MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
886 produits trouvés pour "MAPK"
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HPK1 antagonist-1
CAS :<p>HPK1 antagonist-1 (I-792) is an inhibitor targeting HPK1, with potential applications in cancer and immune disease research [1].</p>Formule :C28H29FN6O2Couleur et forme :SolidMasse moléculaire :500.57HG6-64-1
CAS :HG6-64-1 (HMSL 10017-101-1, compound 9 (XI-1)) is a potent and selective B-Raf inhibitor with an IC50 = 0.09 μM in B-raf V600E-transformed Ba/F3 cells.Formule :C32H34F3N5O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :577.64Kras4B G12D-IN-1
CAS :<p>Kras4B G12D-IN-1 is an inhibitor of Kras4B G12D with anticancer activity.Kras4B G12D-IN-1 inhibits Kras protein expression.</p>Formule :C16H21ClN2O4SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :372.87BI-2493
CAS :<p>BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth.Cost-effective and quality-assured.</p>Formule :C24H27N7OSDegré de pureté :97.74% - 99.88%Couleur et forme :SoildMasse moléculaire :461.58ZYF0033
CAS :<p>ZYF0033(HPK1-IN-22) is an orally effective inhibitor of HPK1 that inhibits the phosphorylation of MBP proteins and decreases the phosphorylation of SLP76.</p>Formule :C26H30N4O2SDegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :462.61JWG-071
CAS :<p>JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.</p>Formule :C34H44N8O3Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :612.77Exarafenib
CAS :<p>Exarafenib (RAF/KIN_2787) is an oral pan-RAF inhibitor with antitumor properties, targeting MAPK signaling in cancer research.</p>Formule :C26H34F3N5O3Degré de pureté :98.36% - 99.84%Couleur et forme :SolidMasse moléculaire :521.58Pan-RAS-IN-1
CAS :<p>Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.</p>Formule :C36H41Cl2F3N6O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :717.65MK-8353
CAS :<p>MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)</p>Formule :C37H41N9O3SDegré de pureté :96.15% - 97.19%Couleur et forme :SolidMasse moléculaire :691.84AZD4625
<p>AZD4625 (Compound 21) is a selective, potent, orally active, covalent and mutagenic mutant GTPaseKRASG12C inhibitor.</p>Formule :C24H21ClF2N4O3Couleur et forme :SolidMasse moléculaire :486.9KU004
CAS :<p>KU004, a potent dual EGFR/HER2 inhibitor, exhibits anticancer properties. It inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR, and the downstream Akt and Erk pathways, primarily inducing apoptosis (Apoptosis) through the extrinsic pathway. Additionally, KU004 is a novel quinazoline derivative.</p>Formule :C29H27ClFN4O2PCouleur et forme :SolidMasse moléculaire :548.98KRAS inhibitor-27
CAS :<p>KRAS inhibitor-27 (Compound 15h) is a KRAS inhibitor that effectively targets KRAS G12D/G12V mutated cells (AsPC-1 and SW620) and wild-type KRAS cells (HT-29), with IC50 values of 378 nM, 0.6 nM, and 3230 nM, respectively. It reduces ERK phosphorylation, with IC50 values of 0.6 nM and 1 nM in AsPC-1 and SW620 cells, respectively, and decreases DUSP4 expression, thereby inhibiting the MAPK signaling pathway.</p>Formule :C31H28ClF3N6O3SCouleur et forme :SolidMasse moléculaire :657.106KRAS inhibitor-35
CAS :<p>KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.</p>Formule :C38H32F4N6O3SCouleur et forme :SolidMasse moléculaire :728.76BBO-8520
CAS :<p>BBO-8520 is a dual KRASG12C inhibitor that blocks ON and OFF states, disables effector binding, suppresses signaling, and induces tumor regression.</p>Formule :C35H33F6N7O2SDegré de pureté :97.879%Couleur et forme :SolidMasse moléculaire :729.74KRAS ligand 5
CAS :<p>KRAS ligand 5 acts as the target protein ligand for PROTACK-Ras Degrader-3, which specifically targets and degrades mutated KRAS proteins.</p>Formule :C30H30F2N4O4Couleur et forme :SolidMasse moléculaire :548.58p38α-MK2-IN-1
CAS :<p>p38α-MK2-IN-1 (Compound 36) is an inhibitor of the p38α-MK2 complex, with an IC50 of 5 nM. This compound exhibits significant anti-inflammatory properties and has the ability to aid in joint repair.</p>Formule :C27H26F3N5O3Couleur et forme :SolidMasse moléculaire :525.522KRAS G12D inhibitor 19
CAS :<p>KRAS G12D inhibitor 19 (Compound 7) is used in cancer research [1]. As a specific inhibitor of KRAS G12D, it targets and potentially suppresses this mutation, which is frequently associated with various cancers.</p>Formule :C35H34F2N6O3Couleur et forme :SolidMasse moléculaire :624.68KRAS inhibitor-8
CAS :<p>KRAS inhibitor-8 is a potent KRAS G12C inhibitor.</p>Formule :C26H24ClF4N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.95RGT-018
CAS :<p>RGT-018 is a potent oral SOS1 inhibitor with antitumor properties. It exerts its anticancer activity by inhibiting KRAS activation, thereby hindering cancer cell proliferation.</p>Formule :C27H24F3N7O2Couleur et forme :SolidMasse moléculaire :535.52PF-03715455
CAS :<p>PF-03715455 is a potent p38 MAPK inhibitor, reducing TNFα in blood (IC50=1.7 nM) with selectivity for p38α, and may treat COPD.</p>Formule :C35H34ClN7O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :700.27
