Canal calcique
Les canaux calciques sont des protéines membranaires qui régulent le flux d'ions calcium dans et hors des cellules, ce qui est essentiel pour diverses fonctions cellulaires, y compris la contraction musculaire, la libération de neurotransmetteurs et l'expression génique. La dysrégulation de l'activité des canaux calciques est associée à des conditions telles que l'hypertension, les arythmies cardiaques et les troubles neurologiques. Chez CymitQuimica, nous proposons une large sélection de modulateurs des canaux calciques pour soutenir vos recherches en santé cardiovasculaire, neurobiologie et transduction du signal.
578 produits trouvés pour "Canal calcique".
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JTV-519 Formate
JTV-519 Formate is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA).Formule :C26H34N2O4SDegré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :470.62Kurtoxin
Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca2+ channel gating inhibitor, exhibiting a dissociation constant (Kd) of 15 nM for the Cav3.1 (α1G T-type)Formule :C324H478N94O90S8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7386.36Calcium Channel antagonist 4
CAS :Calcium Channel antagonist 4 is a voltage-gated calcium channel inhibitor (IC50 : 5-20 μM).Formule :C23H26N2O4SDegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :426.53O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine
CAS :O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine is a major metabolite of the calcium channel inhibitor amlodipine .1Formule :C20H20ClNO7Couleur et forme :SolidMasse moléculaire :421.83Ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate
CAS :ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate inhibits NAD(P)H: quinone oxidoreductase 1.Formule :C12H10ClNO3Degré de pureté :99.17%Couleur et forme :White SolidMasse moléculaire :251.67Calcium Ionophore I
CAS :Calcium Ionophore I is a selective calcium ionophore. Primarily used in the fabrication of Ca2+-selective microelectrodes, it allows for the precise measurement of intracellular calcium levels in physiological and electrophysiological research.Formule :C38H72N2O8Couleur et forme :Transparent LiquidMasse moléculaire :685Cd1a
Cd1a, a β-toxin from the African spider Ceratogyrus darlingi, modulates calcium ion channels and inhibits human calcium ion channels (Ca v 2.2)(IC 50 2.6 μM) asCouleur et forme :Odour Solidω-Conotoxin MVIIC
CAS :Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.Formule :C106H178N40O32S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2749RyRs activator 5
Compound A-1 (RyRs activator 5) is an efficacious agonist of ryanodine receptors, exhibiting activity against Spodoptera frugiperda [1].Couleur et forme :Odour SolidEthacrynic acid-D5
CAS :Ethacrynic acid: a diuretic, anti-inflammatory, inhibits calcium channels, GSTs, NF-kB pathway, and modulates leukotriene; has deuterium-labeled form.Formule :C13H12Cl2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.17Katacalcin
CAS :Katacalcin (PDN 21) is a potent plasma calcium-lowering peptide[1].Formule :C97H154N34O36S2Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :2436.6ω-Agatoxin IVA
CAS :Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.Formule :C217H360N68O60S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5202.25Amlodipine aspartic acid impurity
CAS :Amlodipine aspartic acid: a calcium blocker with antihypertensive effects; contains specific impurities.Formule :C24H29ClN2O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :524.95Lyso-Globotriaosylceramide (d18:1)
CAS :Lyso-Gb3, lacking fatty acyl, binds Stx1 with cholesterol and phosphatidylcholine, not Stx2; lowers neutrophil viability; accumulates in Fabry disease.Formule :C36H67NO17Couleur et forme :SolidMasse moléculaire :785.922WU-07047
CAS :WU-07047 is a simplified analog of the selective Gαq/11 inhibitor YM-25489.Formule :C39H58N4O11Couleur et forme :SolidMasse moléculaire :758.90CALP3
CAS :Cell-permeable CaM agonist, binds EF-hand, activates phosphodiesterase without Ca2+, inhibits Ca2+ toxicity, IC50=33μM.Formule :C44H68N10O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :881.08MMK 1
CAS :Potent hFPR2 agonist; EC50: 1 nM (mFPR2), 2 nM (hFPR2), >10,000 nM (hFPR1). Induces monocyte/neutrophil migration, boosts IL-1β/IL-6, activates NADPH-oxidase.Formule :C75H123N19O18SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1610.97Caloxin 3A1
Caloxin 3A1, a biologically active peptide, is a member of the caloxins, which are inhibitors of the extracellular plasma membrane (PM) Ca2+ pumps.Formule :C83H126N22O30Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1912.02ω-conotoxin MoVIA
ω-Conotoxin MVIIA is a potent, selective inhibitor of Ca_v2.2, exhibiting an IC_50 of 0.33 μM in the SH-SY5Y fluorimetric hCa_v2.2 assay [1].Formule :C147H233N45O47S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3607.15ILS-920
CAS :ILS-920, a Rapamycin analog, has reduced immunosuppression, enhanced neuroprotection, and preferentially binds FKBP52 and L-type VGCC β1.Formule :C57H86N2O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1023.32,4,6-Tri-tert-butylphenol
CAS :Produit contrôlé2,4,6-Tri-tert-butylphenol inhibits the Ca2+ ATPase activity of human red blood cell membranes and can be used in related research in the field of life sciences.Formule :C18H30ODegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :262.44Maurocalcine TFA
Maurocalcine TFA acts as an agonist for ryanodine receptor (RyR) channels 1, 2, and 3, demonstrating cell-penetrating capabilities. It induces binding of [3H]ryanodine to RyR1 with an EC50 of 2558 nM and exhibits an apparent affinity of 14 nM for RyR2. This compound is applicable for in vivo cell tracking or other cellular imaging techniques.Formule :C156H270N56O46S6·xC2HF3O2Couleur et forme :SolidMasse moléculaire :3858.55 (free base)ω-Conotoxin GVIA
CAS :Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.Formule :C120H182N38O43S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3037TAT-CBD3A6K
CAS :TAT-CBD3A6K is a modified TAT-CBD3 peptide. It reduces T-type and R-type voltage-dependent calcium currents in dorsal root ganglion (DRG) neurons. By inhibiting CRMP-2-mediated enhancement of T-type and R-type calcium channel function, TAT-CBD3A6K exhibits anti-nociceptive effects in models of AIDS-induced peripheral neuropathy.Formule :C137H250N60O32Masse moléculaire :3249.83Cyclic ADP-ribose ammonium
cADPR ammonium is a second messenger that boosts cytosolic calcium via Ryanodine receptors and TRPM2 channels.Couleur et forme :Solidω-Tbo-IT1
ω-Tbo-IT1, a peptide toxin extracted from the venom of Tibellus oblongus, functions as an inhibitor of insect calcium channels [1].Formule :C171H285N61O53S9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4332.05Flosatidil
CAS :Flosatidil is a small molecule voltage-gated calcium channel complex (VDCCs) blocker for the treatment of neurological disorders and cardiovascular diseases,Formule :C26H34F3N3O3SDegré de pureté :99.87% - 99.99%Couleur et forme :SolidMasse moléculaire :525.63ω-Conotoxin CVIF
ω-Conotoxin CVIF is a selective inhibitor of Ca v 2.2 channels, demonstrating an IC50 value of 34.3 nM in isolated rat DRG neurons.Formule :C101H170N40O33S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2665.07Nurr1 Agonist 14
Nurr1 Agonist 14 (Compound 32) is a Nurr1 agonist with an EC50 of 0.09 μM for Nurr1. It exhibits significant neuroprotective activity without being hindered by residual DHODH inhibition. This compound can upregulate neuroprotective genes in dopaminergic neurons, such as SOD2, SESN3, BIRC5, XIAP, FLRT2, and CRMP4. Nurr1 Agonist 14 is useful for studying neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS).SNX-482
CAS :Potent CaV2.3 calcium channel blocker, selective, voltage-dependent, with 30 nM IC50. Offers antinociceptive effects on C and Aδ fibres.Formule :C192H274N52O60S7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4495.01ω-Conotoxin SO3
CAS :ω-Conotoxin SO3 is an analgesic peptide that functions as an antagonist to N-type voltage-sensitive calcium channels, and can be isolated from the venom ofFormule :C100H166N36O31S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2561Ins(1,4,5)-P3 hexapotassium salt
CAS :D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is promotes endoplasmic The second messenger of net calcium ions.Formule :C6H9K6O15P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :648.64Mipsagargin
CAS :Mipsagargin (G-202) is a new antibiotic that inhibits DNA biosynthesis.Formule :C66H100N6O27Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1409.52Calcicludine
CAS :Calcicludine, a protein toxin derived from the green mamba (Dendroaspis angusticeps) venom, selectively inhibits high-voltage-activated, particularly L-type,Formule :C321H476N86O78S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6980.132-Nitrobenzoic acid
CAS :2-Nitrobenzoic acid is an anti-growth agent with an IC50 of 8.3 μM against Jurkat cells with T-type Ca²⁺ channel alpha 1H/delta 25.Formule :C7H5NO4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :167.12Selcopintide acetate
Selcopintide acetate (Cpne7-DP), a synthetic peptide, mirrors the 344-353 amino acid sequence of the hCPNE7 protein.Formule :C64H109N21O17Masse moléculaire :1444.68ω-Conotoxin Bu8
ω-Conotoxin Bu8 is a 25-amino-acid-residue ω-conotoxin that features three disulfide bridges.Formule :C103H174N42O35S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2753.13Myoregulin TFA
Myoregulin (MLN peptide) TFA, belonging to the regulin family, is a regulator of muscle performance through modulation of intracellular calcium dynamics.Formule :C239H391N53O67S3·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5175.17 (free base)FS-2
FS-2 is a potent, specific inhibitor of L-type CaV channels, effectively impeding high K+ or glucose-induced L-type Ca2+ influx in RIN beta cells [1].Formule :C297H462N92O86S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7018.06Levamlodipine besylate Hemipentahydrate
CAS :Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.Formule :C20H25ClN2O5·C6H6O3SH2OCouleur et forme :SolidMasse moléculaire :1224.18G-Glu-Ser
CAS :G-Glu-Ser is a calcium receptor activator and Flavor-enriching agent.Formule :C8H14N2O6Couleur et forme :SolidMasse moléculaire :234.21D-myo-Inositol-1,3-diphosphate (sodium salt)
CAS :D-myo-Inositol-1,3-phosphate (Ins(1,3)P) is an inositol phosphate involved in cellular signal transduction.Formule :C6H12Na2O12P2Couleur et forme :SolidMasse moléculaire :384.08L-Phenylalanine-13C6
CAS :L-Phenylalanine-13C6 is a carbon-13 labeled version of L-Phenylalanine. L-Phenylalanine (T3377) ( (S)-2-Amino-3-phenylpropionic acid) is an essential amino acid derived from Escherichia coli. It acts as a voltage-dependent α2δ subunit Ca2+ channel antagonist with a Ki of 980 nM. Additionally, it is a competitive antagonist at the glycine and glutamate binding sites of NMDARs (KB 573 μM) and non-NMDARs. L-Phenylalanine (T3377) is extensively utilized in the production of food flavors and pharmaceuticals.Formule :C9H11NO2Couleur et forme :SolidMasse moléculaire :171.15Chlorocresol
CAS :Chlorocresol is a pharmaceutical preservative that activates the Ca²⁺ channel of the Ry1 receptor.Formule :C7H7ClODegré de pureté :99.10%Couleur et forme :White SolidMasse moléculaire :142.58Nesiritide
CAS :Nesiritide, recombinant human B-type natriuretic peptide, binds NPR-A/C with Kd 7.3/13 pM.Formule :C143H244N50O42S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3464.04(±)5(6)-DiHETE
CAS :Eicosapentaenoic acid is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils.Formule :C20H32O4Couleur et forme :SolidMasse moléculaire :336.472Mast cell degranulating peptide (28-49)
CAS :Mast cell degranulating peptide (28-49) is a bee venom depolarizer that can improve the cGMP content of cerebellum tablets in mice.Formule :C110H196N40O24S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2591.25ω-Agatoxin TK
CAS :Selective blocker of CaV2.1 P/Q-type calcium channels.Formule :C215H337N65O70S10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5273.02Sarafotoxin S6d
CAS :Sarafotoxin S6d (STX-b) is a peptide toxin isolated from the venom of the Israeli burrowing asp. It induces various Electrocardiogram (ECG) changes such as myocardial ischemia and hyperkalemia. In rat aortas, Sarafotoxin S6d causes intense vasoconstriction dependent on extracellular calcium ions and exhibits positive inotropic effects in rat atria. This compound is useful for research into cardiovascular diseases.Formule :C112H163N27O34S5Masse moléculaire :2591.98Ziconotide
CAS :Ziconotide: analgesic from cone snail for severe, chronic pain; synthetic ω-conotoxin.Formule :C102H172N36O32S7Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :2639.13
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