Raf
Les kinases Raf sont des composants clés de la voie de signalisation MAPK/ERK, jouant un rôle critique dans la transmission des signaux de la membrane cellulaire au noyau. L'activation de Raf conduit à la phosphorylation de MEK, qui active ensuite ERK, influençant ainsi la division cellulaire, la différenciation et la survie. Les mutations de Raf, en particulier dans B-Raf, sont associées à divers cancers, ce qui fait de Raf une cible cruciale en thérapie anticancéreuse. Chez CymitQuimica, nous offrons une variété d'inhibiteurs et de modulateurs de Raf pour soutenir vos recherches en oncologie, transduction de signaux et développement thérapeutique.
83 produits trouvés pour "Raf"
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MRTX0902
CAS :<p>MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.</p>Formule :C22H24N6ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :388.47Sorafenib
CAS :<p>Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57</p>Formule :C21H16ClF3N4O3Degré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :464.82Xl-281
CAS :<p>XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.</p>Formule :C24H19ClN4O4Degré de pureté :95.77% - 98.83%Couleur et forme :SolidMasse moléculaire :462.89Sorafenib tosylate
CAS :<p>Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).</p>Formule :C21H16ClF3N4O3·C7H8O3SDegré de pureté :99.24% - 99.94%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :637.03LXH254
CAS :<p>LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.</p>Formule :C25H25F3N4O4Degré de pureté :98.3% - 99.92%Couleur et forme :SolidMasse moléculaire :502.49Regorafénib N-oxyde (M2)
CAS :<p>Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.</p>Formule :C21H15ClF4N4O4Degré de pureté :98.03% - 98.26%Couleur et forme :SolidMasse moléculaire :498.81LUT014
CAS :<p>LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.</p>Formule :C27H19F3N8ODegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :528.49B-Raf IN 2
CAS :<p>B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.</p>Formule :C20H17F2N5O4SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :461.44R18
CAS :<p>14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.</p>Formule :C101H157N27O29S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2309.69SOS1-IN-17
<p>SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.</p>Formule :C29H34F3N5O2Couleur et forme :SolidMasse moléculaire :541.61Cyclorasin 9A5
CAS :<p>Cyclorasin 9A5 is a cell-permeable, 11-residue cyclic peptide that orthosterically disrupts the Ras-Raf protein interaction, demonstrating an inhibition</p>Formule :C75H108FN25O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1586.82Cyclorasin 9A5 TFA
<p>Cyclorasin 9A5 TFA is a cell-penetrating cyclic peptide consisting of 11 residues that inhibits the interaction between Ras and Raf proteins, with an IC50 of 120 nM.</p>Formule :C75H108FN25O13·xC2HF3O2Couleur et forme :SolidMasse moléculaire :1586.82 (free base)Vem-L-Cy5
<p>Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAF</p>Formule :C63H68F5N7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1194.31KG5
CAS :<p>KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).</p>Formule :C20H16F3N7OSDegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :459.45PROTAC B-Raf degrader 1
CAS :<p>PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.</p>Formule :C36H37N5O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :763.77SOS1-IN-11
CAS :<p>SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).</p>Formule :C22H24F3N5ODegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :431.45MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Couleur et forme :Odour SolidAnti-Phospho-RAF1 (Ser259) Antibody (5X237)
<p>Anti-Phospho-RAF1 (Ser259) Antibody (5X237) is an antibody targeting Phospho-RAF1 (Ser259). Anti-Phospho-RAF1 (Ser259) Antibody (5X237) can be used in ELISA, WB, IHC, IF.</p>Couleur et forme :Odour LiquidAnti-Phospho-RAF1 (Ser621) Antibody (2K681)
<p>Anti-Phospho-RAF1 (Ser621) Antibody (2K681) is an antibody targeting Phospho-RAF1 (Ser621). Anti-Phospho-RAF1 (Ser621) Antibody (2K681) can be used in ELISA, WB, IF.</p>Couleur et forme :Odour LiquidRAS GTPase inhibitor 1
CAS :<p>RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.</p>Formule :C27H28ClF4N5O2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :565.99Anti-Phospho-RAF1 (Ser43) Antibody (8R108)
<p>Anti-Phospho-RAF1 (Ser43) Antibody (8R108) is an antibody targeting Phospho-RAF1 (Ser43). Anti-Phospho-RAF1 (Ser43) Antibody (8R108) can be used in ELISA, IF.</p>Couleur et forme :Odour LiquidRegorafenib monohydrate
CAS :<p>Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine</p>Formule :C21H17ClF4N4O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :500.83ZM 336372
CAS :<p>ZM 336372 is a potent and selective c-Raf inhibitor.</p>Formule :C23H23N3O3Degré de pureté :97.24% - 97.51%Couleur et forme :SolidMasse moléculaire :389.45GW 5074
CAS :<p>GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor.</p>Formule :C15H8Br2INO2Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :520.94Regorafenib
CAS :<p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>Formule :C21H15ClF4N4O3Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :482.82PLX8394
CAS :<p>Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.</p>Formule :C25H21F3N6O3SDegré de pureté :98.75% - >99.99%Couleur et forme :SolidMasse moléculaire :542.53Ro 5126766
CAS :<p>RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.</p>Formule :C21H18FN5O5SDegré de pureté :98.3% - 98.81%Couleur et forme :SolidMasse moléculaire :471.46Kobe2602
CAS :<p>Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.</p>Formule :C14H9F4N5O4SDegré de pureté :98.36% - 99.39%Couleur et forme :SolidMasse moléculaire :419.31Agerafenib
CAS :<p>Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.</p>Formule :C24H22F3N5O5Degré de pureté :95.78% - 99.23%Couleur et forme :SolidMasse moléculaire :517.46Takeda-6d
CAS :<p>Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.</p>Formule :C27H19ClFN5O3SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :547.99AZ304
CAS :<p>AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).</p>Formule :C27H25N5O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :451.52TAK-632
CAS :<p>TAK-632 is a potent pan-Raf inhibitor.</p>Formule :C27H18F4N4O3SDegré de pureté :98% - 99.5%Couleur et forme :SolidMasse moléculaire :554.52RAF265
CAS :<p>RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 trials.</p>Formule :C24H16F6N6ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :518.41AD80
CAS :<p>AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.</p>Formule :C22H19F4N7ODegré de pureté :99.49% - 99.75%Couleur et forme :SolidMasse moléculaire :473.43Raf inhibitor 2
CAS :<p>Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.</p>Formule :C15H8Br2ClNO2Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :429.49Encorafenib
CAS :<p>Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.</p>Formule :C22H27ClFN7O4SDegré de pureté :99.51% - 99.83%Couleur et forme :SolidMasse moléculaire :540.01B-Raf IN 11
CAS :<p>B-Raf IN 11 is a novel selective inhibitor.</p>Formule :C17H14BrF2N3O3SDegré de pureté :99.947%Couleur et forme :SolidMasse moléculaire :458.28BAY-293
CAS :<p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>Formule :C25H28N4O2SDegré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :448.58NVP-BHG712
CAS :<p>NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and</p>Formule :C26H20F3N7ODegré de pureté :97.32% - 98.63%Couleur et forme :SolidMasse moléculaire :503.48RAF709
CAS :<p>RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.</p>Formule :C28H29F3N4O4Degré de pureté :99.28% - 99.8%Couleur et forme :SolidMasse moléculaire :542.55BI-882370
CAS :<p>BI-882370 is a specific RAF kinase inhibitor.</p>Formule :C28H33F2N7O2SDegré de pureté :97.33% - 99.07%Couleur et forme :SolidMasse moléculaire :569.67K-Ras(G12C) inhibitor 9
CAS :<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Formule :C16H21ClIN3O4SDegré de pureté :97.33% - 97.45%Couleur et forme :SolidMasse moléculaire :513.78SB-590885
CAS :<p>SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).</p>Formule :C27H27N5O2Degré de pureté :95.42% - 99.06%Couleur et forme :SolidMasse moléculaire :453.54Plx-4032
CAS :<p>Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.</p>Formule :C23H18ClF2N3O3SDegré de pureté :98.53% - 99.36%Couleur et forme :SolidMasse moléculaire :489.92K-Ras(G12C) inhibitor 6
CAS :<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Formule :C17H22Cl2N2O3SDegré de pureté :89.07% - 97.09%Couleur et forme :SolidMasse moléculaire :405.34L-779450
CAS :<p>L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.</p>Formule :C20H14ClN3ODegré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :347.8PLX-4720
CAS :<p>PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.</p>Formule :C17H14ClF2N3O3SDegré de pureté :97.78% - 99.83%Couleur et forme :SolidMasse moléculaire :413.83CCT196969
CAS :<p>CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.</p>Formule :C27H24FN7O3Degré de pureté :98.93% - 99.65%Couleur et forme :SolidMasse moléculaire :513.52Belvarafenib
CAS :<p>Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.</p>Formule :C23H16ClFN6OSDegré de pureté :98% - 99.65%Couleur et forme :SolidMasse moléculaire :478.93I-49 free base
<p>I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novel</p>Formule :C23H26ClF3N4O2Degré de pureté :99.64% - 99.88%Couleur et forme :SolidMasse moléculaire :482.92
