Canal calcique
Les canaux calciques sont des protéines membranaires qui régulent le flux d'ions calcium dans et hors des cellules, ce qui est essentiel pour diverses fonctions cellulaires, y compris la contraction musculaire, la libération de neurotransmetteurs et l'expression génique. La dysrégulation de l'activité des canaux calciques est associée à des conditions telles que l'hypertension, les arythmies cardiaques et les troubles neurologiques. Chez CymitQuimica, nous proposons une large sélection de modulateurs des canaux calciques pour soutenir vos recherches en santé cardiovasculaire, neurobiologie et transduction du signal.
575 produits trouvés pour "Canal calcique"
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IAB15
CAS :IAB15 is a potent inhibitor of T-type calcium channel that can be used in the research of epilepsy [1].Formule :C15H14F3NO2Couleur et forme :SolidMasse moléculaire :297.27MP-010
CAS :MP-010 is an FKBP12 ligand that regulates cytosolic calcium by stabilizing RyR channel activity. It facilitates functional improvement in SOD1G93A mice with amyotrophic lateral sclerosis (ALS), evidenced by enhanced motor coordination, increased integrity of neuromuscular junctions, and significantly higher spinal motor neuron survival rates. MP-010 is applicable for research in the field of neurological disorders.Formule :C14H20N4O2SCouleur et forme :SolidMasse moléculaire :308.399PDE1-IN-4
PDE1-IN-4: inhibits PDE1C/A/B with IC50s 10/145/354 nM, may help study idiopathic pulmonary fibrosis.Formule :C33H33N3O4Couleur et forme :SolidMasse moléculaire :535.63IAA65
CAS :IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 μM, and holds potential for use in epilepsy research [1].Formule :C16H13F6NO2Couleur et forme :SolidMasse moléculaire :365.27Cav 3.2 inhibitor 3
Cav 3.2 inhibitor 3 is a potent inhibitor of the Cav3.2 T-type Ca2+channel (IC50: 0.1534 μM) and has a low binding affinity for D2 receptors.Formule :C32H37N3O2Couleur et forme :SolidMasse moléculaire :495.66TTA-P1
CAS :TTA-P1: potent T-type calcium channel inhibitor; impacts neuron firing, hormone secretion, cell growth; potential in absence epilepsy research.Formule :C19H27Cl2FN2OCouleur et forme :SolidMasse moléculaire :389.33Mibefradil dihydrochloride hydrate
CAS :Mibefradil dihydrochloride hydrate is a long-acting antihypertensive blocking high-voltage L calcium channels.Formule :C29H42Cl2FN3O4Couleur et forme :SolidMasse moléculaire :586.57T-Type calcium channel inhibitor 2
Compound 6g inhibits T-type Ca channels (IC50: Cav3.1-31μM, Cav3.2-83μM), cytotoxic to A549 (IC50: 5μM) & HCT-116 cells (IC50: 6.4μM).Formule :C36H39FN4OSCouleur et forme :SolidMasse moléculaire :594.78Emopamil
CAS :Emopamil, a calcium channel inhibitor, reduces neuronal damage caused by ischemia.Formule :C23H30N2Couleur et forme :SolidMasse moléculaire :334.5CAD204520
CAS :CAD204520 functions as an inhibitor of SERCA (IC50 = 0.34 μM), specifically targeting mutations in the wild-type NOTCH1 protein associated with T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL).Formule :C23H32F3N3O2Couleur et forme :SolidMasse moléculaire :439.51Cav 3.2 inhibitor 2
Cav 3.2 inhibitor 2 blocks T-type Ca2+ channels (IC50=0.09339 μM) and reduces mouse somatic/visceral pain. Used for intractable pain studies.Formule :C32H37F2N3OCouleur et forme :SolidMasse moléculaire :517.65Cav 3.1 blocker 1
CAS :Cav 3.1 blocker 1 (compound 12) is a T-type calcium channel inhibitor with an IC50 value of 160 nM for Cav3.1. It exhibits weaker inhibition on Cav 3.2 with an IC50 of 5000 nM and shows no inhibitory effect on Cav 3.3 and Cav 1.2 (IC50 > 10000 nM).Formule :C26H19F6N3O2Couleur et forme :SolidMasse moléculaire :519.438Cav 2.2/3.2 blocker 1
Compound 9e is a Cav 2.2/3.2 blocker; IC50: 1.22 μM & 80 μM, respectively; penetrates CNS.Formule :C28H30N2O3Couleur et forme :SolidMasse moléculaire :442.55SR 33805 oxalate
CAS :Ca2+ channel antagonistFormule :C34H42N2O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.77SB-423557
CAS :SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nMFormule :C28H36N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.60AZD 2066 hydrate
AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].Formule :C19H18ClN5O3Couleur et forme :SolidMasse moléculaire :386.33Calpain Inhibitor-2
CAS :Calpain Inhibitor-2: Lipophilic, moderates growth of A-375, B-16F1, PC-3 cancers, and hinders 80% DU-145 cell invasion.Formule :C26H33N3O5SCouleur et forme :SolidMasse moléculaire :499.62CCR4 antagonist 2
CAS :CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits TregFormule :C26H28Cl2N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.45Sesamodil
CAS :Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension.Formule :C29H32N2O6SDegré de pureté :98.87% - 99.87%Couleur et forme :SolidMasse moléculaire :536.64(rel)-Mirogabalin
CAS :(rel)-Mirogabalin ((rel)-DS5565) is an inhibitor of voltage-dependent calcium channels, specifically targeting the α2δ-1 subunit.Formule :C12H19NO2Couleur et forme :SolidMasse moléculaire :209.28PD-217014
CAS :PD-217014 is an α2δ ligand that exhibits visceral analgesic activity and can suppress visceral hypersensitivity. Its antihyperalgesic effects are dose-dependent.Formule :C10H17NO2Couleur et forme :SolidMasse moléculaire :183.25NNC 55-0396
CAS :NNC 55-0396: Selective T-type calcium channel blocker, IC50 6.8 μM, inhibits human ovarian cancer cell growth.Formule :C30H40Cl2FN3O2Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :564.56Ref: TM-T12238
1mg63,00€5mg119,00€1mL*10mM (DMSO)152,00€10mg192,00€25mg335,00€50mg520,00€100mg745,00€(Rac)-PD0299685
CAS :(Rac)-PD0299685 is a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases.
Formule :C10H21NO2Degré de pureté :97.20%Couleur et forme :SolidMasse moléculaire :187.28Verapamil EP Impurity C hydrochloride
CAS :NSC-609249 hydrochloride, an impurity of Verapamil, is a calcium channel blocker with potent orally active properties. It also functions as a first-generation P-glycoprotein (P-gp) inhibitor.Formule :C12H20ClNO2Couleur et forme :SolidMasse moléculaire :245.75Fostedil
CAS :Fostedil enhances heart function, maintains blood flow during partial/total coronary occlusions, and lowers aortic pressure.Formule :C18H20NO3PSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :361.4
