MEK
La MEK est une kinase à double spécificité qui joue un rôle central dans la voie de signalisation MAPK/ERK en activant ERK par phosphorylation. La signalisation MEK est cruciale pour réguler la croissance, la survie et la différenciation cellulaires. Une activité anormale de la MEK a été impliquée dans divers cancers et troubles du développement, ce qui en fait une cible thérapeutique importante. Chez CymitQuimica, nous offrons une variété d'inhibiteurs et de modulateurs de la MEK pour soutenir vos recherches en oncologie, signalisation cellulaire et développement thérapeutique.
73 produits trouvés pour "MEK"
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Lidocaine
CAS :<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Formule :C14H22N2ODegré de pureté :99.95% - >99.99%Couleur et forme :Needles From Benzene Or Alcohol SolidMasse moléculaire :234.34Lidocaine hydrochloride
CAS :<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Formule :C14H23ClN2ODegré de pureté :99.81% - 99.92%Couleur et forme :White Crystal PowderMasse moléculaire :270.798Lidocaine Hydrochloride hydrate
CAS :<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Formule :C14H22N2O·HCl·H2ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :288.82MEK ligand-2
CAS :<p>MEK ligand-2, a ligand for the target protein for PROTAC (Ligand for Target Protein for PROTAC), functions as an inhibitor for both MEK1 and MEK2. This compound plays a crucial role in MS934, which is a VHL-recruiting MEK1/2 PROTAC degrader.</p>Formule :C13H8F3IN2O2Couleur et forme :SolidMasse moléculaire :408.12MEK/PI3K-IN-1
CAS :<p>MEK/PI3K-IN-1 (6r) is a dual MEK/PI3K inhibitor; IC50: 124 nM (MEK1), 130 nM (PI3Kα), 236 nM (PI3Kδ). It reduces pAKT, pERK1/2, and hinders tumor growth.</p>Formule :C36H37F5IN9O6Couleur et forme :SolidMasse moléculaire :913.63BAY-6035
CAS :<p>BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.</p>Formule :C22H28N4O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :396.48MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Couleur et forme :Odour SolidFDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Couleur et forme :LiquidMEK/PI3K-IN-2
CAS :<p>MEK/PI3K-IN-2 is a potent dual inhibitor (MEK1 IC50: 352 nM, PI3Kα: 107 nM, PI3Kδ: 137 nM) that reduces pAKT, pERK1/2, and hinders tumor cell growth.</p>Formule :C38H41F5IN9O7Couleur et forme :SolidMasse moléculaire :957.68NST-628
CAS :<p>NST-628 is a pan-RAF-MEK molecular glue that prevents RAF from phosphorylating and activating MEK. NST-628 inhibits the RAF-MEK signaling complex.</p>Formule :C22H18F2N4O5SDegré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :488.46U0124
CAS :<p>Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative control</p>Formule :C8H10N4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :226.32Debromohymenialdisine
CAS :<p>Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.</p>Formule :C11H11N5O2Couleur et forme :SolidMasse moléculaire :245.242Cobimetinib (R-enantiomer)
CAS :<p>Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.</p>Formule :C21H21F3IN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.318MEK1/2-IN-3
<p>MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.</p>Formule :C28H23F3IN3O4Couleur et forme :SolidMasse moléculaire :649.4MEK4 inhibitor-1
CAS :<p>MEK4 inhibitor-1 targets MEK4 enzyme in pancreatic cancer, IC50=61 nM.</p>Formule :C13H10FN3O2SCouleur et forme :SolidMasse moléculaire :291.3DS03090629
<p>DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.</p>Formule :C25H26ClN5O2Couleur et forme :SolidMasse moléculaire :463.96PD 198306
CAS :<p>PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.</p>Formule :C18H16F3IN2O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :476.23Midkine Protein, Mouse, Recombinant (His)
<p>Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as</p>Degré de pureté :> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC - > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLCCouleur et forme :Lyophilized PowderMasse moléculaire :14.03 kDa (predicted). The protein migrates to 17-20 kDa based on Tris-Bis PAGE result.Midkine Protein, Human, Recombinant (His & Avi)
<p>Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as</p>Couleur et forme :Lyophilized PowderMasse moléculaire :16.46 kDa (predicted) same as Tris-Bis PAGE result.Anti-Midkine Antibody (5T766)
<p>Anti-Midkine Antibody (5T766) is an antibody targeting Midkine. Anti-Midkine Antibody (5T766) can be used in ELISA, IHC.</p>Couleur et forme :Odour LiquidMidkine Protein, Human, Recombinant (His & Avi), Biotinylated
<p>Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as</p>Couleur et forme :Lyophilized PowderMasse moléculaire :16.46 kDa (predicted) same as Tris-Bis PAGE result.Pimasertib
CAS :<p>Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Formule :C15H15FIN3O3Degré de pureté :98.25% - 99.57%Couleur et forme :SolidMasse moléculaire :431.2zapnometinib
CAS :<p>Zapnometinib (ATR-002) is a MEK inhibitor.</p>Formule :C13H7ClF2INO2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :409.55Ro 5126766
CAS :<p>RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.</p>Formule :C21H18FN5O5SDegré de pureté :98.3% - 98.81%Couleur et forme :SolidMasse moléculaire :471.46anemarsaponin B
CAS :<p>Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity</p>Formule :C45H74O18Degré de pureté :99.06% - 99.81%Couleur et forme :SolidMasse moléculaire :903.06BIX02189
CAS :<p>BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).</p>Formule :C27H28N4O2Degré de pureté :97.84%Couleur et forme :SolidMasse moléculaire :440.54PD98059
CAS :<p>PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.</p>Formule :C16H13NO3Degré de pureté :98.63% - >99.99%Couleur et forme :Yellow SolidMasse moléculaire :267.28CI-1040
CAS :<p>CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM).</p>Formule :C17H14ClF2IN2O2Degré de pureté :99.64%Couleur et forme :Off-White To Pale Beige SolidMasse moléculaire :478.66Refametinib
CAS :<p>Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).</p>Formule :C19H20F3IN2O5SDegré de pureté :99.53% - >99.99%Couleur et forme :SolidMasse moléculaire :572.34RGB-286638 free base
CAS :<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Formule :C29H35N7O4Degré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63Selumetinib
CAS :<p>Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and quality-assured.</p>Formule :C17H15BrClFN4O3Degré de pureté :98.1% - 99.90%Couleur et forme :White Or Pale White SolidMasse moléculaire :457.68TAK-733
CAS :<p>TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Formule :C17H15F2IN4O4Degré de pureté :98.31% - 99.53%Couleur et forme :SolidMasse moléculaire :504.23APS-2-79
CAS :<p>APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.</p>Formule :C23H21N3O3Couleur et forme :SolidMasse moléculaire :387.43Trametinib (DMSO solvate)
CAS :<p>Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)</p>Formule :C28H29FIN5O5SDegré de pureté :98.82% - 99.92%Couleur et forme :SolidMasse moléculaire :693.53Binimetinib
CAS :<p>Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.</p>Formule :C17H15BrF2N4O3Degré de pureté :98.03% - >99.99%Couleur et forme :SolidMasse moléculaire :441.23GW 284543 hydrochloride
CAS :<p>GW 284543 hydrochloride is a selective inhibitor of MEK5 .</p>Formule :C23H21ClN2O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :408.87Mirdametinib
CAS :<p>Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.</p>Formule :C16H14F3IN2O4Degré de pureté :99.11% - 99.63%Couleur et forme :White PowderMasse moléculaire :482.19GDC-0623
CAS :<p>GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.</p>Formule :C16H14FIN4O3Degré de pureté :98.95% - 99.02%Couleur et forme :SolidMasse moléculaire :456.21AZD8330
CAS :<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Formule :C16H17FIN3O4Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :461.23Aurothiomalate sodium
CAS :<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Formule :C4H3AuNa2O4SDegré de pureté :99.66%Couleur et forme :SoildMasse moléculaire :390.07SL327
CAS :<p>SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.</p>Formule :C16H12F3N3SDegré de pureté :97.98% - >99.99%Couleur et forme :SolidMasse moléculaire :335.35PD184161
CAS :<p>PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].</p>Formule :C17H13BrClF2IN2O2Degré de pureté :99.40%Couleur et forme :SolidMasse moléculaire :557.56BI-847325
CAS :<p>BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.</p>Formule :C29H28N4O2Degré de pureté :97.13% - 97.54%Couleur et forme :SolidMasse moléculaire :464.56U0126-EtOH
CAS :<p>U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!</p>Formule :C18H16N6S2·C2H6ODegré de pureté :99.72% - 99.88%Couleur et forme :SolidMasse moléculaire :426.6trans-Zeatin
CAS :<p>trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient</p>Formule :C10H13N5ODegré de pureté :97.13% - 98.96%Couleur et forme :White To Light Yellow Crystal PowderMasse moléculaire :219.24Cobimetinib
CAS :<p>Cobimetinib (GDC-0973) is a MEK1 inhibitor with selective and oral activity. Cobimetinib exhibits antitumor activity. Cost-effective and quality-assured.</p>Formule :C21H21F3IN3O2Degré de pureté :98% - 99.61%Couleur et forme :SolidMasse moléculaire :531.31U0126
CAS :<p>U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively.</p>Formule :C18H16N6S2Degré de pureté :99.61%Couleur et forme :White SolidMasse moléculaire :380.49APS-2-79 hydrochloride
CAS :<p>APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.</p>Formule :C23H21N3O3·HClDegré de pureté :98.64% - 99.55%Couleur et forme :SolidMasse moléculaire :423.89Isorhamnetin
CAS :<p>Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.</p>Formule :C16H12O7Degré de pureté :99.20% - >99.99%Couleur et forme :SolidMasse moléculaire :316.26PD318088
CAS :<p>PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-</p>Formule :C16H13BrF3IN2O4Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :561.09
