Canal sodique
Les canaux sodiques sont des protéines membranaires essentielles qui permettent le passage des ions sodium (Na+) à travers la membrane cellulaire, générant et propageant des signaux électriques dans les neurones, les cellules musculaires et d'autres tissus excitables. Ces canaux sont vitaux pour l'initiation et la conduction des potentiels d'action, ce qui les rend cruciaux dans des processus tels que la transmission de l'influx nerveux, la contraction musculaire et la fonction cardiaque. La dysrégulation des canaux sodiques peut entraîner des troubles neurologiques, des arythmies et des conditions de douleur chronique. Chez CymitQuimica, nous proposons une variété de modulateurs de canaux sodiques pour soutenir vos recherches en neurobiologie, cardiologie et gestion de la douleur.
273 produits trouvés pour "Canal sodique".
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Lubeluzole dihydrochloride
CAS :Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.Formule :C22H27Cl2F2N3O2SCouleur et forme :SolidMasse moléculaire :506.44Quinacainol dihydrochloride
CAS :Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.Formule :C21H32Cl2N2OCouleur et forme :SolidMasse moléculaire :399.398Nav1.8-IN-20
CAS :Nav1.8-IN-20 (Compound I) is an orally active inhibitor of the voltage-gated sodium channel Nav1.8, with an IC50 value of 14 nM. It effectively blocks the generation and propagation of action potentials in peripheral nociceptive neurons, providing analgesic effects. Nav1.8-IN-20 shows potential for research in several pain types, including acute, chronic, inflammatory, and neuropathic pain.Formule :C18H10Cl2F3N3O4Masse moléculaire :460.19Nav1.8-IN-19
CAS :Nav1.8-IN-19 (Compound 122) is a potent inhibitor of Nav1.8.Formule :C21H20F3N5O3SMasse moléculaire :479.48Nav1.8-IN-15
CAS :Nav1.8-IN-15 (compound 6) is a potent inhibitor of Nav1.8. It exhibits analgesic properties and holds potential for research in chronic pain management.Formule :C23H26ClNO4S2Couleur et forme :SolidMasse moléculaire :480.04LBA-3
CAS :LBA-3, a selective and orally active inhibitor of the sodium-coupled citrate transporter SLC13A5, exhibits an IC50 of 67 nM. This compound effectively reduces triglyceride and total cholesterol levels in both oleic and palmitic acid (OPA)-stimulated AML12 cells and PCN-stimulated primary mouse hepatocytes, as well as in mouse models, without showing detectable toxicity. Additionally, LBA-3 is permeable to the blood-brain barrier [1].Formule :C18H18O5Couleur et forme :SolidMasse moléculaire :314.33Vormatrigine
CAS :Vormatrigine effectively inhibits sodium channels (sodium channel).Formule :C16H12F6N4O2Couleur et forme :SolidMasse moléculaire :406.28Nav1.8-IN-5
CAS :Nav1.8-IN-5 (Example 1), a voltage-gated sodium channel Nav1.8 inhibitor, is applicable in the research of Nav1.8-mediated diseases including pain, pain-related disorders, and cardiovascular diseases (such as atrial fibrillation) [1].Formule :C23H15F4N3O2Couleur et forme :SolidMasse moléculaire :441.38Olisutrigine bromide
CAS :Olisutrigine bromide is a sodium channel blocker used as an analgesic.Formule :C25H35BrN2Couleur et forme :SolidMasse moléculaire :443.463ErSO-TFPy
CAS :ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.Formule :C19H13F7N2O2Couleur et forme :SolidMasse moléculaire :434.307Olorigliflozin
CAS :Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.Formule :C23H27ClO7Couleur et forme :SolidMasse moléculaire :450.909Zilvetrigine
CAS :Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.Formule :C20H20ClN3O2Couleur et forme :SolidMasse moléculaire :369.845Suzetrigine
CAS :Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.Formule :C21H20F5N3O4Degré de pureté :98.08% - 99.95%Couleur et forme :White SolidMasse moléculaire :473.39Ref: TM-T69552
300gÀ demander1mg55,00€5mg108,00€1mL*10mM (DMSO)112,00€10mg161,00€25mg253,00€50mg434,00€100mg707,00€200mg973,00€
