MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
902 produits trouvés pour "MAPK".
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pan-KRAS-IN-8
pan-KRAS-IN-8 (Compound 38) is an inhibitor of the human tumor mutated gene KRAS. It effectively suppresses the proliferation of KRAS mutant cells AsPC-1 (G12D mutant) and SW480 (G12V mutant), with IC50 values of 0.07 nM and 0.18 nM, respectively.Formule :C48H61N7O7SMasse moléculaire :879.43532CC-401
CAS :CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).Formule :C22H24N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.47Mitogen-activated protein kinase 1
CAS :Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Degré de pureté :98%Couleur et forme :SolidS6 Kinase Substrate Peptide 32
S6 Kinase Substrate Peptide 32 is a peptide that measures the activity of kinases that phosphorylate ribosomal protein S6. It can also be used as a substrate.Formule :C149H270N56O49Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3630.1Rac1 Inhibitor F56, control peptide TFA
Rac1 Inhibitor F56, control peptide TFA, is a peptide containing Rac1 residues 45-60. It features a mutation from Trp56 to Phe56. This inhibitor does not affect the interaction between Rac1 and guanine nucleotide exchange factors (GEFs).Formule :C72H116N18O23S·xC2HF3O2HSND80
HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.Couleur et forme :Odour SolidPROTAC ERK5 degrader-1
CAS :PROTACERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. It induces the degradation of ERK5 in MOLT-4 cells via a VHL-mediated proteasome pathway. PROTACERK5 degrader-1 is useful for studying diseases or disorders characterized by abnormal ERK5 activity.Formule :C54H67F3N10O6SCouleur et forme :SolidMasse moléculaire :1041.23(S)-BAY-293
CAS :(S)-BAY-293 is a potent pan-KRAS inhibitor for the study of primary non-small lung and pancreatic cancers.Formule :C25H28N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.58KRAS-IN-43
KRAS-IN-43 (Compound 9) is a broad-spectrum KRAS inhibitor with IC50 values of 0.15 μM for KRASG12V, 0.14 μM for KRASG12C, and 0.47 μM for wild-type KRAS. It disrupts the interaction between KRAS and cRAF and suppresses ERK phosphorylation. KRAS-IN-43 shows potential for research in KRAS mutation-associated cancers, including pancreatic, colorectal, and lung cancers.Couleur et forme :Odour SolidKRAS G12C inhibitor 69
KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.Formule :C29H29ClF3N5O3Couleur et forme :SolidMasse moléculaire :588.02TUS-007
CAS :TUS-007, a non-proteasome inhibiting CANDDY, is an oral KRAS G12D/V degrader for cell-free chemical knockdown and tumor suppression.Formule :C44H54Cl2N8O5Couleur et forme :SolidMasse moléculaire :845.86HPK1-IN-8
CAS :HPK1-IN-8 is an allosteric, inactive, conformation-selective triazolopyrimidine ketone HPK1 inhibitor.Formule :C19H17FN6O2SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :412.44KRAS G12C inhibitor 18
CAS :KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.Formule :C25H20ClFN4O3SCouleur et forme :SolidMasse moléculaire :510.97Rutamycin
CAS :Rutamycin: a macrolide antibiotic from Streptomyces rutgersensis; blocks ATPases, uncouples oxidative phosphorylation.Formule :C44H72O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :777.049KRAS G12C inhibitor 60
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, andFormule :C31H30F5N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.61GNE-9815
CAS :GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selectiveFormule :C26H22FN5O2Degré de pureté :99.08% - 99.1%Couleur et forme :SolidMasse moléculaire :455.48Ref: TM-T9585
1mg60,00€5mg138,00€1mL*10mM (DMSO)138,00€10mg215,00€25mg358,00€50mg510,00€100mg692,00€500mg1.386,00€JTP10-△-TATi TFA
JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.Formule :C120H213F3N48O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2833.28AM-001
CAS :AM-001 is a non-competitive Epac1 inhibitor that blocks Rap1 activation and is used in heart disease research.Formule :C24H16FN3OS2Degré de pureté :99.92%Couleur et forme :Yellow SolidMasse moléculaire :445.53R18
CAS :14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Formule :C101H157N27O29S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2309.69ZZ151
ZZ151 is an effective and selective SOS1 PROTAC with in vivo anti-tumor efficacy against KRAS-mutant cancers. This compound induces rapid and specific degradation of SOS1 and exhibits strong anti-proliferative activity against a wide range of KRAS mutation-driven cancer cells. In murine xenograft models with KRASG12D and G12V mutations, ZZ151 demonstrates superior anticancer activity. It represents a promising lead compound for developing new chemotherapeutic agents targeting KRAS mutations.Formule :C54H68F3N9O6SCouleur et forme :SolidMasse moléculaire :1028.23MC 976
CAS :MC 976 is a derivative of Vitamin D3.Formule :C27H42O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.63Rac1 Inhibitor W56
CAS :Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.Formule :C74H117N19O23SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1671.93RAS GTPase inhibitor 1
CAS :RAS GTPase inhibitor 1 Free Base is a highly potent RAS GTPase inhibitor with antitumor activity.Formule :C25H27ClFN5Couleur et forme :White SolidMasse moléculaire :451.97PROTAC BRAF-V600E degrader-2
CAS :PROTAC BRAF-V600E degrader-2 is a useful organic compound for research related to life sciences. The catalog number is T8744 and the CAS number is 2417296-82-1.Formule :C42H39F2N7O8SCouleur et forme :SolidMasse moléculaire :839.87(RS)-G12Di-1
(RS)-G12Di-1 is a selective covalent inhibitor of K-Ras-G12D.Formule :C37H35FN6O4Couleur et forme :SolidMasse moléculaire :646.27038NecroX-2
CAS :NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.Formule :C25H32N4O4S2Degré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :516.68BTX6654
BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. This compound exhibits antiproliferative activity against cells with various KRAS mutations by reducing the expression of downstream signaling markers pERK and pS6.Formule :C50H57F4N9O5Couleur et forme :SolidMasse moléculaire :940.04KRAS inhibitor-38
CAS :KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.Formule :C53H68ClF2N9O8SCouleur et forme :SolidMasse moléculaire :1064.68NK7-902 TFA
NK7-902 TFA is a CRBN molecular glue degrader of NEK7. It effectively degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. While NK7-902 TFA achieves deep and lasting NEK7 degradation, it temporarily blocks NLRP3 inflammasome activation in non-human primates when administered orally. Additionally, NK7-902 TFA demonstrates activity in mouse systems.Couleur et forme :Odour SolidJNK3 inhibitor-8
JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.Formule :C32H30FN7O3Couleur et forme :SolidMasse moléculaire :579.62Peraquinsin
CAS :Peraquinsin is a MK2 activator that can be utilized in the research of vascular or endothelial barrier disorders and functions as an antihypertensive agent [1].Formule :C23H28N4O4Couleur et forme :SolidMasse moléculaire :424.49LC 2 Epimer
CAS :Negative control for LC 2.Formule :C59H71ClFN11O7SCouleur et forme :SolidMasse moléculaire :1132.8Ibetazol
Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.Formule :C13H11F3N2OSCouleur et forme :SolidMasse moléculaire :300.3p38 MAP Kinase Inhibitor Ⅵ
CAS :p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Formule :C16H13FN2OS2Degré de pureté :98.53%Couleur et forme :Yellow SolidMasse moléculaire :332.42Anticancer agent 207
Anticanceragent 207 (compound 10b) is an effective anticancer agent. It binds to NRAS rG4 with a KD value of 2.31 µM. It exhibits cytotoxicity and reduces NRAS protein expression, demonstrating antitumor activity.Formule :C29H39FN4O2Masse moléculaire :494.3057OVA-E1 peptide
CAS :OVA-E1 peptide, as SIINFEKL variant, triggers similar p38/JNK activation in mutant and normal thymocytes.Formule :C47H76N10O14Couleur et forme :SolidMasse moléculaire :1005.181MRTF-A-IN-1
MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Formule :C22H21N3Couleur et forme :SolidMasse moléculaire :327.42HPK1-IN-20
CAS :HPK1-IN-19 is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1).Formule :C26H28N6O2Couleur et forme :SolidMasse moléculaire :456.55NK7-902
NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.Couleur et forme :Odour SolidKRAS G12D inhibitor 1
CAS :KRAS G12D inhibitor 1 (example 243) is an inhibitor of KRAS G12D with an IC 50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation [1].Formule :C33H32F2N6O2Couleur et forme :SolidMasse moléculaire :582.64L-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Formule :C164H286N66O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.44MS432
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.Formule :C50H65F3IN7O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1076.06Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidRef: TM-L1600
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderPROTAC K-Ras Degrader-2
CAS :PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V/RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.Formule :C52H60F4N8O5Couleur et forme :SolidMasse moléculaire :953.077KRAS G12D inhibitor 3 TFA
CAS :KRAS G12D Inhibitor 3 TFA, exhibiting an inhibitory concentration (IC50) of less than 500 nM, is effective as an antitumor agent.Formule :C36H32ClF6N5O4Couleur et forme :SolidMasse moléculaire :748.11Pan-RAS-IN-6
Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.Formule :C46H60N8O5SCouleur et forme :SolidMasse moléculaire :837.08MAPK Inhibitor Library
A unique collection of xnum cancer cell differentiation inducing compounds for high throughput and high content screening;Couleur et forme :Odour SolidRef: TM-L1400
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderPDE4-IN-26
PDE4-IN-26 (Compound A5) is an orally active, highly selective inhibitor of PDE4. It exhibits anti-inflammatory properties by inhibiting p38 MAPK phosphorylation. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 reduces lung inflammation, damage, and fibrosis, while promoting sputum secretion and alleviating cough. It is useful for researching lung injury-related diseases.Formule :C22H18F2N4O3SCouleur et forme :SolidMasse moléculaire :456.47DB-10
DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.Couleur et forme :Odour SolidSetidegrasib
CAS :Setidegrasib is a PROTAC-mediated KRAS degrader (DC50: 37 nM). Setidegrasib induces the ubiquitination and proteasomal degradation of the oncogenic protein.Formule :C60H65FN12O7SDegré de pureté :99.49% - 99.80%Couleur et forme :White SolidMasse moléculaire :1117.30
