Canal potassique
Les canaux potassiques sont un groupe diversifié de protéines membranaires qui facilitent le flux des ions potassium (K+) à travers la membrane cellulaire. Ces canaux jouent un rôle crucial dans le maintien du potentiel de membrane au repos, la régulation du volume cellulaire et le contrôle de l'excitabilité des neurones et des cellules musculaires. Les canaux potassiques sont impliqués dans divers processus physiologiques, y compris la régulation du rythme cardiaque, la sécrétion d'insuline et la libération de neurotransmetteurs. La dysrégulation des canaux potassiques est liée à des conditions telles que les arythmies, l'épilepsie et l'hypertension. Chez CymitQuimica, nous proposons une large gamme de modulateurs de canaux potassiques pour soutenir vos recherches en électrophysiologie, santé cardiovasculaire et neurobiologie.
304 produits trouvés pour "Canal potassique"
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AVE-0118
CAS :AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation.Formule :C30H29N3O3Degré de pureté :97.04% - 98.93%Couleur et forme :SolidMasse moléculaire :479.57Ref: TM-T26689
1mg70,00€5mg132,00€10mg173,00€25mg304,00€50mg449,00€100mg652,00€500mg1.369,00€1mL*10mM (DMSO)159,00€B-TPMF
CAS :B-TPMF is a highly efficient and selective KCa2.1 channel inhibitor with an IC50 of 31 nM, interacting with serine residue at position 293 to inhibit KCa2.1.Formule :C19H24N6O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :368.43VU0405601
CAS :VU0405601 is a hERG channel activator that protects against drug-induced cardiac arrhythmias.Formule :C17H13BrN2O2Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :357.2RY796
CAS :RY796 is a selective voltage-gated potassium (KV2) channel inhibitor that inhibits KV2.1 and KV2.2, used in research on neurological disorders.Formule :C21H27N3O2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :353.46Vernakalant Hydrochloride
CAS :Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.Formule :C20H32ClNO4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :385.93Ref: TM-T17227
1mg71,00€2mg92,00€5mg166,00€10mg260,00€25mg495,00€50mg713,00€100mg982,00€1mL*10mM (DMSO)170,00€TWIK-1/TREK-1-IN-2
CAS :TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 valuesFormule :C20H29F3N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.45TWIK-1/TREK-1-IN-1
CAS :Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers andFormule :C21H24F3NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.42Vernakalant
CAS :Vernakalant (RSD-1235) is a mixed ion channel blocker.Formule :C20H31NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.46Psora 4
CAS :Psora 4 (5-(4-Phenylbutoxy)psoralen) is a Kv1.3 blocker and a caloric restriction mimetic.Formule :C21H18O4Couleur et forme :SolidMasse moléculaire :334.37Pinacidil
CAS :Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure andFormule :C13H19N5Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :245.32TRAM 39
CAS :TRAM 39 (2-Chloro-α,α-diphenylbenzeneacetonitrile) is a selective blocker of intermediate-conductance Ca2+-activated K+channels.Formule :C20H14ClNDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :303.78Ref: TM-T23471
1mg34,00€2mg47,00€5mg71,00€10mg102,00€25mg200,00€50mg318,00€100mg502,00€500mg1.063,00€GAL-021 sulfate
CAS :GAL-021 sulfate is a BKCa channel blocker that inhibits the analgesic effects of opioids and is used in the study of respiratory control diseases.Formule :C11H24N6O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :352.41Nifekalant hydrochloride
CAS :Nifekalant hydrochloride is an IKr potassium channel blocker with an IC50 of 10 µM.Formule :C19H28ClN5O5Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :441.91Almokalant
CAS :Almokalant: Class III antiarrhythmic, K+ channel blocker, inhibits Ikr current.Formule :C18H28N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :352.49CM-TPMF
CAS :CM-TPMF is a highly efficient and potent activator of the K(Ca)2.1 channel, Ser293 in the transmembrane segment 5, neurological disorders.Formule :C16H17ClN6O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :360.8Aprikalim
CAS :Aprikalim opens KATP channels, protects the heart, and at high doses, dilates blood vessels.Formule :C12H16N2OS2Degré de pureté :99.42% - 99.90%Couleur et forme :SolidMasse moléculaire :268.4SCH-23390 maleate
CAS :SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM,Formule :C21H22ClNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :403.86AVE1231
CAS :AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation.Formule :C20H27N3O4SDegré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :405.51(+)-KCC2 blocker 1
CAS :(+)-KCC2 blocker 1 is a selective blocker of KCC2 (IC50 = 0.4 μM).Formule :C22H25NO5SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :415.5Ref: TM-T12504
1mg115,00€2mg172,00€5mg255,00€10mg374,00€25mg562,00€50mg787,00€100mg1.074,00€500mg2.147,00€1mL*10mM (DMSO)284,00€DMP-543
CAS :DMP-543 (XR-543) is a potassium channel (KV7 channel) blocker that enhances the release of neurotransmitters.Formule :C26H18F2N2ODegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :412.43XE991
CAS :XE991 is a Kv7 (KCNQ) channel blocker.XE 991 dihydrochloride inhibits Kv7.1 (KCNQ1) and M-current and can be used in the study of neurological disorders.Formule :C26H20N2ODegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :376.45TWIK-1/TREK-1-IN-3
CAS :TWIK-1/TREK-1-IN-3 is a potassium channel TREK-1 inhibitor TWIK-1/TREK-1-IN-3 has antidepressant activity and can be used to study depression.Formule :C19H27F3N2O2Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :372.43RL648_81
CAS :RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.Formule :C17H17F4N3O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :371.33ZM 226600
CAS :ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.Formule :C16H14F3NO4SDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :373.35Ref: TM-T23563
2mg34,00€5mg52,00€10mg75,00€25mg138,00€50mg215,00€100mg318,00€200mg444,00€1mL*10mM (DMSO)52,00€PD-118057
CAS :PD-118057, a potent hERG activator, may treat long QT syndrome and heart failure without hERG activity inhibition.Formule :C21H17Cl2NO2Degré de pureté :99.95% - 99.97%Couleur et forme :SolidMasse moléculaire :386.27Ref: TM-T16444
1mg84,00€2mg107,00€5mg175,00€10mg263,00€25mg464,00€50mg692,00€100mg1.035,00€200mg1.396,00€1mL*10mM (DMSO)192,00€KT-362 fumarate
CAS :KT-362 fumarate, a novel antagonist of Ca, K, and Na channels, induces vasodilation and relaxes rabbit arterial strips.
Formule :C26H32N2O7SDegré de pureté :99.75% - 99.98%Couleur et forme :SolidMasse moléculaire :516.61TASK-1-IN-1
CAS :TASK-1-IN-1: Potent, selective TASK-1 blocker (IC50: 148 nM), weaker on TASK-3 (IC50: 1750 nM), anticancer properties.
Formule :C22H20N2O2Degré de pureté :99.57%Couleur et forme :SoildMasse moléculaire :344.41ZTZ240
CAS :ZTZ240 is a KCNQ2 channel activator used in the study of epilepsy.Formule :C12H8ClFN2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :250.66MK-0448
CAS :MK-0448 is a novel and selective blocker of the Kv1.5 (KCNA5) channel, a key channel involved in cardiac repolarization current I Kur.Formule :C24H21FN4O2SDegré de pureté :99.25% - 99.79%Couleur et forme :SolidMasse moléculaire :448.51UK 66914
CAS :UK 66914 is a K(+) channel blocker for the study of cardiac arrhythmias.Formule :C18H24N4O3SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :376.47IKs124
CAS :IKs124 is a KCNE2/KCNQ1 potassium channel blocker, for hKCNE1 and hKCNE3, and can be used to study peptic ulcers.Formule :C18H26N2O3SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :350.48CyPPA
CAS :CyPPA enhances SK channels, reducing firing rate and extending apamin-sensitive afterhyperpolarization.Formule :C16H23N5Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :285.39Ref: TM-T20968
2mg42,00€5mg62,00€10mg87,00€25mg166,00€50mg266,00€100mg442,00€500mg973,00€1mL*10mM (DMSO)66,00€SKA-111
CAS :SKA-111 activates KCa3.1 potassium channels, modulates membrane potential in endothelial cells, and dilates rat coronary arteries.Formule :C12H10N2SDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :214.29GW 542573X
CAS :GW 542573X is a potent and selective small molecule Ca2+-activated K+ 2 (SK2) channel activator.GW 542573X induces a leftward shift in the Ca2+ response curveFormule :C19H28N2O5Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :364.44Clobutinol hydrochloride
CAS :Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].Formule :C14H23Cl2NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.25DPO-1
CAS :DPO-1 可以高效抑制电压门控钾离子通道Kv1.5，也可以阻断超快速延迟整流钾电流。它能够预防房性心律失常。Formule :C22H29OPDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :340.44Ref: TM-T22745
5mg46,00€10mg71,00€25mg142,00€50mg205,00€100mg296,00€200mg414,00€1mL*10mM (DMSO)50,00€11-deoxy-PGF2a
CAS :11-deoxy-PGF2a is a thromboxane A2 receptor agonist that partially alleviates crowding in Lpar3(−/−) female embryos and induces smooth muscle contractionFormule :C20H34O4Couleur et forme :SolidMasse moléculaire :338.48MCHR1 antagonist 2
CAS :MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.Formule :C23H21FN2O5Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :424.42Ref: TM-T11966
2mg43,00€5mg66,00€10mg100,00€25mg210,00€50mg334,00€100mg537,00€200mg710,00€1mL*10mM (DMSO)80,00€P-1075
CAS :P-1075 activates SUR2-KIR6 channels at 45 nM; may open mitoKATP channels and protect the heart.Formule :C12H17N5Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :231.3Ref: TM-T16420
1mg57,00€5mg119,00€10mg192,00€25mg349,00€50mg530,00€100mg708,00€200mg964,00€1mL*10mM (DMSO)90,00€Glibornuride
CAS :Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).Formule :C18H26N2O4SDegré de pureté :98.94% - 99.5%Couleur et forme :SolidMasse moléculaire :366.48Ref: TM-T15385
1mg71,00€5mg152,00€10mg236,00€25mg409,00€50mg580,00€100mg803,00€1mL*10mM (DMSO)167,00€Sigma-1 receptor antagonist 3
CAS :Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).Formule :C19H23ClFN3ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :363.86CLP257
CAS :CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.Formule :C14H14FN3O2SDegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :307.34Linaprazan
CAS :Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.Formule :C21H26N4O2Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :366.46VU0463271
CAS :VU0463271: KCC2 antagonist, IC50 61 nM, >100x selective over NKCC1, inactive on other GPCRs, channels, transporters.Formule :C19H18N4OS2Degré de pureté :97.84% - 99.55%Couleur et forme :SolidMasse moléculaire :382.5Ref: TM-T17243
5mg48,00€10mg75,00€25mg152,00€50mg236,00€100mg350,00€200mg497,00€1mL*10mM (DMSO)49,00€Kv3 modulator 1
CAS :Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.Formule :C20H20N4O4Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :380.4C 101248
CAS :C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.Formule :C15H12N6ODegré de pureté :99.14% - 99.31%Couleur et forme :SolidMasse moléculaire :292.3KV1.3-IN-2
CAS :KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.Formule :C16H23ClN2O4Couleur et forme :SolidMasse moléculaire :342.818Opakalim
CAS :Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.Formule :C18H22F2N4OCouleur et forme :SolidMasse moléculaire :348.39cis-KV1.3-IN-1
CAS :cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.Formule :C23H30N2O4SCouleur et forme :SolidMasse moléculaire :430.56Kv7.2/Kv7.3 agonist 1
CAS :Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.Formule :C14H14FN3O2Couleur et forme :SolidMasse moléculaire :275.28
