MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
893 produits trouvés pour "MAPK". Les 500 premiers sont affichés.
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PROTAC MLKL Degrader-1
PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.Formule :C46H55F2N9O9SCouleur et forme :SolidMasse moléculaire :948.05pan-KRAS-IN-8
pan-KRAS-IN-8 (Compound 38) is an inhibitor of the human tumor mutated gene KRAS. It effectively suppresses the proliferation of KRAS mutant cells AsPC-1 (G12D mutant) and SW480 (G12V mutant), with IC50 values of 0.07 nM and 0.18 nM, respectively.Formule :C48H61N7O7SMasse moléculaire :879.43532S6 Kinase Substrate Peptide 32
S6 Kinase Substrate Peptide 32 is a peptide that measures the activity of kinases that phosphorylate ribosomal protein S6. It can also be used as a substrate.Formule :C149H270N56O49Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3630.1Mitogen-activated protein kinase 1
CAS :Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Degré de pureté :98%Couleur et forme :SolidRac1 Inhibitor F56, control peptide TFA
Rac1 Inhibitor F56, control peptide TFA, is a peptide containing Rac1 residues 45-60. It features a mutation from Trp56 to Phe56. This inhibitor does not affect the interaction between Rac1 and guanine nucleotide exchange factors (GEFs).Formule :C72H116N18O23S·xC2HF3O2PROTAC ERK5 degrader-1
CAS :PROTACERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. It induces the degradation of ERK5 in MOLT-4 cells via a VHL-mediated proteasome pathway. PROTACERK5 degrader-1 is useful for studying diseases or disorders characterized by abnormal ERK5 activity.Formule :C54H67F3N10O6SCouleur et forme :SolidMasse moléculaire :1041.23HSND80
HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.Couleur et forme :Odour SolidERK2 IN-5
CAS :ERK2IN-5 (Compound 5g) is an inhibitor of ERK2 and demonstrates good affinity for both ERK2 and JNK3, with Ki values of 86 nM and 550 nM, respectively.Formule :C21H17ClN4OMasse moléculaire :376.84TAT-PAK18 R192A
TAT-PAK18 R192A is an inactive Tat-Pak peptide. It does not influence Rac1 translocation triggered by any tested proteins.Formule :C143H247N55O37Masse moléculaire :3326.91369TUS-007
CAS :TUS-007, a non-proteasome inhibiting CANDDY, is an oral KRAS G12D/V degrader for cell-free chemical knockdown and tumor suppression.Formule :C44H54Cl2N8O5Couleur et forme :SolidMasse moléculaire :845.86GGDPS-IN-1
GGDPS-IN-1 (Compound 37) is an inhibitor of geranylgeranyl diphosphate synthase (GGDPS) with an IC50 of 49.4 nM, disrupting protein geranylgeranylation in myeloma cells.Formule :C15H28N4O6P2Couleur et forme :SolidMasse moléculaire :422.14841Cyclorasin 9A5 TFA
Cyclorasin 9A5 TFA is a cell-penetrating cyclic peptide consisting of 11 residues that inhibits the interaction between Ras and Raf proteins, with an IC50 of 120 nM.Formule :C75H108FN25O13·xC2HF3O2Couleur et forme :SolidMasse moléculaire :1586.82 (free base)HPK1-IN-8
CAS :HPK1-IN-8 is an allosteric, inactive, conformation-selective triazolopyrimidine ketone HPK1 inhibitor.Formule :C19H17FN6O2SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :412.44KRAS G12C inhibitor 18
CAS :KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.Formule :C25H20ClFN4O3SCouleur et forme :SolidMasse moléculaire :510.97CC-401
CAS :CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).Formule :C22H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.47KRAS G12C inhibitor 60
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, andFormule :C31H30F5N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.61GNE-9815
CAS :GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selectiveFormule :C26H22FN5O2Degré de pureté :99.08% - 99.1%Couleur et forme :SolidMasse moléculaire :455.48Ref: TM-T9585
1mg60,00€5mg138,00€1mL*10mM (DMSO)138,00€10mg215,00€25mg358,00€50mg510,00€100mg692,00€500mg1.386,00€JTP10-△-TATi TFA
JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.Formule :C120H213F3N48O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2833.28AM-001
CAS :AM-001, a non-competitive inhibitor of Epac1, effectively blocks the activation of Rap1, a downstream effector of Epac1, in cultured cells, and is commonly used in heart disease-related research.Formule :C24H16FN3OS2Degré de pureté :99.92%Couleur et forme :Yellow SolidMasse moléculaire :445.53KRAS G12D inhibitor 6
CAS :KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.Formule :C32H37ClN8O2Couleur et forme :SolidMasse moléculaire :601.15KRAS G12D inhibitor 15
CAS :Potent KRAS G12D inhibitor 15 targets cancer, potential for disease research. (WO2022042630A1, compound 243)Formule :C53H71F2N7O5Couleur et forme :SolidMasse moléculaire :924.17MC 976
CAS :MC 976 is a derivative of Vitamin D3.Formule :C27H42O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.63Rac1 Inhibitor W56
CAS :Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.Formule :C74H117N19O23SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1671.93RM-018
CAS :RM-018 inhibits active KRAS G12C & G12C/Y96D, possibly beating resistance with unique traits.Formule :C56H72N8O8Couleur et forme :SolidMasse moléculaire :985.24NG 25 (hydrochloride hydrate)
NG 25 is a type II kinase inhibitor targeting multiple kinases with various IC50 values and reduces colorectal cancer cell viability and tumors.Couleur et forme :SolidKRAS-IN-43
KRAS-IN-43 (Compound 9) is a broad-spectrum KRAS inhibitor with IC50 values of 0.15 μM for KRASG12V, 0.14 μM for KRASG12C, and 0.47 μM for wild-type KRAS. It disrupts the interaction between KRAS and cRAF and suppresses ERK phosphorylation. KRAS-IN-43 shows potential for research in KRAS mutation-associated cancers, including pancreatic, colorectal, and lung cancers.Couleur et forme :Odour SolidNecroX-2
CAS :NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.Formule :C25H32N4O4S2Degré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :516.68SOS1-IN-11
CAS :SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).Formule :C22H24F3N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :431.45Ref: TM-T60029
1mg72,00€5mg160,00€1mL*10mM (DMSO)172,00€10mg269,00€25mg427,00€50mg610,00€100mg820,00€KRAS inhibitor-38
CAS :KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.Formule :C53H68ClF2N9O8SCouleur et forme :SolidMasse moléculaire :1064.68NK7-902 TFA
NK7-902 TFA is a CRBN molecular glue degrader of NEK7. It effectively degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. While NK7-902 TFA achieves deep and lasting NEK7 degradation, it temporarily blocks NLRP3 inflammasome activation in non-human primates when administered orally. Additionally, NK7-902 TFA demonstrates activity in mouse systems.Couleur et forme :Odour SolidJNK3 inhibitor-8
JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.Formule :C32H30FN7O3Couleur et forme :SolidMasse moléculaire :579.62G12Si-5
CAS :G12Si-5: covalent K-RasG12S inhibitor, Ki 26 μM, targets S-IIP domain, hinders oncogenic signaling, lowers ERK phosphorylation in mutant cells.Formule :C31H29ClFN5O3Couleur et forme :SolidMasse moléculaire :574.05LC 2 Epimer
CAS :Negative control for LC 2.Formule :C59H71ClFN11O7SCouleur et forme :SolidMasse moléculaire :1132.8(S)-BAY-293
CAS :(S)-BAY-293 is a potent pan-KRAS inhibitor for the study of primary non-small lung and pancreatic cancers.Formule :C25H28N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.58GADGVGKSA
CAS :GADGVGKSA, a mutant KRAS G12D 9mer peptide, serves as an immunogenic neoantigen for cancer immunotherapy research [1].Formule :C30H52N10O13Couleur et forme :SolidMasse moléculaire :760.79XY-02-082
CAS :XY-02-082 is a covalent guanosine-mimetic inhibitor targeting G12C KRAS.Formule :C15H21ClF2N6O11P2Couleur et forme :SolidMasse moléculaire :596.76Deltasonamide 1 TFA
CAS :Deltasonamide 1 TFA: PDE6δ-KRas inhibitor, K D 203 pM, used in tumor research.Formule :C32H40ClF3N6O6S2Couleur et forme :SolidMasse moléculaire :761.28R18
CAS :14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Formule :C101H157N27O29S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2309.69PROTAC SOS1 degrader-5
CAS :PROTAC SOS1 degrader-5 (compound 4) serves as an effective degrader of PROTAC SOS1, exhibiting a DC50 of 13 nM. It robustly suppresses the proliferation of NCI-H358 cells, with an IC50 value of 5 nM [1].Formule :C45H51F3N8O7Couleur et forme :SolidMasse moléculaire :872.93KRpep-2d
CAS :KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras.Formule :C109H183N43O25S2Couleur et forme :SolidMasse moléculaire :2560.02StRIP16
Rab8a GTPase-binding stapled peptide (Kd = 12.7 μM). Cell permeable; localizes to the endomembrane system.Couleur et forme :SolidDB-10
DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.Couleur et forme :Odour SolidKinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidRef: TM-L1600
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demander(RS)-G12Di-1
(RS)-G12Di-1 is a selective covalent inhibitor of K-Ras-G12D.Formule :C37H35FN6O4Couleur et forme :SolidMasse moléculaire :646.27038YN14
YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with lowDegré de pureté :98%Couleur et forme :Odour SolidSS47
CAS :SS47 is a PROTAC that degrades immunosuppressive HPK1 via proteasome; boosts BCMA CAR-T cell cancer therapy.Formule :C49H56N6O12SCouleur et forme :SolidMasse moléculaire :953.07MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Couleur et forme :Odour SolidRef: TM-L1400
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderMRTF-A-IN-1
MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Formule :C22H21N3Couleur et forme :SolidMasse moléculaire :327.42KRASG12C IN-2
KRASG12C IN-2 (compound 17) is an orally active inhibitor of KRAS G12C, which effectively suppresses tumor growth in mice [1].Couleur et forme :SolidTagarafdeg
CAS :Tagarafdeg (CFT1946) is a PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E, G469A, G466V mutations, anti proliferation.Formule :C45H49F2N11O9SDegré de pureté :99.34% - ＞99.99%Couleur et forme :SolidMasse moléculaire :958
