Canal calcique
Les canaux calciques sont des protéines membranaires qui régulent le flux d'ions calcium dans et hors des cellules, ce qui est essentiel pour diverses fonctions cellulaires, y compris la contraction musculaire, la libération de neurotransmetteurs et l'expression génique. La dysrégulation de l'activité des canaux calciques est associée à des conditions telles que l'hypertension, les arythmies cardiaques et les troubles neurologiques. Chez CymitQuimica, nous proposons une large sélection de modulateurs des canaux calciques pour soutenir vos recherches en santé cardiovasculaire, neurobiologie et transduction du signal.
573 produits trouvés pour "Canal calcique"
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Flunarizine
CAS :Flunarizine is an orally administered peripheral vasodilator, a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist.Formule :C26H26F2N2Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :404.50sFTX-3.3
CAS :sFTX-3.3 is a calcium ion channel antagonist, exhibiting IC50 values of approximately 0.24 mM and 0.70 mM against P-type and N-type channels respectively.Formule :C12H29N7OCouleur et forme :SolidMasse moléculaire :287.412Lnd 796
CAS :Lnd 796 is an aminosteroid related to LND 623.Formule :C27H45NO7Couleur et forme :SolidMasse moléculaire :495.65Cyclic ADP-ribose ammonium
cADPR ammonium is a second messenger that boosts cytosolic calcium via Ryanodine receptors and TRPM2 channels.Couleur et forme :LiquidCalcium Channel antagonist 2
CAS :Calcium Channel antagonist 2 is a calcium channel antagonist (IC50=5-20 μM) that can be used to study diseases due to Ca2+ channels like pain and diabetes.Formule :C23H25FN2O4SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :444.52(R)-IDHP
CAS :(R)-IDHP, a salvia derivative, relaxes blood vessels by blocking calcium channels, aiding cardiovascular research.Formule :C12H16O5Couleur et forme :SolidMasse moléculaire :240.25CALP3
CAS :Cell-permeable CaM agonist, binds EF-hand, activates phosphodiesterase without Ca2+, inhibits Ca2+ toxicity, IC50=33μM.Formule :C44H68N10O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :881.08D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
CAS :Ins(1,4,5,6)-P4, a signal-transducing inositol oligophosphate, increases 2-14x in cells post-Salmonella infection and modulates EGF signaling.Formule :C6H12Na4O18P4Couleur et forme :SolidMasse moléculaire :588Nesiritide acetate
CAS :Nesiritide, a 32-amino acid natriuretic peptide and recombinant form of human brain natriuretic peptide, enhances vasorelaxation ex vivo in porcine hearts from an acute coronary occlusion model when given as a 2 µg/kg bolus dose followed by a 0.01 µg/kg per minute infusion, facilitated by the calcium ionophore A23187. Formulations containing nesiritide have been utilized in managing congestive heart failure.Formule :C143H244N50O42S4C2H4O2Couleur et forme :SolidMasse moléculaire :3524.1RyRs activator 5
Compound A-1 (RyRs activator 5) is an efficacious agonist of ryanodine receptors, exhibiting activity against Spodoptera frugiperda [1].Couleur et forme :Odour SolidAraguspongin B
CAS :Xestospongins and araguspongins, marine natural products originally isolated from sponges in the Pacific basin, exhibit vasodilatory effects. Inositol phosphates (IP) serve as crucial signal transduction messengers, activating IP3 receptors to facilitate Ca2+ release from intracellular stores. Araguspongin B specifically hinders the calcium-releasing function of inositol 1,4,5-trisphosphate at the receptor level within cerebral microsomes, demonstrating an inhibition concentration (IC50) of 0.6 µM. This potency places it nearly on par with xestospongin C in obstructing the IP3 receptor's activity.Formule :C28H50N2O2Couleur et forme :SolidMasse moléculaire :446.7Ethacrynic acid D5
CAS :Ethacrynic acid: a diuretic, anti-inflammatory, inhibits calcium channels, GSTs, NF-kB pathway, and modulates leukotriene; has deuterium-labeled form.Formule :C13H12Cl2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.17O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine
CAS :O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine is a major metabolite of the calcium channel inhibitor amlodipine .1Formule :C20H20ClNO7Couleur et forme :SolidMasse moléculaire :421.83Huwentoxin I
CAS :Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels and N-type calcium channels.Formule :C161H246N48O44S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3750.36ω-Conotoxin GVIA
CAS :Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.Formule :C120H182N38O43S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :30371-(aminomethyl)cyclopropanecarboxylic acid hydrochloride
CAS :1-(aminomethyl)cyclopropanecarboxylic acid hydrochloride inhibits L amino acid transporter proteins and the α2δ subunit of voltage-gated calcium channels.1-(
Formule :C5H10ClNO2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :151.59Cd1a
Cd1a, a β-toxin from the African spider Ceratogyrus darlingi, modulates calcium ion channels and inhibits human calcium ion channels (Ca v 2.2)(IC 50 2.6 μM) asCouleur et forme :Odour SolidImperatoxin A TFA
Imperatoxin A TFA, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, acts as an activator of Ca2+-release channels/ryanodine receptors (RyRs). It facilitates the influx of Ca2+ from the sarcoplasmic reticulum into the cell.Formule :C148H254N58O45S6·xC2HF3O2Couleur et forme :SolidMasse moléculaire :3758.35 (free base)Cholecystokinin-J
CAS :Cholecystokinin-J can be used in cholecystography, radiomanometry and biliary cinematography.Formule :C49H66N6O16SCouleur et forme :SolidMasse moléculaire :1027.14Ser-Ala-alloresact acetate
Ser-Ala-alloresact acetate is a sperm-activating peptide (SAP) that is released by marine invertebrate eggs and plays an important role in fertilization.Formule :C44H75N13O16S2Degré de pureté :98.52%Couleur et forme :SolidMasse moléculaire :1106.28Calcium Channel Compound Library
A unique collection of 140 calcium channel blockers and agonists for high throughput and high content screening;Couleur et forme :Odour SolidRef: TM-L7200
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderNSC156529
CAS :NSC156529 suppresses AKT1, reduces cancer cell growth in vitro, and inhibits prostate tumors in vivo.Formule :C28H21ClS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.05Katacalcin
CAS :Katacalcin (PDN 21) is a potent plasma calcium-lowering peptide[1].Formule :C97H154N34O36S2Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :2436.6PDDHV
CAS :PDDHV: a capsaicin-like vanilloid selective for rat TRPV1; induces Ca2+ uptake in neurons, EC50 of 70 nM.Formule :C49H72O11Couleur et forme :SolidMasse moléculaire :837.0917R(18S)-EpETE
CAS :17R(18S)-EpETE: Oxylipin, eicosapentaenoic acid metabolite, activates BKCa channels, has negative chronotropic effects.Formule :C20H30O3Couleur et forme :SolidMasse moléculaire :318.457ProTx-I
CAS :Selective blocker for CaV3.1 (IC50 = 0.2 μM), CaV3.2 (31.8 μM), also inhibits NaV1.8 and blocks KV2.1 channels.
Formule :C171H245N53O47S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3987.51FS-2
FS-2 is a potent, specific inhibitor of L-type CaV channels, effectively impeding high K+ or glucose-induced L-type Ca2+ influx in RIN beta cells [1].Formule :C297H462N92O86S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7018.06Myoregulin TFA
Myoregulin (MLN peptide) TFA, belonging to the regulin family, is a regulator of muscle performance through modulation of intracellular calcium dynamics.Formule :C239H391N53O67S3·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5175.17 (free base)Calcicludine
CAS :Calcicludine, a protein toxin derived from the green mamba (Dendroaspis angusticeps) venom, selectively inhibits high-voltage-activated, particularly L-type,Formule :C321H476N86O78S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6980.13ω-Conotoxin CVIF
ω-Conotoxin CVIF is a selective inhibitor of Ca v 2.2 channels, demonstrating an IC50 value of 34.3 nM in isolated rat DRG neurons.Formule :C101H170N40O33S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2665.07Elgodipine
CAS :Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.Formule :C29H33FN2O6Degré de pureté :99.84% - 99.98%Couleur et forme :SolidMasse moléculaire :524.58Flosatidil
CAS :Flosatidil is a small molecule voltage-gated calcium channel complex (VDCCs) blocker for the treatment of neurological disorders and cardiovascular diseases,Formule :C26H34F3N3O3SDegré de pureté :99.87% - 99.99%Couleur et forme :SolidMasse moléculaire :525.632-Nitrobenzoic acid
CAS :2-Nitrobenzoic acid is an anti-growth agent with an IC50 of 8.3 μM against Jurkat cells with T-type Ca²⁺ channel alpha 1H/delta 25.Formule :C7H5NO4Degré de pureté :99.97%Couleur et forme :SoildMasse moléculaire :167.12ω-Conotoxin SO3
CAS :ω-Conotoxin SO3 is an analgesic peptide that functions as an antagonist to N-type voltage-sensitive calcium channels, and can be isolated from the venom ofFormule :C100H166N36O31S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2561Calciseptin
CAS :Calciseptine, a neurotoxin isolated from the Black Mamba (Dendroaspis p.Formule :C299H468N90O87S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7036.12Nesiritide
CAS :Nesiritide, recombinant human B-type natriuretic peptide, binds NPR-A/C with Kd 7.3/13 pM.Formule :C143H244N50O42S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3464.04ω-Agatoxin TK
CAS :Selective blocker of CaV2.1 P/Q-type calcium channels.Formule :C215H337N65O70S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5273.02D-myo-Inositol-1,3-diphosphate (sodium salt)
CAS :D-myo-Inositol-1,3-phosphate (Ins(1,3)P) is an inositol phosphate involved in cellular signal transduction.
Formule :C6H12Na2O12P2Couleur et forme :SolidMasse moléculaire :384.08Ryanodine
CAS :Ryanodine: a diterpenoid modulating Ca2+ release via ryanodine receptors; concentration-dependent effects; found in Ryania speciosa; toxic.Formule :C25H35NO9Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :493.553ω-Agatoxin IVA
CAS :Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.Formule :C217H360N68O60S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5202.25(±)5(6)-DiHETE
CAS :Eicosapentaenoic acid is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils.Formule :C20H32O4Couleur et forme :SolidMasse moléculaire :336.472Ziconotide
CAS :Ziconotide: analgesic from cone snail for severe, chronic pain; synthetic ω-conotoxin.Formule :C102H172N36O32S7Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :2639.13D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)
CAS :Ins(1,3,4,5)-P4, made via Ins(1,4,5)P3 phosphorylation, boosts calcium by opening ER and plasma membrane channels.Formule :C6H8Na8O18P4Couleur et forme :SolidMasse moléculaire :675.93Lyso-Globotriaosylceramide (d18:1)
CAS :Lyso-Gb3, lacking fatty acyl, binds Stx1 with cholesterol and phosphatidylcholine, not Stx2; lowers neutrophil viability; accumulates in Fabry disease.Formule :C36H67NO17Couleur et forme :SolidMasse moléculaire :785.922Chlorocresol
CAS :Chlorocresol (4-Chloro-3-methylphenol) is an antiseptic medication.Formule :C7H7ClOCouleur et forme :SolidMasse moléculaire :142.58ω-Conotoxin MVIIC
CAS :Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.Formule :C106H178N40O32S7Degré de pureté :98%Couleur et forme :White Lyophilised SolidMasse moléculaire :2749Ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate
CAS :ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate inhibits NAD(P)H: quinone oxidoreductase 1.Formule :C12H10ClNO3Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :251.67Ins(1,4,5)-P3 hexapotassium salt
CAS :D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is promotes endoplasmic The second messenger of net calcium ions.Formule :C6H9K6O15P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :648.64Triphenylethylene
CAS :Compound PDK0283, with CAS No. 58-72-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0283 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C20H16Couleur et forme :White PowderMasse moléculaire :256.34G-Glu-Ser
CAS :G-Glu-Ser is a calcium receptor activator and Flavor-enriching agent.Formule :C8H14N2O6Couleur et forme :SolidMasse moléculaire :234.21
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