Ras
Les protéines Ras sont de petites GTPases qui agissent comme des commutateurs moléculaires dans la voie de signalisation MAPK, contrôlant la croissance, la différenciation et la survie cellulaires. Ras activé initie une cascade de signalisation qui inclut Raf, MEK et ERK, conduisant à diverses réponses cellulaires. Les mutations des gènes Ras sont courantes dans les cancers, faisant de Ras un point focal important de la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme de modulateurs de Ras pour soutenir vos recherches en biologie du cancer, transduction de signaux et développement thérapeutique.
154 produits trouvés pour "Ras"
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KRAS G12D modulator-1
CAS :KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and isFormule :C30H36FN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :549.64pan-KRAS-IN-4
CAS :Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].Formule :C36H34F2N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :636.69KRAS G12C inhibitor 58
CAS :KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].Formule :C51H64ClF4N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1074.62KRAS G12C inhibitor 13
CAS :KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .Formule :C40H46F3N7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :745.83BDP9066
CAS :BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.Formule :C20H24N6Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :348.44Ref: TM-T14521
1mg54,00€5mg114,00€10mg178,00€25mg409,00€50mg708,00€100mg1.224,00€500mg2.448,00€1mL*10mM (DMSO)126,00€Pan-RAS-IN-1
CAS :Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.Formule :C36H41Cl2F3N6O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :717.65Ref: TM-T16432
1mg75,00€2mg92,00€5mg137,00€10mg205,00€25mg416,00€50mg625,00€100mg888,00€500mg1.783,00€1mL*10mM (DMSO)210,00€INCB159020
CAS :INCB159020 is an orally active inhibitor of KRAS G12D, exhibiting a KRAS G12D SPR value of 2.2 nM. It demonstrates anti-tumor activity.Formule :C37H35ClFN7O2Couleur et forme :SolidMasse moléculaire :664.171SOS2 ligand 1
CAS :SOS2 ligand 1 (compound 2) is a selective ligand for son of sevenless 2 (SOS2), exhibiting a KD value of 4.6 µM.Formule :C19H21N5OCouleur et forme :SolidMasse moléculaire :335.403RGT-018
CAS :RGT-018 is a potent oral SOS1 inhibitor with antitumor properties. It exerts its anticancer activity by inhibiting KRAS activation, thereby hindering cancer cell proliferation.Formule :C27H24F3N7O2Couleur et forme :SolidMasse moléculaire :535.52pan-KRAS-IN-17
CAS :pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.Formule :C34H33F3N5O8PCouleur et forme :SolidMasse moléculaire :727.623KRAS inhibitor-31
CAS :KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.Formule :C33H30F3N5O4Couleur et forme :SolidMasse moléculaire :617.62KRas G12C inhibitor 2
CAS :KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.Formule :C32H37N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :567.68KRAS G12D inhibitor 26
CAS :KRAS G12D inhibitor 26 (Compound 64B) is an inhibitor of KRAS G12D with an IC50 ≤ 100 nM.Formule :C35H44ClFN8O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :663.23Dorrigocin A
CAS :Dorrigocin A, an analog of Migrastatin, inhibits the carboxymethyltransferase involved in Ras processing, reversing the morphology of Ras-transformed NIH/3T3 cells. Dorrigocin A holds potential for research as an anticancer and anti-arthritis agent.Formule :C27H41NO8Couleur et forme :SolidMasse moléculaire :507.616ZCL279
CAS :ZCL279 is a small molecule modulator (SMM) that inhibits the interaction between CDC42 and intersectin (ITSN). At lower concentrations (<10 μM), ZCL279 activates Cdc42, a cytoplasmic small GTPase in the Ras superfamily, while at higher concentrations (<10 μM) it significantly inhibits it.Formule :C24H18N2O7S2Couleur et forme :SolidMasse moléculaire :510.539KRAS inhibitor-35
CAS :KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.Formule :C38H32F4N6O3SCouleur et forme :SolidMasse moléculaire :728.76XMU-MP-9
CAS :XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of K-Ras. It enhances the interaction and induces conformational changes within the Nedd4-1/K-Ras complex. Furthermore, XMU-MP-9 facilitates the ubiquitination and degradation of various K-Ras mutants and inhibits the proliferation of cells with these mutants. This compound is useful in cancer research.Formule :C19H13ClFN3OSCouleur et forme :SolidMasse moléculaire :385.84KRAS inhibitor-34
CAS :KRAS inhibitor-34 (compound 27) is a KRAS inhibitor with an IC50 of 6.4 nM and is utilized in oncological research.Formule :C43H41F3N6O3Couleur et forme :SolidMasse moléculaire :746.82SOF-436
CAS :SOF-436 is a KRAS inhibitor that can suppress SOS1-mediated KRAS nucleotide exchange (IC50 = 60 μM) and inhibit the interaction between KRAS and the effector protein RAF. SOF-436 is applicable to cancer research.Formule :C15H13F2NO4S2Couleur et forme :SolidMasse moléculaire :373.395KRAS inhibitor-37
CAS :KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.Formule :C32H33ClFN7O3Couleur et forme :SolidMasse moléculaire :618.10
