MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Setidegrasib
CAS :<p>KRAS G12D inhibitor 17, a quinazoline-linked prolinamide, degrades mutant KRAS protein; a PROTAC.</p>Formule :C60H65FN12O7SCouleur et forme :SolidMasse moléculaire :1117.3Rapaprutug
CAS :<p>Rapaprutug is a monoclonal antibody that targets human KARS1 (lysyl-tRNA synthetase 1). It can block inflammation-related signaling pathways involving KARS1, thereby reducing the production and release of inflammatory factors. Rapaprutug shows potential for research into inflammatory diseases.</p>Couleur et forme :LiquidTagarafdeg
CAS :<p>Tagarafdeg (CFT1946) is a PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E, G469A, G466V mutations, anti proliferation.</p>Formule :C45H49F2N11O9SDegré de pureté :＞99.99%Couleur et forme :SolidMasse moléculaire :958Klotho-derived peptide 1 hydrochloride
<p>Klotho-derived peptide 1 (KP1 human) hydrochloride inhibits the interaction between TGF-β and TGF-β receptor 2, suppressing the activation of TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK). Additionally, it exhibits antifibrotic and renal protective effects in mouse models.</p>Couleur et forme :Odour SolidMEK/RAF-IN-1
<p>MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.</p>Formule :C28H29F3N6O5SCouleur et forme :SolidMasse moléculaire :618.63MEK4 inhibitor-1
CAS :<p>MEK4 inhibitor-1 targets MEK4 enzyme in pancreatic cancer, IC50=61 nM.</p>Formule :C13H10FN3O2SCouleur et forme :SolidMasse moléculaire :291.3R18
CAS :<p>14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.</p>Formule :C101H157N27O29S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2309.69KS-58
CAS :<p>KS-58 is a derivative of KRpep-2d. It acts as an inhibitory peptide for K-Ras(G12D), selectively binding to K-Ras. KS-58 is capable of penetrating cells and interrupts the interaction between intracellular Ras and effector proteins. It inhibits the proliferation of tumor cells and exhibits antitumor activity.</p>Formule :C64H89FN12O14S2Couleur et forme :SolidMasse moléculaire :1333.59(R)-BI-2852
CAS :<p>(R)-5-hydroxy isoindolin-1-one is an RAS protein inhibitor with antiproliferative and antitumor properties.</p>Formule :C31H28N6O2Degré de pureté :97.78%Couleur et forme :SoildMasse moléculaire :516.59PROTAC K-Ras Degrader-1
CAS :<p>PROTAC K-Ras Degrader-1 is a PROTAC degrader based on the Cereblon E3 ligase ligand, capable of degrading K-Ras.</p>Formule :C53H62N10O10Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :999.12p38 MAP Kinase Inhibitor Ⅵ
CAS :<p>p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.</p>Formule :C16H13FN2OS2Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :332.42Pan-RAS-IN-7
CAS :<p>Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.</p>Formule :C59H76N8O8Couleur et forme :SolidMasse moléculaire :1025.28HPK1-IN-20
CAS :<p>HPK1-IN-19 is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1).</p>Formule :C26H28N6O2Couleur et forme :SolidMasse moléculaire :456.55Pan-RAS-IN-6
Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.Formule :C46H60N8O5SCouleur et forme :SolidMasse moléculaire :837.08SIAIS562055
<p>SIAIS562055, a potent cereblon-based SOS1PROTAC, exhibits a dissociation constant (Kd) of 95.9 nM. It effectively degrades SOS1 and inhibits the downstream ERK pathway. SIAIS562055 disrupts the interaction between KRASG12C or KRASG12D and SOS1, with IC50 values of 95.7 nM and 134.5 nM, respectively. This compound demonstrates strong anticancer activity.</p>Formule :C49H62F3N7O5SCouleur et forme :SolidMasse moléculaire :918.12L-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Formule :C164H286N66O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.44BI1701963
<p>BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.</p>Formule :C47H62N8O4SCouleur et forme :SolidMasse moléculaire :835.11MEK1/2-IN-3
<p>MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.</p>Formule :C28H23F3IN3O4Couleur et forme :SolidMasse moléculaire :649.4KRAS G12C inhibitor 60
<p>KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and</p>Formule :C31H30F5N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.61PROTAC MLKL Degrader-1
<p>PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.</p>Formule :C46H55F2N9O9SCouleur et forme :SolidMasse moléculaire :948.05PROTAC K-Ras Degrader-2
CAS :<p>PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V/RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.</p>Formule :C52H60F4N8O5Couleur et forme :SolidMasse moléculaire :953.077Cobimetinib (R-enantiomer)
CAS :<p>Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.</p>Formule :C21H21F3IN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.318MRTX1133 formic
<p>MRTX1133: Selective inhibitor of KRAS G12D, effective in all protein states, targeting mutant cells.</p>Formule :C34H33F3N6O4Couleur et forme :SoildMasse moléculaire :646.67PROTAC SOS1 degrader-2
CAS :<p>PROTAC SOS1 degrader-2 reduces pERK & RAS-GTP, inhibiting tumor growth dose-dependently in vivo.</p>Formule :C57H76ClFN10O4SCouleur et forme :SolidMasse moléculaire :1051.79(S)-BAY-293
CAS :<p>(S)-BAY-293 is a potent pan-KRAS inhibitor for the study of primary non-small lung and pancreatic cancers.</p>Formule :C25H28N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.58ADT-007
CAS :<p>ADT-007 is a pan-RAS inhibitor with potent anticancer activity.</p>Formule :C26H24FNO5Degré de pureté :97.75%Couleur et forme :SoildMasse moléculaire :449.47NK7-902
<p>NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.</p>Couleur et forme :Odour SolidIbetazol
<p>Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.</p>Formule :C13H11F3N2OSCouleur et forme :SolidMasse moléculaire :300.3(+)-Oxanthromicin
CAS :<p>(+)-Oxanthromicin, an enantiomer of the rare Streptomyces metabolite (−)-oxanthromicin, demonstrates inhibitory activity against K-Ras plasma membrane localization in MDCK cells, exhibiting an IC50 value of 62.5 μM.</p>Formule :C36H30O12Couleur et forme :SolidMasse moléculaire :654.624NUCC-0200808
<p>NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.</p>Couleur et forme :Odour SolidDebromohymenialdisine
CAS :<p>Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.</p>Formule :C11H11N5O2Couleur et forme :SolidMasse moléculaire :245.242S6 Kinase Substrate Peptide 32
<p>S6 Kinase Substrate Peptide 32 is a peptide that measures the activity of kinases that phosphorylate ribosomal protein S6. It can also be used as a substrate.</p>Formule :C149H270N56O49Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3630.1Rac1 Inhibitor W56
CAS :<p>Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.</p>Formule :C74H117N19O23SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1671.93KRAS G12C inhibitor 69
<p>KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.</p>Formule :C29H29ClF3N5O3Couleur et forme :SolidMasse moléculaire :588.02KRAS inhibitor-33
<p>KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.</p>Formule :C33H39ClF2N6O3Couleur et forme :SolidMasse moléculaire :641.15HPK1-IN-4
CAS :<p>HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.</p>Formule :C23H26N6O3Degré de pureté :97.2%Couleur et forme :SolidMasse moléculaire :434.49HPK1-IN-39
<p>HPK1-IN-39 (Compound 10n), a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) with an inhibitory concentration (IC50) of 29 nM, impedes the</p>Formule :C26H27N7O2Couleur et forme :SolidMasse moléculaire :469.54Vacquinol-1
CAS :<p>Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.</p>Formule :C21H21ClN2ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :352.86Z16078526
CAS :<p>Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.</p>Formule :C18H17N3O4SDegré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :371.41HPK1-IN-8
CAS :<p>HPK1-IN-8 is an allosteric, inactive, conformation-selective triazolopyrimidine ketone HPK1 inhibitor.</p>Formule :C19H17FN6O2SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :412.44KRAS G12C inhibitor 18
CAS :<p>KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.</p>Formule :C25H20ClFN4O3SCouleur et forme :SolidMasse moléculaire :510.97JTP10-△-TATi TFA
<p>JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.</p>Formule :C120H213F3N48O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2833.28HSND80
<p>HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.</p>Couleur et forme :Odour SolidGNE-9815
CAS :<p>GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selective</p>Formule :C26H22FN5O2Degré de pureté :99.08% - 99.1%Couleur et forme :SolidMasse moléculaire :455.48MAP4K4-IN-6
<p>MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor with an IC50 of 80 nM. It reduces the phosphorylation of c-Jun and exhibits neuroprotective effects. Additionally, MAP4K4-IN-6 enhances the vitality of motor neurons and can be utilized in the study of amyotrophic lateral sclerosis (ALS).</p>Couleur et forme :Odour SolidNecroX-2
CAS :<p>NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.</p>Formule :C25H32N4O4S2Degré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :516.68MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Couleur et forme :Odour SolidAnti-inflammatory agent 31
<p>Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.</p>Formule :C19H30O3Couleur et forme :SolidMasse moléculaire :306.44MC 976
CAS :<p>MC 976 is a derivative of Vitamin D3.</p>Formule :C27H42O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.63SS47
CAS :<p>SS47 is a PROTAC that degrades immunosuppressive HPK1 via proteasome; boosts BCMA CAR-T cell cancer therapy.</p>Formule :C49H56N6O12SCouleur et forme :SolidMasse moléculaire :953.07
