P-gp
La P-glycoprotéine est une pompe d'efflux dépendante de l'ATP qui transporte une grande variété de substrats, y compris des médicaments, des toxines et des lipides, hors des cellules. Elle joue un rôle crucial dans la résistance aux médicaments, en particulier dans le cancer, en réduisant la concentration intracellulaire des agents chimiothérapeutiques. La P-gp est également impliquée dans la barrière hémato-encéphalique, influençant l'exposition du système nerveux central à divers composés. Chez CymitQuimica, nous proposons une gamme de modulateurs de la P-gp pour soutenir vos recherches en résistance aux médicaments, pharmacocinétique et développement thérapeutique.
56 produits trouvés pour "P-gp".
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γ-Tocotrienol
CAS :γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Formule :C28H42O2Degré de pureté :97.27% - 98.13%Couleur et forme :SolidMasse moléculaire :410.63Ref: TM-T19768
1mg44,00€2mg58,00€1mL*10mM (DMSO)92,00€5mg96,00€10mg137,00€25mg224,00€50mg333,00€100mg489,00€200mg705,00€Sinapine thiocyanate
CAS :Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.Formule :C16H24NO5·CNSDegré de pureté :99.79% - ≥95%Couleur et forme :SolidMasse moléculaire :368.45Solamargine
CAS :Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Formule :C45H73NO15Degré de pureté :99.17% - 99.96%Couleur et forme :SolidMasse moléculaire :868.06Ref: TM-T4034
1mg56,00€2mg78,00€5mg109,00€1mL*10mM (DMSO)158,00€10mg165,00€25mg289,00€50mg434,00€100mg655,00€200mg883,00€Talinolol
CAS :(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.Formule :C20H33N3O3Degré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :363.49Elacridar
CAS :Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.Formule :C34H33N3O5Degré de pureté :98.12% - >99.99%Couleur et forme :SolidMasse moléculaire :563.64Chrysosplenetin
CAS :Chrysosplenetin is a metabolic inhibitor of artemisinin.Formule :C19H18O8Degré de pureté :97.43% - 98.4%Couleur et forme :Yellow SolidMasse moléculaire :374.34Ref: TM-TJS1159
1mg57,00€5mg120,00€1mL*10mM (DMSO)133,00€10mg178,00€25mg329,00€50mg485,00€100mg692,00€500mg1.404,00€HTT-D3
CAS :HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.Formule :C23H25FN6Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :404.48Verapamil
CAS :Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Formule :C27H38N2O4Degré de pureté :99.61% - 99.93%Couleur et forme :White OilMasse moléculaire :454.6Ref: TM-T20656
10mg34,00€25mg49,00€1mL*10mM (DMSO)52,00€50mg70,00€100mg90,00€200mg136,00€500mg219,00€P-gp inhibitor 1
CAS :P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).Formule :C32H31N5O2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :517.62PGP-4008
CAS :PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.Formule :C26H23N3ODegré de pureté :97.41% - 97.99%Couleur et forme :SolidMasse moléculaire :393.48ONT-093
CAS :ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.Formule :C32H38N4ODegré de pureté :98.86%Couleur et forme :Yellow SolidMasse moléculaire :494.67coniferyl ferulate
CAS :Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.Formule :C20H20O6Degré de pureté :97.09% - 99.39%Couleur et forme :White SolidMasse moléculaire :356.37P-gp inhibitor 17
CAS :P-gp Inhibitor 17 (compound 2g), a potent inhibitor, directly interacts with the transmembrane domain of P-gp. This compound is useful for studying P-gp-mediated multidrug resistance in tumor cells [1].Formule :C36H49N3O3Couleur et forme :SolidMasse moléculaire :571.79NSC73306
CAS :NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.Formule :C16H14N4O2SCouleur et forme :SolidMasse moléculaire :326.3738-Prenylchrysin
CAS :8-Prenylchrysin is a C8-isopentenyl flavonoid compound. It acts as an inhibitor of P-glycoprotein (P-gp) and can be utilized in cancer research.Formule :C20H18O4Couleur et forme :SolidMasse moléculaire :322.354P-gp-IN-30
CAS :P-gp-IN-30 (Compound 13) is an inhibitor of P-glycoprotein (P-gp) that targets YB-1. It reduces the expression of total YB-1 protein and nuclear YB-1 protein, thereby inhibiting the expression and function of downstream P-gp, which significantly enhances sensitivity to paclitaxel by inhibiting its efflux rate. When combined with paclitaxel, P-gp-IN-30 effectively suppresses tumor growth in A549/Taxol xenograft mouse models. This compound is useful for research on non-small cell lung cancer (NSCLC).Formule :C34H36N2O9Masse moléculaire :616.66
