.7 nM for MLK3.</p>Formule :C26H27ClN4OCouleur et forme :SolidMasse moléculaire :446.972Everafenib
<p>Everafenib: potent BRAF inhibitor, crosses blood-brain barrier, hinders MAPK, effective on V600EBRAF cells, outperforms other drugs in trials.</p>Formule :C20H23ClFN5O2S2Couleur et forme :SolidMasse moléculaire :484.01TH-Z816
CAS :<p>TH-Z816 acts as a reversible inhibitor targeting the KRAS(G12D) mutation, exhibiting an IC50 of 14 µM. This compound is utilized in cancer research [1].</p>Formule :C29H38N6OCouleur et forme :SolidMasse moléculaire :486.65HPK1-IN-41
CAS :<p>HPK1-IN-41 (compound Z389) functions as an HPK1 inhibitor, exhibiting an IC50 value of 0.21 nM [1].</p>Formule :C28H33N5O2Couleur et forme :SolidMasse moléculaire :471.59(+)-Perillyl alcohol
CAS :<p>(+)-Perillyl alcohol (0.25-1 mM) inhibits cell growth in SW480 cells. At a concentration of 1 mM and a duration of 24 hours, (+)-Perillyl alcohol increases the number of cells in the G0/G1 phase and reduces the number in the S phase in SW480 cells.</p>Formule :C10H16OCouleur et forme :SolidMasse moléculaire :152.23
