MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
903 produits trouvés pour "MAPK".
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Z16078526
CAS :Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.Formule :C18H17N3O4SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :371.41DB-10
DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.Couleur et forme :Odour SolidR18
CAS :14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Formule :C101H157N27O29S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2309.6912-Oxo phytodienoic acid
CAS :12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.Formule :C18H28O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.41PROTAC SOS1 degrader-8
CAS :PROTA CSOS1 degrader-8 (Compd 1) acts as a PROTAC degrader targeting SOS1.Formule :C50H60ClN11O4Couleur et forme :SolidMasse moléculaire :914.54Ras Inhibitory Peptide acetate
Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.Formule :C55H95N19O13Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :1230.46(RS)-G12Di-1
(RS)-G12Di-1 is a selective covalent inhibitor of K-Ras-G12D.Formule :C37H35FN6O4Couleur et forme :SolidMasse moléculaire :646.27038(S,R,S)-AHPC-Me-C10-Br
CAS :(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate and ligand-linker for E3 ligase, MS432 for MEK1/2 inhibitors and a VHL E3 ligase linker.Formule :C34H51BrN4O4SDegré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :691.76Ref: TM-T18668
10mgÀ demander25mgÀ demander50mgÀ demander100mgÀ demander1mg34,00€5mg70,00€1mL*10mM (DMSO)101,00€PROTAC K-Ras Degrader-1
CAS :PROTAC K-Ras Degrader-1 is a PROTAC degrader based on the Cereblon E3 ligase ligand, capable of degrading K-Ras.Formule :C53H62N10O10Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :999.12Klotho-derived peptide 1 hydrochloride
Klotho-derived peptide 1 (KP1 human) hydrochloride inhibits the interaction between TGF-β and TGF-β receptor 2, suppressing the activation of TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK). Additionally, it exhibits antifibrotic and renal protective effects in mouse models.Couleur et forme :Odour SolidASP6918
ASP6918 is a potent, orally active KRAS G12C inhibitor with an IC50 of 0.028 µM. It inhibits cell growth and demonstrates antitumor activity.Formule :C36H43N7O3Couleur et forme :SolidMasse moléculaire :621.34274Rineterkib hydrochloride
CAS :Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.Formule :C26H28BrClF3N5O2Couleur et forme :SolidMasse moléculaire :614.89PROTAC SOS1 degrader-2
CAS :PROTAC SOS1 degrader-2 reduces pERK & RAS-GTP, inhibiting tumor growth dose-dependently in vivo.Formule :C57H76ClFN10O4SCouleur et forme :SolidMasse moléculaire :1051.79MRTX1133 formic
MRTX1133: Selective inhibitor of KRAS G12D, effective in all protein states, targeting mutant cells.Formule :C34H33F3N6O4Couleur et forme :SolidMasse moléculaire :646.67MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Formule :C28H23F3IN3O4Couleur et forme :SolidMasse moléculaire :649.4Antimicrobial agent-21
CAS :Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFormule :C18H13N3OSDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :319.38Ref: TM-T67942
1mg54,00€5mg116,00€10mg172,00€1mL*10mM (DMSO)180,00€25mg278,00€50mg371,00€100mg510,00€200mg687,00€PROTAC KRAS G12C degrader-1
PROTAC KRAS G12C degrader-1, a cereblon-based degrader, promotes CRBN/KRAS G12C dimerization and facilitates the degradation of GFP-KRAS G12C in reporter cellsFormule :C50H54ClFN8O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :917.47(S)-BAY-293
CAS :(S)-BAY-293 is a potent pan-KRAS inhibitor for the study of primary non-small lung and pancreatic cancers.Formule :C25H28N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.58G12 TFA
G12 (Ras5-17) TFA is a wild-type Ras peptide comprising amino acids 5-17 (KLVVVGAGGVGKS). It serves as a control in studies involving mutant Ras peptides, such as V12.Formule :C54H96F3N15O17Couleur et forme :SolidMasse moléculaire :1283.70607PROTAC K-Ras Degrader-3
CAS :PROTAC K-Ras Degrader-3 is a PROTAC degrader targeting K-Ras, exhibiting a DC50 value of ≤ 1 nM against SW620 KRAS G12D and a GI50 value of ≤ 10 nM in inhibiting the growth of SW620 3D cells. It is used in cancer research.Formule :C57H67F2N9O6Couleur et forme :SolidMasse moléculaire :1012.20Ras Inhibitory Peptide
CAS :Sos1, a GEF, activates ERK by converting Ras-GDP to Ras-GTP via Grb2. The PVPPR peptide inhibits this by blocking Sos1/Grb2 binding.Formule :C53H91N19O11Couleur et forme :SolidMasse moléculaire :1170.433MRTX849 acid
CAS :MRTX849 acid, used to make PROTAC LC-2, effectively degrades KRAS G12C at 0.25-0.76 μM DC50.Formule :C34H37ClFN7O4Couleur et forme :SolidMasse moléculaire :662.16RP03707
CAS :RP03707 is a PROTAC degrader of KRASG12D.Formule :C55H58F3N11O4Couleur et forme :SolidMasse moléculaire :994.12PROTAC K-Ras Degrader-6
CAS :Pan-KRAS degrader 5 (compound 102) is a cereblon-based PROTAC KRAS degrader with a DC50 value less than 100 nM, exhibiting anticancer activity.Formule :C57H65F2N11O5Couleur et forme :SolidMasse moléculaire :1022.19Setidegrasib
CAS :Setidegrasib is a PROTAC-mediated KRAS degrader (DC50: 37 nM). Setidegrasib induces the ubiquitination and proteasomal degradation of the oncogenic protein.Formule :C60H65FN12O7SDegré de pureté :99.49% - 99.80%Couleur et forme :White SolidMasse moléculaire :1117.30L-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Formule :C164H286N66O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.44KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Formule :C51H65F4N9O9S2Couleur et forme :SolidMasse moléculaire :1088.24SOS1-IN-18
SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.Formule :C26H29F3N4O2Couleur et forme :SolidMasse moléculaire :486.53PROTAC BRAF-V600E degrader-2
CAS :PROTAC BRAF-V600E degrader-2 is a useful organic compound for research related to life sciences. The catalog number is T8744 and the CAS number is 2417296-82-1.Formule :C42H39F2N7O8SCouleur et forme :SolidMasse moléculaire :839.87SOS1-IN-11
CAS :SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).Formule :C22H24F3N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :431.45Ref: TM-T60029
1mg72,00€5mg160,00€1mL*10mM (DMSO)172,00€10mg269,00€25mg427,00€50mg610,00€100mg820,00€Pan-RAS-IN-5
Pan-RAS-IN-5 (compound 7A) is a molecular glue that facilitates the formation of a ternary complex with cyclophilin A (CYPA) and RAS(ON) protein. This complex inhibits the binding of RAF downstream of RAS, demonstrating antitumor activity.Formule :C45H58N8O5SCouleur et forme :SolidMasse moléculaire :822.42509PPM-3
PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.Formule :C54H69N11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1000.26LYMTAC-2
LYMTAC-2 is a lysosome-targeting chimera (LYMTAC) developed to degrade membrane-associated proteins through lysosomal membrane proteins (LMP) such as RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with target proteins like KRASG12D, facilitating their relocation to lysosomes and resulting in ubiquitin-dependent degradation. This compound has potential for studying membrane protein regulation and devising strategies to counter resistance in KRAS-driven signaling pathways.Couleur et forme :SolidMasse moléculaire :1248.44Peraquinsin
CAS :Peraquinsin is a MK2 activator that can be utilized in the research of vascular or endothelial barrier disorders and functions as an antihypertensive agent [1].Formule :C23H28N4O4Couleur et forme :SolidMasse moléculaire :424.49MRTX849 ethoxypropanoic acid
CAS :MRTX849 is a KRAS G12C ligand and PROTAC linker for creating potent LC-2, degrading KRAS G12C with DC50 of 0.25-0.76 μM.Formule :C37H43ClFN7O5Couleur et forme :SolidMasse moléculaire :720.24Pan-RAS-IN-6
Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.Formule :C46H60N8O5SCouleur et forme :SolidMasse moléculaire :837.08JNK-IN-15, Cell-Permeable, Negative Control
JNK-IN-15, Cell-Permeable, Negative Control serves as the negative control for JNK-IN-15, Cell-Permeable. JNK-IN-15, Cell-Permeable functions as an inhibitor of JNK.Formule :C191H336N70O48SCouleur et forme :SolidMasse moléculaire :4410.57236CGP78850
CAS :CGP78850 is a potent and selective Grb2 SH2-phosphopeptide interaction antagonist that holds potential for cancer research.Formule :C36H46N5O9PCouleur et forme :SolidMasse moléculaire :723.764KRAS inhibitor-42
KRAS inhibitor-42 (compound 8) is an effective USP7 inhibitor that exhibits high affinity for GDP-bound KRASG12D, with a Ki value of 2.7 μM.Formule :C34H47ClN8O4S2Couleur et forme :SolidMasse moléculaire :730.28502GADGVGKSA
CAS :GADGVGKSA, a mutant KRAS G12D 9mer peptide, serves as an immunogenic neoantigen for cancer immunotherapy research [1].Formule :C30H52N10O13Couleur et forme :SolidMasse moléculaire :760.794′-Demethylnobiletin
CAS :4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, andFormule :C20H20O8Couleur et forme :SolidMasse moléculaire :388.37KRAS G12D inhibitor 1
CAS :KRAS G12D inhibitor 1 (example 243) is an inhibitor of KRAS G12D with an IC 50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation [1].Formule :C33H32F2N6O2Couleur et forme :SolidMasse moléculaire :582.64KRAS inhibitor-33
KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.Formule :C33H39ClF2N6O3Couleur et forme :SolidMasse moléculaire :641.15MRTF-A-IN-1
MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Formule :C22H21N3Couleur et forme :SolidMasse moléculaire :327.42PROTAC KRAS G12D degrader 2
PROTACKRAS G12D degrader 2 is a peptidomimetic molecule capable of inducing the degradation of SARS-CoV-2 3-chymotrypsin-like protease (3CLPro). Designed as a PROTAC molecule, it combines a dipeptidyl 3CLPro ligand based on GC-376 with a pomalidomide moiety, linked through a piperazine-piperidine linker.Formule :C46H57FN8O9Couleur et forme :SolidMasse moléculaire :884.42325YN14
YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with lowDegré de pureté :98%Couleur et forme :Odour SolidFluconazole-PEG6-XMU-MP-9
Fluconazole-PEG6-XMU-MP-9, PEG-linked conjugate, fluconazole antifungal plus XMU-MP-9, promotes Nedd4-1 mediated K-Ras mutant degradation.Formule :C48H53F3N10O10SDegré de pureté :98.73%Couleur et forme :Yellow SolidMasse moléculaire :1019.06NK7-902
NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.Couleur et forme :Odour SolidFAM49B (190-198) mouse
CAS :FAM49B (190-198) mouse represents a peptide fragment of the mitochondria-localized protein FAM49B, which is instrumental in regulating mitochondrial fission, function, and integrity, in addition to influencing tumor progression. Beyond its role in mitochondrial dynamics, FAM49B serves as a negative regulator of T cell activation by inhibiting GTPase Rac activity and affecting cytoskeleton reorganization.Formule :C49H71N9O14SCouleur et forme :SolidMasse moléculaire :1042.2KRAS G12D inhibitor 20
KRAS G12D inhibitor 20 (Compound 14) is a selective G12D KRAS inhibitor with antitumor activity.Formule :C18H26N6OCouleur et forme :SolidMasse moléculaire :342.21681
