Canal potassique
Les canaux potassiques sont un groupe diversifié de protéines membranaires qui facilitent le flux des ions potassium (K+) à travers la membrane cellulaire. Ces canaux jouent un rôle crucial dans le maintien du potentiel de membrane au repos, la régulation du volume cellulaire et le contrôle de l'excitabilité des neurones et des cellules musculaires. Les canaux potassiques sont impliqués dans divers processus physiologiques, y compris la régulation du rythme cardiaque, la sécrétion d'insuline et la libération de neurotransmetteurs. La dysrégulation des canaux potassiques est liée à des conditions telles que les arythmies, l'épilepsie et l'hypertension. Chez CymitQuimica, nous proposons une large gamme de modulateurs de canaux potassiques pour soutenir vos recherches en électrophysiologie, santé cardiovasculaire et neurobiologie.
276 produits trouvés pour "Canal potassique"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
4-Aminopyridine
CAS :<p>4-Aminopyridine (Dalfampridine) is a nonselective potassium (K+) channel blocker that binds to the cytoplasmic side of the cell membrane.</p>Formule :C5H6N2Degré de pureté :91.61%Couleur et forme :SolidMasse moléculaire :94.11Ropivacaine hydrochloride
CAS :<p>Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity</p>Formule :C17H26N2O·HClDegré de pureté :99.85% - 99.95%Couleur et forme :SolidMasse moléculaire :310.861-EBIO
CAS :<p>1-EBIO (1-EBIO) is a calium channel agonist.</p>Formule :C9H10N2ODegré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :162.19Oxybutynin
CAS :<p>Oxybutynin (Ditropan) is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.</p>Formule :C22H31NO3Degré de pureté :97.81% - 99.57%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :357.49Quinine
CAS :<p>Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria.</p>Formule :C20H24N2O2Degré de pureté :99.93% - 99.97%Couleur et forme :White Solid PowderMasse moléculaire :324.42Ketanserin
CAS :<p>Ketanserin: quinazoline derivative, 5-HT2 receptor antagonist, may lower blood pressure and inhibit blood clots.</p>Formule :C22H22FN3O3Degré de pureté :99.19% - 99.73%Couleur et forme :SolidMasse moléculaire :395.43Halothane
CAS :<p>Halothane (Anestan) 可以减弱内皮依赖性舒张作用。</p>Formule :C2HBrClF3Degré de pureté :98.50% - >99.99%Couleur et forme :Colorless Volatile Liquid Density 1 875 G / Cm3 Boiling Point 122 4°F (50 2°C) NoncombustibleMasse moléculaire :197.38VU6036720
<p>VU6036720 is a potent and selective inhibitor of the isomeric Kir4.1/5.1.VU6036720 inhibits Kir4.1/5.1 activity by decreasing the channel open-circuit</p>Formule :C20H22ClFN4O2SDegré de pureté :98.1%Couleur et forme :SoildMasse moléculaire :436.93Minoxidil
CAS :<p>Minoxidil (U10858) is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.</p>Formule :C9H15N5ODegré de pureté :99.885% - >99.99%Couleur et forme :Crystals From Methanol-Acetonitrile SolidMasse moléculaire :209.25Clofilium tosylate
CAS :<p>Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.</p>Formule :C28H44ClNO3SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :510.17Mefloquine
CAS :<p>Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.</p>Formule :C17H16F6N2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :378.31Rosuvastatin calcium
CAS :<p>Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic</p>Formule :(C22H27FN3O6S)CaDegré de pureté :98.21% - 99.68%Couleur et forme :White To Off-White Crystalline SolidMasse moléculaire :1001.14Miconazole
CAS :<p>Miconazole (R18134) is an imidazole antifungal agent that is used topically and by intravenous infusion.</p>Formule :C18H14Cl4N2ODegré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :416.13Flindokalner
CAS :<p>Flindokalner (BMS-204352) modulates potassium channels, enhances Kv7 subtypes and BKca, inhibits Kv7.1 (Ki=3.7μM), GABAA; has anxiolytic effects in vivo.</p>Formule :C16H10ClF4NO2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :359.7Topiramate
CAS :<p>Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.</p>Formule :C12H21NO8SDegré de pureté :99.79% - 99.92%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :339.36Nicorandil
CAS :<p>Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system.</p>Formule :C8H9N3O4Degré de pureté :98.14% - >99.99%Couleur et forme :White Or Off-White PowderMasse moléculaire :211.17Dequalinium chloride
CAS :<p>Dequalinium chloride: topical bacteriostat, blocks apamin-sensitive K+ channels, used for wounds, oral infections, potential antifungal, risk of skin ulcers.</p>Formule :C30H40Cl2N4Degré de pureté :99.79% - 99.9%Couleur et forme :SolidMasse moléculaire :527.59NS3623
CAS :<p>NS3623 is an activator of human ether-a-go-go-related gene potassium channels.</p>Formule :C15H10BrF3N6ODegré de pureté :97.06%Couleur et forme :SolidMasse moléculaire :427.18Tannic acid
CAS :<p>Tannic acid (Gallotannic acid) is a novel hERG channel blocker.</p>Formule :C76H52O46Degré de pureté :AR - ARCouleur et forme :Light Yellow To Light Brown Solid Solid Particulate/PowderMasse moléculaire :1701.2Glibenclamide
CAS :<p>Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.</p>Formule :C23H28ClN3O5SDegré de pureté :99.05% - 99.75%Couleur et forme :SolidMasse moléculaire :494.00VU591 hydrochloride
CAS :<p>VU591 hydrochloride is a selective Kir1.1 (ROMK) blocker with IC50 of 0.24 μM, not affecting Kir7.1, Kir2.1, Kir2.3, or Kir4.1, similar to VU 590.</p>Formule :C16H13ClN6O5Degré de pureté :98.93% - 99.22%Couleur et forme :SolidMasse moléculaire :404.76Terfenadine
CAS :<p>Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.</p>Formule :C32H41NO2Degré de pureté :98.76% - 99.75%Couleur et forme :SolidMasse moléculaire :471.67Butamben
CAS :<p>Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.</p>Formule :C11H15NO2Degré de pureté :99.43%Couleur et forme :Crystals From Alc Physical Description Yellow Powder Insoluble In Water (Ntp 1992)Masse moléculaire :193.24Oxybutynin chloride
CAS :<p>Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties.</p>Formule :C22H32ClNO3Degré de pureté :99.27% - >99.99%Couleur et forme :White PowderMasse moléculaire :393.96Diazoxide
CAS :<p>Diazoxide (Proglycem) is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies.</p>Formule :C8H7ClN2O2SDegré de pureté :99% - 99.83%Couleur et forme :SolidMasse moléculaire :230.67ICA-27243
CAS :<p>ICA-27243: Potent KCNQ2/Q3 opener, oral, EC50 0.38 μM; less effective on KCNQ4, KCNQ3/Q5; antiepileptic.</p>Formule :C12H7ClF2N2ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :268.65Hydrochlorothiazide
CAS :<p>Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。</p>Formule :C7H8ClN3O4S2Degré de pureté :99.43% - 99.50%Couleur et forme :Crystals Physical Description Crystals Or White Powder (Ntp 1992)Masse moléculaire :297.74NS5806
CAS :<p>NS5806 activates K+ currents, slows KV4.2/4.3 decay with KChIP2, and boosts KV4.3/KChIP2 peaks (EC50=5.3μM).</p>Formule :C16H8Br2F6N6ODegré de pureté :97.95%Couleur et forme :SolidMasse moléculaire :574.07Proflavine Hemisulfate
CAS :<p>Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) is the hemisulfate salt of proflavine, an acridine-derived fluorescent contrast and disinfectant agent.</p>Formule :C13H12N3O2S0Degré de pureté :99.55%Couleur et forme :Orange To Red PowderMasse moléculaire :258.29Ropivacaine
CAS :<p>Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.</p>Formule :C17H26N2ODegré de pureté :97.75% - >99.99%Couleur et forme :SolidMasse moléculaire :274.40Repaglinide
CAS :<p>Repaglinide, a benzoic acid derivative, stimulates insulin, treats type 2 diabetes, and may rarely cause acute liver injury.</p>Formule :C27H36N2O4Degré de pureté :99.73% - >99.99%Couleur et forme :White To Off-White SolidMasse moléculaire :452.59N-Acetylprocainamide
CAS :<p>N-Acetylprocainamide (NAPA), the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic</p>Formule :C15H23N3O2Degré de pureté :99.65% - 99.74%Couleur et forme :SolidMasse moléculaire :277.36Cloperastine hydrochloride
CAS :<p>Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid.</p>Formule :C20H25Cl2NODegré de pureté :97.74% - 99.42%Couleur et forme :SolidMasse moléculaire :366.33VU591
CAS :VU591 is a selective extra-renal potassium channel inhibitor with an IC₅₀ of 0.24 μM.Formule :C16H12N6O5Degré de pureté :99.29% - 99.53%Couleur et forme :SolidMasse moléculaire :368.3BMS-394136
CAS :<p>BMS-394136 (BMS 394136) is a KV1.5 antagonist for the treatment of cardiovascular diseases such as arrhythmias and atrial fibrillation.</p>Formule :C24H21Cl2FN4ODegré de pureté :98.19% - 98.67%Couleur et forme :SolidMasse moléculaire :471.35Quinidine hydrochloride monohydrate
CAS :<p>Quinidine hydrochloride monohydrate is an optical isomer of quinine. Quinidine prolongs cellular action potential and decreases automaticity.</p>Formule :C20H27ClN2O3Degré de pureté :94.4% - 99.68%Couleur et forme :SolidMasse moléculaire :378.89AZD 7009
CAS :<p>AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM.</p>Formule :C23H34N4O5Degré de pureté :98.42% - 98.51%Couleur et forme :SoildMasse moléculaire :446.54Propafenone
CAS :<p>Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.</p>Formule :C21H27NO3Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :341.44Ifenprodil Tartrate
CAS :<p>Ifenprodil is a selective NMDA receptor (glutamate) antagonist.</p>Formule :C21H27NO2C4H6O6Degré de pureté :99.02% - 99.55%Couleur et forme :SolidMasse moléculaire :400.49DCPIB
CAS :<p>DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM</p>Formule :C22H28Cl2O4Degré de pureté :99.79% - 99.87%Couleur et forme :SolidMasse moléculaire :427.36Astemizole
CAS :<p>Astemizole (Laridal) is a long-acting antihistamine for allergies like rhinitis and asthma, with fewer anticholinergic effects.</p>Formule :C28H31FN4ODegré de pureté :98.24% - 99.67%Couleur et forme :White Crystals SolidMasse moléculaire :458.57Linoleoyl glycine
CAS :<p>Linoleoyl glycine activates hKCNQ1/hKCNE1 channels, has analgesic properties, and is found in skin, spinal cord, and brain.</p>Formule :C20H35NO3Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :337.5Minocycline hydrochloride
CAS :<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>Formule :C23H28ClN3O7Degré de pureté :99.28% - >99.99%Couleur et forme :Bright Yellow-Orange Amorphous Solid Crystalline YellowMasse moléculaire :493.94Gliclazide
CAS :<p>Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the</p>Formule :C15H21N3O3SDegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :323.41Linopirdine
CAS :<p>Linopirdine (DuP 996) is a TRPV1 agonist.</p>Formule :C26H21N3ODegré de pureté :99.45% - 99.78%Couleur et forme :SolidMasse moléculaire :391.46Tipepidine hydrochloride
CAS :<p>Tipepidine hydrochloride: reversible DA D2 receptor inhibitor, IC50 7.0 μM, with antidepressant effects.</p>Formule :C15H18ClNS2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :311.89Amiodarone hydrochloride
CAS :<p>Amiodarone HCl: Antianginal, class III antiarrhythmic. Lengthens heart muscle action, slows heart rate, reduces vascular resistance.</p>Formule :C25H29I2NO3·HClDegré de pureté :99.82% - ≥95%Couleur et forme :White To Cream Crystalline PowderMasse moléculaire :681.78NS19504
CAS :<p>NS19504 is an activator of Ca2+-activated K+ channel with EC50 of 11.0 µM.</p>Formule :C10H9BrN2SDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :269.16NS8593 hydrochloride
CAS :<p>NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .</p>Formule :C17H18ClN3Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :299.8Bupivacaine hydrochloride
CAS :<p>Bupivacaine hydrochloride (Vivacaine) is a long-lasting, amide local anesthetic that blocks sodium channels, inhibiting nerve impulses and sensation.</p>Formule :C18H28N2O·HClDegré de pureté :99.9% - >99.99%Couleur et forme :SolidMasse moléculaire :324.89Glipizide
CAS :<p>Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.</p>Formule :C21H27N5O4SDegré de pureté :99.67% - 99.75%Couleur et forme :SolidMasse moléculaire :445.54Phenformin hydrochloride
CAS :<p>Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.</p>Formule :C10H16ClN5Degré de pureté :97.11% - 99.80%Couleur et forme :Lactic AcidosisMasse moléculaire :241.72Disopyramide
CAS :<p>Disopyramide, or Triombrin, a class I anti-arrhythmic with membrane-stabilizing effects, has heart depressant, anticholinergic, and anesthetic properties.</p>Formule :C21H29N3ODegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :339.47NS13001
CAS :<p>NS13001, an oral SK channel modulator, shows promise for SCA2 therapy; EC50: 1.8 µM (SK2), 0.14 µM (SK3).</p>Formule :C17H16ClN7Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :353.81Mefloquine hydrochloride
CAS :<p>Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.</p>Formule :C17H17ClF6N2ODegré de pureté :99% - 99.74%Couleur et forme :Off-White To Yellow SolidMasse moléculaire :414.77Brompheniramine maleate
CAS :<p>Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.</p>Formule :C16H19BrN2·C4H4O4Degré de pureté :99.80%Couleur et forme :Crystal PowderMasse moléculaire :435.31Dronedarone hydrochloride
CAS :<p>Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.</p>Formule :C31H44N2O5S·HClDegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :593.22DCEBIO
CAS :<p>DCEBIO, a 1-EBIO derivative, enhances Cl- secretion via hIK1 K+ channel and apical conductance in T84 cells.</p>Formule :C9H8Cl2N2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :231.08Tolbutamide
CAS :<p>Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.</p>Formule :C12H18N2O3SDegré de pureté :99.80% - 99.93%Couleur et forme :White Crystalline PowderMasse moléculaire :270.35Flufenamic acid
CAS :<p>Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.</p>Formule :C14H10F3NO2Degré de pureté :98.68%Couleur et forme :White To Light Yellow Crystalline PowderMasse moléculaire :281.23VU0134992 hydrochloride
CAS :<p>VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 μM).</p>Formule :C20H32BrClN2O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :447.84BMS-191095
CAS :<p>BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.</p>Formule :C22H21ClN4O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :408.88IK1 inhibitor PA-6
CAS :<p>IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse</p>Formule :C31H32N4O2Degré de pureté :98.9%Couleur et forme :SolidMasse moléculaire :492.61ML418
CAS :<p>ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.</p>Formule :C19H24ClN3O3Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :377.87Eleclazine hydrochloride
CAS :<p>Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).</p>Formule :C21H17ClF3N3O3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :451.83Doxapram hydrochloride hydrate
CAS :<p>Doxapram hydrochloride hydrate (Doxapram HCl) inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 0.41, 37, 9 μM, respectively.</p>Formule :C24H33ClN2O3C24H30N2O2·ClH·H2ODegré de pureté :99.64% - >99.99%Couleur et forme :SolidMasse moléculaire :432.99Hydroxyhexamide
CAS :<p>Hydroxyhexamide ((±)-Hydroxyhexamid) is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agent.</p>Formule :C15H22N2O4SDegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :326.41ADWX 1 TFA
<p>ADWX 1 TFA is a novel peptide that potently targets and inhibits the Kv1.3 channel, with an IC50 of 1.89 pM. It specifically suppresses the activity of the Kv1.3 channel, in addition to inhibiting initial calcium signaling and NF-κB activation. This compound has been shown to ameliorate symptoms in rats with experimental autoimmune encephalomyelitis (EAE). ADWX 1 TFA is utilized in research focused on T-cell-mediated autoimmune diseases.</p>Formule :C169H281N57O46S7·xC2HF3O2Couleur et forme :SolidMasse moléculaire :4071.85 (free base)Iberiotoxin
CAS :<p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>Formule :C179H274N50O55S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4230CHET3
CAS :<p>CHET3 is a highly selective allosteric activator for TASK-3-containing K2P channels. CHET3 has shown potent in vivo analgesic effects. Cost-effective and quality-assured.</p>Formule :C21H21N5O3SDegré de pureté :99.64% - >99.99%Couleur et forme :SoildMasse moléculaire :423.49Cesium chloride
CAS :<p>Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth.</p>Formule :ClCsDegré de pureté :98%Couleur et forme :White Solid CrystallineMasse moléculaire :168.36Tertiapin LQ
<p>Kir1.1 channel blocker, 250x selective; Kd: Kir1.1 (1.1 nM), Kir3.1/3.2 (274 nM), Kir3.1/3.4 (361 nM). Tertiapin-Q derivative.</p>Formule :C106H179N33O24S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2428.03Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Couleur et forme :Odour SolidMyomodulin
CAS :<p>Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A the</p>Formule :C36H67N11O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :846.12Mesoridazine Besylate
CAS :<p>Mesoridazine Besylate (Serentil), a piperidine antipsychotic and phenothiazine, treats schizophrenia; it's a thioridazine metabolite.</p>Formule :C27H32N2O4S3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :544.75Apamin acetate
<p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>Degré de pureté :96.97%Couleur et forme :SolidPhe-Met-Arg-Phe amide trifluoroacetate
CAS :<p>Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.</p>Formule :C33H44F6N8O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :826.81Dalazatide HCl
<p>Dalazatide HCl is a peptide and specific Kv1.3 inhibitor that suppresses the activation and proliferation of memory effector T cells,</p>Couleur et forme :SolidMasse moléculaire :4317.53 (Free base)Pinacidil monohydrate
CAS :<p>Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.</p>Formule :C13H21N5ODegré de pureté :99.94% - 99.98%Couleur et forme :PowderMasse moléculaire :263.34Ebio2
<p>Ebio2 is an effective activator of KCNQ2.</p>Formule :C17H19F2N3O2Couleur et forme :SolidMasse moléculaire :335.349BeKm-1
CAS :<p>Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.</p>Formule :C174H261N51O52S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4091.65Dendrotoxin K
CAS :<p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>Formule :C294H462N84O75S6Couleur et forme :SolidMasse moléculaire :6559.66MASP-2-IN-1
<p>MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.</p>Formule :C22H21N7O3SCouleur et forme :SolidMasse moléculaire :463.512Guangxitoxin 1E
CAS :<p>Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.</p>Formule :C178H248N44O45S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3948.61Phe-Met-Arg-Phe, amide
CAS :<p>Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.</p>Formule :C29H42N8O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :598.76Lei-Dab7
CAS :Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.Formule :C141H236N46O39S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3392.06GsAF-II
<p>GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodium</p>Formule :C176H261N47O45S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3979.7Potassium Channel Targeted Library
<p>A unique collection of xnum potassium channel blockers and agonists for high throughput and high content screening;</p>Couleur et forme :Odour SolidHeteropodatoxin-1
<p>Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9</p>Formule :C168H238N46O51S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3910.35Guanfu base A
CAS :<p>Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.</p>Formule :C24H31NO6Degré de pureté :99.71% - 99.85%Couleur et forme :SolidMasse moléculaire :429.5AmmTX3
<p>KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.</p>Formule :C158H262N50O48S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.47HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Formule :C337H503N103O97S6Masse moléculaire :7736.59176GsAF-I
<p>GsAF-I is a potent blocker of Na_v and hERG1 channels, exhibiting half-maximal inhibitory concentrations (IC50s) of 0.36 μM (Na_v 1.1), 0.6 μM (Na_v 1.2), 1.28</p>Formule :C160H244N46O42S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3708.39Aekatperone
<p>Aekatperone, a reversible KATP channel inhibitor, exhibits an IC50 of 9 μM. It is utilized in research related to congenital hyperinsulinism (CHI).</p>Formule :C20H25N5O2SCouleur et forme :SolidMasse moléculaire :399.51Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Formule :C19H23F2N3O2Couleur et forme :SolidMasse moléculaire :363.4BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Formule :C22H23F7N2O3Couleur et forme :SolidMasse moléculaire :496.418RU-TRAAK-2
CAS :<p>RU-TRAAK-2 reversibly inhibits TWIK-related K+ channel, inactive on Kv1.2, GIRK2, Slo1.</p>Formule :C19H17N3OSDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :335.42Agitoxin-2
CAS :<p>Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).</p>Formule :C169H278N54O48S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4090.87Apamin
CAS :<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Formule :C79H131N31O24S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2027.34ADWX 1
<p>Potent KV1.3 blocker, IC50: 0.0019 nM; less effective on KV1.1. Curbs CD4+ T cell activation; eases rat multiple sclerosis model.</p>Formule :C169H281N57O46S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4071.86
