Canal potassique
Les canaux potassiques sont un groupe diversifié de protéines membranaires qui facilitent le flux des ions potassium (K+) à travers la membrane cellulaire. Ces canaux jouent un rôle crucial dans le maintien du potentiel de membrane au repos, la régulation du volume cellulaire et le contrôle de l'excitabilité des neurones et des cellules musculaires. Les canaux potassiques sont impliqués dans divers processus physiologiques, y compris la régulation du rythme cardiaque, la sécrétion d'insuline et la libération de neurotransmetteurs. La dysrégulation des canaux potassiques est liée à des conditions telles que les arythmies, l'épilepsie et l'hypertension. Chez CymitQuimica, nous proposons une large gamme de modulateurs de canaux potassiques pour soutenir vos recherches en électrophysiologie, santé cardiovasculaire et neurobiologie.
304 produits trouvés pour "Canal potassique"
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Mefloquine hydrochloride
CAS :Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Formule :C17H17ClF6N2ODegré de pureté :99% - 99.99%Couleur et forme :Off-White To Yellow SolidMasse moléculaire :414.77Brompheniramine maleate
CAS :Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.Formule :C16H19BrN2·C4H4O4Degré de pureté :99.80%Couleur et forme :Crystal PowderMasse moléculaire :435.31Dronedarone hydrochloride
CAS :Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.Formule :C31H44N2O5S·HClDegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :593.22Ref: TM-T1073
5mg35,00€10mg50,00€25mg82,00€50mg111,00€100mg166,00€200mg236,00€500mg403,00€1mL*10mM (DMSO)52,00€DCPIB
CAS :DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μMFormule :C22H28Cl2O4Degré de pureté :99.79% - 99.87%Couleur et forme :SolidMasse moléculaire :427.36Ref: TM-T10979
2mg39,00€5mg57,00€10mg87,00€25mg177,00€50mg301,00€100mg485,00€200mg690,00€1mL*10mM (DMSO)63,00€Glibenclamide
CAS :Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formule :C23H28ClN3O5SDegré de pureté :99.05% - 99.75%Couleur et forme :SolidMasse moléculaire :494.00VU0134992 hydrochloride
CAS :VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of Kir4.1 potassium channel pore(IC50 : 0.97 μM).Formule :C20H32BrClN2O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :447.84Ifenprodil Tartrate
CAS :Ifenprodil is a selective NMDA receptor (glutamate) antagonist.Formule :C21H27NO2C4H6O6Degré de pureté :99.02% - 99.55%Couleur et forme :SolidMasse moléculaire :400.49Amiodarone hydrochloride
CAS :Amiodarone HCl: Antianginal, class III antiarrhythmic. Lengthens heart muscle action, slows heart rate, reduces vascular resistance.Formule :C25H29I2NO3·HClDegré de pureté :99.82% - ≥95%Couleur et forme :White To Cream Crystalline PowderMasse moléculaire :681.78IK1 inhibitor PA-6
CAS :IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouseFormule :C31H32N4O2Degré de pureté :98.9%Couleur et forme :SolidMasse moléculaire :492.61Clofilium tosylate
CAS :Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.Formule :C28H44ClNO3SDegré de pureté :99.68% - >99.99%Couleur et forme :SolidMasse moléculaire :510.17Eleclazine hydrochloride
CAS :Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).Formule :C21H17ClF3N3O3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :451.83Ref: TM-T15207
1mg58,00€5mg110,00€10mg166,00€25mg268,00€50mg403,00€100mg532,00€200mg705,00€1mL*10mM (DMSO)122,00€Tannic acid
CAS :Tannic acid (Gallotannic acid) is a novel hERG channel blocker.Formule :C76H52O46Degré de pureté :AR - ARCouleur et forme :Light Yellow To Light Brown Solid Solid Particulate/PowderMasse moléculaire :1701.2Ketanserin
CAS :Ketanserin: quinazoline derivative, 5-HT2 receptor antagonist, may lower blood pressure and inhibit blood clots.Formule :C22H22FN3O3Degré de pureté :99.19% - 99.73%Couleur et forme :SolidMasse moléculaire :395.43Flindokalner
CAS :Flindokalner (BMS-204352) modulates potassium channels, enhances Kv7 subtypes and BKca, inhibits Kv7.1 (Ki=3.7μM), GABAA; has anxiolytic effects in vivo.Formule :C16H10ClF4NO2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :359.7ML418
CAS :ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.Formule :C19H24ClN3O3Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :377.87Ref: TM-T16110
1mg37,00€5mg79,00€10mg111,00€25mg178,00€50mg288,00€100mg414,00€200mg583,00€1mL*10mM (DMSO)84,00€Doxapram hydrochloride hydrate
CAS :Doxapram hydrochloride hydrate (Doxapram HCl) inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 0.41, 37, 9 μM, respectively.Formule :C24H33ClN2O3C24H30N2O2·ClH·H2ODegré de pureté :99.64% - >99.99%Couleur et forme :SolidMasse moléculaire :432.99Apamin
CAS :Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.Formule :C79H131N31O24S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2027.34Margatoxin
CAS :KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.Formule :C178H286N52O50S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4178.96Charybdotoxin
CAS :Specific inhibitor of the big conductance Ca2+-activated K+ channel.Formule :C176H277N57O55S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4295.95Aam-KTX
Aam-KTX, a toxic peptide sourced from Mesobuthus eupeus scorpion venom, acts as a selective K_v channel inhibitor, exhibiting IC_50 values of 1.1 nM for K_v1.3Formule :C174H288N58O48S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4184.96Tamapin TFA
Tamapin TFA, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small conductance Ca(2+)-activated KFormule :C146H238N44O41S6·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3458.11 (free base)AmmTX3 TFA
AmmTX3 TFA, a peptide toxin derived from Androctonus mauretanicus scorpion venom, functions as a selective blocker of the K_v4 channel.Formule :C158H262N50O48S6·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3822.47 (free acid)Hongotoxin-1
Hongotoxin-1, a chemical compound isolated from the venom of Centruroides limbatus, functions as a potassium channel inhibitor.Formule :C181H299N53O49S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4226.13Vm24-toxin
CAS :Vm24-toxin, a peptide toxin isolated from the Mexican scorpion Vaejovis mexicanus smithi, serves as an inhibitor of the Kv1.3 potassium channel [1].Formule :C157H253N51O45S9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3863.59Stromatoxin 1
CAS :Stromatoxin 1, a peptide isolated from tarantulas, acts as an inhibitor of various potassium channels, including K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3.Formule :C156H237N49O48S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3791.31HsTX1
CAS :HsTX1, a 34-residue, C-terminally amidated peptide isolated from the scorpion Heterometrus spinnifer, features four disulfide bridges and acts as a potassiumFormule :C149H246N54O46S9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3818.47Tamapin
Tamapin, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small-conductance Ca(2+)-activated KFormule :C146H238N44O41S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3458.11Iberiotoxin TFA
Iberiotoxin (TFA) is a selective inhibitor of high conductance Ca2+-activated K+ channels, exhibiting a dissociation constant (Kd) of approximately 1 nM, yet itFormule :C179H274N50O55S7·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4230.85 (free base)Spinoxin
CAS :Spinoxin, a 34-residue peptide neurotoxin extracted from the venom of Heterometrus spinifer, is characterized by four disulfide bridges.Formule :C147H236N48O46S9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3700.33Jingzhaotoxin-X
Jingzhaotoxin-X (JZTX-X) selectively inhibits Kv4.2 and Kv4.3 potassium channels, resulting in prolonged mechanical hyperalgesia [1].Formule :C164H242N46O41S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3706.35Ssm spooky toxin
Ssm Spooky Toxin, derived from Scolopendra mutilans, exhibits potent lethality affecting both hematological and respiratory systems primarily through theFormule :C270H413N69O79S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6017.84ShK toxin
CAS :ShK toxin, isolated from the Caribbean sea anemone (Stichodactyla helianthus), is an inhibitor of the voltage-dependent potassium channel (Kv1.3 channel).Formule :C169H274N54O48S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4054.8Dendrotoxin K
CAS :Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.Formule :C294H462N84O75S6Couleur et forme :SolidMasse moléculaire :6559.66δ-Dendrotoxin
CAS :δ-Dendrotoxin is a potassium (K+) channel blocker derived from black mamba snake venom and is utilized in neurological disease research [1].Formule :C296H452N82O76S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6567.65Iberiotoxin
CAS :Selective blocker of the big conductance Ca2+-activated K+ channel.Formule :C179H274N50O55S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4230ADWX 1
Potent KV1.3 blocker, IC50: 0.0019 nM; less effective on KV1.1. Curbs CD4+ T cell activation; eases rat multiple sclerosis model.Formule :C169H281N57O46S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4071.86BmP02
BmP02, a compound isolated from Chinese scorpion (Buthus martensi Karsch) venom, acts as a selective Kv1.3 channel blocker and a highly-selective Kv4.2Formule :C115H182N36O41S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2949.35Noxiustoxin
CAS :Noxiustoxin, a toxin extracted from the venom of the Mexican scorpion Centruroides noxius, inhibits both the voltage-dependent potassium channel (Kv1.3, IC50 =Formule :C174H286N52O54S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4195Pandinotoxin Kα
CAS :Pandinotoxin Kα, a chemical compound extracted from the emperor scorpion (Pandinus imperator) venom, functions as an inhibitor of the A-type potassium channel [Formule :C169H267N53O48S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4033.71Tertiapin-RQ
Tertiapin-RQ, an inward rectifier potassium (K+) channel-blocking peptide, exhibits antidepressant effects [1].Formule :C106H175N37O25S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2496.02Tertiapin LQ
Kir1.1 channel blocker, 250x selective; Kd: Kir1.1 (1.1 nM), Kir3.1/3.2 (274 nM), Kir3.1/3.4 (361 nM). Tertiapin-Q derivative.Formule :C106H179N33O24S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2428.03Jingzhaotoxin-XII TFA
Jingzhaotoxin-XII (JzTx-XII) TFA is a specific inhibitor of the Kv4.1 channel, exhibiting an IC50 of 0.363 μM. It interacts with the channel by altering gating behavior.Couleur et forme :Odour SolidBDS-I
CAS :BDS-I, a marine toxin derived from Anemonia sulcata, functions as a selective inhibitor of the potassium channel, specifically targeting Kv3.4.Formule :C210H297N57O56S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4708.346-FAM-AEEAC-SHK TFA
6-FAM-AEEAC-SHK TFA, a peptide neurotoxin derived from Stichodactyla helianthus and conjugated with a fluorescent marker, selectively blocks voltage-gated potassium channels (kv1.1 and kv1.2). By prolonging action potentials, it interferes with neural signal conduction, making it valuable in neuroscience research.Formule :C196H295N55O57S7·xCHF3O2Couleur et forme :SolidMasse moléculaire :4558.23 (free acid)Aekatperone
Aekatperone, a reversible KATP channel inhibitor, exhibits an IC50 of 9 μM. It is utilized in research related to congenital hyperinsulinism (CHI).Formule :C20H25N5O2SCouleur et forme :SolidMasse moléculaire :399.51Hemitoxin
Hemitoxin, a scorpion-venom peptide, functions as a K+ channel blocker and selectively inhibits rat Kv1.1, Kv1.2, and Kv1.3 channels expressed in XenopusFormule :C159H259N49O49S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3897.58GsAF-I
GsAF-I is a potent blocker of Na_v and hERG1 channels, exhibiting half-maximal inhibitory concentrations (IC50s) of 0.36 μM (Na_v 1.1), 0.6 μM (Na_v 1.2), 1.28Formule :C160H244N46O42S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3708.39Heteropodatoxin-2
CAS :Heteropodatoxin-2, a 30-amino acid peptide, inhibits the Kv4.2 current in Xenopus laevis oocytes through a voltage-dependent mechanism, exhibiting reducedFormule :C144H207N39O46S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3412.81Tertiapin-Q acetate
Tertiapin-Q acetate is a bee toxin derivative that inhibits BK-type K(+) channels in a concentration-dependent manner.Formule :C108H179N35O26S4Degré de pureté :96.44%Couleur et forme :SolidMasse moléculaire :2512.06Phe-Met-Arg-Phe amide trifluoroacetate
CAS :Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.Formule :C33H44F6N8O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :826.81
