Transporteur membranaire/Canal ionique
Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont des composés qui bloquent la fonction des protéines responsables du transport des ions, des nutriments et d'autres molécules à travers les membranes cellulaires. Ces inhibiteurs sont essentiels pour étudier la régulation de l'homéostasie cellulaire, la transduction des signaux et la neurotransmission. Les inhibiteurs des transporteurs membranaires et des canaux ioniques sont également importants pour développer des traitements contre des troubles tels que l'épilepsie, les maladies cardiovasculaires et les syndromes métaboliques. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de haute qualité des transporteurs membranaires et des canaux ioniques pour soutenir vos recherches en physiologie, neurosciences et pharmacologie.
Sous-catégories appartenant à la catégorie "Transporteur membranaire/Canal ionique"
- ABC(3 produits)
- ATPase(93 produits)
- Récepteur de l'adiponectine(5 produits)
- CFTR(64 produits)
- Récepteur CGRP(51 produits)
- Canal calcique(493 produits)
- Canal chlorure(49 produits)
- Récepteur GABA(336 produits)
- Transporteur de monoamine(23 produits)
- Transporteur de monocarboxylate(17 produits)
- NKCC(2 produits)
- NPC1L1(3 produits)
- Cotransporteur Na-K-Cl(8 produits)
- OAT(27 produits)
- OCT(7 produits)
- P-gp(53 produits)
- Canal potassique(276 produits)
- Pompe à protons(39 produits)
- SGLT(30 produits)
- Canal sodique(202 produits)
- Canal TRP/TRPV(92 produits)
Affichez 13 plus de sous-catégories
2270 produits trouvés pour "Transporteur membranaire/Canal ionique"
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Anticonvulsant agent 8
<p>Anticonvulsant agent 8 (compound D4) is a chemical used in treating epilepsy by inhibiting GABAA currents. In mouse models, its ED50 values are 2.23 mg/kg for the maximal electroshock (MES) test and 24.60 mg/kg for the pentylenetetrazol (PTZ) test.</p>Formule :C15H11N5OCouleur et forme :SolidMasse moléculaire :277.28Urease-IN-19
<p>Urease-IN-19 (Compound 3c) is a potent inhibitor of urease, demonstrating an IC50 value of 2.7 µM. It shows potential for use in research related to kidney stones and gastric ulcers.</p>Formule :C17H16FN3SCouleur et forme :SolidMasse moléculaire :313.39Chlorocresol
CAS :<p>Chlorocresol (4-Chloro-3-methylphenol) is an antiseptic medication.</p>Formule :C7H7ClOCouleur et forme :SolidMasse moléculaire :142.58NF864
CAS :<p>NF864, a suramin analog, is a P2X1 receptor inhibitor.</p>Formule :C57H28N6Na12O41S12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2113.5FD 12-9
CAS :<p>FD 12-9, Anti-glioblastoma activity. is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively.</p>Formule :C51H47N3O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :877.93Lei-Dab7
CAS :<p>Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.</p>Formule :C141H236N46O39S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3392.06(S)-PF-03716556
CAS :<p>(S)-PF-03716556 can be used as an acid pump inhibitor for the treatment of disease conditions mediated by acid pump inhibitory activity.</p>Formule :C22H26N4O3Degré de pureté :99.8% - 99.91%Couleur et forme :SoildMasse moléculaire :394.47AP14145 hydrochloride
CAS :<p>AP14145 hydrochloride inhibits KCa2.2 and KCa2.3 channels with 1.1 μM IC50, affecting AERP and antiarrhythmic in AF models.</p>Formule :C18H18ClF3N4OCouleur et forme :SolidMasse moléculaire :398.81Elgodipine
CAS :<p>Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.</p>Formule :C29H33FN2O6Degré de pureté :98.95% - 99.50%Couleur et forme :SolidMasse moléculaire :524.58ATP synthase inhibitor 2 TFA
<p>ATP Synthase Inhibitor 2 (Compound 22) TFA is a potent inhibitor of Pseudomonas aeruginosa ATP synthase with an IC50 value of 10 μg/mL.</p>Formule :C23H23F3N2O5SCouleur et forme :SolidMasse moléculaire :496.5D-GsMTx4
<p>TRPC1/6 & Piezo2 inhibitor; mimics GsMTx4; blocks ~70% mechanosensitive currents; aids in mouse heart attack models; protease-resistant.</p>Couleur et forme :SoildDendrotoxin K
CAS :<p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>Formule :C294H462N84O75S6Couleur et forme :SolidMasse moléculaire :6559.66Sulcardine 2HCl
CAS :<p>Sulcardine 2HCl is a multi-ion channel blocker that blocks the properties of hERG and hNav1.5 channels and can be used to study atrial fibrillation.</p>Formule :C24H35Cl2N3O4SDegré de pureté :99.33% - 99.76%Couleur et forme :SoildMasse moléculaire :532.523Cevadine
<p>Cevadine is a natural product that can be used as a reference standard.</p>Formule :C32H49NO9Couleur et forme :SolidMasse moléculaire :591.742Tacrine hydrochloride
CAS :<p>Tacrine: a cholinergic agonist, anticholinesterase; inhibits AChE/BChE with IC50s of 31/25.6 nM.</p>Formule :C13H15ClN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :234.73P2X4 antagonist-4
<p>P2X4 antagonist-4 (compound 64) is a potent P2X4R antagonist with an IC50 value of 8 µM. It can inhibit ATP-induced activation of the NLRP3 inflammasome and the subsequent release of IL-1β.</p>Formule :C27H22FN3O4SCouleur et forme :SolidMasse moléculaire :503.545Halazone
CAS :<p>Halazone (Pantocid) is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.</p>Formule :C7H5Cl2NO4SDegré de pureté :98.64%Couleur et forme :Physical Description Fine White Powder With An Odor Of Chlorine (Ntp 1992)Masse moléculaire :270.09sFTX-3.3
CAS :<p>sFTX-3.3 is a calcium ion channel antagonist, exhibiting IC50 values of approximately 0.24 mM and 0.70 mM against P-type and N-type channels respectively.</p>Formule :C12H29N7OCouleur et forme :SolidMasse moléculaire :287.412Lesogaberan napadisylate
CAS :<p>Lesogaberan (AZD-3355) is a selective GABAB agonist with EC50 of 8.6 nM, Ki of 5.1 nM in rats, and acts peripherally on the esophageal sphincter.</p>Formule :C13H17FNO5PSCouleur et forme :SolidMasse moléculaire :349.31Oleoyl-D-lysine
CAS :<p>Oleoyl-D-lysine: lipid-based GlyT2 inhibitor, eases neuropathic pain in mice, safe, non-sedative, no respiratory depression.</p>Formule :C24H46N2O3Couleur et forme :SolidMasse moléculaire :410.63Ziconotide
CAS :<p>Ziconotide: analgesic from cone snail for severe, chronic pain; synthetic ω-conotoxin.</p>Formule :C102H172N36O32S7Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :2639.13S-Sulfo-L-cysteine sodium salt
CAS :<p>S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.</p>Formule :C3H6NNaO5S2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :223.2NF279
CAS :<p>P2X1 antagonist</p>Formule :C49H36N6Na6O23S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1407.17Margatoxin
CAS :<p>KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.</p>Formule :C178H286N52O50S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4178.96CP-628006
CAS :<p>CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.</p>Formule :C32H35F3N2O2Couleur et forme :SolidMasse moléculaire :536.639rac-trans-4-hydroxy Glyburide
CAS :<p>rac-trans-4-hydroxy Glyburide, a metabolite of glyburide, inhibits binding at SUR1/Kir6.2 sites with IC50 values of 0.95 and 100 nM.</p>Formule :C23H28ClN3O6SCouleur et forme :SolidMasse moléculaire :510.0SNX-482
CAS :<p>Potent CaV2.3 calcium channel blocker, selective, voltage-dependent, with 30 nM IC50. Offers antinociceptive effects on C and Aδ fibres.</p>Formule :C192H274N52O60S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4495.01BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Formule :C22H23F7N2O3Couleur et forme :SolidMasse moléculaire :496.418ω-Agatoxin IVA
CAS :<p>Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.</p>Formule :C217H360N68O60S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5202.25ABCB1-IN-1
<p>ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1 that promotes cell apoptosis.</p>Formule :C36H33F3FeN2O4PSCouleur et forme :SolidMasse moléculaire :733.54ProTx II
CAS :<p>Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.</p>Formule :C168H250N46O41S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3826.59(±)5(6)-DiHETE
CAS :<p>Eicosapentaenoic acid is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils.</p>Formule :C20H32O4Couleur et forme :SolidMasse moléculaire :336.472PptT-IN-4
<p>PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.</p>Formule :C17H23N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :269.38α5-GABAA receptor modulator 1
<p>α5-GABAA receptor modulator 1 (Compound A-4) is a selective silent allosteric modulator (SAM) targeting the α5 subunit of GABAA receptors, useful for research into central nervous system (CNS) disorders.</p>Formule :C21H20FN3O4Couleur et forme :SolidMasse moléculaire :397.4Dalazatide HCl
<p>Dalazatide HCl is a peptide and specific Kv1.3 inhibitor that suppresses the activation and proliferation of memory effector T cells,</p>Couleur et forme :SolidMasse moléculaire :4317.53 (Free base)Zatonacaftor
CAS :<p>Zatonacaftor, a cystic fibrosis transmembrane regulator (CFTR) modulator, is utilized in the research of cystic fibrosis [1] [2].</p>Formule :C24H27N3O4SCouleur et forme :SolidMasse moléculaire :453.55Quinine hemisulfate hydrate
CAS :<p>Quinine hemisulfate hydrate: anti-malaria, derived from cinchona bark, inhibits mouse Slo3 channels with IC50 169 μM.</p>Formule :C20H26N2O3H2O4S·H2OCouleur et forme :SolidMasse moléculaire :391.47BuChE-IN-9
<p>BuChE-IN-9 (compound 22a), an eqBuChE (equine serum-derived butyrylcholinesterase) inhibitor, exhibits potent activity with an IC50 of 173 nM.</p>Formule :C28H34N4O2Couleur et forme :SolidMasse moléculaire :458.6α-Casozepine
CAS :<p>α-Casozepine,Bioactive peptide from milk α-S1 casein. Binds GABA receptors. Anti-anxiety effects.</p>Formule :C60H94N14O16Couleur et forme :SolidMasse moléculaire :1267.47Dofetilide N-oxide
CAS :<p>Dofetilide N-oxide (UK-116856) is a metabolite of dofetilide. Dofetilide can block potassium channels and is a tertiary antiarrhythmic drug.</p>Formule :C19H27N3O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.56Vedroprevir
CAS :<p>Vedroprevir (GS9451), a selective HCV NS3 protease inhibitor, targets genotype 1 HCV.</p>Formule :C45H60ClN7O9SCouleur et forme :SolidMasse moléculaire :910.53A-317567
CAS :<p>A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM, and it has antidepressant and antinociception effects[1][2].</p>Formule :C27H31N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.56BMS 199264
CAS :<p>BMS 199264 hydrochlorid a inhibitor of mitochondrial F1F0 ATP hydrolase, thus preventing ATP reduction to ameliorate cardiac necrosis during ischemia.</p>Formule :C26H31ClN4O4SDegré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :531.07Prilocaine acetate
<p>Prilocaine acetate, an amino amide compound, functions as a Na/K-ATPase inhibitor, exhibiting neurotoxic effects [1] [2].</p>Formule :C15H24N2O3Couleur et forme :SolidMasse moléculaire :280.36Resolvin D2
CAS :<p>Resolvin D2 (RvD2) is a TRPV1 inhibitor and pro-ablative mediator with anti-inflammatory, anti-infective and pro-ablative effects.</p>Formule :C22H32O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.493-Aminopropylphosphinic acid
CAS :<p>3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of gamma-aminobutyric acid (GABA).</p>Formule :C3H10NO2PCouleur et forme :SolidMasse moléculaire :123.092Sinapine hydroxide
CAS :<p>Sinapine hydroxide from crucifer seeds has anti-inflammatory, anti-oxidant, anti-tumor properties, and inhibits AChE, aiding neurodegenerative research.</p>Formule :C16H25NO6Couleur et forme :SolidMasse moléculaire :327.377L-Palmitoylcarnitine TFA
<p>L-Palmitoylcarnitine TFA: long-chain fat metabolite that disrupts membranes in ischaemia & inhibits KATP channels via Kir6.2 interaction.</p>Formule :C25H46F3NO6Couleur et forme :SolidMasse moléculaire :513.63(-)-(S)-Cibenzoline
CAS :<p>Cibenzoline, also known as Escibenzoline, is the S(+)-enantiomer of Cibenzoline and functions as an antiarrhythmic agent.</p>Formule :C18H18N2Couleur et forme :SolidMasse moléculaire :262.35AQP4 (201-220)
CAS :<p>AQP4 (201-220) is the encephalitogenic epitope of AQP-4. AQP4 (201-220) can induce experimental autoimmune encephalomyelitis (EAE), characterized by midline brain lesions, retinal lesions, and lesions at the gray matter/white matter boundary of the spinal cord. AQP-4 is the target antigen in neuromyelitis optica.</p>Formule :C97H143N27O27SCouleur et forme :SolidMasse moléculaire :2151.4
