Canal potassique
Les canaux potassiques sont un groupe diversifié de protéines membranaires qui facilitent le flux des ions potassium (K+) à travers la membrane cellulaire. Ces canaux jouent un rôle crucial dans le maintien du potentiel de membrane au repos, la régulation du volume cellulaire et le contrôle de l'excitabilité des neurones et des cellules musculaires. Les canaux potassiques sont impliqués dans divers processus physiologiques, y compris la régulation du rythme cardiaque, la sécrétion d'insuline et la libération de neurotransmetteurs. La dysrégulation des canaux potassiques est liée à des conditions telles que les arythmies, l'épilepsie et l'hypertension. Chez CymitQuimica, nous proposons une large gamme de modulateurs de canaux potassiques pour soutenir vos recherches en électrophysiologie, santé cardiovasculaire et neurobiologie.
318 produits trouvés pour "Canal potassique".
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Linaprazan
CAS :Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.Formule :C21H26N4O2Degré de pureté :99.54%Couleur et forme :White SolidMasse moléculaire :366.4611-deoxy-PGF2a
CAS :11-deoxy-PGF2a is a thromboxane A2 receptor agonist that partially alleviates crowding in Lpar3(−/−) female embryos and induces smooth muscle contractionFormule :C20H34O4Couleur et forme :SolidMasse moléculaire :338.48Glibornuride
CAS :Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).Formule :C18H26N2O4SDegré de pureté :98.94% - 99.5%Couleur et forme :White SolidMasse moléculaire :366.48Ref: TM-T15385
1mg71,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg236,00€25mg409,00€50mg580,00€100mg803,00€P-1075
CAS :P-1075 activates SUR2-KIR6 channels at 45 nM; may open mitoKATP channels and protect the heart.Formule :C12H17N5Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :231.3Ref: TM-T16420
1mg57,00€1mL*10mM (DMSO)90,00€5mg119,00€10mg192,00€25mg349,00€50mg530,00€100mg708,00€200mg964,00€Clobutinol hydrochloride
CAS :Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].Formule :C14H23Cl2NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.25MCHR1 antagonist 2
CAS :MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.Formule :C23H21FN2O5Degré de pureté :98.29%Couleur et forme :White SolidMasse moléculaire :424.42Ref: TM-T11966
2mg43,00€5mg66,00€1mL*10mM (DMSO)80,00€10mg100,00€25mg210,00€50mg334,00€100mg537,00€200mg710,00€CLP257
CAS :CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.Formule :C14H14FN3O2SDegré de pureté :99.5%Couleur et forme :Yellow SolidMasse moléculaire :307.34C 101248
CAS :C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.Formule :C15H12N6ODegré de pureté :99.14% - 99.31%Couleur et forme :SolidMasse moléculaire :292.3Kv3 modulator 1
CAS :Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.Formule :C20H20N4O4Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :380.4Kv7.2/Kv7.3 activator-1
CAS :Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.Formule :C19H22F2N4OCouleur et forme :SolidMasse moléculaire :360.40cis-KV1.3-IN-1
CAS :cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.Formule :C23H30N2O4SCouleur et forme :SolidMasse moléculaire :430.56BMS-986308
CAS :BMS-986308 is a selective, orally active renal outer medullary potassium (ROMK) channel inhibitor. It demonstrates greater selectivity for ROMK over hERG channels and is applicable in heart failure research.Formule :C24H25N7O2Couleur et forme :SolidMasse moléculaire :443.50Kv7.2/Kv7.3 agonist 1
CAS :Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.Formule :C14H14FN3O2Couleur et forme :SolidMasse moléculaire :275.28Kv3 modulator 5
CAS :Kv3 modulator 5 (Example 5), a Kv3 channel modulator, enhances the Kv3.2 current and may be employed in research of hearing disorders [1].Formule :C20H20N4O4Couleur et forme :SolidMasse moléculaire :380.4Kv7.2/Kv7.3 modulator-1
CAS :Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.Formule :C20H21F4N3O3Couleur et forme :SolidMasse moléculaire :427.393Opakalim
CAS :Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.Formule :C18H22F2N4OCouleur et forme :SolidMasse moléculaire :348.39KCC2 Modulator-2
CAS :KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.Formule :C35H45N5O3Couleur et forme :SolidMasse moléculaire :583.76KV1.3-IN-2
CAS :KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.Formule :C16H23ClN2O4Couleur et forme :SolidMasse moléculaire :342.818
