Canal potassique
Les canaux potassiques sont un groupe diversifié de protéines membranaires qui facilitent le flux des ions potassium (K+) à travers la membrane cellulaire. Ces canaux jouent un rôle crucial dans le maintien du potentiel de membrane au repos, la régulation du volume cellulaire et le contrôle de l'excitabilité des neurones et des cellules musculaires. Les canaux potassiques sont impliqués dans divers processus physiologiques, y compris la régulation du rythme cardiaque, la sécrétion d'insuline et la libération de neurotransmetteurs. La dysrégulation des canaux potassiques est liée à des conditions telles que les arythmies, l'épilepsie et l'hypertension. Chez CymitQuimica, nous proposons une large gamme de modulateurs de canaux potassiques pour soutenir vos recherches en électrophysiologie, santé cardiovasculaire et neurobiologie.
276 produits trouvés pour "Canal potassique"
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BeKm-1
CAS :<p>Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.</p>Formule :C174H261N51O52S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4091.65Dendrotoxin K
CAS :<p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>Formule :C294H462N84O75S6Couleur et forme :SolidMasse moléculaire :6559.66MASP-2-IN-1
<p>MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.</p>Formule :C22H21N7O3SCouleur et forme :SolidMasse moléculaire :463.512Guangxitoxin 1E
CAS :<p>Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.</p>Formule :C178H248N44O45S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3948.61Phe-Met-Arg-Phe, amide
CAS :<p>Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.</p>Formule :C29H42N8O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :598.76Lei-Dab7
CAS :Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.Formule :C141H236N46O39S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3392.06GsAF-II
<p>GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodium</p>Formule :C176H261N47O45S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3979.7Potassium Channel Targeted Library
<p>A unique collection of xnum potassium channel blockers and agonists for high throughput and high content screening;</p>Couleur et forme :Odour SolidHeteropodatoxin-1
<p>Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9</p>Formule :C168H238N46O51S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3910.35Guanfu base A
CAS :<p>Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.</p>Formule :C24H31NO6Degré de pureté :99.71% - 99.85%Couleur et forme :SolidMasse moléculaire :429.5AmmTX3
<p>KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.</p>Formule :C158H262N50O48S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.47HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Formule :C337H503N103O97S6Masse moléculaire :7736.59176GsAF-I
<p>GsAF-I is a potent blocker of Na_v and hERG1 channels, exhibiting half-maximal inhibitory concentrations (IC50s) of 0.36 μM (Na_v 1.1), 0.6 μM (Na_v 1.2), 1.28</p>Formule :C160H244N46O42S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3708.39Aekatperone
<p>Aekatperone, a reversible KATP channel inhibitor, exhibits an IC50 of 9 μM. It is utilized in research related to congenital hyperinsulinism (CHI).</p>Formule :C20H25N5O2SCouleur et forme :SolidMasse moléculaire :399.51Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Formule :C19H23F2N3O2Couleur et forme :SolidMasse moléculaire :363.4BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Formule :C22H23F7N2O3Couleur et forme :SolidMasse moléculaire :496.418RU-TRAAK-2
CAS :<p>RU-TRAAK-2 reversibly inhibits TWIK-related K+ channel, inactive on Kv1.2, GIRK2, Slo1.</p>Formule :C19H17N3OSDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :335.42Agitoxin-2
CAS :<p>Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).</p>Formule :C169H278N54O48S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4090.87Apamin
CAS :<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Formule :C79H131N31O24S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2027.34ADWX 1
<p>Potent KV1.3 blocker, IC50: 0.0019 nM; less effective on KV1.1. Curbs CD4+ T cell activation; eases rat multiple sclerosis model.</p>Formule :C169H281N57O46S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4071.86
