Ras
Les protéines Ras sont de petites GTPases qui agissent comme des commutateurs moléculaires dans la voie de signalisation MAPK, contrôlant la croissance, la différenciation et la survie cellulaires. Ras activé initie une cascade de signalisation qui inclut Raf, MEK et ERK, conduisant à diverses réponses cellulaires. Les mutations des gènes Ras sont courantes dans les cancers, faisant de Ras un point focal important de la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme de modulateurs de Ras pour soutenir vos recherches en biologie du cancer, transduction de signaux et développement thérapeutique.
154 produits trouvés pour "Ras"
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AM-001
CAS :AM-001 is a non-competitive inhibitor of Epac1, preventing the activation of its downstream effector Rap1 in cultured cells. This compound is utilized in research related to cardiac diseases.Formule :C24H16FN3OS2Couleur et forme :SolidMasse moléculaire :445.53J-104871
CAS :J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.Formule :C38H32N2O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :708.67ADT-1004
CAS :ADT-1004 is an inhibitor of RAS. It can be used for research involving Ras-mediated diseases.Formule :C33H36FN3O6Couleur et forme :SoildMasse moléculaire :589.65BMS-214662
CAS :BMS-214662 is a selective farnesyl transferase inhibitor with anti-tumor activity, used in research on pancreatic cancer, head and neck cancer, and lung cancer.Formule :C25H23N5O2S2Degré de pureté :99.58% - 99.58%Couleur et forme :SolidMasse moléculaire :489.61KRAS G12C inhibitor 15
CAS :KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .Formule :C25H21ClF2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.91PAT-IN-1
CAS :PAT-IN-1, a protein acyl transferases (PAT) inhibitor, competitively inhibits Erf2 autopalmitoylation (WO2017011518A1; compound 13) [1].Formule :C45H68N4OCouleur et forme :SolidMasse moléculaire :681.05(+)-Perillyl alcohol
CAS :(+)-Perillyl alcohol (0.25-1 mM) inhibits cell growth in SW480 cells. At a concentration of 1 mM and a duration of 24 hours, (+)-Perillyl alcohol increases the number of cells in the G0/G1 phase and reduces the number in the S phase in SW480 cells.Formule :C10H16OCouleur et forme :SolidMasse moléculaire :152.23KRAS inhibitor-32
CAS :KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor utilized in cancer research.Formule :C29H35FN10OS2Couleur et forme :SolidMasse moléculaire :622.78pan-KRAS degrader 1
CAS :Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.Formule :C22H26N8OSCouleur et forme :SolidMasse moléculaire :450.56Rho GTPase inhibitor 1
CAS :Rho GTPase inhibitor 1 (compound 7) is a potent inhibitor of Rho GTPase. It exhibits high affinity for Cdc42, Rac1, and RhoA, with dissociation constants (KDs) of 151 μM, 352 μM, and 232 μM, respectively. Additionally, Rho GTPase inhibitor 1 reduces cell migration in glioblastoma cell lines.Formule :C18H16N2OCouleur et forme :SolidMasse moléculaire :276.33Sosimerasib
CAS :Sosimerasib is an inhibitor of the kirsten rat sarcoma viral oncogene homolog (KRAS) and exhibits antitumor activity.
Formule :C36H39ClFN7O4Couleur et forme :SolidMasse moléculaire :688.191KRAS G12D inhibitor 28
CAS :KRAS G12D inhibitor 28 (Compound 1) is an inhibitor of KRAS G12D and can be utilized in cancer research.Formule :C35H32Cl2FN5OCouleur et forme :SolidMasse moléculaire :628.57KRAS inhibitor-41
CAS :KRAS inhibitor-41 is a KRAS inhibitor with an IC50 value of less than 0.01 μM for both KRAS G12D and KRAS G12V mutations. It effectively inhibits RAS mutant cell lines GP2D (KRAS-G12D) and SW620 (KRAS-G12V). KRAS inhibitor-41 is applicable for cancer research.Formule :C30H37FN10OSCouleur et forme :SolidMasse moléculaire :604.745KRAS inhibitor-8
CAS :KRAS inhibitor-8 is a potent KRAS G12C inhibitor.Formule :C26H24ClF4N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.95
