mAPK p38
Les p38 MAPK sont un sous-groupe de MAPK qui répondent aux signaux de stress et sont impliqués dans la régulation de l'inflammation, de la différenciation cellulaire, de l'apoptose et de l'autophagie. La signalisation p38 MAPK est cruciale dans les réponses immunitaires et est impliquée dans diverses maladies, y compris les affections inflammatoires chroniques, le cancer et les troubles neurodégénératifs. Chez CymitQuimica, nous proposons une gamme complète d'inhibiteurs et de modulateurs de p38 MAPK pour soutenir vos recherches sur l'inflammation, la réponse au stress et le développement thérapeutique.
117 produits trouvés pour "mAPK p38"
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Ralimetinib dimesylate
CAS :<p>Ralimetinib dimesylate (LY2228820 dimesylate) is a orally available, p38 MAPK inhibitor with potential anti-inflammatory and antineoplastic activities.</p>Formule :C24H29FN6·2CH4O3SDegré de pureté :98% - 99.38%Couleur et forme :SolidMasse moléculaire :612.74Skepinone-L
CAS :<p>Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.</p>Formule :C24H21F2NO4Degré de pureté :99.56% - >99.99%Couleur et forme :SolidMasse moléculaire :425.42SKF-86002
CAS :<p>SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).</p>Formule :C16H12FN3SDegré de pureté :98% - 99.85%Couleur et forme :SolidMasse moléculaire :297.35SB 242235
CAS :<p>SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.</p>Formule :C19H20FN5ODegré de pureté :99.13% - 99.68%Couleur et forme :SolidMasse moléculaire :353.39Rhoifolin
CAS :<p>Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.</p>Formule :C27H30O14Degré de pureté :98.11% - 98.58%Couleur et forme :SolidMasse moléculaire :578.52TAK-715
CAS :<p>TAK-715 is a p38 MAPK inhibitor for p38α.</p>Formule :C24H21N3OSDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :399.51PD 169316
CAS :<p>PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.</p>Formule :C20H13FN4O2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :360.34AMG-47a
CAS :<p>AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.</p>Formule :C29H28F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.56Acumapimod
CAS :<p>Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).</p>Formule :C22H19N5O2Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :385.42Skatole
CAS :<p>Skatole (3-Methyl-1H-indole), produced by bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.</p>Formule :C9H9NDegré de pureté :99.74%Couleur et forme :Leaves From Petroleum Ether; White-Brown Scales SolidMasse moléculaire :131.17MW-150
CAS :<p>MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.</p>Formule :C24H23N5Degré de pureté :97.35% - 99.27%Couleur et forme :SolidMasse moléculaire :381.47Isoliquiritin apioside
CAS :<p>Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.</p>Formule :C26H30O13Degré de pureté :98.84% - 99.27%Couleur et forme :SolidMasse moléculaire :550.51Esculin
CAS :<p>Esculin (Aesculin) is a glucoside found in horse chestnuts.</p>Formule :C15H16O9Degré de pureté :97.93% - 99.83%Couleur et forme :Cream PowderMasse moléculaire :340.28Doramapimod
CAS :<p>Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.</p>Formule :C31H37N5O3Degré de pureté :97.14% - 98.80%Couleur et forme :SolidMasse moléculaire :527.66Bakuchiol
CAS :<p>Bakuchiol: anti-tumor, anti-helminthic, DNA polymerase1 inhibitor, cytotoxic, and anti-bacterial, may prevent dental caries.</p>Formule :C18H24ODegré de pureté :98.04% - 99.05%Couleur et forme :Brownish Yellow Liquid ViscousMasse moléculaire :256.38PH-797804
CAS :<p>PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.</p>Formule :C22H19BrF2N2O3Degré de pureté :97.90% - 98.27%Couleur et forme :SolidMasse moléculaire :477.3Dehydrocorydaline
CAS :<p>1.</p>Formule :C22H24NO4Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :366.43Bisabolangelone
CAS :<p>Bisabolangelone: anti-tumor, anti-inflammatory, anti-microbial, antioxidant, blocks MAPK/NF-κB in dendritic cells.</p>Formule :C15H20O3Degré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :248.32SM-7368
CAS :<p>The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.</p>Formule :C10H5ClN4O5SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :328.69AMG 900
CAS :<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Formule :C28H21N7OSDegré de pureté :98.4% - 99.51%Couleur et forme :SolidMasse moléculaire :503.58SD-169
CAS :<p>SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.</p>Formule :C9H8N2ODegré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :160.17Afatinib
CAS :<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Formule :C24H25ClFN5O3Degré de pureté :98.56% - 99.9%Couleur et forme :Off-White SolidMasse moléculaire :485.94N-Feruloyloctopamine
CAS :<p>N-Feruloyloctopamine is a natural product.</p>Formule :C18H19NO5Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :329.35Sesamolin
CAS :<p>Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.</p>Formule :C20H18O7Degré de pureté :98.77% - 99.04%Couleur et forme :SolidMasse moléculaire :370.35Pamapimod
CAS :<p>Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.</p>Formule :C19H20F2N4O4Degré de pureté :99.52% - 99.99%Couleur et forme :SolidMasse moléculaire :406.38Losmapimod
CAS :<p>Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).</p>Formule :C22H26FN3O2Degré de pureté :98.35% - 99.89%Couleur et forme :SolidMasse moléculaire :383.46RWJ-67657
CAS :<p>RWJ-67657 is a selective oral p38α/β MAPK inhibitor with IC50s of 1/11μM; inactive on p38γ/δ with cardioprotection.</p>Formule :C27H24FN3ODegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :425.5Sertaconazole
CAS :<p>Sertaconazole is a broad-spectrum antifungal.</p>Formule :C20H15Cl3N2OSDegré de pureté :99.483%Couleur et forme :SolidMasse moléculaire :437.77Paris saponin VII
CAS :<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formule :C51H82O21Degré de pureté :99.51% - 99.63%Couleur et forme :SolidMasse moléculaire :1031.18Talmapimod
CAS :<p>Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.</p>Formule :C27H30ClFN4O3Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :513BMS582949
CAS :<p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>Formule :C22H26N6O2Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :406.48Pexmetinib
CAS :<p>Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.</p>Formule :C31H33FN6O3Degré de pureté :99.07% - 99.66%Couleur et forme :SolidMasse moléculaire :556.63Dehydrocorydaline nitrate
CAS :<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Formule :C22H24N2O7Degré de pureté :99.79% - 99.92%Couleur et forme :SolidMasse moléculaire :428.44VX-702
CAS :<p>VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.</p>Formule :C19H12F4N4O2Degré de pureté :99% - >99.99%Couleur et forme :SolidMasse moléculaire :404.32TLC1566-0618
CAS :<p>TLC1566-0618 shows antitumor activity and targets stat.</p>Formule :C20H15NO3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :413.53(S)-(-)-PH-797804
CAS :Produit contrôléFormule :C19H38N5O5Couleur et forme :NeatMasse moléculaire :416.536LY 294002 Hydrochloride
CAS :Produit contrôlé<p>Applications LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).<br>References Lin, C., et. al.: J. Biol. Chem., 286, 10483 (2011); Cao, H., et. al.: J. Biol. Chem., 288, 30399 (2013);<br></p>Formule :C19H17NO3·(HCl)Couleur et forme :NeatMasse moléculaire :343.8SB 706504
CAS :<p>SB 706504 is an effective p38 MAPK inhibitor that suppresses inflammatory gene expression in macrophages and inhibits TNFα production in COPD.</p>Formule :C24H19F3N8ODegré de pureté :98.686%Couleur et forme :SolidMasse moléculaire :492.46AL 8697
CAS :<p>AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases.</p>Formule :C21H21F3N4ODegré de pureté :99.55% - 99.89%Couleur et forme :SolidMasse moléculaire :402.41PF-05381941
CAS :<p>PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.</p>Formule :C27H26N6O2Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :466.53EO-1606
CAS :<p>EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.</p>Formule :C21H17ClFNODegré de pureté :98.28% - 98.84%Couleur et forme :SolidMasse moléculaire :353.82p38α inhibitor 4
CAS :<p>p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.</p>Formule :C14H7F6N3ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :347.215UR13870
CAS :<p>UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.</p>Formule :C24H16F2N4Degré de pureté :99.18% - >99.99%Couleur et forme :SolidMasse moléculaire :398.41AKP-001
CAS :<p>AKP-001 is a selective inhibitor of MAPK of the p38α isoform and is used in the study of immune and digestive disorders.</p>Formule :C21H13ClF2N4O2Degré de pureté :99.50% - 99.92%Couleur et forme :SolidMasse moléculaire :426.8p38 MAPK Inhibitor
CAS :<p>p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.</p>Formule :C20H13ClFN3ODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :365.79SB-747651A Dihydrochloride
CAS :<p>SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.</p>Formule :C16H24Cl2N8ODegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :415.32Org OD 02-0
CAS :<p>10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activate</p>Formule :C22H30O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.47p38-α MAPK-IN-1
CAS :<p>p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.</p>Formule :C27H35N5O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :477.6PLK1/p38γ-IN-1
CAS :<p>PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellular</p>Formule :C21H26ClN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.9
