Canal potassique
Les canaux potassiques sont un groupe diversifié de protéines membranaires qui facilitent le flux des ions potassium (K+) à travers la membrane cellulaire. Ces canaux jouent un rôle crucial dans le maintien du potentiel de membrane au repos, la régulation du volume cellulaire et le contrôle de l'excitabilité des neurones et des cellules musculaires. Les canaux potassiques sont impliqués dans divers processus physiologiques, y compris la régulation du rythme cardiaque, la sécrétion d'insuline et la libération de neurotransmetteurs. La dysrégulation des canaux potassiques est liée à des conditions telles que les arythmies, l'épilepsie et l'hypertension. Chez CymitQuimica, nous proposons une large gamme de modulateurs de canaux potassiques pour soutenir vos recherches en électrophysiologie, santé cardiovasculaire et neurobiologie.
276 produits trouvés pour "Canal potassique"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Rosuvastatin
CAS :<p>Rosuvastatin (ZD4522) is an inhibitor of HMG-CoA reductase (HMGCR). Rosuvastatin has hypolipidemic and antiatherosclerotic effects. Cost-effective and quality-assured.</p>Formule :C22H28FN3O6SDegré de pureté :95.24% - 99.8%Couleur et forme :SolidMasse moléculaire :481.54Levosimendan
CAS :<p>Levosimendan (OR1259) is a calcium sensitizer for acute heart failure, enhancing cardiac contractility without raising calcium levels.</p>Formule :C14H12N6ODegré de pureté :99.37% - 99.91%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :280.28QO-40
CAS :<p>QO-40 is a KCNQ2/3 potassium channels activator.</p>Formule :C18H11ClF3N3ODegré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :377.75H3B-120
CAS :<p>H3B-120: selective, competitive CPS1 inhibitor with anti-cancer properties. IC50: 1.5 μM, Ki: 1.4 μM.</p>Formule :C19H24N4O2SDegré de pureté :99.03% - 99.2%Couleur et forme :SolidMasse moléculaire :372.48CLP290
CAS :<p>CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric</p>Formule :C19H21FN4O3SDegré de pureté :99.93% - >99.99%Couleur et forme :SolidMasse moléculaire :404.46BMS-191011
CAS :<p>BMS-191011 (BMS-A) is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models</p>Formule :C16H10ClF3N2O3Degré de pureté :97.43%Couleur et forme :SolidMasse moléculaire :370.71Tetrandrine
CAS :<p>Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Cost-effective and quality-assured.</p>Formule :C38H42N2O6Degré de pureté :99.61% - 99.94%Couleur et forme :White SolidMasse moléculaire :622.75BL-1249
CAS :<p>BL-1249 is a selective and potent non-steroidal potassium channel activator with anti-inflammatory activity that activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2).</p>Formule :C17H17N5Degré de pureté :98% - 98.25%Couleur et forme :SolidMasse moléculaire :291.35VU590
CAS :<p>VU590 is an inhibitor of extrarenal medullary potassium ROMK.VU590 inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling.</p>Formule :C24H32N4O7Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :488.53HUP30
CAS :<p>HUP30 is a potent vasodilating agent. HUP30 can stimulate soluble guanylyl cyclase, activate K+ channels, and block extracellular Ca2+ influx.</p>Formule :C14H15N3O3SDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :305.35Doxapram
CAS :<p>Doxapram (Dopram) is a respiratory stimulant that inhibits TASK-1, TASK-3, and TASK-1/TASK-3 heterodimer channels.</p>Formule :C24H30N2O2Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :378.51Dofetilide D4
CAS :<p>Dofetilide D4 (UK 68789 D4), a deuterium-labeled version of Dofetilide, is categorized as a Class III antiarrhythmic medication.</p>Formule :C19H27N3O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.59Repaglinide D5
CAS :<p>Repaglinide D5 is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for treatment type-2 diabetes mellitus.</p>Formule :C27H36N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.62LY 303511
CAS :<p>LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.</p>Formule :C19H18N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.36Meclofenamic acid
CAS :<p>Meclofenamic acid: non-selective gap-junction blocker, FTO inhibitor, anti-inflammatory.</p>Formule :C14H11Cl2NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :296.15AVE-0118
CAS :<p>AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation.</p>Formule :C30H29N3O3Degré de pureté :97.04% - 98.93%Couleur et forme :SolidMasse moléculaire :479.57ML402
CAS :<p>ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.</p>Formule :C14H14ClNO2SDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :295.78ICA
CAS :<p>ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM).</p>Formule :C13H10N4SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :254.31UK 78282 hydrochloride
CAS :<p>UK-78282 hydrochloride, a Kv1.3 blocker.UK-78282 hydrochloride inhibits Kv1.3 voltage-gated potassium channels and suppresses human T cell activation.</p>Formule :C29H36ClNO2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :466.05TWIK-1/TREK-1-IN-2
CAS :<p>TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 values</p>Formule :C20H29F3N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.45B-TPMF
CAS :<p>B-TPMF is a highly efficient and selective KCa2.1 channel inhibitor with an IC50 of 31 nM, interacting with serine residue at position 293 to inhibit KCa2.1.</p>Formule :C19H24N6O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :368.43SCH-23390 maleate
CAS :<p>SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM,</p>Formule :C21H22ClNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :403.86Vernakalant
CAS :<p>Vernakalant (RSD-1235) is a mixed ion channel blocker.</p>Formule :C20H31NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.46CM-TPMF
CAS :<p>CM-TPMF is a highly efficient and potent activator of the K(Ca)2.1 channel, Ser293 in the transmembrane segment 5, neurological disorders.</p>Formule :C16H17ClN6O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :360.8HN37
CAS :<p>HN37, KCNQ2 activator (EC50=37 nM). Affordable Excellence: Reliable Quality You Can Trust</p>Formule :C20H21FN2O2Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :340.39Pinacidil
CAS :<p>Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and</p>Formule :C13H19N5Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :245.32VU0405601
CAS :<p>VU0405601 is a hERG channel activator that protects against drug-induced cardiac arrhythmias.</p>Formule :C17H13BrN2O2Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :357.2Nifekalant hydrochloride
CAS :<p>Nifekalant hydrochloride is an IKr potassium channel blocker with an IC50 of 10 µM.</p>Formule :C19H28ClN5O5Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :441.91Almokalant
CAS :<p>Almokalant: Class III antiarrhythmic, K+ channel blocker, inhibits Ikr current.</p>Formule :C18H28N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :352.49Aprikalim
CAS :<p>Aprikalim opens KATP channels, protects the heart, and at high doses, dilates blood vessels.</p>Formule :C12H16N2OS2Degré de pureté :99.42% - 99.90%Couleur et forme :SolidMasse moléculaire :268.4TWIK-1/TREK-1-IN-1
CAS :<p>Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and</p>Formule :C21H24F3NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.42AVE1231
CAS :<p>AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation.</p>Formule :C20H27N3O4SDegré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :405.51GAL-021 sulfate
CAS :<p>GAL-021 sulfate is a BKCa channel blocker that inhibits the analgesic effects of opioids and is used in the study of respiratory control diseases.</p>Formule :C11H24N6O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :352.41TRAM 39
CAS :<p>TRAM 39 (2-Chloro-α,α-diphenylbenzeneacetonitrile) is a selective blocker of intermediate-conductance Ca2+-activated K+channels.</p>Formule :C20H14ClNDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :303.78RY796
CAS :<p>RY796 is a selective voltage-gated potassium (KV2) channel inhibitor that inhibits KV2.1 and KV2.2, used in research on neurological disorders.</p>Formule :C21H27N3O2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :353.46Psora 4
CAS :<p>Psora 4 (5-(4-Phenylbutoxy)psoralen) is a Kv1.3 blocker and a caloric restriction mimetic.</p>Formule :C21H18O4Couleur et forme :SolidMasse moléculaire :334.37Vernakalant Hydrochloride
CAS :<p>Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.</p>Formule :C20H32ClNO4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :385.93Amsacrine
CAS :<p>Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.</p>Formule :C21H19N3O3SDegré de pureté :99.2%Couleur et forme :Yellow Crystalline Powder SolidMasse moléculaire :393.46DMP-543
CAS :<p>DMP-543 (XR-543) is a potassium channel (KV7 channel) blocker that enhances the release of neurotransmitters.</p>Formule :C26H18F2N2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :412.43TASK-1-IN-1
CAS :<p>TASK-1-IN-1: Potent, selective TASK-1 blocker (IC50: 148 nM), weaker on TASK-3 (IC50: 1750 nM), anticancer properties.</p>Formule :C22H20N2O2Degré de pureté :99.57%Couleur et forme :SoildMasse moléculaire :344.41MK-0448
CAS :<p>MK-0448 is a novel and selective blocker of the Kv1.5 (KCNA5) channel, a key channel involved in cardiac repolarization current I Kur.</p>Formule :C24H21FN4O2SDegré de pureté :99.25% - 99.79%Couleur et forme :SolidMasse moléculaire :448.51CyPPA
CAS :<p>CyPPA enhances SK channels, reducing firing rate and extending apamin-sensitive afterhyperpolarization.</p>Formule :C16H23N5Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :285.39Sipatrigine
CAS :<p>Sipatrigine (619C89) is an inhibitor of glutamate release, TREK ion channels, TRESK channels, sodium channels, and calcium channels.</p>Formule :C15H16Cl3N5Degré de pureté :98.64% - 99.77%Couleur et forme :SolidMasse moléculaire :372.68RL648_81
CAS :<p>RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.</p>Formule :C17H17F4N3O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :371.33SKA-111
CAS :<p>SKA-111 activates KCa3.1 potassium channels, modulates membrane potential in endothelial cells, and dilates rat coronary arteries.</p>Formule :C12H10N2SDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :214.29ZTZ240
CAS :<p>ZTZ240 is a KCNQ2 channel activator used in the study of epilepsy.</p>Formule :C12H8ClFN2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :250.66ZM 226600
CAS :<p>ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.</p>Formule :C16H14F3NO4SDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :373.35PD-118057
CAS :<p>PD-118057, a potent hERG activator, may treat long QT syndrome and heart failure without hERG activity inhibition.</p>Formule :C21H17Cl2NO2Degré de pureté :99.16% - 99.97%Couleur et forme :SolidMasse moléculaire :386.27UK 66914
CAS :<p>UK 66914 is a K(+) channel blocker for the study of cardiac arrhythmias.</p>Formule :C18H24N4O3SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :376.47(+)-KCC2 blocker 1
CAS :<p>(+)-KCC2 blocker 1 is a selective blocker of KCC2 (IC50 = 0.4 μM).</p>Formule :C22H25NO5SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :415.5GW 542573X
CAS :<p>GW 542573X is a potent and selective small molecule Ca2+-activated K+ 2 (SK2) channel activator.GW 542573X induces a leftward shift in the Ca2+ response curve</p>Formule :C19H28N2O5Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :364.44XE991
CAS :<p>XE991 is a Kv7 (KCNQ) channel blocker.XE 991 dihydrochloride inhibits Kv7.1 (KCNQ1) and M-current and can be used in the study of neurological disorders.</p>Formule :C26H20N2ODegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :376.45TWIK-1/TREK-1-IN-3
CAS :<p>TWIK-1/TREK-1-IN-3 is a potassium channel TREK-1 inhibitor TWIK-1/TREK-1-IN-3 has antidepressant activity and can be used to study depression.</p>Formule :C19H27F3N2O2Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :372.43IKs124
CAS :<p>IKs124 is a KCNE2/KCNQ1 potassium channel blocker, for hKCNE1 and hKCNE3, and can be used to study peptic ulcers.</p>Formule :C18H26N2O3SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :350.48KT-362 fumarate
CAS :<p>KT-362 fumarate, a novel antagonist of Ca, K, and Na channels, induces vasodilation and relaxes rabbit arterial strips.</p>Formule :C26H32N2O7SDegré de pureté :99.75% - 99.98%Couleur et forme :SolidMasse moléculaire :516.61JNJ-26489112
CAS :<p>JNJ-26489112 is a CNS-active agent and an inhibitor of voltage-gated Na+ channels and N-type Ca2+ channels.</p>Formule :C9H11ClN2O4SDegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :278.71Linaprazan
CAS :<p>Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.</p>Formule :C21H26N4O2Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :366.46DPO-1
CAS :<p>DPO-1 可以高效抑制电压门控钾离子通道Kv1.5，也可以阻断超快速延迟整流钾电流。它能够预防房性心律失常。</p>Formule :C22H29OPDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :340.44Clobutinol hydrochloride
CAS :<p>Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].</p>Formule :C14H23Cl2NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.25VU0463271
CAS :<p>VU0463271: KCC2 antagonist, IC50 61 nM, >100x selective over NKCC1, inactive on other GPCRs, channels, transporters.</p>Formule :C19H18N4OS2Degré de pureté :97.84% - 99.55%Couleur et forme :SolidMasse moléculaire :382.511-deoxy-PGF2a
CAS :<p>11-deoxy-PGF2a is a thromboxane A2 receptor agonist that partially alleviates crowding in Lpar3(−/−) female embryos and induces smooth muscle contraction</p>Formule :C20H34O4Couleur et forme :SolidMasse moléculaire :338.48Glibornuride
CAS :<p>Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).</p>Formule :C18H26N2O4SDegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :366.48Sigma-1 receptor antagonist 3
CAS :<p>Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).</p>Formule :C19H23ClFN3ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :363.86CLP257
CAS :<p>CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.</p>Formule :C14H14FN3O2SDegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :307.34MCHR1 antagonist 2
CAS :<p>MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.</p>Formule :C23H21FN2O5Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :424.42P-1075
CAS :<p>P-1075 activates SUR2-KIR6 channels at 45 nM; may open mitoKATP channels and protect the heart.</p>Formule :C12H17N5Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :231.3C 101248
CAS :<p>C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.</p>Formule :C15H12N6ODegré de pureté :99.14% - 99.31%Couleur et forme :SolidMasse moléculaire :292.3Kv3 modulator 1
CAS :<p>Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.</p>Formule :C20H20N4O4Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :380.4Kv7.2/Kv7.3 agonist 1
CAS :<p>Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.</p>Formule :C14H14FN3O2Couleur et forme :SolidMasse moléculaire :275.28KCC2 Modulator-2
CAS :<p>KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.</p>Formule :C35H45N5O3Couleur et forme :SolidMasse moléculaire :583.76KV1.3-IN-2
CAS :<p>KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.</p>Formule :C16H23ClN2O4Couleur et forme :SolidMasse moléculaire :342.818cis-KV1.3-IN-1
CAS :<p>cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.</p>Formule :C23H30N2O4SCouleur et forme :SolidMasse moléculaire :430.56Kv7.2/Kv7.3 modulator-1
CAS :<p>Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.</p>Formule :C20H21F4N3O3Couleur et forme :SolidMasse moléculaire :427.393Opakalim
CAS :<p>Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.</p>Formule :C18H22F2N4OCouleur et forme :SolidMasse moléculaire :348.39Kv7.2/Kv7.3 activator-1
CAS :<p>Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.</p>Formule :C19H22F2N4OCouleur et forme :SolidMasse moléculaire :360.40Indapamide
CAS :<p>Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.</p>Formule :C16H16ClN3O3SDegré de pureté :98.97% - 99.83%Couleur et forme :SolidMasse moléculaire :365.83
