Canal sodique
Les canaux sodiques sont des protéines membranaires essentielles qui permettent le passage des ions sodium (Na+) à travers la membrane cellulaire, générant et propageant des signaux électriques dans les neurones, les cellules musculaires et d'autres tissus excitables. Ces canaux sont vitaux pour l'initiation et la conduction des potentiels d'action, ce qui les rend cruciaux dans des processus tels que la transmission de l'influx nerveux, la contraction musculaire et la fonction cardiaque. La dysrégulation des canaux sodiques peut entraîner des troubles neurologiques, des arythmies et des conditions de douleur chronique. Chez CymitQuimica, nous proposons une variété de modulateurs de canaux sodiques pour soutenir vos recherches en neurobiologie, cardiologie et gestion de la douleur.
202 produits trouvés pour "Canal sodique"
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Ancistrotecine B
<p>Ancistrotecine B (Compound 2), a Nav1.7 channel inhibitor (IC50: 0.73 μM), has been shown to alleviate inflammatory pain in mice [1].</p>Formule :C26H31NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.53PF-06456384 trihydrochloride
CAS :<p>PF-06456384 trihydrochloride is a selective NaV1.7 inhibitor acting through protein-ligand binding. intravenous infusion and pain research.</p>Formule :C35H35Cl3F3N7O3S2Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :829.18Solpecainol
CAS :<p>solpecainol is a sodium channel blocker used in the study of neurological and cardiovascular diseases.</p>Formule :C18H23NO3Degré de pureté :99.71%Couleur et forme :SoildMasse moléculaire :301.38Analgesic agent-2
<p>Analgesic Agent-2, a selective orally active inhibitor of the NaV1.8 channel, demonstrates an IC50 of 50.18 nM in HEK293 cells that stably express the human</p>Formule :C21H21ClF2N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.871-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS :<p>1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.</p>Formule :C6H8N2ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :124.14Nav1.7-IN-18
<p>Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, demonstrating analgesic effects in transgenic mice with inherited erythromelalgia (IEM).</p>Formule :C30H33Cl2F2NO4Couleur et forme :SolidMasse moléculaire :580.49Myomodulin
CAS :<p>Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A the</p>Formule :C36H67N11O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :846.12ASG-5ME
<p>ASG-5ME is a drug-antibody coupling targeting SLC44A4 that shows anti-tumor activity in xenograft models and may be used to study pancreatic and gastric cancer.</p>Degré de pureté :98.1% (SDS-PAGE); 98.5% (SEC-HPLC) - 98.1% (SDS-PAGE); 98.5% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.5 kDaZandatrigine
CAS :<p>Zandatrigine (NBI-921352) is a blocker of sodium channel protein type 8 subunit alpha and can be used in studies about nervous system pathologies of epilepsy</p>Formule :C22H25FN4O2S2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :460.59Zoniporide hydrochloride
CAS :<p>Zoniporide hydrochloride: selective NHE-1 inhibitor, IC50 14 nM, >150x selectivity over other NHEs, inhibits platelet swelling (IC50 59 nM).</p>Formule :C17H17ClN6ODegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :356.81ETD001
CAS :<p>ETD001 is a long-acting ENaC inhibitor with an IC50 value of 57.5 nM in HBE cells. It is applicable for research in cystic fibrosis.</p>Formule :C41H57F6N9O16Couleur et forme :SolidMasse moléculaire :1045.935-Tridecanol
CAS :<p>5-Tridecanol blocks ion flux in sodium channels.</p>Formule :C13H28ODegré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :200.36NHE-1-IN-2
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.Formule :C23H20ClN3O3Couleur et forme :SolidMasse moléculaire :421.11932APETx2
CAS :<p>ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.</p>Formule :C196H280N54O61S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4561.06Mambalgin 1
CAS :<p>ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.</p>Formule :C272H429N85O84S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6554.51CL-424032
CAS :<p>CL-424032 is an inhibitor of sodium channels (sodium channel).</p>Formule :C12H7F3N4O2Couleur et forme :SolidMasse moléculaire :296.21ProTx II
CAS :<p>Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.</p>Formule :C168H250N46O41S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3826.59Indenebart
<p>Indenebart is a humanized IgG1λ2 monoclonal antibody targeting SNCA, with HumanIgG1lambda2, Isotype Control serving as the corresponding isotype control.</p>Couleur et forme :Odour LiquidIon Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Couleur et forme :Odour SolidHuwentoxin-IV
CAS :<p>Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.</p>Formule :C174H278N52O51S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4106.79OD1
<p>Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.</p>Formule :C308H466N90O95S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7206.1Phrixotoxin 3
CAS :<p>Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.</p>Formule :C176H269N51O48S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4059.74Sodium Channel Targeted Library
<p>A unique collection of xnum sodium channel blockers and agonists for high throughput and high content screening;</p>Couleur et forme :Odour SolidLifarizine FA
<p>Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke.</p>Formule :C30H34N4O2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :482.62Benzonatate (PEGn)
CAS :<p>Benzonatate (PEGn) is a unique non-narcotic cough suppressant featuring sodium channel blocking properties and anesthetic effects on respiratory tract stretch receptors.</p>Formule :(C2H4O)nC12H17NO2Couleur et forme :SolidGX 201
CAS :<p>GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.</p>Formule :C25H27ClF4N2O4SDegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :563Mepivacaine hydrochloride
CAS :<p>Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.</p>Formule :C15H22N2O·HClDegré de pureté :98.76% - 99.94%Couleur et forme :White Or Off White Crystalline PowderMasse moléculaire :282.81Amlenetug
<p>Amlenetug is a humanized IgG1κ antibody targeting SNCA, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidMexiletine-d6 hydrochloride
CAS :<p>Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic.</p>Formule :C11H18ClNODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :221.76Triamterene D5
CAS :<p>Triamterene D5 is a deuterium-labeled Triamterene and can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, used as a mild diuretic.</p>Formule :C12H11N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.29BI-9627
CAS :<p>BI-9627 is an inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) (EC50: 31 nM).</p>Formule :C16H19F3N4O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :356.34Poneratoxin acetate
<p>Poneratoxin acetate is a neurotoxic peptide and modulator of NaV1.6/NaV1.7, lowering the activation threshold of voltage-gated sodium channels and causing pain.</p>Formule :C129H215N33O31S·xC2H4O2Couleur et forme :SolidMasse moléculaire :2756.35 (free base)Ethacizine hydrochloride
CAS :<p>Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity and can be used to study arrhythmias and myocardial infarction.</p>Formule :C22H28ClN3O3SDegré de pureté :98.08% - 98.08%Couleur et forme :SolidMasse moléculaire :449.99Dibucaine hydrochloride
CAS :<p>Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.</p>Formule :C20H30ClN3O2Degré de pureté :99.66%Couleur et forme :White PowderMasse moléculaire :379.92Bulleyaconitine A
CAS :<p>Bulleyaconitine A, an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels.</p>Formule :C35H49NO9Degré de pureté :99.56% - 99.76%Couleur et forme :SolidMasse moléculaire :627.76AM-2099
CAS :<p>AM-2099 is a selective voltage-gated sodium channel Nav1.7 inhibitor used in pain research.</p>Formule :C19H13F3N4O3S2Couleur et forme :SolidMasse moléculaire :466.46PF-04856264
CAS :<p>PF-04856264 is a Nav1.7 blocker.,modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain analgesic.</p>Formule :C20H15N5O3S2Degré de pureté :97.43%Couleur et forme :SolidMasse moléculaire :437.5Mepivacaine
CAS :<p>Mepivacaine (Carbocaine) is an amide local anesthetic, blocking sodium channels for nerve blocks and epidurals.</p>Formule :C15H22N2ODegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :246.35Raxatrigine
CAS :<p>Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.</p>Formule :C18H19FN2O2Degré de pureté :98% - 99.43%Couleur et forme :SolidMasse moléculaire :314.35DS-1971a
CAS :<p>DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.</p>Formule :C20H21ClFN5O3SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :465.93A-803467
CAS :<p>A-803467 is a selective NaV1.8 channel blocker.</p>Formule :C19H16ClNO4Degré de pureté :96.94% - 98%Couleur et forme :SolidMasse moléculaire :357.79Flecainide hydrochloride
CAS :<p>Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.</p>Formule :C17H21ClF6N2O3Degré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :450.81Ropivacaine hydrochloride monohydrate
CAS :<p>Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction through inhibiting sodium ion influx reversibly.</p>Formule :C17H29ClN2O2Degré de pureté :99.94% - 99.95%Couleur et forme :White SolidMasse moléculaire :328.88Fosphenytoin disodium
CAS :<p>Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker</p>Formule :C16H13N2Na2O6PDegré de pureté :99.97%Couleur et forme :White Crystalline PowderMasse moléculaire :406.24Metergoline
CAS :<p>Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist.</p>Formule :C25H29N3O2Degré de pureté :99.83% - 99.97%Couleur et forme :SolidMasse moléculaire :403.52Rimeporide
CAS :<p>Rimeporide (EMD-87580) (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.</p>Formule :C11H15N3O5S2Degré de pureté :97.66%Couleur et forme :SolidMasse moléculaire :333.38λ-Cyhalothrin
CAS :<p>λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group.</p>Formule :C23H19ClF3NO3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :449.85Flecainide acetate
CAS :<p>Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).</p>Formule :C19H24F6N2O5Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :474.39Nicainoprol
CAS :<p>Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.</p>Formule :C21H27N3O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :369.46Pilsicainide HCl
CAS :<p>Pilsicainide HCl (SUN 1165) is a pure sodium channel blocker</p>Formule :C17H25ClN2ODegré de pureté :99.01% - 99.80%Couleur et forme :SolidMasse moléculaire :308.85
