Canal potassique
Les canaux potassiques sont un groupe diversifié de protéines membranaires qui facilitent le flux des ions potassium (K+) à travers la membrane cellulaire. Ces canaux jouent un rôle crucial dans le maintien du potentiel de membrane au repos, la régulation du volume cellulaire et le contrôle de l'excitabilité des neurones et des cellules musculaires. Les canaux potassiques sont impliqués dans divers processus physiologiques, y compris la régulation du rythme cardiaque, la sécrétion d'insuline et la libération de neurotransmetteurs. La dysrégulation des canaux potassiques est liée à des conditions telles que les arythmies, l'épilepsie et l'hypertension. Chez CymitQuimica, nous proposons une large gamme de modulateurs de canaux potassiques pour soutenir vos recherches en électrophysiologie, santé cardiovasculaire et neurobiologie.
304 produits trouvés pour "Canal potassique"
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Phe-Met-Arg-Phe, amide
CAS :Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.Formule :C29H42N8O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :598.76Potassium Channel Targeted Library
A unique collection of xnum potassium channel blockers and agonists for high throughput and high content screening;Couleur et forme :Odour SolidRef: TM-L7300
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderGuanfu base A
CAS :Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.Formule :C24H31NO6Degré de pureté :99.71% - 99.85%Couleur et forme :SolidMasse moléculaire :429.5BeKm-1
CAS :Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.Formule :C174H261N51O52S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4091.65Guangxitoxin 1E
CAS :Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.Formule :C178H248N44O45S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3948.61Slotoxin
Slotoxin, a peptide extracted from the venom of the Centruroides noxius Hoffmann scorpion, inhibits high-conductance calcium-activated potassium channels with aFormule :C177H275N47O50S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4085.82Lei-Dab7
CAS :Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.Formule :C141H236N46O39S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3392.06GsAF-II
GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodiumFormule :C176H261N47O45S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3979.7Jingzhaotoxin-XII TFA
Jingzhaotoxin-XII (JzTx-XII) TFA is a specific inhibitor of the Kv4.1 channel, exhibiting an IC50 of 0.363 μM. It interacts with the channel by altering gating behavior.Couleur et forme :Odour SolidκM-Conotoxin RIIIJ
κM-Conotoxin RIIIJ (κM-RIIIJ) selectively inhibits Kv1.2 channels, exhibiting an IC50 value of 33 nM [1].Formule :C117H184N32O36S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2807.3KTX-Sp2
KTX-Sp2, a potassium channel toxin, effectively blocks exogenous voltage-gated potassium channels Kv1.1, Kv1.2, and Kv1.3, as well inhibits the endogenous Kv1.3Formule :C155H244N58O49S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3928.41Tertiapin-Q acetate
Tertiapin-Q acetate is a bee toxin derivative that inhibits BK-type K(+) channels in a concentration-dependent manner.Formule :C108H179N35O26S4Degré de pureté :96.44%Couleur et forme :SolidMasse moléculaire :2512.06Iberiotoxin TFA
Iberiotoxin (TFA) is a selective inhibitor of high conductance Ca2+-activated K+ channels, exhibiting a dissociation constant (Kd) of approximately 1 nM, yet itFormule :C179H274N50O55S7·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4230.85 (free base)Dendrotoxin-I
CAS :Dendrotoxin-I, a neurotoxin from Dendroaspis snake venom, potently blocks K⁺ channels, specifically targeting voltage-gated potassium channel subunits KV1.1 andFormule :C312H491N99O83S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7149.24Heteropodatoxin-1
Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9Formule :C168H238N46O51S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3910.35ShK-Dap22
CAS :Potent KV1.3 channel blocker; Kd 23 pM; selective; inhibits T cell activation; IC50 < 500 pM for mKV1.3.Formule :C166H268N54O48S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4012.7Tertiapin-RQ
Tertiapin-RQ, an inward rectifier potassium (K+) channel-blocking peptide, exhibits antidepressant effects [1].Formule :C106H175N37O25S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2496.02Maurotoxin
CAS :Maurotoxin, a 34-residue peptide featuring four disulfide bridges, is extracted from the chactoid scorpion (Scorpio maurus) and known to impede Shaker potassiumFormule :C145H232N46O46S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3612.19Phrixotoxin 2
CAS :Phrixotoxin 2 selectively blocks the KV 4.2 and KV 4.3 channels, demonstrating high specificity in its interaction with these voltage-gated ion channels [1].Formule :C169H259N49O43S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3921.69Vm24-toxin
CAS :Vm24-toxin, a peptide toxin isolated from the Mexican scorpion Vaejovis mexicanus smithi, serves as an inhibitor of the Kv1.3 potassium channel [1].Formule :C157H253N51O45S9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3863.59Charybdotoxin
CAS :Specific inhibitor of the big conductance Ca2+-activated K+ channel.Formule :C176H277N57O55S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4295.95Hongotoxin-1
Hongotoxin-1, a chemical compound isolated from the venom of Centruroides limbatus, functions as a potassium channel inhibitor.Formule :C181H299N53O49S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4226.13Tamapin
Tamapin, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small-conductance Ca(2+)-activated KFormule :C146H238N44O41S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3458.11BKCa activator-1
BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.Formule :C22H23F7N2O3Couleur et forme :SolidMasse moléculaire :496.418Stromatoxin 1
CAS :Stromatoxin 1, a peptide isolated from tarantulas, acts as an inhibitor of various potassium channels, including K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3.Formule :C156H237N49O48S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3791.31Apamin
CAS :Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.Formule :C79H131N31O24S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2027.34Aam-KTX
Aam-KTX, a toxic peptide sourced from Mesobuthus eupeus scorpion venom, acts as a selective K_v channel inhibitor, exhibiting IC_50 values of 1.1 nM for K_v1.3Formule :C174H288N58O48S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4184.96Agitoxin-2
CAS :Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).Formule :C169H278N54O48S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4090.87HG1 Toxin
HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.Formule :C337H503N103O97S6Masse moléculaire :7736.59176ShK toxin
CAS :ShK toxin, isolated from the Caribbean sea anemone (Stichodactyla helianthus), is an inhibitor of the voltage-dependent potassium channel (Kv1.3 channel).Formule :C169H274N54O48S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4054.8RU-TRAAK-2
CAS :RU-TRAAK-2 reversibly inhibits TWIK-related K+ channel, inactive on Kv1.2, GIRK2, Slo1.
Formule :C19H17N3OSDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :335.42BmP02
BmP02, a compound isolated from Chinese scorpion (Buthus martensi Karsch) venom, acts as a selective Kv1.3 channel blocker and a highly-selective Kv4.2Formule :C115H182N36O41S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2949.35Ssm spooky toxin
Ssm Spooky Toxin, derived from Scolopendra mutilans, exhibits potent lethality affecting both hematological and respiratory systems primarily through theFormule :C270H413N69O79S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6017.84Foslevcromakalim
CAS :Foslevcromakalim (QLS-101) is an KATP opener, converted to its active form by alkaline phosphatase in vivo, reduces intraocular pressure in normotensive mice.Formule :C16H19N2O6PDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :366.31Hemitoxin
Hemitoxin, a scorpion-venom peptide, functions as a K+ channel blocker and selectively inhibits rat Kv1.1, Kv1.2, and Kv1.3 channels expressed in XenopusFormule :C159H259N49O49S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3897.58Spinoxin
CAS :Spinoxin, a 34-residue peptide neurotoxin extracted from the venom of Heterometrus spinifer, is characterized by four disulfide bridges.Formule :C147H236N48O46S9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3700.33Tamapin TFA
Tamapin TFA, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small conductance Ca(2+)-activated KFormule :C146H238N44O41S6·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3458.11 (free base)Aa1 toxin
Aa1 toxin, sourced from Androctonus australis Garzoni venom, is a neurotoxic peptide that specifically blocks potassium channels and has applications inFormule :C156H260N54O49S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3868.46Cromakalim
CAS :Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener, a smooth muscle relaxant with antiepileptic activity.Formule :C16H18N2O3Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :286.33Neosolaniol
CAS :Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.Formule :C19H26O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.4Endoxifen Z-isomer hydrochloride
CAS :Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.Formule :C25H28ClNO2Couleur et forme :SolidMasse moléculaire :409.95KCNQ1 activator-1
CAS :N-[4-(4-Methoxyphenyl)-2-thiazolyl]-2-piperidinecarboxamide is a potent KCNQ1 activator for LQTS research.Formule :C22H23N3O4S2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :457.57Ref: TM-T9778
1mg40,00€5mg89,00€10mg130,00€25mg219,00€50mg324,00€100mg462,00€200mg655,00€1mL*10mM (DMSO)96,00€Nateglinide D5
CAS :Nateglinide D5 is a deuterium labeled Nateglinide.Formule :C19H27NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :322.45QO-58
CAS :QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, danti-nociceptive effects on inflammatory painFormule :C18H8Cl2F4N4ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :443.18Flecainide
CAS :Flecainide is an orally administered antiarrhythmic agent acting as a sodium channel blocker and IKr inhibitor,PSVT.Formule :C17H20F6N2O3Degré de pureté :99.896%Couleur et forme :SolidMasse moléculaire :414.34Ref: TM-T21391
5mg46,00€10mg66,00€25mg111,00€50mg177,00€100mg268,00€200mg335,00€1mL*10mM (DMSO)49,00€Clamikalant sodium
CAS :Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.Formule :C19H21ClN3NaO5S2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :493.96Ref: TM-T63330
1mg48,00€5mg90,00€10mg172,00€25mg346,00€50mg546,00€100mg855,00€200mg1.170,00€1mL*10mM (DMSO)99,00€ICA-069673
CAS :ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).Formule :C11H6ClF2N3ODegré de pureté :99.04% - 99.68%Couleur et forme :SolidMasse moléculaire :269.63A2793
CAS :A2793 is a dual inhibitor of TWIK-associated acid-sensitive K+ channel 1 (TASK-1)/TRESK, with an IC50 for mTRESK of 6.8 μM.Formule :C13H12ClNO3Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :265.69Mitiglinide calcium hydrate
CAS :Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes.Formule :C38H52CaN2O8Degré de pureté :98.97% - 99.96%Couleur et forme :White SolidMasse moléculaire :704.91Loureirin B
CAS :Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.Formule :C18H20O5Degré de pureté :99.33% - 99.86%Couleur et forme :SolidMasse moléculaire :316.35
