Canal chlorure
Les canaux chlorure sont des protéines membranaires qui contrôlent le mouvement des ions chlorure à travers les membranes cellulaires, jouant un rôle essentiel dans le maintien du volume cellulaire, de l'excitabilité électrique et de l'équilibre acido-basique. La dysrégulation des canaux chlorure est liée à des maladies telles que la mucoviscidose, l'épilepsie et les troubles rénaux. Chez CymitQuimica, nous proposons une variété de modulateurs des canaux chlorure pour soutenir vos recherches sur le transport des ions, l'homéostasie cellulaire et les mécanismes des maladies.
49 produits trouvés pour "Canal chlorure"
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Halothane
CAS :<p>Halothane (Anestan) 可以减弱内皮依赖性舒张作用。</p>Formule :C2HBrClF3Degré de pureté :98.50% - >99.99%Couleur et forme :Colorless Volatile Liquid Density 1 875 G / Cm3 Boiling Point 122 4°F (50 2°C) NoncombustibleMasse moléculaire :197.38Flufenamic acid
CAS :<p>Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.</p>Formule :C14H10F3NO2Degré de pureté :98.68%Couleur et forme :White To Light Yellow Crystalline PowderMasse moléculaire :281.23DCPIB
CAS :<p>DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM</p>Formule :C22H28Cl2O4Degré de pureté :99.79% - 99.87%Couleur et forme :SolidMasse moléculaire :427.36Eact
CAS :<p>Eact is a potent TMEM16A activator that also triggers TRPV1, causing itch, pain, and heat sensitivity.</p>Formule :C22H24N2O5SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :428.5Meticrane
CAS :<p>Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.</p>Formule :C10H13NO4S2Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :275.34T16Ainh-A01
CAS :<p>T16Ainh-A01 is a potent TMEM16A chloride channel inhibitor with a 1 μM IC50, targeting CaCC.</p>Formule :C19H20N4O3S2Degré de pureté :97.18% - 98.15%Couleur et forme :SolidMasse moléculaire :416.52Niflumic acid
CAS :<p>Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.</p>Formule :C13H9F3N2O2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :282.22NS1652
CAS :<p>NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.</p>Formule :C15H11F3N2O3Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :324.25Endovion
CAS :<p>Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.</p>Formule :C16H9BrF6N6ODegré de pureté :98.51%Couleur et forme :SolidMasse moléculaire :495.18Afoxolaner
CAS :<p>Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.</p>Formule :C26H17ClF9N3O3Degré de pureté :99.1% - 99.38%Couleur et forme :SolidMasse moléculaire :625.87GaTx2
CAS :<p>High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.</p>Formule :C125H199N39O47S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3192.54Chlorotoxin
CAS :<p>Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.</p>Formule :C158H249N53O47S11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3995.71Chlorotoxin TFA
<p>Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.</p>Formule :C160H250F3N53O49S11Couleur et forme :SolidMasse moléculaire :4109.74ANO1-IN-4
CAS :<p>ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.</p>Formule :C19H19BrF2N2O2SCouleur et forme :SolidMasse moléculaire :457.33Chlorotoxin(linear)
<p>Chlorotoxin(linear): 36-amino-acid peptide from Egyptian scorpion venom, used in research as chloride channel blocker.</p>Formule :C158H256N52O48S11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4004.76Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Couleur et forme :Odour SolidLubiprostone hemiketal
CAS :<p>Lubiprostone (hemiketal) (RU-0211 (hemiketal)), a selective activator of the chloride channel 2 (CLCN2), facilitates the treatment of chronic idiopathic constipation and opioid-induced constipation. It functions by enhancing CLCN2 channel activity, which boosts chloride ion secretion in the intestines, subsequently increasing fluid secretion and improving intestinal peristalsis. Additionally, Lubiprostone (hemiketal) may be utilized in research related to chronic constipation and cancer.</p>Formule :C20H32F2O5Couleur et forme :SolidMasse moléculaire :390.46NPPB
CAS :<p>NPPB is a chloride channel blocker with IC50 of 80 nM .</p>Formule :C16H16N2O4Degré de pureté :99.95%Couleur et forme :Light Yellow To Yellow SolidMasse moléculaire :300.31MONNA
CAS :<p>MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.</p>Formule :C18H14N2O5Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :338.31Guanidinoethyl sulfonate
CAS :<p>Guanidinoethyl sulfonate (Taurocyamine) is a competitive glycine receptor antagonist.</p>Formule :C3H9N3O3SDegré de pureté :99.43% - 99.47%Couleur et forme :SolidMasse moléculaire :167.19Adjudin
CAS :<p>Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.</p>Formule :C15H12Cl2N4ODegré de pureté :96.51% - ≥95%Couleur et forme :SolidMasse moléculaire :335.19Anthracene-9-carboxylic acid
CAS :<p>Anthracene-9-carboxylic acid is an inhibitor of chloride transport with a moderate to strong inhibitory action on PKA activated cardiac IcI.</p>Formule :C15H10O2Degré de pureté :99.05%Couleur et forme :Yellow Cystalline PowderMasse moléculaire :222.24Phenyl benzoate
CAS :<p>Phenyl benzoate is a benzoate ester obtained by the formal condensation of phenol with benzoic acid.It is an important organic synthesis intermediate.</p>Formule :C13H10O2Degré de pureté :99.63%Couleur et forme :White Crystalline PowderMasse moléculaire :198.22Org 25543
CAS :<p>Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.</p>Formule :C24H32N2O4Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :412.52CaCCinh-A01
CAS :<p>CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).</p>Formule :C18H21NO4SDegré de pureté :99.36% - >99.99%Couleur et forme :SolidMasse moléculaire :347.43Selamectin
CAS :<p>Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in</p>Formule :C43H63NO11Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :769.96Irisolidone
CAS :<p>Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.</p>Formule :C17H14O6Degré de pureté :99.41% - 99.87%Couleur et forme :SolidMasse moléculaire :314.29Fenamic acid
CAS :<p>Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats.</p>Formule :C13H11NO2Degré de pureté :99.6%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :213.2319Lubiprostone
CAS :<p>Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.</p>Formule :C20H32F2O5Degré de pureté :97.31% - 98.54%Couleur et forme :White Odorless Crystals Or Crystalline PowderMasse moléculaire :390.46Talniflumate
CAS :<p>Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell</p>Formule :C21H13F3N2O4Degré de pureté :98% - 99.81%Couleur et forme :White To Pale Yellow Crystalline PowderMasse moléculaire :414.33NS5818
CAS :<p>NS5818 inhibits ClC.</p>Formule :C23H19Cl2N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :496.35Alilusem
CAS :<p>Alilusem is a new diuretic that is beneficial to the clinical treatment of hypertension.</p>Formule :C17H15ClKN2O5SCouleur et forme :SolidMasse moléculaire :433.92H100
CAS :<p>H100 inhibits Cl- transport, mildly affects NaK2Cl cotransporter and Band 3 anion exchanger, not KCl cotransporter.</p>Formule :C18H16N2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.4ANO1-IN-2
CAS :<p>ANO1-IN-2: potent ANO1 blocker (IC50: 1.75 μM), less effective on ANO2 (IC50: 7.43 μM), inhibits glioblastoma cell growth.</p>Formule :C16H14ClN3O2S2Couleur et forme :SolidMasse moléculaire :379.88BTG-1640
CAS :<p>BTG-1640 is used potentially for the treatment of anxiety and panic disorder.</p>Formule :C15H19NO2Couleur et forme :SolidMasse moléculaire :245.32Bts 39542
CAS :<p>Bts 39542 is a diuretic that plays a major role in the Henle circulation and increases renal blood flow without affecting glomerular filtration rate.</p>Formule :C16H11ClN4O3SCouleur et forme :SolidMasse moléculaire :374.8IAA-94
CAS :<p>IAA-94 is an inhibitor of chloride channels, it binds channels in bovine kidney cortex microsomes with a Ki value of 1 µM.</p>Formule :C17H18Cl2O4Couleur et forme :SolidMasse moléculaire :357.23Hydroflumethiazide
CAS :<p>Hydroflumethiazide is a thiazide diuretic. It has also shown the activity of anti-hypertensive.</p>Formule :C8H8F3N3O4S2Couleur et forme :Crystals SolidMasse moléculaire :331.29Losigamone
CAS :<p>Losigamone (AO-33) is an agonist of GABA receptor and can be used in studies about the treatment of partial seizures.</p>Formule :C12H11ClO4Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :254.67R(+)-IAA-94
CAS :<p>R(+)-IAA-94 (Methylindazone) blocks epithelial chloride channels; inhibits Nef-sdAb19 binding.</p>Formule :C17H18Cl2O4Degré de pureté :98.95% - 99.17%Couleur et forme :SolidMasse moléculaire :357.23Stepronin
CAS :<p>Stepronin (TTPG) shows expectorant activities and inhibits airway secretion.</p>Formule :C10H11NO4S2Degré de pureté :99.59%Couleur et forme :White Or Off White CrystallineMasse moléculaire :273.33ANO1-IN-1
CAS :<p>ANO1-IN-1 blocks ANO1/2 channels (IC50: 2.56/15.43 μM) and hinders glioma cell growth.</p>Formule :C18H28N2O2SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :336.49Ani9
CAS :<p>Ani9 selectively blocks ANO1/TMEM16A with a 77 nM IC50, useful for ANO1 research and treating cancer, hypertension, pain, diarrhea, asthma.</p>Formule :C17H17ClN2O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :332.78ARN 11391
CAS :<p>ARN 11391 enhances the function of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1), boosting intracellular calcium ion</p>Formule :C22H29N3O3Couleur et forme :SolidMasse moléculaire :383.49OADS
CAS :<p>OADS is an inhibitor of ClC-ec1 with low micromolar affinity. OADS has no specific effect on a CLC channel (ClC-1).</p>Formule :C30H42N2O8S2Couleur et forme :SolidMasse moléculaire :622.79S9-A13
CAS :<p>S9-A13 is a potent and selective inhibitor of SLC26A9, exhibiting an IC50 of 90.9 nM without inhibiting other members of the SLC26 family, such as SLC26A3, SLC26A4, and SLC26A6. It also inhibits the SLC26A9 Cl- current in cells lacking CFTR expression.</p>Formule :C20H18ClN3O2SCouleur et forme :SolidMasse moléculaire :399.89NMD670
CAS :<p>NMD670 is an orally active, partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. It enhances muscle excitability and neuromuscular transmission, restoring muscle function and mobility. NMD670 has a favorable safety profile and improves muscle function in rats, particularly in an MG rat model [1].</p>Formule :C12H10BrNO4Couleur et forme :SolidMasse moléculaire :312.12DFBTA
<p>DFBTA inhibits ANO1 with IC50 of 24 nM, effectively treating inflammatory pain orally.</p>Formule :C18H10ClF2NO3SCouleur et forme :SolidMasse moléculaire :393.79T16A(inh)-C01
CAS :<p>T16A(inh)-C01 is the Ca(2+)-activated Cl(-) Channel, Ano1 class C inhibitor.</p>Formule :C18H16O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.32
