Canal potassique
Les canaux potassiques sont un groupe diversifié de protéines membranaires qui facilitent le flux des ions potassium (K+) à travers la membrane cellulaire. Ces canaux jouent un rôle crucial dans le maintien du potentiel de membrane au repos, la régulation du volume cellulaire et le contrôle de l'excitabilité des neurones et des cellules musculaires. Les canaux potassiques sont impliqués dans divers processus physiologiques, y compris la régulation du rythme cardiaque, la sécrétion d'insuline et la libération de neurotransmetteurs. La dysrégulation des canaux potassiques est liée à des conditions telles que les arythmies, l'épilepsie et l'hypertension. Chez CymitQuimica, nous proposons une large gamme de modulateurs de canaux potassiques pour soutenir vos recherches en électrophysiologie, santé cardiovasculaire et neurobiologie.
276 produits trouvés pour "Canal potassique"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Dendrotoxin K TFA
<p>Dendrotoxin K TFA, a Kv1.1 channel blocker, modulates glutamate release in CA3 neurons by time-dependently regulating the presynaptic spike waveform [1].</p>Formule :C294H462N84O75S6·XC2HF3OC2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6559.66 (free base)BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Formule :C22H23F7N2O3Couleur et forme :SolidMasse moléculaire :496.418Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Formule :C19H23F2N3O2Couleur et forme :SolidMasse moléculaire :363.4KNa1.1-IN-2
CAS :<p>KNa1.1-IN-2 (Compound Z05) is a selective KNa1.1 channel inhibitor capable of penetrating the blood-brain barrier, and exhibits significant efficacy on hERG channels. It binds to KNa1.1 channels, effectively blocking channel activity caused by Gain-of-function (GOF) mutations, thus intervening in KCNT1-related seizures. Additionally, it inhibits the GOF mutant Y796H, making KNa1.1-IN-2 a promising candidate for research into KCNT1-associated epilepsy disorders.</p>Formule :C24H27NOCouleur et forme :SolidMasse moléculaire :345.48Vesnarinone HCl
<p>Vesnarinone HCl is an oral PDE3 inhibitor improving heart contractility, affecting calcium and potassium flux. Used in heart failure research.</p>Formule :C22H26ClN3O4Degré de pureté :99.17%Couleur et forme :SoildMasse moléculaire :431.91Ebio2
<p>Ebio2 is an effective activator of KCNQ2.</p>Formule :C17H19F2N3O2Couleur et forme :SolidMasse moléculaire :335.349Iberiotoxin
CAS :<p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>Formule :C179H274N50O55S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4230Cromakalim
CAS :<p>Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener, a smooth muscle relaxant with antiepileptic activity.</p>Formule :C16H18N2O3Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :286.33Nateglinide D5
CAS :<p>Nateglinide D5 is a deuterium labeled Nateglinide.</p>Formule :C19H27NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :322.45QO-58
CAS :<p>QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, danti-nociceptive effects on inflammatory pain</p>Formule :C18H8Cl2F4N4ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :443.18Flecainide
CAS :<p>Flecainide is an orally administered antiarrhythmic agent acting as a sodium channel blocker and IKr inhibitor,PSVT.</p>Formule :C17H20F6N2O3Degré de pureté :99.896%Couleur et forme :SolidMasse moléculaire :414.34Neosolaniol
CAS :<p>Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.</p>Formule :C19H26O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.4KCNQ1 activator-1
CAS :<p>N-[4-(4-Methoxyphenyl)-2-thiazolyl]-2-piperidinecarboxamide is a potent KCNQ1 activator for LQTS research.</p>Formule :C22H23N3O4S2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :457.57Endoxifen Z-isomer hydrochloride
CAS :<p>Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.</p>Formule :C25H28ClNO2Couleur et forme :SolidMasse moléculaire :409.95Clamikalant sodium
CAS :<p>Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.</p>Formule :C19H21ClN3NaO5S2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :493.96Oxypeucedanin
CAS :<p>1.</p>Formule :C16H14O5Degré de pureté :98.66% - 98.85%Couleur et forme :SolidMasse moléculaire :286.28Ibutilide Fumarate
CAS :<p>Ibutilide Fumarate is a class III antiarrhythmic, prolonging action potentials by enhancing sodium influx, and can extend QT interval.</p>Formule :(C20H36N2O3S)2·C4H4O4Degré de pureté :99.68% - 99.74%Couleur et forme :SolidMasse moléculaire :885.23Guanosine 5'-diphosphate disodium salt
CAS :<p>5'-GDP-Na2: a nucleoside diphosphate, iron mobilizer, blocks hepcidin-ferroportin, affects IL-6/stat-3.</p>Formule :C10H13N5Na2O11P2Degré de pureté :99.40%Couleur et forme :White PowderMasse moléculaire :487.16XE 991 dihydrochloride
CAS :<p>XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker.</p>Formule :C26H22Cl2N2ODegré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :449.37SKA-31
CAS :<p>SKA-31 (Naphtho[1,2-d]thiazol-2-ylamine) is an activator of KCa3.1 and KCa2 channels (EC50s: 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively).</p>Formule :C11H8N2SDegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :200.26Ropivacaine hydrochloride monohydrate
CAS :<p>Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction through inhibiting sodium ion influx reversibly.</p>Formule :C17H29ClN2O2Degré de pureté :99.94% - 99.95%Couleur et forme :White SolidMasse moléculaire :328.88Cholesterol myristate
CAS :<p>Cholesterol myristate, a natural steroid in Chinese medicine, affects GABAA, nicotinic receptors, and potassium channels.</p>Formule :C41H72O2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :597.01Quinidine sulfate dihydrate
CAS :<p>Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor</p>Formule :C40H54N4O10SDegré de pureté :99.85%Couleur et forme :White To Light Yellow Crystal PowdeMasse moléculaire :782.9ML277
CAS :<p>ML277 (CID-53347902) was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).</p>Formule :C23H25N3O4S2Degré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :471.59APD668
CAS :<p>APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively.</p>Formule :C21H24FN5O5SDegré de pureté :99.74% - 99.97%Couleur et forme :SolidMasse moléculaire :477.51Amifampridine
CAS :<p>Amifampridine blocks nerve potassium channels, extends action potentials, boosts acetylcholine release, and treats rare muscle diseases.</p>Formule :C5H7N3Degré de pureté :99.82%Couleur et forme :Slightly Beige PowderMasse moléculaire :109.13TKIM
CAS :<p>TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.</p>Formule :C18H14ClN3O2SDegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :371.84ICA-069673
CAS :<p>ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).</p>Formule :C11H6ClF2N3ODegré de pureté :99.04% - 99.68%Couleur et forme :SolidMasse moléculaire :269.63NS309
CAS :<p>NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.</p>Formule :C8H4Cl2N2O2Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :231.04BAPTA-AM
CAS :<p>BAPTA-AM is a calcium chelator that is cell-permeable and selective, blocking hERG, hKv1.3, and hKv1.5 channels (IC50=1.3/1.45/1.23 μM).</p>Formule :C34H40N2O18Degré de pureté :98% - 99.47%Couleur et forme :White Powder Or Crystalline PowderMasse moléculaire :764.68Quinidine
CAS :<p>Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria.</p>Formule :C20H24N2O2Degré de pureté :97.03% - 99.99%Couleur et forme :Crystals With 2 5 Mol Water Of Crystallization; Crystals From Dilute Alcohol Physical Description Crystals Or White Powder (Ntp 1992)Masse moléculaire :324.42Talatisamine
CAS :<p>Talatisamine and TEA mitigate Aβ oligomer effects on I(K), bolstering cell survival and reducing K(+) loss-induced apoptosis; promising for further study.</p>Formule :C24H39NO5Degré de pureté :98.62% - 99.44%Couleur et forme :SolidMasse moléculaire :421.57VU0134992
CAS :<p>VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM</p>Formule :C20H31BrN2O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :411.38Endoxifen (Z-isomer)
CAS :<p>Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.</p>Formule :C25H27NO2Degré de pureté :99.19% - 99.81%Couleur et forme :SolidMasse moléculaire :373.49Paederosidic acid methyl ester
CAS :<p>Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.</p>Formule :C19H26O12SDegré de pureté :99.67% - 99.91%Couleur et forme :SolidMasse moléculaire :478.4720(S)-Ginsenoside Rg3
CAS :<p>20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.</p>Formule :C42H72O13Degré de pureté :98.11% - 99.93%Couleur et forme :SolidMasse moléculaire :785.01KCNQ2/3 activator-1
CAS :<p>KCNQ2/3 activator-1 is a Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator.</p>Formule :C23H29FN2ODegré de pureté :99.16% - 99.47%Couleur et forme :SolidMasse moléculaire :368.492,2,2-Trichloroethanol
CAS :<p>2,2,2-Trichloroethanol is an agonist of the nonclassical K2P channels TREK-1 and TRAAK.</p>Formule :C2H3Cl3ODegré de pureté :99.74%Couleur et forme :LiquidMasse moléculaire :149.4Yoda 1
CAS :<p>Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1. Yoda 1 is also an inhibitor of GlyT2. Cost-effective, quality assurance.</p>Formule :C13H8Cl2N4S2Degré de pureté :98% - 99.98%Couleur et forme :SolidMasse moléculaire :355.27Quinine hydrochloride dihydrate
CAS :<p>Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.</p>Formule :C20H24N2O2·HCl·2H2ODegré de pureté :99.91%Couleur et forme :White To Light Yellow Crystal PowderMasse moléculaire :396.91Kv2-IN-A1
CAS :<p>Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.</p>Formule :C20H17ClN4OSDegré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :396.89Almitrine mesylate
CAS :<p>Almitrine mesylate targets Ca2+-dependent K+ channels in rat cells, used for chronic lung hypoxemia.</p>Formule :C28H37F2N7O6S2Degré de pureté :99.96%Couleur et forme :CoaMasse moléculaire :669.76Azimilide Dihydrochloride
CAS :<p>Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the IKs and IKr with antiarrhythmic activity.</p>Formule :C23H30Cl3N5O3Degré de pureté :97.59% - ≥95%Couleur et forme :SolidMasse moléculaire :530.88ML365
CAS :<p>ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).</p>Formule :C22H20N2O3Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :360.41VU0071063
CAS :<p>VU0071063 is a Kir6.2/SUR1 activator.</p>Formule :C18H22N4O2Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :326.39Quinine dihydrochloride
CAS :<p>Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae).</p>Formule :C20H26Cl2N2O2Degré de pureté :99.79% - 99.97%Couleur et forme :White SolidMasse moléculaire :397.34Sematilide hydrochloride
CAS :<p>Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker.</p>Formule :C14H24ClN3O3SDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :349.87Dofetilide
CAS :<p>Dofetilide (UK 68789), a class III antiarrhythmic sulfonamide, blocks Ikr cardiac channels, prolongs action potential, and treats atrial fibrillation/flutter.</p>Formule :C19H27N3O5S2Degré de pureté :97.85% - 99.06%Couleur et forme :Off-White Or Yellowish Crystalline PowderMasse moléculaire :441.56AUT1
CAS :<p>AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).</p>Formule :C18H19N3O4Degré de pureté :99.8% - 99.95%Couleur et forme :SolidMasse moléculaire :341.36Iptakalim Hydrochloride
CAS :<p>Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine</p>Formule :C9H22ClNDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :179.731
