MLK
Les MLK (Mixed-Lineage Kinases) sont un groupe de kinases capables d'activer plusieurs voies MAPK, y compris JNK et p38, en phosphorylant les kinases MAP en amont (MAP2K). Les MLK sont impliquées dans les réponses cellulaires au stress, l'apoptose et la neuroinflammation. La dérégulation de l'activité des MLK est associée à des maladies neurodégénératives et à certains cancers. Chez CymitQuimica, nous proposons une gamme de modulateurs de MLK de haute qualité pour soutenir vos recherches en neurobiologie, réponse au stress et transduction de signaux.
22 produits trouvés pour "MLK"
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GW806742X
CAS :<p>GW806742X inhibits MLKL with Kd 9.3 μM, preventing necroptosis; also targets VEGFR2.</p>Formule :C25H22F3N7O4SDegré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :573.55Anticancer agent 267
<p>Anticanceragent 267 (Compound 5q) serves as an activator of RIPK3 and MLKL. It effectively inhibits the proliferation of several cancer cell lines, with IC50 values of 9.79, 10.77, and 5.94 μM for MDA-MB-231, MDA-MB-486, and MCF-7, respectively. The compound induces cell cycle arrest at the subG1 phase and triggers necroptosis in MDA-MB-231 cells. Additionally, Anticanceragent 267 demonstrates antitumor activity in mouse xenograft models.</p>Formule :C13H11N5O4SCouleur et forme :SolidMasse moléculaire :333.32PROTAC MLKL Degrader-1
<p>PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.</p>Formule :C46H55F2N9O9SCouleur et forme :SolidMasse moléculaire :948.05MLKL-IN-2
CAS :<p>MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases.</p>Formule :C26H25N5ODegré de pureté :98.30%Couleur et forme :SolidMasse moléculaire :423.51KWCN-41
CAS :<p>KWCN-41, a RIPK1 inhibitor with 88 nM IC50, blocks necrosis, spares apoptosis, and is anti-inflammatory.</p>Formule :C18H17N3O2Couleur et forme :SolidMasse moléculaire :307.35NecroX-2
CAS :<p>NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.</p>Formule :C25H32N4O4S2Degré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :516.68PROTAC MLKL Degrader-2
<p>PROTAC MLKL Degrader-2, a PROTAC that targets MLKL (Mixed Lineage Kinase), incorporates the PROTAC target protein ligand, E3 ligase ligand Thalidomide, and PROTAC Linker N-Methylpiperazine. The conjugate of the E3 ubiquitin ligase ligand and Linker is Thalidomide-N-Methylpiperazine. This compound exhibits antinecroptotic activity in human cell lines and effectively degrades MLKL in the HT-29 xenograft mouse model.</p>Formule :C36H35N9O9SCouleur et forme :SolidMasse moléculaire :769.78RIPK3-IN-3
<p>RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM.</p>Formule :C16H11N5SCouleur et forme :SolidMasse moléculaire :305.36MLKL-IN-7
<p>MLKL-IN-7 (compound 9) is an MLKL inhibitor that exhibits anti-necrotic activity in HT-29 cells, with an IC50 value of 148.4 nM.</p>Formule :C21H15N5O5S2Masse moléculaire :481.05146Necrosulfonamide
CAS :<p>Necrosulfonamide ((E)-Necrosulfonamide) is a necroptosis inhibitor that targets MLKL and is selective. High-Quality, Low-Cost!</p>Formule :C18H15N5O6S2Degré de pureté :98.85% - 99.49%Couleur et forme :SolidMasse moléculaire :461.47LY-364947
CAS :<p>LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.</p>Formule :C17H12N4Degré de pureté :99.41% - 99.96%Couleur et forme :SolidMasse moléculaire :272.3AZ7550
CAS :<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formule :C27H31N7O2Degré de pureté :97.07% - 99.75%Couleur et forme :SolidMasse moléculaire :485.58Cerdulatinib hydrochloride
CAS :<p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.</p>Formule :C20H28ClN7O3SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :482SZM-1209
CAS :<p>SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM.</p>Formule :C31H29F5N4O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :696.71MLKL-IN-5
CAS :<p>MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .</p>Formule :C18H20N6O4SCouleur et forme :SolidMasse moléculaire :416.45IM-54
CAS :<p>IM-54 is a cell-permeable, effective, and selective necrosis inhibitor.</p>Formule :C19H23N3O2Degré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :325.4TC13172
CAS :<p>TC13172 is a potent, covalent MLKL inhibitor, selective over RIPK1/RIPK3. It blocks TSZ-induced necroptosis (EC50=2nM) and MLKL oligomerization at 100nM.</p>Formule :C17H16N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.4MLKL-IN-1
<p>MLKL-IN-1 is a covalent inhibitor of MLKL with a Kd value of 50 μM.</p>Formule :C19H20N2O3Couleur et forme :SolidMasse moléculaire :324.37MLKL-IN-6
<p>MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.</p>Formule :C20H18N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.38Topoisomerase I/II inhibitor 8
CAS :<p>TopoisomeraseI/II inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of TopoisomeraseI/II that induces DNA damage and activates PARP-1, leading to the activation of RIPK1, RIPK3, and MLKL, ultimately causing necroptosis. It shows significant anticancer activity by effectively targeting cancer cell nuclei and inducing cell death through necroptosis, offering substantial clinical potential in overcoming resistance in cancer treatment.</p>Formule :C14H11Br2NO5S2Couleur et forme :SolidMasse moléculaire :497.179
